La Ricerca in clinica e in laboratorio最新文献_第2页

Alloantibodies in congenital von Willebrand's disease. 先天性血管性血友病的同种抗体。

La Ricerca in clinica e in laboratorio Pub Date : 1991-01-01 DOI: 10.1007/BF02919121

P M Mannucci, M Cattaneo

{"title":"Alloantibodies in congenital von Willebrand's disease.","authors":"P M Mannucci, M Cattaneo","doi":"10.1007/BF02919121","DOIUrl":"https://doi.org/10.1007/BF02919121","url":null,"abstract":"In a review of the literature published in 1984 we identified (from 13 kindreds) 15 patients with severe von Willebrand's disease (vWD) reported to have developed alloantibodies. In order to reexamine the problem, a questionnaire was sent in 1989 to 141 hemophilia centers in America and Europe; 101 answers were received. These dealt with a total number of 1,720 patients with vWD (all types) and 231 patients with severe (type III) vWD. Besides the 15 cases reported in 1984, 6 additional cases of anti-vWF alloantibodies were reported, i.e., one from Spain (a relative of a previously reported case), two from Venezuela (brother and sister) and three from North Carolina (unrelated patients). All these cases and those previously reported share the following features: occurrence of alloantibodies in multitransfused patients with severe vWD, poor clinical and laboratory response to replacement therapy with cryoprecipitate, inhibition of ristocetin-induced platelet aggregation. During the survey, an unusual antibody to FVIII:C with no reactivity towards vWF was reported in a multitransfused girl (from Tennessee) with type III vWD. It seems therefore that although the development of alloantibodies is a rare complication of severe vWD, due to its negative effect on the response to treatment it needs a prompt identification.","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"21 1","pages":"119-25"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02919121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13026581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

The use of recombinant factor VIII in the management of hemophilia. 重组因子VIII在血友病治疗中的应用。

La Ricerca in clinica e in laboratorio Pub Date : 1991-01-01 DOI: 10.1007/BF02919111

P M Mannucci, A Gringeri

引用次数: 0

Role of prostaglandin E2 on defective interferon-gamma production during type B acute viral hepatitis. 前列腺素E2在乙型急性病毒性肝炎中干扰素γ产生缺陷中的作用。

La Ricerca in clinica e in laboratorio Pub Date : 1991-01-01 DOI: 10.1007/BF02919120

M Baraldini, P Andreone, C Cursaro, P Pasini, G Verucchi, M Mazzetti, G F Stefanini, G Gasbarrini

{"title":"Role of prostaglandin E2 on defective interferon-gamma production during type B acute viral hepatitis.","authors":"M Baraldini, P Andreone, C Cursaro, P Pasini, G Verucchi, M Mazzetti, G F Stefanini, G Gasbarrini","doi":"10.1007/BF02919120","DOIUrl":"https://doi.org/10.1007/BF02919120","url":null,"abstract":"Interferon-gamma (IFN-gamma) and prostaglandin E2 (PGE2) production was evaluated in cultured peripheral blood mononuclear cells taken from patients with type B acute viral hepatitis at the onset of symptoms, at 1st and 2nd week of disease, and from healthy controls. Concanavalin A-stimulated cells cultured for 24, 48 and 72h showed significantly higher IFN-gamma levels compared to basal release in both groups, whereas no statistically significant differences were found in most experimental conditions as regard PGE2 synthesis. No differences were found in IFN-gamma production by comparing patients with acute viral hepatitis to the control group, whereas PGE2 was significantly increased during the disease. IFN-gamma and PGE2 levels did not show any significant change in acute viral hepatitis during the follow-up. A statistically significant correlation was found only in control group between IFN-gamma and PGE2 levels in unstimulated cultures. PGE2 seems to play a central role in regulating interferon production during viral infection. This may suggest a new therapeutic approach in viral hepatitis utilizing a combination of interferon and prostanoid inhibitory substances, above all in patients who do not respond to interferon therapy alone.","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"21 1","pages":"111-7"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02919120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13068224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Determination of Lp(a) and APO(a) in an Italian population. 意大利人群Lp(a)和APO(a)的测定。

