Nihon Gan Chiryo Gakkai shi最新文献_第8页

[Study on the clinical usefulness of NCC-ST-439 in cases of digestive tract cancer]. 【NCC-ST-439在消化道肿瘤中的临床应用研究】。

Nihon Gan Chiryo Gakkai shi Pub Date : 1990-07-20

K Anzai, M Kurihara, T Izumi

{"title":"[Study on the clinical usefulness of NCC-ST-439 in cases of digestive tract cancer].","authors":"K Anzai, M Kurihara, T Izumi","doi":"","DOIUrl":"","url":null,"abstract":"NCC-ST-439 is a monoclonal antibody established from human stomach cancer xenografted nude mice. The values of NCC-ST-439 were measured in 139 cases with various digestive tract cancers and 294 cases with benign digestive tract diseases with the NCC-ST-439 EIA kit (Nihon Kayaku Co., Ltd.), and its clinical usefulness was compared with those of CA19-9 and CEA. The positive rates of NCC-ST-439 in cases of digestive tract cancer were high, i.e., 66.7% for cancer of the bile duct, 58.3% for pancreatic cancer and 52.9% for colorectal cancer. In the benign digestive tract diseases, the overall positive rate seen in case of cholelithiasis and cholangitis, chronic gastritis, benign colorectal diseases and hepatitis, was only 3.7%. The positive rate of NCC-ST-439 was lower than those for CA19-9 and CEA in cases of stomach cancer, colorectal cancer and liver cancer, but it was the same as that of CA19-9 and higher than that of CEA in cases of biliary tract cancer and pancreatic cancer. The false positive rate of NCC-ST-439 in benign diseases of the digestive tract was the lowest among the three markers. With respect to sensitivity, specificity and efficiency, CA19-9 showed the highest sensitivity, but NCC-ST-439 and CEA showed better specificity than CA19-9, and NCC-ST-439 showed the highest efficiency. In combination assays using combinations of NCC-ST-439, CA19-9 and CEA, the positive rates for ST-439 alone were 22.1% for stomach cancer, 52.9% for colorectal cancer, 15.0% for liver cancer and 58.3% for pancreatic cancer, while the combined rates increased to 51.9%, 70.6%, 75.0% and 66.7%, respectively. In an investigation of changes with time in NCC-ST-439 values during chemotherapy of various types of digestive tract cancer, there was a decrease in PR cases, no change in NC cases and a tendency to increase in PD cases. These results suggested that it was possible to apply NCC-ST-439 clinically.","PeriodicalId":76232,"journal":{"name":"Nihon Gan Chiryo Gakkai shi","volume":"25 7","pages":"1437-47"},"PeriodicalIF":0.0,"publicationDate":"1990-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13365379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Index of tumor response by in-vivo 31P-MRS--T1 effect as a new predicting index of therapeutic effects]. [体内31P-MRS- T1效应作为肿瘤反应指标作为新的治疗效果预测指标]。

Nihon Gan Chiryo Gakkai shi Pub Date : 1990-07-20

M Harada, H Nishitani, T Shiramhama, K Koga, I Miura

引用次数: 0

[A clinical study of recombinant human G-CSF in gynecological tumor patients with neutropenia due to chemotherapy (rG.CSF Clinical Study Group)]. 重组人G-CSF在妇科肿瘤化疗后中性粒细胞减少患者中的临床研究[j]。脑脊液临床研究组)。

Nihon Gan Chiryo Gakkai shi Pub Date : 1990-07-20

Y Terashima, K Ochiai, M Hashimoto, I Nishiya, H Takamizawa, K Hasumi, M Takada, K Akiya, Y Negishi, Y Takeda

{"title":"[A clinical study of recombinant human G-CSF in gynecological tumor patients with neutropenia due to chemotherapy (rG.CSF Clinical Study Group)].","authors":"Y Terashima, K Ochiai, M Hashimoto, I Nishiya, H Takamizawa, K Hasumi, M Takada, K Akiya, Y Negishi, Y Takeda","doi":"","DOIUrl":"","url":null,"abstract":"We evaluated clinical efficacy of recombinant human granulocyte colony stimulating factor (rG-CSF), successfully expressed in Chinese hamster ovarian cell, in gynecological tumor patients (pts) with neutropenia due to chemotherapy (CT). Fifty-eight pts with advance or relapsed gynecological malignancy were entered into this study. These pts had neutropenia below 1,000/cmm by CT and in the next cycle of CT they were treated with daily rG-CSF (2 micrograms/kg/day, subcutaneously) starting from the next day of CT for 14 days. The activities of rG-CSF were evaluated using following indices calculated for each cycle: a) the absolute neutrophil count (ANC) at nadir, b) the period for restoration in ANC above 1,500/cmm, and c) the total area below the 1,000/cmm level in ANC calculated by a computer. Forty-seven out of 52 evaluable pts (90.4%) showed good response to rG-CSF. Only adverse events considered possibly due to rG-CSF were transient fever and anorexia, one case each. In conclusion, rG-CSF appears to be well tolerated by gynecological tumor patients and to considerably rescue them from neutropenia caused by intensive chemotherapy.","PeriodicalId":76232,"journal":{"name":"Nihon Gan Chiryo Gakkai shi","volume":"25 7","pages":"1461-71"},"PeriodicalIF":0.0,"publicationDate":"1990-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12864206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Informed consent of the family in the chemotherapy for lung cancer]. 【肺癌化疗家属知情同意书】。

