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Dysplastic granulo-molecular hypertrophy of the cerebellar cortex (L'hermitte-Duclos disease): report of three cases. 小脑皮质发育不良颗粒分子肥大(L'hermitte-Duclos病):附3例报告。
Neurologija Pub Date : 1990-01-01
Z Poljaković, D Jadro-Santel, N Besenski, M Popović, L Pazanin, L Negovetić
{"title":"Dysplastic granulo-molecular hypertrophy of the cerebellar cortex (L'hermitte-Duclos disease): report of three cases.","authors":"Z Poljaković,&nbsp;D Jadro-Santel,&nbsp;N Besenski,&nbsp;M Popović,&nbsp;L Pazanin,&nbsp;L Negovetić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this paper three cases with peculiar disease of the cerebellar cortex are presented. The disease is well known as L'hermitte-Duclos disease (LDD), but nowadays it is also called \"dysplastic granulo-molecular hypertrophy of the cerebellar cortex\" according to the modern theories of its etiology. Curious changes of the cerebellum in LDD are probably the result of a combination of delayed migration of Purkinje cells which occurs during the intrauterine period of cerebellar development, and of reactive hypertrophy of granular cells. Presented cases of L'hermitte-Duclos disease are, according to the literature, more or less typical by their clinical appearance and by their histological findings. Our electromicroscopical data support the findings of those authors who found only axodendritic sinapses on the hypertrophied ganglion cells, according to the idea that those cells are originally granular cells of the cerebellar cortex. CT scan of all our patients revealed parallel, worm-like, hyperdense formations in a hypodense process of the cerebellum. The same picture existed in some other described patients, but attention was paid to it. We consider this picture on the computed tomography to be characteristic, if not even patognomonic for the L'hermitte-Duclos disease, which gives us an entirely new scientific contribution in the process of the diagnosis of this peculiar disease.</p>","PeriodicalId":76210,"journal":{"name":"Neurologija","volume":"39 4","pages":"259-71"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13440734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anastomoses among the perforating arteries of the brain. Microanatomy and clinical significance. 吻合于脑部的穿通动脉之间。显微解剖及临床意义。
Neurologija Pub Date : 1990-01-01
S Marinković, M Milisavljević, Z Marinković
{"title":"Anastomoses among the perforating arteries of the brain. Microanatomy and clinical significance.","authors":"S Marinković,&nbsp;M Milisavljević,&nbsp;Z Marinković","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Anastomoses among the perforating arteries were examined in 50 human brains using injection technique with India ink and gelation, or methylmethacrylate. Anastomoses were not found among the perforators of the internal carotid artery and the thalamogeniculate branches. Anastomotic channels involving perforating branches of the anterior choroidal, middle cerebral, and anterior cerebral arteries were noted in 1% of the cases. Vascular connections of the premamillary arteries were observed in 30% of the brains. They varied from 60 to 280 microns) in diameter, and from 0.3 to 3.6 (mean 1.5 mm) in length. Anastomoses among the interpeduncular (thalamoperforating) branches of the posterior cerebral artery were present in 79% of the cases. They ranged from 80 to 400 microns (mean 146 microns) in caliber, and from 0.9 to 6.1 mm (mean 3.3 mm) in length. Since anastomoses among the interpeduncular and the premamillary arteries are much more frequent than those among other perforators, thalamic, subthalamic, and midbrain's infarctions seem to be less frequent than capsular and ganglionic ischemic lesions.</p>","PeriodicalId":76210,"journal":{"name":"Neurologija","volume":"39 2","pages":"107-14"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13418088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A 2-year study of patients up to 55 years of age with cerebrovascular disorders]. [一项对55岁以下脑血管疾病患者为期2年的研究]。
Neurologija Pub Date : 1990-01-01
M Povse, J Kobal
{"title":"[A 2-year study of patients up to 55 years of age with cerebrovascular disorders].","authors":"M Povse,&nbsp;J Kobal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During the years 1986, 1987, all patients with cerebrovascular accident (CVA) under 55, admitted to Department of Neurology Ljubljana were prospectively studied. The significant differences between this group and the group of patients with CVA in all ages were found in relation to sex, frequency of different forms of CVA, and early and late mortality.</p>","PeriodicalId":76210,"journal":{"name":"Neurologija","volume":"39 3","pages":"209-13"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13440731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of piracetam on the recurrent inhibition of motor neurones. 吡拉西坦对运动神经元复发性抑制的影响。
Neurologija Pub Date : 1990-01-01
J Geber, J Cop, B Cvitanović, T Anić, M Bjegović