La Ricerca in clinica e in laboratorio Pub Date : 1991-01-01 DOI: 10.1007/BF02919122

M Cuchel, G Merati, M Clerici, B Grumelli, G A Giudici, C Vergani

引用次数: 2

Liver system. V. Activation-extinction line of cyclic hepatocyte activities. 肝脏系统。五、循环肝细胞活性的激活-消退线。

La Ricerca in clinica e in laboratorio Pub Date : 1991-01-01 DOI: 10.1007/BF02919114

N Dioguardi, F Brambilla, M Dell'Oca, E Arosio, L Parmeggiani

引用次数: 0

Cryptogenic chronic active liver disease. Evaluation of serum aminoterminal peptide of type III procollagen as a marker of histological activity. 隐源性慢性活动性肝病。血清III型前胶原氨基末端肽作为组织活性标志物的评价。

La Ricerca in clinica e in laboratorio Pub Date : 1990-10-01 DOI: 10.1007/BF02900710

G Diodati, P Bonetti, M Plebani, A Giacomini, M Rugge, G Realdi, A Burlina

引用次数: 3

A new Italian family with severe prekallikrein deficiency. Desmopressin-induced fibrinolysis and coagulation changes in homozygous and heterozygous members. 一个新发现的意大利家族患有严重的前钾likrein缺乏症。去氨加压素诱导纯合子和杂合子纤维蛋白溶解和凝血的变化。

La Ricerca in clinica e in laboratorio Pub Date : 1990-10-01 DOI: 10.1007/BF02900708

G Castaman, M Ruggeri, F Rodeghiero

{"title":"A new Italian family with severe prekallikrein deficiency. Desmopressin-induced fibrinolysis and coagulation changes in homozygous and heterozygous members.","authors":"G Castaman, M Ruggeri, F Rodeghiero","doi":"10.1007/BF02900708","DOIUrl":"https://doi.org/10.1007/BF02900708","url":null,"abstract":"In this paper we report the case of a new Italian family with severe cross-reacting material prekallikrein deficiency (CRM-). The proposita is a 22-year-old woman referred for evaluating an extremely prolonged activated partial thromboplastin time (APTT) detected during a routine screening. No clearcut bleeding history was reported. Prekallikrein antigen and activity were not measurable. The other contact-phase factors were within the normal range. Using an electromechanical coagulometer, six different commercial reagents yielded a markedly prolonged APTT (ratio greater than 2). By prolonging the incubation time up to 10 min, APTT was normalized only with reagents employing ellagic acid as activator. On the contrary, APTT remained markedly prolonged using particulate activators (i.e. micronized silica and celite). No differences were observed using either rabbit or bovine brain cephalin. APTT was also performed on a laser automated ACL instrument; in this case reagents using ellagic acid yielded only moderately prolonged APTT values (ratio 1.3 vs 1.4). The intrinsic fibrinolytic activity, as assessed by blood activator inventory test, was found to be moderately reduced (about 50% of normal) in the proposita, whereas normal values were measured in the heterozygous relatives. After infusion of 0.3 micrograms/kg 1-desamino-8-D-arginine vasopressin (DDAVP), kallikrein levels did not change in the proposita and her heterozygous relatives. A normal release of tissue-plasminogen activator, as assessed by fibrin-plate assay, was observed in all family members including the proposita.","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"20 4","pages":"239-44"},"PeriodicalIF":0.0,"publicationDate":"1990-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02900708","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13282365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

A retrospective study on oral anticoagulant prophylaxis in 103 Italian patients with hereditary thrombophilia and thrombosis. ad hoc Study Group. 103例意大利遗传性血栓和血栓患者口服抗凝预防的回顾性研究。特设研究小组。

La Ricerca in clinica e in laboratorio Pub Date : 1990-10-01 DOI: 10.1007/BF02900709

