{"title":"Pre-term infant volume measurements by acoustic plethysmography","authors":"O.S. Valerio Jimenez, J.K. Moon, C.L. Jensen, F.A. Vohra, H.P. Sheng","doi":"10.1016/0141-5425(93)90036-X","DOIUrl":"10.1016/0141-5425(93)90036-X","url":null,"abstract":"<div><p>An acoustic plethysmograph has been developed to provide routine total body volume measurements of pre-term (1.5–3.0 kg) infants. It operates near 50 Hz and is excited by band-limited 25 Hz span noise. Excitation, measurement, analysis, and environment are computer controlled for greater accuracy, speed, and objectivity in volume determinations. Performance tests produced volume measurements with a mean per cent error (± SD) of 0.77 ± 0.66% for two phantoms with volumes of 2880 and 2130 cm<sup>3</sup>. Ten, one-minute volume measurements were obtained for 14 infants over a 20 to 30 min period. Their mean density was 1.061 ± 0.028 g cm<sup>−3</sup> and their weight ranged from 1294 to 2025 g.</p></div>","PeriodicalId":75992,"journal":{"name":"Journal of biomedical engineering","volume":"15 2","pages":"Pages 91-98"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0141-5425(93)90036-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19441778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Croal, J. Birkmyre, M. McNally, C. Hamilton, R. Mollan
{"title":"Strain gauge plethysmography for the detection of deep venous thrombosis","authors":"S. Croal, J. Birkmyre, M. McNally, C. Hamilton, R. Mollan","doi":"10.1016/0141-5425(93)90043-X","DOIUrl":"10.1016/0141-5425(93)90043-X","url":null,"abstract":"<div><p>Deep venous thrombosis is a widely recognized medical problem which results in significant morbidity and mortality. Venography is the current ‘gold standard’ diagnostic test for deep venous thrombosis; however it is costly, invasive and is unnecessarily performed in 50% of cases. This paper describes a self-contained, non-invasive system for automatic venous occlusion plethysmographic measurement and analysis. An examination of 274 symptomatic limbs was conducted using strain gauge plethysmography and a subsequent venographic examination was then performed. The plethysmographic results were then compared with venography so as to develop a means of discrimination for thrombotic and non-thrombotic limbs. Strain gauge plethysmography using the Belfast DVT Screener yielded a sensitivity of 100% and a sensitivity of 66.3% for proximal segment DVT. The efficacy of the discriminatory algorithm was then tested for the diagnosis of DVT in a further 101 symptomatic patients. A sensitivity of 94.7% and a specificity of 81.7% were observed for strain gauge plethysmography for proximal segment thrombosis in this patient group. The Belfast DVT Screener is highly sensitive for deep venous thrombosis and may be used to reduce the need for venography, which is of benefit to both the patient and clinician.</p></div>","PeriodicalId":75992,"journal":{"name":"Journal of biomedical engineering","volume":"15 2","pages":"Pages 135-139"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0141-5425(93)90043-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19443265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A feasibility study of a filtration type autotransfusion device","authors":"C. Legallais, M.Y. Jaffrin","doi":"10.1016/0141-5425(93)90045-Z","DOIUrl":"10.1016/0141-5425(93)90045-Z","url":null,"abstract":"<div><p>This paper describes a feasibility study of a disposable autotransfusion device for blood salvage during surgery. The goal was to concentrate hemolyzed blood at 20% hematocrit to 50% while reducing the plasma free hemoglobin concentration from 10 to 1.5 g/l. The device should have a total membrane area of less than 0.6 m<sup>2</sup> and should be able to process ten 500 ml blood bags. The processing time for each blood bag should not exceed 5 min. The basic idea was to use several polypropylene hollow fibre plasma filters of 0.1 m<sup>2</sup> in series with saline addition between them. Since the mean pore size is 0.5μ m, anticoagulant and plasma hemoglobin can pass freely across the membrane and their concentration is reduced by dilution. The process was first modelled using mass balance equations for red blood cells and plasma hemoglobin in order to find the best device configuration (number of filters and dilutions). It was found that a three filter system could theoretically meet the requirements, if the last filter had a larger surface area (0.3 m<sup>2</sup>). Some experiments permitted us to prove the validity of this model and to define fully the third filtration stage. Finally, it was shown that the treatment of a 500 ml blood bag required three filtration stages (whose surface areas were respectively 0.1, 0.1 and 0.3 m<sup>2</sup>) and the use of 750 ml of saline solution added between the filters. This configuration also offers the possibility of using a vacuum driving force instead of pumps, so that the device becomes completely disposable.