Perspectives in nephrology and hypertension最新文献_第3页

A prospective study of factors affecting intrauterine growth (with an emphasis on blood pressure and diuretics). 影响宫内生长因素的前瞻性研究(重点是血压和利尿剂)。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

I MacGillivray, D M Campbell

引用次数: 0

Normal development and experimental models of cystic renal disease. 囊性肾病的正常发育及实验模型。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

J S Resnick, D M Brown, R L Vernier

{"title":"Normal development and experimental models of cystic renal disease.","authors":"J S Resnick, D M Brown, R L Vernier","doi":"","DOIUrl":"","url":null,"abstract":"From a review of renal development and experimental cystic disease, the following observations can be made: 1. The previous theories developed to explain cystic renal disease (nonunion, failure of regression, and obstruction to urine flow) do not adequately fit with the numerous recent observations made in studies of most experimental models or in human renal cystic disease. 2. The most acceptable theory to date for most types of renal cystic abnormalities (except those due to known obstruction of urine flow) is that abnormalities of the tubular supporting wall occur, probably as a result of toxic or metabolic injury to the tubular cells of the wall and the related interstitial tissues, which are exposed to the highest concentrations of these compounds. This theory would also help explain the etiology of cystic renal diseases in man and should lead to attempts to isolate toxic factors or enzyme abnormalities in susceptible families and in early cases. 3. Induction of cystic abnormalities through a variety of experimental manipulations and drugs reveals impressive strain, sex, and species variability, and these differences should be more carefully examined. 4. The same chemical that induces a cystic change in the mature, fully developed kidney may cause changes which are quite different (location, severity, etc.) in both the fetal and newborn kidney, in which continual nephrogenesis is occurring. 5. Many of the previous explanations of cystic changes require careful reinterpretation of the findings (to reconcile certain differences), and confirmatory studies should be performed to help piece together some of the puzzling observations noted, such as the cystic changes seen with adrenocorticosteroids, and their relationship to potassium depletion.","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"4 ","pages":"221-41"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12440769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The morphology of renal cystic disease. 肾囊性疾病的形态学。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

J M Kissane

引用次数: 0

The clearance rate of maternal plasma prehormones of placental estrogen formation. 母体血浆胎盘雌激素形成前激素清除率。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

N F Gant, R J Worley, P C MacDonald

{"title":"The clearance rate of maternal plasma prehormones of placental estrogen formation.","authors":"N F Gant, R J Worley, P C MacDonald","doi":"","DOIUrl":"","url":null,"abstract":"A method has been established for the determination of the placental clearance of maternal plasma prehormones by placental estrogen formation during human pregnancy. Utilizing this concept, the placental clearance is calculated as the product of the metabolic clearance rate from maternal plasma of the prehormone and its fractional conversion to estrogen by the placenta. This value equals the volume of maternal plasma cleared of that prehormone by the irreversible formation of its estrogenic product hormone per unit of time. The placental clearance rate technique can be performed by intravenous infusion of isotope-labeled prehormone and product, and the metabolic clearance rate as well as the transfer constant can be measured by techniques employing plasma values or by a combination of plasma and urinary methods. Utilizing this type of study, the placental clearance of plasma prehormones has been observed to be increased initially in women destined to develop pregnancy-induced hypertension but declines prior to the onset of hypertension and continues to decline until delivery is effected. Moreover, the administration of diuretics and/or the institution oental clearance of plasma prehormones from the maternal compartment in normal gravidas, in those destined to develop pregnancy-induced hypertension, and in gravidas who are hypertensive from any cause.","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"5 ","pages":"309-14"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11355749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cystic diseases of the kidney in children. 儿童肾囊性疾病

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

B H Landing, J L Gwinn, E Lieberman

引用次数: 0

Sequential changes in the renin--angiotensin--aldosterone systems and plasma progesterone concentration in normal and abnormal human pregnancy. 正常和异常妊娠中肾素-血管紧张素-醛固酮系统和血浆孕酮浓度的顺序变化。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

