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[Free and esterified cholesterol of the skin in atherogenic hyperlipidemias]. [动脉粥样硬化性高脂血症中皮肤游离胆固醇和酯化胆固醇]。
Paroi arterielle Pub Date : 1981-01-01
A A Melico-Sylvestre, B Jacotot, J C Buxtorf, V Beaumont, J L Beaumont
{"title":"[Free and esterified cholesterol of the skin in atherogenic hyperlipidemias].","authors":"A A Melico-Sylvestre,&nbsp;B Jacotot,&nbsp;J C Buxtorf,&nbsp;V Beaumont,&nbsp;J L Beaumont","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Skin free and esterified cholesterol were assayed using gaseous chromatography following plaque histochromatography separation in 20 control, 36 patients with Type II a hyperlipoproteinemia, 27 with Type II b hyperlipoproteinemia and 19 with Type IV hyperlipoproteinemia. Skin esterified cholesterol was higher in females with Type II a hyperlipoproteinemia without or with xanthomatosis. But the skin esterified cholesterol level was not correlated with skin free cholesterol nor with blood total cholesterol levels, while in males these parameters were well correlated. On the other hand skin cholesterol was assayed in 15 patients with Type II hypercholesterolemia before and after a 6-month treatment with Probucol: there was 10p. 100 reduction of cholesterol level, and a weak decrease in skin free-cholesterol; in contrast, skin esterified cholesterol increased significantly as well as the skin esterified cholesterol/skin total cholesterol ratio (EC/TC). These data suggest a connection between weak vascular risk and skin esterified cholesterol high level (or high EC/TC in skin).</p>","PeriodicalId":76306,"journal":{"name":"Paroi arterielle","volume":"7 2","pages":"59-65"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18333879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional characteristics of the endothelium on the dynamics of experimental atherosclerosis. 内皮细胞功能特征对实验性动脉粥样硬化动态的影响。
Paroi arterielle Pub Date : 1981-01-01
A N Klimov, V A Nagornev, T N Lovyagina
{"title":"Functional characteristics of the endothelium on the dynamics of experimental atherosclerosis.","authors":"A N Klimov,&nbsp;V A Nagornev,&nbsp;T N Lovyagina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aortic endothelium of rabbits, fed an atherogenic diet, has been studied by electron microscopy and by analysis of the distribution of intravenously injected, labeled, LDL and VLDL in plasma and aortic wall. It has been proposed that, in experimental hypercholesterolemia, when the receptor mechanism of lipoprotein uptake is saturated, a receptor-independent endocytosis plays the main role in the uptake of lipoproteins particles by endothelial cells. It has been established that, during the early stages of experimental hypercholesterolemia and atherosclerosis, there was an increase in the number of vesicles of 100-250 A in diameter, even up to 750 A, in the endothelial cells. Thus, it seems probable that there is transendothelial passage, not only of LDL, but also of particles like VLDL. Furthermore, the electron microscopy data have shown the possible formation of transedothelial canals by fusion of 3-4 vesicles. As hypercholesterolemia and atherosclerosis increase, the transport of lipoproteins occurs mostly through intercellular spaces and impaired endothelial regions. The intravenous administration to rabbits of LDL and VLDL, labeled with 14C-palmitic acid in their outer shell (phospholipids) and core (triglycerides + esters of cholesterol), has revealed a preferential penetration of small lipoprotein particles and of phospholipid-rich triglyceride-poor residues, both in normal and atherosclerotic aortas.</p>","PeriodicalId":76306,"journal":{"name":"Paroi arterielle","volume":"7 2","pages":"47-57"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18335088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Appearance of grossly-visible aortic sclerosis in breeder rats: reconfirmation and up-date, 1957-1981. 繁殖大鼠明显可见的主动脉硬化的出现:重新确认和更新，1957-1981。
Paroi arterielle Pub Date : 1981-01-01
B C Wexler