G Finazzi, T Barbui

{"title":"A retrospective study on oral anticoagulant prophylaxis in 103 Italian patients with hereditary thrombophilia and thrombosis. ad hoc Study Group.","authors":"G Finazzi, T Barbui","doi":"10.1007/BF02900709","DOIUrl":"https://doi.org/10.1007/BF02900709","url":null,"abstract":"The clinical records of 103 Italian patients with inherited thrombophilia and thrombosis were reviewed to estimate the incidence of thrombotic recurrences and major bleeding complications according to the different duration of oral anticoagulant prophylaxis (OAP). The incidence of the first thrombotic recurrence was 2.9, 7.4 and 10.8 x 100 patients/year, respectively, in subjects receiving lifelong OAP, stopping OAP after a mean of 9 months (range 1-30 months) or not receiving OAP. The probability to remain free from thrombotic recurrences in patients undergoing lifelong OAP, as estimated by the Kaplan-Meier method, was significantly higher in comparison with untreated patients (p less than 0.001), but did not reach the statistical significance in comparison with patients who stopped prophylaxis. The incidence of further thrombotic recurrences was 1.2, 21.1 and 22.3 x 100 patients/year, respectively, in the three groups defined above. The difference between patients who prolonged indefinitely OAP vs those who stopped or did not receive OAP was statistically significant (p = 0.003). Two intracranial bleedings, one of which fatal, were observed in patients undergoing lifelong OAP, whereas no major bleeding complications occurred in the other two groups. Our study supports the recommendations to continue indefinitely OAP in patients with inherited thrombophilia and recurrent thrombosis, but suggests caution in starting lifelong prophylaxis soon after the first thrombotic event in all patients.","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"20 4","pages":"245-52"},"PeriodicalIF":0.0,"publicationDate":"1990-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02900709","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13230323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Markers of increased thrombin generation. 凝血酶生成增加的标志。

La Ricerca in clinica e in laboratorio Pub Date : 1990-10-01 DOI: 10.1007/BF02900706

D Prisco

引用次数: 10

Interleukin-2, soluble interleukin-2 receptor and tumor necrosis factor in sera from patients with rheumatoid arthritis. 类风湿关节炎患者血清白细胞介素-2、可溶性白细胞介素-2受体及肿瘤坏死因子的研究

La Ricerca in clinica e in laboratorio Pub Date : 1990-10-01 DOI: 10.1007/BF02900713

A Corvetta, M M Luchetti, G Pomponio, R Della Bitta, A Recchioni, P Strusi, G De Sio, G Danieli

{"title":"Interleukin-2, soluble interleukin-2 receptor and tumor necrosis factor in sera from patients with rheumatoid arthritis.","authors":"A Corvetta, M M Luchetti, G Pomponio, R Della Bitta, A Recchioni, P Strusi, G De Sio, G Danieli","doi":"10.1007/BF02900713","DOIUrl":"https://doi.org/10.1007/BF02900713","url":null,"abstract":"Interleukin-2 (IL-2), soluble interleukin-2 receptor (IL-2R) and tumor necrosis factor (TNF) have been measured in sera from 47 patients affected by classic rheumatoid arthritis (RA) using an enzyme-linked immunosorbent assay. The patients were divided into 4 groups as follows: group A, 18 patients with inactive disease; group B, 19 patients with active disease under treatment with non-steroidal antiinflammatory drugs (NSAID) and second-line drugs; group C, 5 patients with active disease under treatment with NSAID and cyclosporine A (CSA) for at least 4 months; group D, 5 patients in the same condition as patients of group C, but treated with azathioprine (AZA) instead of CSA. IL-2 was undetectable in all patients except two, both characterized by active disease. Soluble IL-2R levels were above the upper limit of the normal range in most of the patients studied, but the mean value ( +/- 1 SD) was significantly higher in patients of group B (1,288 +/- 421 U/ml) than in patients of group A (686 +/- 205 U/ml) and group C (842 +/- 414 U/ml). In two patients affected by active RA treated with pulse methylprednisolone therapy (1 g/day for 3 alternate days) the values of soluble IL-2R dropped from 948 to 662 U/ml and from 660 to 518 U/ml, respectively. No statistically significant correlation was observed between the serum level of IL-2R and the RF titre or percentage of C1q-binding activity, respectively. TNF was found within the normal range in all patients except one, who was characterized by active arthritis, high number of rheumatoid skin nodules and extremely high RF titre.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"20 4","pages":"275-81"},"PeriodicalIF":0.0,"publicationDate":"1990-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02900713","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13230329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2