Neurobehavioral toxicology最新文献

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Personality and long term exposure to organic solvents. 性格和长期接触有机溶剂。
Neurobehavioral toxicology Pub Date : 1980-01-01
K Lindström, T Martelin
{"title":"Personality and long term exposure to organic solvents.","authors":"K Lindström,&nbsp;T Martelin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Personality, especially emotional reactions of two solvent exposed groups and a nonexposed reference group were described by means of 20 formal, content and check-list type of Rorschach variables. Another objective of the study was to explore the suitability and psychological meaning of other types of Rorschach variables than those applied earlier in the field of behavioral toxicology. The factor analyses grouped the applied variables into factors of Productivity, Ego Strength, Control of Emotionality, Defensive Introversion and Aggressiveness. One solvent group, a patient groups (N=53), was characterized by a high number of Organic signs and a low Genetic Level, indicating possible psychoorganic deterioration. The other solvent group, styrene exposed but subjectively healthy (N=98), was characterized by few emotional reactions, low Anxiety and a low number of Neurotic Signs. the long duration of exposure of the solvent patient group (mean 10.2 +/- 8.7 years) was related to variables of the Productivity factor, a finding that indicates a possible better adjustment of those exposed for a longer time. The duration of exposure of the styrene exposed group (mean 4.9 +/- 3.2 years) revealed a very slight relation to personality variables, but the mean urinary mandelic acid concentration, indicating the level of styrene exposure, correlated with increased emotional reactions. For the most part definite causal conclusions could not be drawn because of the cross-sectional design of the study.</p>","PeriodicalId":76207,"journal":{"name":"Neurobehavioral toxicology","volume":"2 2","pages":"89-100"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18303362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The kindled seizure: production of and modification by dieldrin in rats. 点燃癫痫:狄氏剂在大鼠体内的产生及改变。
Neurobehavioral toxicology Pub Date : 1980-01-01
R M Joy, L G Stark, S L Peterson, J F Bowyer, T E Albertson
{"title":"The kindled seizure: production of and modification by dieldrin in rats.","authors":"R M Joy,&nbsp;L G Stark,&nbsp;S L Peterson,&nbsp;J F Bowyer,&nbsp;T E Albertson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the rat dieldrin can evoke a progressive increase in the severity of convulsive responses (kindling) during repetitive exposures that cannot be attributed to simple accumulation of dieldrin in the brain. It can also replace pentylenetetrazol as a kindling stimulus in previously pentylenetetrazol-kindled rats (cross-kindling). Chronic exposure to dieldrin facilitates kindling produced by daily electrical stimulation of the amygdala. Even single, acute exposure, can facilitate kindling produced by electrical stimulation of the amygdala, 1 to 3 weeks later. We propose that the procedure of kindling is a useful one with which to assess neurotoxicity. Agents affecting kindling in laboratory animals are of particular concern to those individuals in a population with demonstrable seizure susceptibility, those predisposed to convulsive disorders and others vulnerable to increased levels of CNS excitability.</p>","PeriodicalId":76207,"journal":{"name":"Neurobehavioral toxicology","volume":"2 2","pages":"117-24"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18304926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
L-tyrosine hydroxylase activity in the rat brain after chronic oral administration of manganese chloride. 慢性口服氯化锰对大鼠脑内l -酪氨酸羟化酶活性的影响。
Neurobehavioral toxicology Pub Date : 1980-01-01
E Bonilla
{"title":"L-tyrosine hydroxylase activity in the rat brain after chronic oral administration of manganese chloride.","authors":"E Bonilla","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In rats chronically treated with a high oral load of MnCl2 a significant increase in the activity of L-tyrosine hydroxylase was observed in neostriatum, midbrain and hippocampus one month after the beginning of the experiment. The augmented enzymatic activity persisted in neostriatum, midbrain and hypothalamus on the third month and remained elevated only in neostriatum on the sixth month. After eight months a significant decrease in the activity of the enzyme was found in neostriatum with no changes in the remaining regions studied. These findings are interesting since human manganese intoxication starts with a psychiatric phase bearing similarities to schizophrenia in which the primary disturbance has been suggested to be an overactivity of dopamine neurons. On the contrary, the permanent neurological phase is associated with reduced striatal dopamine, presumably due to a decrease in L-tyrosine hydroxylase activity.</p>","PeriodicalId":76207,"journal":{"name":"Neurobehavioral toxicology","volume":"2 1","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17175341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioral effects of chlorpromazine and diazepam combined with low-level microwaves. 氯丙嗪和地西泮联合低强度微波对行为的影响。
