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Neuropatologia polska最新文献

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Ultrastructural evaluation of neuronal damages induced by low doses of quinolinic acid in dissociated hippocampal culture. 低剂量喹啉酸诱导离体海马神经元损伤的超微结构评价。
Neuropatologia polska Pub Date : 1993-01-01
E Matyja, A Szmielew, L Khaspekov, I Victorov
{"title":"Ultrastructural evaluation of neuronal damages induced by low doses of quinolinic acid in dissociated hippocampal culture.","authors":"E Matyja,&nbsp;A Szmielew,&nbsp;L Khaspekov,&nbsp;I Victorov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of a subtoxic level of quinolinic acid (QUIN) on the morphological picture of the rat hippocampus in dissociated cultures was investigated. Addition of 50 microM of QUIN to the culture medium induced only slight advanced and reversible changes of the postsynaptic elements, whereas the majority of pyramidal neurons were undamaged. The results suggest that subtoxic concentration of QUIN is insufficient to produce stable depolarization of cell membranes and severe neuronal damage.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"31 3-4","pages":"133-41"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18793362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of heavy metals content in the brain with the use of electron paramagnetic resonance in a clinically unusual case of hepato-lenticular degeneration. 电子顺磁共振分析脑重金属含量在临床上罕见的肝-晶状体变性病例。
Neuropatologia polska Pub Date : 1993-01-01
M Wender, J Szczech, S Hoffmann
{"title":"Analysis of heavy metals content in the brain with the use of electron paramagnetic resonance in a clinically unusual case of hepato-lenticular degeneration.","authors":"M Wender,&nbsp;J Szczech,&nbsp;S Hoffmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An analysis of heavy metals content in the brain of a clinically unusual case of hepatolenticular degeneration was performed with the use of paramagnetic resonance. The studies established a manyfold increase of copper content in the brain in the form of free ions, and, less significant, also in the form of copper multi-ion clusters. The content of iron in the studied brain was lower than in controls. These results confirmed significantly the neuropathological diagnosis of hepato-lenticular degeneration.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"31 1-2","pages":"17-24"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19198556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adrenal medulla grafts into the rat striatum--an evaluation of survival and dynamics of the host brain response. 肾上腺髓质移植到大鼠纹状体——对宿主脑反应的生存和动态的评估。
Neuropatologia polska Pub Date : 1993-01-01
H Mierzewska-Rzeszot
{"title":"Adrenal medulla grafts into the rat striatum--an evaluation of survival and dynamics of the host brain response.","authors":"H Mierzewska-Rzeszot","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Allogenic adrenal medullary tissue was implanted into the striatum of 68 rats. The material was evaluated by routine histological, histochemical, immunocytochemical as well as histofluorescence techniques 1, 3, 7, 14, 21 and 42 days after implantation. The viability of chromaffin cells continued through the 21st day after the implantation. The host brain tissue responded in two ways. First, by macrophagic resorption of the progressively necrotic graft in the experimental group and of the damaged area along the needle tract, noted both in experimental and control animals. This was accompanied by demarcation by proliferating reactive astrocytes and microglial cells. Second, by lymphocyte infiltration in the graft and around it, detected only in the experimental group which suggested immunological rejection.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"31 1-2","pages":"25-35"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19198557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphological changes in the peripheral nervous system in the case of congenital malformations of the spinal cord. 脊髓先天性畸形的周围神经系统形态学改变。
Neuropatologia polska Pub Date : 1993-01-01
H Drac, J Pniewski, J Rafałowska
{"title":"Morphological changes in the peripheral nervous system in the case of congenital malformations of the spinal cord.","authors":"H Drac,&nbsp;J Pniewski,&nbsp;J Rafałowska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 21-year-old oligophrenic man developed after upper respiratory tract infection, quadriplegia with sphincter and respiratory disturbances. Lumbar punction revealed subarachnoid bleeding and elevated cerebrospinal protein level. Guillain-Barré syndrome and subarachnoid hemorrhage were diagnosed. At autopsy intraspinal angioma (C2-D6) and diastematomyelia (D11-lumbar segments) were found. Beside, intraspinal hemorrhage was present. Morphological examination of posterior and anterior spinal roots as well as peripheral nerves was done. Spheroids, axonal degeneration and prominent loss of myelinated fibers were observed in the proximal parts of the spinal roots. Axonal degeneration of myelinated fibers and regenerated fibers were noted in the distal parts of spinal roots and in peripheral nerves. Abnormal, fetal-like vessels were present in the spinal roots. Two mechanisms of acute and chronic changes (transneuronal and Wallerian degeneration) are discussed.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"31 1-2","pages":"55-61"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19198560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paraneoplastic subacute sensory neuronopathy. Clinical-pathological study. 副肿瘤亚急性感觉神经病变。Clinical-pathological研究。
Neuropatologia polska Pub Date : 1993-01-01
E Kida, M Barcikowska, E Joachimowicz, T Michalska, A Siekierzyńska, A Walasik, K Roszkowski, E Figura
{"title":"Paraneoplastic subacute sensory neuronopathy. Clinical-pathological study.","authors":"E Kida,&nbsp;M Barcikowska,&nbsp;E Joachimowicz,&nbsp;T Michalska,&nbsp;A Siekierzyńska,&nbsp;A Walasik,&nbsp;K Roszkowski,&nbsp;E Figura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report 2 cases of subacute sensory neuropathy (SSN) in small cell cancer of the lung. In both cases motor disturbances were caused by motor neuropathy and neuropathy as well. In both cases we observed altered immunoreactivity of the nervous tissue, suggesting the participation of humoral immunity in the tissue damage.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"31 1-2","pages":"63-73"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19198561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glial differentiation in medulloblastoma. Case report. 髓母细胞瘤的神经胶质分化。病例报告。