Nihon Gan Chiryo Gakkai shi Pub Date : 1990-07-20

H Tazawa, I Satoh, J Ishihara, T Ohmori, N Horichi, N Kashima, T Hiraizumi, T Takahashi, M Yamamoto, K Kasahara

引用次数: 0

[The effect of a protein-bound polysaccharide (PSK) on lymphocyte subsets of peripheral venous blood and thoracic duct lymph]. [蛋白结合多糖(PSK)对外周静脉血和胸导管淋巴细胞亚群的影响]。

Nihon Gan Chiryo Gakkai shi Pub Date : 1990-07-20

H Hanaue, Y Tokuda, T Fujimoto, K Mizutani, A Okumura, A Kamijoh, K Ogoshi, H Makuuchi, H Nakasaki, T Tajima

{"title":"[The effect of a protein-bound polysaccharide (PSK) on lymphocyte subsets of peripheral venous blood and thoracic duct lymph].","authors":"H Hanaue, Y Tokuda, T Fujimoto, K Mizutani, A Okumura, A Kamijoh, K Ogoshi, H Makuuchi, H Nakasaki, T Tajima","doi":"","DOIUrl":"","url":null,"abstract":"To study the effects of a protein bound polysaccharide (PSK) on the immune system in normal animal, lymphocytes subsets of both peripheral (PBL) and thoracic duct lymphocytes (TDL) were analyzed in 6 week old male SPF Wistar-Imamichi rats before and after free feeding of forage which contained 2% of PSK. PBL and TDL were obtained at the time before, 4 weeks after and 8 weeks after administration of PSK. Age matched rats without administration of PSK were used as a control. Following the peripheral blood cell counts were carried out, lymphocytes subsets such as ratio of total T cells helper/inducer T (Th) cell, suppressor/cytotoxic T (Ts) cell and B cell were assayed using W3/13, W3/25, 0 X 8 and 0 X 4 monoclonal antibodies with laser flow cytometric technique (Orthospectrum III Orthodiagnostics). In terms of the PBL, number of total T cells and Th cells in PSK treated group were significantly lower than that of controls. However no statistical different could be obtained between these two groups in relation to the number of Ts cells and B cells. On the other hand, the number of T cells and Th cells in TDL of PSK treated groups were significantly higher than that of controls while Ts cell and B cell number did not show no apparent differences between these two groups. These findings indicate that oral administration of PSK have a potency to accelerate the transport of T cells from blood stream to lymphatic channel and also regulate their distribution in a normal healthy animals.","PeriodicalId":76232,"journal":{"name":"Nihon Gan Chiryo Gakkai shi","volume":"25 7","pages":"1410-8"},"PeriodicalIF":0.0,"publicationDate":"1990-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13365427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Radiotherapy and chemotherapy in stages I and II non-Hodgkin's lymphomas of Waldeyer's ring]. [I期和II期非霍奇金淋巴瘤的放疗和化疗]。