{"title":"Appearance of grossly-visible aortic sclerosis in breeder rats: reconfirmation and up-date, 1957-1981.","authors":"B C Wexler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Multiparous Sprague-Dawley rats were killed at 7, 14, and 21 days of gestation, at parturition, after 7, 14 and 21 days of lactation, and at 7 and 14 days post-weaning of their fourth reproductive cycle. Grossly visible aortic sclerosis appeared and became progressively more severe during gestation, parturition, and early lactation. Although some of the female breeders had no detectable, grossly-visible aortic sclerosis, all of the 4-time breeders had microscopic aortic sclerosis. Progressive deterioration of the aortic elastic tissue and ground substance was particularly prevalent during the gestation and lactation phases. Calcification and cartilaginous metaplasia appeared during the post-weaning phase. Virgin control rats, equal in age to the 4-time breeders, were completely free of arterial disease. It is believed that abnormal activity of the hypothalamic-pituitary-adrenal axis in association with repeated breeding conditions these animals toward premature arteriosclerosis.</p>","PeriodicalId":76306,"journal":{"name":"Paroi arterielle","volume":"7 4","pages":"143-53"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18361098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma thromboxane B2 levels and atherosclerotic disorders. 血浆血栓素B2水平与动脉粥样硬化性疾病。
Paroi arterielle Pub Date : 1981-01-01
F Numano, K Omori, K Nishiyama, Y Kishi, K Shimokado, F Numano, M Yajima, H Maezawa
{"title":"Plasma thromboxane B2 levels and atherosclerotic disorders.","authors":"F Numano,&nbsp;K Omori,&nbsp;K Nishiyama,&nbsp;Y Kishi,&nbsp;K Shimokado,&nbsp;F Numano,&nbsp;M Yajima,&nbsp;H Maezawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In our ongoing studies of the interrelationship between platelets and the vascular wall we found that an accurate estimate could be made of the clinical condition and more effective therapy prescribed when we monitored alterations in the plasma levels of TXB2. For this purpose we devised a radioimmunoassay with I125-TXB2-Tyramide. Patients with ischemic heart disorders, cerebral apoplexy, diabetes mellitus, Buerger's disease, Takayasu disease etc., all had statistically high levels of TXB2 as compared with healthy controls. In particular, patients with myocardial infarction, cerebral thrombosis and/or hemorrhage all revealed increases in levels of TXB2 and these levels increased in parallel with a worsening of the clinical condition, and there was always a re-increase in TXB2 level before a recurrence of an attack. As plasma TXB2 levels clearly reflect thrombogenic disorders, the assessment of these levels on a routine basis, enables a more accurate diagnosis, an indication of possible recurrences, and more effective chemotherapy and rehabilitation.</p>","PeriodicalId":76306,"journal":{"name":"Paroi arterielle","volume":"7 3","pages":"99-105"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17187931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accessibility of epsilon-amino groups of lysine to guanidination in kappa-elastin from bovine ligamentum nuchae. 牛颈韧带弹性蛋白中赖氨酸ε -氨基对胍化的可及性。
Paroi arterielle Pub Date : 1981-01-01
K Han, M Davril, M Moczar, E Moczar
{"title":"Accessibility of epsilon-amino groups of lysine to guanidination in kappa-elastin from bovine ligamentum nuchae.","authors":"K Han,&nbsp;M Davril,&nbsp;M Moczar,&nbsp;E Moczar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Kappa-Elastin contains 3.81 lysyl residues per 1000 residues of amino acids. Among these residues, free epsilon-amino groups represent about 16 p. 100, as revealed by guanidination, the buried lysyl residues (buried epsilon-amino groups) represent about 33 p. 100, as revealed by dansylation. After drastic reduction by borohydride, no aldimine bonds were detected and only 6 p. 100 of \"deeply buried\" amino groups of lysyl residues were detected by a second dansylation. The remaining lysines (about 46 p. 100) are engaged or inaccessible.</p>","PeriodicalId":76306,"journal":{"name":"Paroi arterielle","volume":"7 1","pages":"37-40"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17855129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoradiographic studies of the smooth muscle cells in human arteries. 人体动脉平滑肌细胞的放射自显影研究。
Paroi arterielle Pub Date : 1981-01-01
