{"title":"Heparin treatment in severe preeclampsia and glomerulonephritis in pregnancy.","authors":"K F Fairley, F D Adey, I C Ross, P Kincaid-Smith","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thirty patients have been treated with heparin during pregnancy or in the immediate postpartum period. Twenty had severe preclamptic toxemia. Five presented before 30 weeks and in addition had low estriol levels and high blood ureas. The chance of a successful pregnancy in such patients is very low indeed; however 3 of these 5 patients had living babies. Even in patients presenting after 30 weeks of gestation, if severe preeclampsia is accompanied by low estriol levels and high blood urea levels, the anticipated fetal survival is poor. However, all 5 patients in this group were treated with heparin and had living babies. In the small group of patients with glomerulonephritis, there was a suggestion that heparin treatment may have been of value. Biopsy studies suggested that heparin may help to prevent lesions in arteries and arterioles which have been noted to develop in association with preeclamptic toxemia. In four patients treated in the postpartum period, there was possible benefit in terms of renal function, intravascular coagulation, vessel lesions, and subsequent successful pregnancies.</p>","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"5 ","pages":"103-12"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12184647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pregnancy, outcome as related to hypertension, edema, and proteinuria.","authors":"E A Friedman, R K Neff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clinical variables of blood pressure, proteinuria, edema, and maternal weight have been studied extensively, with particular reference to associated adverse fetal and infant outcomes. The levels of these variables, as well as their relative patterns of change with advancing pregnancy, were investigated by several analytic methods. It was determined that diastolic blood pressure and proteinuria, alone and in combination, profect on fetal and infant outcomes to enable us to create an empirical classification of gravidas whose fetuses were probably at risk. The results must be considered preliminary in view of the fact that the work is still in progress.</p>","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"5 ","pages":"13-22"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12184649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Weight gain in pregnancy.","authors":"F E Hytten, A M Thomson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"5 ","pages":"179-87"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12188291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The properties and possible role of renin-like enzymes in the uterus and amniotic gluid.","authors":"O A Carretero","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"5 ","pages":"293-306"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12188300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Extrarenal manifestations of cystic kidney disease.","authors":"M Hartnett, W Bennett","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cystic disorders of the kidney may manifest their presence not only through renal but also through systemic signs and symptoms. Extrarenal manifestations include cerebral aneurysms, hepatic cysts, hepatic fibrosis, polycythemia, and retinal changes. Awareness of such associations strengthens the likelihood that renal cystic disease will be detected in its earlier stages. Involvement of organs other than the kidneys takes on added significance as the lives of affected individuals are prolonged through dialysis and renal transplantation.</p>","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"4 ","pages":"201-19"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12440768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lipid and lipoprotein abnormalities in renal disease.","authors":"R Segura, A M Gotto","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"3 ","pages":"159-200"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12001400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L Speroff, R V Haning, E J Ewaschuk, S L alberino, F X Kieliszek
{"title":"Uterine artery blood flow studies in the pregnant monkey.","authors":"L Speroff, R V Haning, E J Ewaschuk, S L alberino, F X Kieliszek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Studies were performed in anesthetized monkeys in the third trimester of pregnancy, with continuous monitoring of maternal blood pressure and uterine artery blood flow by electromagnetic flow probe and with measurement of prostaglandin levels in uterine vein samples. Acute elevation of the systemic blood pressure by intravenous infusion of angiotensin II was associated with increased uterine artery blood flow and an increase in the levels of prostaglandin E measured in the uterine vein. An increase in PGE levels was also observed following the discontinuation of the angiotensin II infusion, when blood pressure and uterine artery blood flow returned to baseline levels. Intravenous administration of indomethacin was associated with a slight rise in maternal blood pressure. The changes in uterine artery blood flow following indomethacin treatment were variable, perhaps reflecting the stresses of surgery and anesthesia. In single experiments, intravenous diazoxide produced a profound hypotension, and intravenous furosemide induced a prompt and marked diuresis, associated with a very marked fall in uterine artery blood flow.</p>","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"5 ","pages":"315-27"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12013444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of the renin-angiotensin system, aldosterone, and cortisol in mother and fetus at term.","authors":"M B Vallotton, C Godard, R Gaillard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"5 ","pages":"281-6"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12188298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Renal injury in mu.","authors":"J P Knochel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"3 ","pages":"129-40"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11963571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The kidney in progressive systemic sclerosis (scleroderma).","authors":"C C Dichoso","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76319,"journal":{"name":"Perspectives in nephrology and hypertension","volume":"3 ","pages":"57-74"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11963574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}