Neurobehavioral toxicology Pub Date : 1980-01-01
J R Thomas, J Schrot, R A Banvard
{"title":"Behavioral effects of chlorpromazine and diazepam combined with low-level microwaves.","authors":"J R Thomas,&nbsp;J Schrot,&nbsp;R A Banvard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Previous research findings on the interaction between drugs and microwave radiation were extended to chlorpromazine and to diazepam. The drugs were combined with a 1 mW/cm2 pulsed microwave field (2.8 GHz) and effects were measured on a fixed interval (FI 1) schedule of food reinforcement with rats. Dose-effect functions with and without sham irradiation were established for each drug. At effective doses chlorpromazine consistently decreased rate of responding and reduced with-interval response patterning. Low to moderate doses of diazepam produced little change or increases in response rate, and higher doses produced a decline in response rate. Response patterning within intervals was reduced by increasing doses of diazepam. The animals were exposed to the microwave field alone before test sessions combining the drugs with microwave radiation. Microwave exposure alone did not affect FI performance. Microwave radiation in combination with either drug did not produce any alterations in the dose-effect functions.</p>","PeriodicalId":76207,"journal":{"name":"Neurobehavioral toxicology","volume":"2 2","pages":"131-5"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18304928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurotoxicology--meet the real world. 神经毒理学——面对现实世界。
Neurobehavioral toxicology Pub Date : 1980-01-01
L W Reiter
{"title":"Neurotoxicology--meet the real world.","authors":"L W Reiter","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76207,"journal":{"name":"Neurobehavioral toxicology","volume":"2 2","pages":"73-4"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18304929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioral effects of microwaves. 微波对行为的影响。
Neurobehavioral toxicology Pub Date : 1980-01-01
S Stern
{"title":"Behavioral effects of microwaves.","authors":"S Stern","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Microwaves can produce sensations of warmth and sound in humans. In other species, they also can serve as cues, they may be avoided, and they can disrupt ongoing behavior. These actions appear to be due to heat produced by energy absorption. The rate of absorption depends on the microwave parameters and the electrical and geometric properties of the subject. We, therefore, cannot predict the human response to microwaves based on data from other animals without appropriate scaling considerations. At low levels of exposure, microwaves can produce changes in behavior without large, or even measureable, changes in body temperature. Thermoregulatory behavior may respond to those low levels of heat, and thereby affect other behavior occurring concurrently. There are no data that demonstrate that behavioral effects of microwaves depend on any mechanism other than reactions to heat. Our interpretation of whether a reported behavioral effect indicates that microwaves may be hazardous depends on our having a complete description of the experiment and on our criteria of behavioral toxicity.</p>","PeriodicalId":76207,"journal":{"name":"Neurobehavioral toxicology","volume":"2 1","pages":"49-58"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18453912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Department of Psychology, State University of New York at Albany. 纽约州立大学奥尔巴尼分校心理学系。
Neurobehavioral toxicology Pub Date : 1980-01-01
E A Lochry, E P Riley
{"title":"Department of Psychology, State University of New York at Albany.","authors":"E A Lochry,&nbsp;E P Riley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of prenatal alcohol on learning and retention of passive avoidance and discriminated shock escape were examined in offspring of rats who consumed isocaloric liquid diets containing either 35, 17.5 or 0% ethanol derived calories (EDC) or lab chow during pregnancy. Alcohol exposed progeny required more trials to reach criterion during passive avoidance acquisition and had shorter second trail latencies into the shock compartment than did controls. Both these measures were found to be direct functions of prenatal alcohol exposure. No differences between groups were evident during retention testing (1, 3, or 7 days later). During the 25 trial acquisition phase of T-maze escape, alcohol exposed progeny made more errors despite equivalent group performance by the end of training. During retention testing 24 hours later, these offspring again evidenced more errors regardless of whether or not the original contingencies were reversed. Both learning and retention deficits in the T-maze were directly related to the percent EDC consumed by the mother during pregnancy.</p>","PeriodicalId":76207,"journal":{"name":"Neurobehavioral toxicology","volume":"2 2","pages":"107-15"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18304925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differences in afterdischarge threshold determination methods: implications for experimental designs. 后放电阈值测定方法的差异:对实验设计的启示。