L G Spagnoli, S Villaschi, L Neri, G Palmieri, M Taurino, V Faraglia, P Fiorani
{"title":"Autoradiographic studies of the smooth muscle cells in human arteries.","authors":"L G Spagnoli,&nbsp;S Villaschi,&nbsp;L Neri,&nbsp;G Palmieri,&nbsp;M Taurino,&nbsp;V Faraglia,&nbsp;P Fiorani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have studied the kinetics of smooth muscle cell growth in the tunica media of human arteries obtained from 12 patients affected by obstructive vascular disease, and one case operated because of a trauma. The studies were carried out on arterial samples by autoradiography after in vitro labelling with 3H-thymidine. Different patterns of radioactive nucleotide uptake were detected. On nine elastic and muscular arteries without pathological changes it was demonstrated that the turnover of smooth muscle cells in human medias was very low, and similar to that found in experimental animals. The medias under atherosclerotic plaques showed variable levels of tritium uptake. Although the number of cases surveyed was limited, a possible explanation is that the different levels of uptake could depend on the different evolutive stages of the atherosclerotic process. It cannot, however, be excluded that the proliferative activity of the smooth muscle cells may be related to focal damages of the tunica media.</p>","PeriodicalId":76306,"journal":{"name":"Paroi arterielle","volume":"7 3","pages":"107-12"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18351327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Changes in serum lipid levels, lipid composition and lipoprotein fractions in patients with ischemic cardiopathies or arterial hypertension]. [缺血性心脏病或动脉性高血压患者血脂水平、血脂组成及脂蛋白含量的变化]。
Paroi arterielle Pub Date : 1981-01-01
L Dakovska, M Orbetzov, V Orbetzova, N Yarovska
{"title":"[Changes in serum lipid levels, lipid composition and lipoprotein fractions in patients with ischemic cardiopathies or arterial hypertension].","authors":"L Dakovska,&nbsp;M Orbetzov,&nbsp;V Orbetzova,&nbsp;N Yarovska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Total cholesterol and triglycerides as well as their distribution among the different hyperlipoproteinemia types were studied in three patients groups: 47 normotensive patients with myocardial infarction, 35 normotensive patients with cardiosclerosis (chronic ischemic heart disease), 29 hypertensive patients without symptoms or signs of clinical atherosclerosis. Their results were compared to those of 45 normal controls. There was no decrease in HDL cholesterol nor increase in LDL cholesterol in patients with chronic or acute ischemic heart disease. A large percentage of patients from these groups had normolipoproteinemia. The most prominent lipidic changes were observed in hypertensive patients: no patient had a HDL cholesterol level above normal values, thirty three per cent had a HDL cholesterol level below 35 mg/dl. A high percentage of patients with acute myocardial infarction or hypertension exhibited atypical lipoproteinemia anomalies (hyper HDL triglyceridemia, hyper LDL triglyceridemia, hyper VLDL cholesterolemia) when they could have normolipoproteinemia. This suggested lipoproteinic metabolism disturbances in such cases.</p>","PeriodicalId":76306,"journal":{"name":"Paroi arterielle","volume":"7 1","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18351323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Glycoconjugate biosynthesis in the arterial wall. VIII. Separation of molecular types in microsomal sialyltransferase]. 动脉壁糖缀合物的生物合成。8微粒体唾液基转移酶分子类型的分离。
Paroi arterielle Pub Date : 1981-01-01
J Guidollet, P Louisot
{"title":"[Glycoconjugate biosynthesis in the arterial wall. VIII. Separation of molecular types in microsomal sialyltransferase].","authors":"J Guidollet,&nbsp;P Louisot","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sialyltransferase activity of the intima-media of arterial walls is located in microsomes. The solubilization of enzyme by Triton X-100, purification by chromatography and isoelectric focusing lead to two isoenzymes (pHi 4.5 and 6.4), the second is widely predominant. Aortic sialyltransferase is sensitive to nucleotides, Mn++ dependent, and the affinity for substrate N-acetyl-neuraminic acid is 300 microM.</p>","PeriodicalId":76306,"journal":{"name":"Paroi arterielle","volume":"7 3","pages":"91-6"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18351329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aortic atherosclerosis in hypertensive rabbits treated with anti-hypertensive agents having different effects on arterial flow disturbances. 1. Extent of surface involvement. 降压药治疗高血压家兔主动脉粥样硬化对动脉血流障碍的不同影响。1. 表面受累程度。