Neuropatologia polska Pub Date : 1993-01-01
H Kroh, J Bidziński
{"title":"Glial differentiation in medulloblastoma. Case report.","authors":"H Kroh,&nbsp;J Bidziński","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 30-year-old man suffered for a year of a typical syndrome of cerebellar tumor. At suboccipital craniectomy a soft tumor infiltrating both hemispheres and vermis, filling up part of the IV ventricle was found. After subtotal removal of the neoplasm the postoperative course was poor and the patient died 5 weeks later. Biopsy material consisted of three types of tissue: 1. large nests of carrot-shaped, hyperchromatic cells, 2. fields of \"halo\" cells presenting myelin basic protein (MBP) immunoreactivity and 3. fields and scattered strongly GFAP-positive cells. The histological and immunocytochemical pattern of the neoplasm indicates differentiation of the tumor into oligodendrogliomatous and astrocytomatous line being an uncommon example of dual glial differentiation capability in medulloblastoma.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"31 1-2","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18523966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebral infarcts in newborns and infants with cyanotic cardiac anomalies. 新生儿和伴有紫绀型心脏异常的婴儿的脑梗死。
Neuropatologia polska Pub Date : 1993-01-01
M Dambska, I Kuchna, M Wróblewska-Kałuzewska
{"title":"Cerebral infarcts in newborns and infants with cyanotic cardiac anomalies.","authors":"M Dambska,&nbsp;I Kuchna,&nbsp;M Wróblewska-Kałuzewska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Neuropathological examination of six brains of newborns and infants who died in the course of congenital cyanotic cardiac anomalies showed focal brain lesions. The material included five cases from two weeks to two months of age, and one two-year-old infant. In two of them, the periventricular ischemic infarcts were found, in one multifocal encephalomalacia due to multiple vascular occlusions, and in three the necrotic foci corresponded to the supply of large cerebral arteries. The character and topography of severe brain lesions, particularly within the hemispheric white matter, were clearly influenced by the immaturity of the cerebral structures.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"31 1-2","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19199182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of chronic administration of sodium valproate on the morphology of the rat brain hemispheres. 长期服用丙戊酸钠对大鼠大脑半球形态的影响。
Neuropatologia polska Pub Date : 1993-01-01
M Sobaniec-Lotowska, W Sobaniec
{"title":"Effect of chronic administration of sodium valproate on the morphology of the rat brain hemispheres.","authors":"M Sobaniec-Lotowska,&nbsp;W Sobaniec","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Effective doses of sodium valproate (200 mg/kg) applied in rats chronically (1, 3, 6, 9 and 12 months) evoked the first morphological changes in the brain hemispheres after 9 months of drug administration. Structural abnormalities of the brain tissue consisted in disseminated nonspecific neuronal lesions and patchy nerve cell loss, more pronounced in the final phase of the experiment. The neuronal lesions were localized predominantly in the 3rd and 5th layers of the neocortex and in the pyramidal cell layer of the hippocampus. They were accompanied by vascular wall alterations, perivascular tissue damage, as well as by microvacuolar changes and spongy degeneration of the subpial and periventricular regions. Vasogenic character of parenchymal changes is stressed by the authors. The possible influence of liver damage on the development of brain pathology is discussed.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"31 3-4","pages":"149-58"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18793364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Damage of maturing brain in the course of toxoplasmic encephalitis. 弓形虫脑炎过程中成熟脑的损伤。
Neuropatologia polska Pub Date : 1992-01-01
M Laure-Kamionowska, M Dambska
{"title":"Damage of maturing brain in the course of toxoplasmic encephalitis.","authors":"M Laure-Kamionowska,&nbsp;M Dambska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of the study is to present the damaging influence of toxoplasmic encephalitis on newborn brains. The material consisted of six cases of toxoplasmosis who died during the first months of life. The neuropathological picture indicated indirectly the mechanism of spread of the inflammatory-necrotic process. In the first stage of pathologic process intensive inflammatory infiltrations in the periventricular white matter were seen. In the next stage the necrotic changes involved the majority of the hemispheric white matter. Further development of the disease transformed the brain hemispheres into thin-walled sacs composed of meninges and remnants of the nervous system. Finally, the inflammatory process resulted in hydranencephaly. Proliferation of subependymal glia evident in all cases and blocking the pathways of the cerebro-spinal fluid circulation, may have played a role in this process.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"30 3-4","pages":"307-14"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12514061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inclusion body myositis (IBM). Morphological study. 包涵体肌炎。形态学研究。
Neuropatologia polska Pub Date : 1992-01-01
A Fidziańska, H Drac, Z Glinka
{"title":"Inclusion body myositis (IBM). Morphological study.","authors":"A Fidziańska,&nbsp;H Drac,&nbsp;Z Glinka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Among the chronic idiopathic inflammatory myopathies inclusion body myositis (IBM) has emerged as a clinicopathologic variant. Slowly progressive weakness of the distal and the proximal muscle groups, the presence of rimmed vacuoles with basophilic granules as well as 15-18-nm filamentous inclusions in affected muscle confirm the clinical and histopathological distinction between inclusion body myositis and chronic polymyositis.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"30 3-4","pages":"199-207"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12514820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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