Neurobehavioral toxicology Pub Date : 1980-01-01
H S Swartzwelder, D A Mobray
{"title":"Differences in afterdischarge threshold determination methods: implications for experimental designs.","authors":"H S Swartzwelder,&nbsp;D A Mobray","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hippocampal afterdischarge (AD) thresholds were determined twice using different threshold determination methods. Fourty-five days later thresholds were redetermined using each of the methods. Method A [3] produced higher AD thresholds which were less stable over time than were those produced using method B [4]. In addition, threshold level ADs produced using method A were of longer duration in the second phase of the experiment than in the first. No such changes were seen over time in the durations of method B ADs.</p>","PeriodicalId":76207,"journal":{"name":"Neurobehavioral toxicology","volume":"2 1","pages":"59-61"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18453913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal carbon monoxide exposure alters behavioral development. 产前一氧化碳暴露会改变行为发育。
Neurobehavioral toxicology Pub Date : 1980-01-01
L D Fechter, Z Annau
{"title":"Prenatal carbon monoxide exposure alters behavioral development.","authors":"L D Fechter,&nbsp;Z Annau","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The potential for mild prenatal carbon monoxide (CO) exposure by means of maternal cigarette smoking or industrial and ambient air sources is extremely high, but the biological consequences and, in particular, the neurobehavioral effects are undetermined. We have exposed pregnant rats to 150 ppm in air and examined the behavioral development of the infant rats using tests of righting reflexes, negative geotaxis and homing. The offspring of CO exposed rats weigh less at birth and show reduced growth rates prior to weaning. Cross fostering does not ameliorate the retarded growth curves of experimental subjects. Behavioral testing revealed poorer than normal performance on the negative geotaxis and homing tests among the CO exposed rats. No difference in steady state brain catecholamine levels was seen between groups. The results complement an earlier report showing reductions in locomotor activity following mild prenatal CO exposure and indicate that such exposure has significant functional consequences for the developing rat.</p>","PeriodicalId":76207,"journal":{"name":"Neurobehavioral toxicology","volume":"2 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18453914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A method for determining cumulative behavioral toxicity after chronic oral administration of l-alpha-acetylmethadol to female rats. 长期口服l- α -乙酰美沙多对雌性大鼠的累积行为毒性测定方法。
Neurobehavioral toxicology Pub Date : 1980-01-01
L Lichtblau, K E Burklund, S B Sparber
{"title":"A method for determining cumulative behavioral toxicity after chronic oral administration of l-alpha-acetylmethadol to female rats.","authors":"L Lichtblau,&nbsp;K E Burklund,&nbsp;S B Sparber","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A behavioral method is described in which fixed-ratio 15 (FR 15) responding for food is measured before and after daily oral administration of l-alpha-acetylmethadol (LAAM) by schedule-induced polydipsia. We hypothesized that if the interval between doses of drug was too great, and the subjects experienced episodes of withdrawal between doses, this would be manifest as diminished responding before drug which improved following drug administration. On the other hand, if the doses of drug given were too high or spaced too closely, any decrement in responding seen prior to drug would worsen following drug administration. Using this method we have shown that daily oral administration of 0.5-2.0 mg LAAM/kg to female rats resulted in apparent cumulative toxicity in 6 of 10 subjects tested in the above manner. Further behavioral testing revealed that those subjects not showing signs of toxicity were both dependent upon LAAM and cross-tolerant to the behavioral suppressant action of morphine.</p>","PeriodicalId":76207,"journal":{"name":"Neurobehavioral toxicology","volume":"2 1","pages":"13-9"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18207658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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