{"title":"低剂量喹啉酸诱导离体海马神经元损伤的超微结构评价。","authors":"E Matyja, A Szmielew, L Khaspekov, I Victorov","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of a subtoxic level of quinolinic acid (QUIN) on the morphological picture of the rat hippocampus in dissociated cultures was investigated. Addition of 50 microM of QUIN to the culture medium induced only slight advanced and reversible changes of the postsynaptic elements, whereas the majority of pyramidal neurons were undamaged. The results suggest that subtoxic concentration of QUIN is insufficient to produce stable depolarization of cell membranes and severe neuronal damage.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"31 3-4","pages":"133-41"},"PeriodicalIF":0.0000,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ultrastructural evaluation of neuronal damages induced by low doses of quinolinic acid in dissociated hippocampal culture.\",\"authors\":\"E Matyja, A Szmielew, L Khaspekov, I Victorov\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effect of a subtoxic level of quinolinic acid (QUIN) on the morphological picture of the rat hippocampus in dissociated cultures was investigated. Addition of 50 microM of QUIN to the culture medium induced only slight advanced and reversible changes of the postsynaptic elements, whereas the majority of pyramidal neurons were undamaged. The results suggest that subtoxic concentration of QUIN is insufficient to produce stable depolarization of cell membranes and severe neuronal damage.</p>\",\"PeriodicalId\":76212,\"journal\":{\"name\":\"Neuropatologia polska\",\"volume\":\"31 3-4\",\"pages\":\"133-41\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuropatologia polska\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuropatologia polska","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Ultrastructural evaluation of neuronal damages induced by low doses of quinolinic acid in dissociated hippocampal culture.
The effect of a subtoxic level of quinolinic acid (QUIN) on the morphological picture of the rat hippocampus in dissociated cultures was investigated. Addition of 50 microM of QUIN to the culture medium induced only slight advanced and reversible changes of the postsynaptic elements, whereas the majority of pyramidal neurons were undamaged. The results suggest that subtoxic concentration of QUIN is insufficient to produce stable depolarization of cell membranes and severe neuronal damage.
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