M H Weinberger, N J Kramer, L P Petersen, R E Cleary, P C Young

{"title":"Sequential changes in the renin--angiotensin--aldosterone systems and plasma progesterone concentration in normal and abnormal human pregnancy.","authors":"M H Weinberger, N J Kramer, L P Petersen, R E Cleary, P C Young","doi":"","DOIUrl":"","url":null,"abstract":"To investigate the role of components of the renin-angiotensin-aldosterone system and plasma progesterone concentrations in the pathophysiology of hypertension in pregnancy, sequential measurements were made throughout pregnancy in 45 normotensive subjects, 41 other pregnant patients in whom hypertension became manifest only during pregnancy and 26 patients with chronic hypertension antedating pregnancy. Among the normotensive subjects plasma renin activity and substrate, plasma aldosterone and progesterone concentrations were elevated as early as the sixth week of gestation. While consistent, progressive, further increases were noted in renin substrate, aldosterone and pregesterone concentrations during pregnancy, plasma renin activity did not continue to rise. In both hypertensive groups, plasma renin activity and aldosterone concentration were significantly suppressed during the last trimester despite levels of renin substrate and progesterone that were not significantly different than those observed in normotensive pregnancy. These observations confirm earlier studies reporting suppression near term of plasma renin activity in toxemia and indicate from these prospective observations that they are secondary effects. These studies, in addition, demonstrate parallel suppression of plasma aldosterone concentration in toxemia. The current report also indicates that this suppression is not due to a decrease in renin substrate concentration and that a hypothesized deficiency of plasma progesterone, which was not observed in the hypertensive subjects, does not play a permissive role in the development of hypertension.","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"5 ","pages":"263-9"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12188297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal cystic disease: radiologic appearance. 肾囊性疾病:影像学表现。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

L F Greene, D M Barrett

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Variability of blood pressure in normal and abnormal pregnancy. 正常妊娠和异常妊娠期间血压的变化。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

C W Redman, L J Beilin, J Bonnar

引用次数: 0

Disseminated intravascular coagulation and experimental disease models in pregnancy. 妊娠期弥散性血管内凝血和实验性疾病模型。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

D G McKay

引用次数: 0

Studies of the renin-angiotension-aldosterone system, cortisol, DOC, and ADH in normal and hypertensive pregnancy. 正常妊娠和高血压妊娠中肾素-血管紧张-醛固酮系统、皮质醇、DOC和ADH的研究。

Perspectives in nephrology and hypertension Pub Date : 1976-01-01

R J Weir, A Doig, R Fraser, J J Morton, J Parboosingh, J I Robertson, A Wilson

{"title":"Studies of the renin-angiotension-aldosterone system, cortisol, DOC, and ADH in normal and hypertensive pregnancy.","authors":"R J Weir, A Doig, R Fraser, J J Morton, J Parboosingh, J I Robertson, A Wilson","doi":"","DOIUrl":"","url":null,"abstract":"Compared with a group of normal pregnant women, matched for age, parity, posture, and length of gestation, women with hypertension and proteinuria in the last trimester had significantly lower plasma concentrations of renin, renin substrate and angiotensin II. Plasma aldosterone and DOC concentrations were also lower in the hypertensive group. The plasma levels of cortisol, corticosterone, and ADH showed no significant difference. Plasma renin concentration was raised throughout normal pregnancy, and part of this increase appeared to be due to the presence of an inactive form of renin. Plasma concentrations of renin substrate, angiotensin II, and aldosterone were also raised in normal pregnant women, but concurrent measurement of these substances showed no significant relationship between them, renin, and plasma electrolytes in mid- or late gestation. A study of five women in the weeks immediately after conception showed increases in plasma angiotensin II and aldosterone concentrations, which were significantly related at this very early stage of pregnancy. Total 24-hour urinary sodium increased gradually from about two weeks after gestation to the end of the study five weeks later. This increase was due mainly to a rise in overnight sodium excretion, with a fall in the day/night ratio. No relationship was found between plasma angiotension II or aldosterone concentrations and day, night, or total 24 hour sodium excretion.","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"5 ","pages":"251-61"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12188296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0