Nihon Gan Chiryo Gakkai shi Pub Date : 1990-07-20

N Hayabuchi, K Jingu, M Miyoshi, Y Akasi, K Masuda, S Komiyama, M Kikuchi

{"title":"[Radiotherapy and chemotherapy in stages I and II non-Hodgkin's lymphomas of Waldeyer's ring].","authors":"N Hayabuchi, K Jingu, M Miyoshi, Y Akasi, K Masuda, S Komiyama, M Kikuchi","doi":"","DOIUrl":"","url":null,"abstract":"Sixty-four patients with stages I and II non-Hodgkin's lymphomas (NHL) involving Waldeyer's ring treated between 1970 and 1987 were reviewed. Patients with stage II NHL were subdivided into stage II 1 (limited type) and stage II2 (advanced type) from the state of neck nodes. Stage II1 was defined as involvement of unilateral cervical nodes less than 4 cm in diameter as well as Waldeyer's ring involvement. Other stage II cases were classified as stage II2. All 17 patients with stage I NHL were treated with radiation therapy alone. Their diseases were well controlled, and none of them died of causes related to the lymphoma. Among 14 patients with stage II1 NHL, the 5-year survival rate for the 9 patients treated with radiation therapy alone was 87.5%. Until 1982, 19 of 21 patients with stage II2 NHL treated with radiation therapy alone or radiation therapy and adjuvant chemotherapy (VEMP or COPP) died within 5 years mainly of disseminated diseases. Since 1983, CHOP has been used as the main treatment as well as radiotherapy for the 12 stage II2 NHL patients. So far, only 3 of them relapsed and 2 of them died of causes related to the lymphoma. Only 1 of these 12 patients was T-cell lymphoma compared to 7 of 9 stage II2 patients before 1982. This suggests that patients with stage I and those with limited stage II can be safely treated with radiotherapy. Also aggressive chemotherapy as well as radiotherapy should be used for patients with advanced stage II NHL involving Waldeyer's ring.","PeriodicalId":76232,"journal":{"name":"Nihon Gan Chiryo Gakkai shi","volume":"25 7","pages":"1428-36"},"PeriodicalIF":0.0,"publicationDate":"1990-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13365429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Esophageal cancer metastatic to the kidney: report of a case]. 食管癌转移至肾脏1例。

Nihon Gan Chiryo Gakkai shi Pub Date : 1990-07-20

N Mikata, S Imao, A Katoh, S Matsuo

引用次数: 0

[Physical effects of treatment for childhood malignant solid tumors--a data to develop an assessment method of quality of life]. [儿童恶性实体瘤治疗的物理效应——开发生活质量评估方法的数据]。

Nihon Gan Chiryo Gakkai shi Pub Date : 1990-07-20

H Ikeda, K Nagashima, H Okumura, M Taguchi, Y Nagamachi, H Ikeda, K Nagashima, S Matsuyama, N Suzuki, M Kuroiwa

引用次数: 0

[Radiation therapy for human renal cell carcinoma transplantable to the nude mice]. 【裸鼠可移植性人肾细胞癌放射治疗】。

Nihon Gan Chiryo Gakkai shi Pub Date : 1990-07-20

Y Yamada, S Hiraiwa, T Muramatsu, N Honda, H Fukatsu, A Segawa, Y Hishikawa-Itoh

{"title":"[Radiation therapy for human renal cell carcinoma transplantable to the nude mice].","authors":"Y Yamada, S Hiraiwa, T Muramatsu, N Honda, H Fukatsu, A Segawa, Y Hishikawa-Itoh","doi":"","DOIUrl":"","url":null,"abstract":"Efficacy of radiation therapy was studied using human renal cell carcinoma strain (AM-RC-3) implantable in nude mice. Cobalt 60 gamma-ray was used dosage of 5 Gy, 10 Gy, 15 Gy and 20 Gy in single, localized exposures of subcutaneously implanted tumors of the lower right femoral region. Therapeutic efficacy was determined using the Battelle Columbus Standard and evaluation of histological changes based on National Cancer Research Institute (Shimosato's classifications). Conclusion based on the obtained data are as follows: I) The T RW/C RW ratio on the tumor growth curve was 42% or less for all dosage groups except the 5 Gy group; dosages other than 5 Gy are believed effective. The 15 and 20 Gy dosage were particularly effective and the respective groups had RW of 0.96 and 0.95. II) Although Grade IIa and IIb changes were observed in the 15 and 20 Gy dosage groups, respectively, two weeks after irradiation, four weeks after irradiation all groups exhibited microscopic tissue formations that could be considered regrowth of tumor cells. Determination of histopathological effectiveness two weeks after irradiation is thought most suitable. III) Radiation therapy is appropriate as an adjuvant treatment in cases of renal cell carcinoma and should be used in combination with other therapies.","PeriodicalId":76232,"journal":{"name":"Nihon Gan Chiryo Gakkai shi","volume":"25 7","pages":"1397-403"},"PeriodicalIF":0.0,"publicationDate":"1990-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13365425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Unresectable stage 4-cancer of the esophagus well responded to combined chemoradiotherapy--a case report]. [不可切除的4期食管癌对联合放化疗反应良好- 1例报告]。

Nihon Gan Chiryo Gakkai shi Pub Date : 1990-07-20

E Hirao, T Saito, A Kuwahara, Y Shigemitsu, T Kinoshita, K Shimoda, M Miyahara, M Kobayashi

引用次数: 0