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Pathologia Europaea最新文献

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Effects of the diazafluoranthen derivative AC-3579 (NSC-170561), a new experimental antitumour drug, on rat hepatoma. 新型实验性抗肿瘤药物重氟蒽醌衍生物AC-3579 (NSC-170561)对大鼠肝癌的作用。
Pathologia Europaea Pub Date : 1975-01-01
O Thys, J Hildebrand, Y Gerin
{"title":"Effects of the diazafluoranthen derivative AC-3579 (NSC-170561), a new experimental antitumour drug, on rat hepatoma.","authors":"O Thys,&nbsp;J Hildebrand,&nbsp;Y Gerin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of AC-3579 (NSC-170561), a new experimental antitumour drug which depresses phospholipid catabolism in liver, were compared in rat aflatoxin-induced hepatoma and in non-neoplastic hepatocytes surrounding the tumour. Ultrastructural lesions, characterized by the hypertrophy of the smooth endoplasmic reticulum and the presence of lamellate cytosomes appeared in both tissues. They were less marked in hepatoma than in non-neoplastic cells. As in control livers, they were related to an invrease in pohspholipid concentration due to the decrease of phospholipid breakdown. In addition, chemical analysis demonstrated differences between hepatoma, non-neoplastic aflatoxin-treated liver and control liver: total and free cholesterol were decreased, relative concentration of sphingomyelin increased and that of phosphatidylethanolamine decreased by about 50%, in both hepatoma and non-neoplastic liver. Phospholipid concentration was decreased by 50% in tumour cells. After AC-3579 treatment total cholesterol was increased 3.2 fold in non-neoplastic liver and 2.5 fold in hepatoma but not in control liver.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 4","pages":"251-62"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11392175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phaeochromocytoma, Electron microscopic study on catecholamine storage. 嗜铬细胞瘤，儿茶酚胺储存的电镜研究。
Pathologia Europaea Pub Date : 1975-01-01
T Wrzolkowa, M Mrozowicz, A Lewiński, J Pryczkowski
{"title":"Phaeochromocytoma, Electron microscopic study on catecholamine storage.","authors":"T Wrzolkowa,&nbsp;M Mrozowicz,&nbsp;A Lewiński,&nbsp;J Pryczkowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The biochemical and electron-microscopical findings of eight cases of phaeochromocytoma and the ultrastructure of two cases of human adrenal medulla are presented here as regards catecholamine storage. Due to the rarity of phaeochromocytoma, other ultrastructural features are also described. The morphological characteristics of catecholamine-containing granules are considered on the basis of our investigations and results of other authors. These characteristics are discussed from the point of view of their value in the morphological differentiating of granules storing norepinephrine and those storing epinephrine.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 3","pages":"179-91"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12364338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alteration of metastases distribution by vaso-dilating drugs. 血管扩张药物对转移分布的改变。
Pathologia Europaea Pub Date : 1975-01-01
B Boeryd, B Hagmar, G Johnsson, W Ryd
{"title":"Alteration of metastases distribution by vaso-dilating drugs.","authors":"B Boeryd,&nbsp;B Hagmar,&nbsp;G Johnsson,&nbsp;W Ryd","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of the two vasodilating substances, dihydralazine and the adrenergic alpha-receptor blocker phenoxybenzamine, were studied on the distribution and growth of MCG-L-SS metastases from intravenously injected tumour cells. Dihydralazine increased the total number of metastases in the body and both drugs increased the number in the lungs and the liver. Both drugs also increased the total metastasis volume in the liver. The effects might be secondary to the haemodynamic effects of the drugs, e.g. a changed distribution of the blood flow, more open capillaries and/or a changed hydrostatic capillary pressure.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 3","pages":"197-201"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12364340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of temporary hypoxia on the permeability of the rat aorta. 暂时性缺氧对大鼠主动脉通透性的影响。
Pathologia Europaea Pub Date : 1975-01-01
G Elemér, T Kerényi, H Jellinek
{"title":"Effect of temporary hypoxia on the permeability of the rat aorta.","authors":"G Elemér,&nbsp;T Kerényi,&nbsp;H Jellinek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hypoxia was produced experimentally in the infrarenal portion of rat abdominal aorta by ligating it at both ends for one hour. Permeability changes of the injured segment were followed up by means of a colloidal iron tracer after different periods of recirculation. The tracer could be demonstrated in intercellular junctions and subendothelial space already after one hour of recirculation. The permeability disorder was at its peak two days after the injury and it ceased by the tenth day. Insudation of the media by plasma increased proportionally with the endothelial permeability change and it was accompanied by marked ultrastructural alterations.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 2","pages":"123-8"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12364565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concentric laminated bodies in muscle pathology. 肌肉病理中的同心层压体。