Paroi arterielle Pub Date : 1981-01-01
J D Spence, D G Perkins, R L Kline, M D Haust
{"title":"Aortic atherosclerosis in hypertensive rabbits treated with anti-hypertensive agents having different effects on arterial flow disturbances. 1. Extent of surface involvement.","authors":"J D Spence,&nbsp;D G Perkins,&nbsp;R L Kline,&nbsp;M D Haust","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hypertension may be considered a disorder of increased energy in the blood, with two components: increased pressure energy may promote arteriolar disease, whereas arterial diseases such as atherosclerosis may be more closely related to flow disturbances (turbulence, boundary layer separation, high shear, or axial stream impingement) due to increased kinetic energy. Previous studies have shown that hydralazine aggravates turbulence in stenosed carotid arteries, whereas propranolol diminishes turbulence. To assess the effect of these drugs on the progression of atherosclerosis, the drugs were administered subcutaneously to rabbits made hypertensive (one kidney Goldblatt) and hypercholesterolemic (1% cholesterol diet for 4 weeks). Appropriate controls with normal, only hypertensive and hypertensive-hypercholesterolemic untreated rabbits were employed. A total of 36 rabbits was used. The extent of the aortic surface involvement with atherosclerotic lesions was assessed by morphometric analysis of magnified photographs. Although the extent or surface involvement did not differ significantly between the untreated or treated hypertensive rabbits, there was an interesting difference in the relationship between blood pressure and extent of surface involvement. In the untreated and hydralazine treated rabbits, there was a direct correlation between increasing blood pressure and extent of lesions; in the propranolol treated group, this relationship was abolished.</p>","PeriodicalId":76306,"journal":{"name":"Paroi arterielle","volume":"7 4","pages":"177-87"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18361103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Heparan sulfate biosynthesis in swine arterial wall: glycosylation and sulfation]. [猪动脉壁硫酸乙酰肝素的生物合成:糖基化和磺化]。
Paroi arterielle Pub Date : 1981-01-01
P Levy, J Picard, A Bruel
{"title":"[Heparan sulfate biosynthesis in swine arterial wall: glycosylation and sulfation].","authors":"P Levy,&nbsp;J Picard,&nbsp;A Bruel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We investigated \"in vitro\" incorporation of labelled (14C) - or (35S) - precursors into microsomal heparan sulfate of pig aortic media-intima. Heparan sulfate, predominantly located on the external surface of smooth muscle cells, may conceivably provide a mean for the selective binding of plasma components to the arterial wall; functional implications of such binding, have been proposed in atherogenesis and thrombogenesis processes. We demonstrated the great metabolic activity of heparan sulfate chains. By evaluation of radioactivity incorporated into monosaccharides residues, we showed that sugar was quantitatively transferred from UDPGlcNAc 14C into endogenous glycosaminoglycans. The relationship between the N- and O-sulfation processes into heparan sulfate chains was studied after different time of sulfation by labelled sulfate nucleotide: PAP(35S). Our results outlined that preferential N-sulfation is obtained with short time exposures to labelled precursor, the O-sulfation occurring on previously N-sulfated heparan sulfate.</p>","PeriodicalId":76306,"journal":{"name":"Paroi arterielle","volume":"7 3","pages":"113-9"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17519560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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