{"title":"The effect of piracetam on the recurrent inhibition of motor neurones.","authors":"J Geber,&nbsp;J Cop,&nbsp;B Cvitanović,&nbsp;T Anić,&nbsp;M Bjegović","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Piracetam as a nootropic agent is known to exert its effect by activating and protecting the neuronal cell functions. The mechanism, how piracetam acts, is still unknown. However, some experimental data point to the facilitating role of piracetam in the cholinergic synaptic transmission. According to the generally accepted fact that the recurrent inhibition of motoneurons occurs as a result of cholinergic activity, this model has been used in our experiments, which were performed on the spinal cord of decerebrated cats. The significant potentiation and prolonged duration of the recurrent inhibition following intravenous application of piracetam (100 mg/kg) obtained in our experiments, as well as the fact that atropine (1.0 mg/kg i.v.) antagonize this effect, offers the conclusive evidence of direct facilitatory action of piracetam in the cholinergic neurotransmission process.</p>","PeriodicalId":76210,"journal":{"name":"Neurologija","volume":"39 3","pages":"163-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13441666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Open study of sustained-release formulation of levodopa and benserazide in parkinsonian patients. 左旋多巴和苯塞拉齐缓释制剂在帕金森病患者中的开放研究。
Neurologija Pub Date : 1990-01-01
V S Kostić, N Covicković-Sternić
{"title":"Open study of sustained-release formulation of levodopa and benserazide in parkinsonian patients.","authors":"V S Kostić,&nbsp;N Covicković-Sternić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The efficacy of a novel oral sustained-release preparation of levodopa/benserazide (Madopar HBS) was compared to that of previous conventional levodopa/benserazide treatment in 15 patients with idiopathic Parkinson's disease and with severe fluctuations in motor response to long-term levodopa therapy. In ten patients who suffered from clear-cut \"end-of-dose\" deterioration, significant benefit was obtained on HBS form, while 5 patients did not respond well to the new levodopa preparation. Plasma levels of levodopa were more stable with HBS compared to conventional levodopa preparation in our patients, although doses of HBS form required for an optimal response averaged 1.48 times that of previous conventional levodopa.</p>","PeriodicalId":76210,"journal":{"name":"Neurologija","volume":"39 2","pages":"99-105"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13418755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A misdiagnosed case of neurinoma of the 8th cranial nerve and adult respiratory distress syndrome. 颅8神经鞘瘤误诊成人呼吸窘迫综合征1例。
Neurologija Pub Date : 1990-01-01
K Marjanović, B Dmitrović
{"title":"A misdiagnosed case of neurinoma of the 8th cranial nerve and adult respiratory distress syndrome.","authors":"K Marjanović,&nbsp;B Dmitrović","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of a 81-year old female patient with a clinically non-verified neurinoma of the 8th cranial nerve is presented. According to symptoms and radiological examinations, esophageal neoplasm with esophago-tracheal fistula was suspected. The patient died on the 4th day after radiological examination due to progressive respiratory failure. Autopsy revealed neurinoma of the 8th cranial nerve as well as adult respiratory distress syndrome due to aspiration of the radiological contrast medium.</p>","PeriodicalId":76210,"journal":{"name":"Neurologija","volume":"39 4","pages":"305-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13440737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-surgical treatment of the solitary brain abscess in children. 儿童孤立性脑脓肿的非手术治疗。
Neurologija Pub Date : 1990-01-01
N Barisić, Z Sabol
{"title":"Non-surgical treatment of the solitary brain abscess in children.","authors":"N Barisić,&nbsp;Z Sabol","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a ten year old girl with operated congenital heart defect: pulmonary stenosis, a solitary brain abscess developed in the right frontotemporal region after teeth extraction. The clinical disease was manifested with fever, headache and by tonic epileptic seizure of the grand mal type dominating on the left side. Suspicion of the abscess existence has been raised on the basis of the EEG finding and proved by the brain CT scan. Agent has not been identified, most probably due to antibiotic therapy applied prior to admission. We decided for the antibiotic treatment with benzilpencillin (500,000/kg/day), chloramphenicol (50 mg/kg/day) cloxacillin (130 mg/kg/day) intravenously during 4 weeks. Clinical improvement of the condition, the EEG and CT findings occurred two weeks after the beginning of the therapy. After a month further marked improvement of the EEG findings occurred as well as the disappearance of the abscess cavity. Three months after the completed therapy the control EEG and the brain CT scan were normal. The girl having been followed up for three years is growing normal and has completely normal neurologic findings.</p>","PeriodicalId":76210,"journal":{"name":"Neurologija","volume":"39 1","pages":"39-48"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13414636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circulating autoantibodies in multiple sclerosis. 多发性硬化症的循环自身抗体。