Pathologia Europaea Pub Date : 1974-01-01
D Gambarelli, J Hassoun, J F Pellissier, M Berard, M Toga
{"title":"Concentric laminated bodies in muscle pathology.","authors":"D Gambarelli,&nbsp;J Hassoun,&nbsp;J F Pellissier,&nbsp;M Berard,&nbsp;M Toga","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Concentric laminated bodies are described in five cases (one case previously reported and four new ones) of various muscle diseases. A general review of previous reports on these structures is made. They appear to be unspecific bodies generally noticed in abnormal skeletal muscle in various disorders; nevertheless they were found in normal muscle fibres of the mothers of children affected by myopathy. They have a complex filamentous structure. According to the authors, their myofilamentous nature is uncertain but seems more probable than a mitochondrial or lipidic one.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"9 4","pages":"289-96"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15558872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modifications of surface coat of aortic endothelial cells in hyperlipemic rats. 高脂血症大鼠主动脉内皮细胞表面涂层的修饰。
Pathologia Europaea Pub Date : 1974-01-01
A Bálint, B Veress, H Jellinek
{"title":"Modifications of surface coat of aortic endothelial cells in hyperlipemic rats.","authors":"A Bálint,&nbsp;B Veress,&nbsp;H Jellinek","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"9 2","pages":"105-8"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15252800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACTH accelerates the formation of cytoplasmic vacuoles in the adrenal cortex of androgen-treated rats. 促肾上腺皮质激素可促进雄激素治疗大鼠肾上腺皮质细胞质空泡的形成。
Pathologia Europaea Pub Date : 1974-01-01
P A Nickerson
{"title":"ACTH accelerates the formation of cytoplasmic vacuoles in the adrenal cortex of androgen-treated rats.","authors":"P A Nickerson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of simultaneous injections of ACTH and methylandrostenediol (MAD), a synthetic androgen, has been studied in the rat. ACTH accelerated the production of cytoplasmic vacuoles by MAD in as much as no such structures were observed in MAD-treated animals at 4 weeks. Adrenal weight was decreased in MAD-treated animals but restored to that of controls by ACTH (MAD plus ACTH group). ACTH by itself did not, however, cause the production of any vacuolar structures nor did it cause any reparation in the number of mitochondrial cristae which were considerably reduced in numbers after MAD plus ACTH.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"9 4","pages":"325-31"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15482409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ganglioside pattern in the brain during experimental allergic encephalomyelitis. 实验性变应性脑脊髓炎时脑内神经节苷脂的分布。
Pathologia Europaea Pub Date : 1974-01-01
M Wender, Z Adamczewska, A Goncerzewicz
{"title":"Ganglioside pattern in the brain during experimental allergic encephalomyelitis.","authors":"M Wender,&nbsp;Z Adamczewska,&nbsp;A Goncerzewicz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"9 1","pages":"25-9"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15523831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thombelastographic and platelet changes induced by chlorpromazine. 氯丙嗪引起的层析图和血小板改变。
Pathologia Europaea Pub Date : 1974-01-01
S Hărăguş, G Uza, I Crîsnic, M Cucuianu
{"title":"Thombelastographic and platelet changes induced by chlorpromazine.","authors":"S Hărăguş,&nbsp;G Uza,&nbsp;I Crîsnic,&nbsp;M Cucuianu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"9 2","pages":"147-50"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15539846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunopathology and microvascular lesions in human sympathetic ganglia. 人类交感神经节的免疫病理和微血管病变。
Pathologia Europaea Pub Date : 1974-01-01
R Scelsi, L Gaspa, L Mosca
{"title":"Immunopathology and microvascular lesions in human sympathetic ganglia.","authors":"R Scelsi,&nbsp;L Gaspa,&nbsp;L Mosca","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lumbar sympathetic ganglia surgically removed from adult patients affected by obstructive peripheral arteriopathies are investigated with traditional histology and fluorescent antibody technique. The presence of various pictures of microangiopathy is confirmed, mainly haemodynamic (hyaline-oedematous perivascular thickening) phenomena. Since specific fluorescence is absent from any lesion, the autoimmune pathogenic hypothesis may be discarded.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"9 4","pages":"259-61"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15715219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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