Neurologija Pub Date : 1990-01-01
L Tomasević, J Nikolić, M Lukić, Z Lević
{"title":"Circulating autoantibodies in multiple sclerosis.","authors":"L Tomasević,&nbsp;J Nikolić,&nbsp;M Lukić,&nbsp;Z Lević","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>By using indirect immunofluorescence method, we analyzed the presence of antinuclear, anticardiac, microsomal, parietal-cell, smooth-muscle and mitochondrial antibodies in sera of 33 patients with definite multiple sclerosis (MS), without clinical evidence of associated autoimmune disorder, and 14 patients with other neurological disorders (OND). In MS patients, the prevalence of both organ-specific and non-organ-specific antibodies was significantly higher (p less than 0.05) than in OND patients. In both groups, the titers of circulating antibodies were low. The presence of low levels of autoantibodies in sera of MS patients might be the result of immunodysregulation in MS.</p>","PeriodicalId":76210,"journal":{"name":"Neurologija","volume":"39 3","pages":"157-61"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13441665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Miller-Fisher syndrome (clinical report)]. 【Miller-Fisher综合征(临床报告)】。
Neurologija Pub Date : 1990-01-01
J Dimitrijević, K Dzirlo, J Dedić
{"title":"[The Miller-Fisher syndrome (clinical report)].","authors":"J Dimitrijević,&nbsp;K Dzirlo,&nbsp;J Dedić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors present a case report of two female patients, aged 16 and 33. Both patients had the same sudden onset of illness, with diplopia and nystagmus and very severe ataxia. The younger patient had absent tendon reflex, while the older one had the tendon reflex preserved. The younger patient had the triparesis present, both patients had no sphincter disorders. They did not have sensibility disturbances, except that the younger patient had hypesthesia of the soft palate (the motor function was preserved). The first patient was somnolent at the beginning. The clinical course being favourable, the younger patient recovered faster than the older one. Electoencephalogram was normal in both patients. CT of the brain was changed at one moment, locking like inflammatory changes. CSF of the younger patient, done twice, was normal. Serologic findings on viruses were normal. Electromyography in both patients showed, beside good motor velocity, the marked sensory velocity which recovered at the control check-ups. The authors present these two cases and they consider the differential-diagnostic difficulties of Fisher's syndrome compared to \"brain stem encephalitis\".</p>","PeriodicalId":76210,"journal":{"name":"Neurologija","volume":"39 1","pages":"49-55"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13414637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of radiotherapy and chemotherapy on cerebral metastases. 放化疗对脑转移瘤的影响。
Neurologija Pub Date : 1990-01-01
L Markulin-Grgić, F Santek, Z Krajina, D Jadro-Santel
{"title":"The influence of radiotherapy and chemotherapy on cerebral metastases.","authors":"L Markulin-Grgić,&nbsp;F Santek,&nbsp;Z Krajina,&nbsp;D Jadro-Santel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A group of 110 patients (68 male and 42 female) with cerebral metastases, treated at the Institute of Clinical Oncology and Radiotherapy, Zagreb University School of Medicine, during the period 1978-1984, were included in the study. Most patients were aged 50-60 years. Out of 110 patients, 52 were treated by radiotherapy and 58 by radiotherapy plus chemotherapy. Metastases from the bronchus carcinoma, breast carcinoma, melanoma and gastrointestinal carcinoma were present in 59%, 21.8% and 4.6% of patients, respectively. In 1.8% metastases from hypernephroma and in 3.6% from other malignant tumors were observed. In 4.6% cases, the origin of metastases could not be identified. Fifty-two out of 110 patients were treated by radiotherapy alone. They received 3000 cGy in 8-10 fractions, to the whole brain, with two parallel opposed fields. Fifty-eight out of 110 patients treated with radiotherapy and chemotherapy were given the same radiotherapeutic treatment. Chemotherapeutically, they were treated with BCNU and CCNU with or without Vincristin in standard doses. In the group of 52 patients treated by radiotherapy alone the median survival was six months (1-16 months), i.e. the same as in the group treated by both radiotherapy and chemotherapy (1-26 months).</p>","PeriodicalId":76210,"journal":{"name":"Neurologija","volume":"39 1","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13414638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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