</p></div>","PeriodicalId":75992,"journal":{"name":"Journal of biomedical engineering","volume":"15 2","pages":"Pages 143-147"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0141-5425(93)90045-Z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19443267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimized 3D coordinate reconstruction from paired stereographs using a calibrated phantom","authors":"C.F. Small, J.T. Bryant","doi":"10.1016/0141-5425(93)90050-9","DOIUrl":"10.1016/0141-5425(93)90050-9","url":null,"abstract":"<div><p>A refinement to a previously described three-dimensional reconstruction algorithm based on point identification in calibrated non-orthogonal radiograms (stereo-pairs) is described. The modification involves a computation of the focal point magnitude of the point in three dimensions, analogous to focusing in two dimensions, as well as the most likely location of the target point in 3-space; the focal point magnitude may be thought of as the precision of the point identification. Multiple observer studies of the same stereopair can be used to estimate three-dimensional reconstruction accuracy by providing an average location and a mean distance from average. Both measures are useful parameters for initial selection of bone landmark references and for error propagation studies.</p></div>","PeriodicalId":75992,"journal":{"name":"Journal of biomedical engineering","volume":"15 2","pages":"Pages 163-166"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0141-5425(93)90050-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19441774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Testing of small connective tissue specimens for the determination of the mechanical behaviour of atherosclerotic plaques","authors":"C.L. Lendon , M.J. Davies , P.D. Richardson , G.V.R. Born","doi":"10.1016/0141-5425(93)90089-H","DOIUrl":"10.1016/0141-5425(93)90089-H","url":null,"abstract":"<div><p>The tearing of the cap of atheromatous plaques is the commonest cause of thrombosis in human coronary arteries. It has been proposed that tearing arises because of structural weakening of the cap's connective tissue around the tear. To test this hypothesis we compared the mechanical properties of the intact edges of torn plaque caps and unbroken caps. Owing to limitations in plaque size, a purpose-built tensometer was developed to study stress-strain relationships of the small connective tissue specimens. The design of the tensometer is reported and was shown to detect accurately, minor differences in connective tissues and to generate complete stress-curves with computer-assisted image analysis.</p></div>","PeriodicalId":75992,"journal":{"name":"Journal of biomedical engineering","volume":"15 1","pages":"Pages 27-33"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0141-5425(93)90089-H","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19403052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on: The energetics of paraplegic walking","authors":"Martin Kemp MSc CEng MBES","doi":"10.1016/0141-5425(93)90099-K","DOIUrl":"10.1016/0141-5425(93)90099-K","url":null,"abstract":"","PeriodicalId":75992,"journal":{"name":"Journal of biomedical engineering","volume":"15 1","pages":"Page 83"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0141-5425(93)90099-K","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19404977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Roozmon , S.A. Gracovetsky , G.J. Gouw , N. Newman
{"title":"Examining motion in the cervical spine I: imaging systems and measurement techniques","authors":"P. Roozmon , S.A. Gracovetsky , G.J. Gouw , N. Newman","doi":"10.1016/0141-5425(93)90086-E","DOIUrl":"10.1016/0141-5425(93)90086-E","url":null,"abstract":"<div><p>Instruments for measuring mobility in the cervical spine range from plumb-lines and inclinometers to sophisticated optoelectronic systems. In order to investigate the need and possible uses for an enhancement to a new diagnostic instrument, we examine some of the available diagnostic systems suitable for cervical motion analysis. These should be of practical use in a clinical setting for the diagnosis of soft tissue injuries. We begin by evaluating the respective roles of plain radiographs, cineradiography, computer tomography, and magnetic resonance imaging in examining the cervical spine. Then we consider Moiré photography, inclinometers, and some opto-electronic scanners, as well as the mathematical techniques needed to correlate skin and spine motion with these devices. We find that there does not appear to be an effective non-invasive tool for comprehensive clinical cervical motion analysis; in particular, coupled joint motion is inadequately quantified. Improperly diagnosed cervical spine injuries, such as hyperextension and hyperflexion, may result in chronic long-term effects. Therefore, instrumentation that would permit objective, routine clinical evaluation of patients could help to avoid such situations.</p></div>","PeriodicalId":75992,"journal":{"name":"Journal of biomedical engineering","volume":"15 1","pages":"Pages 5-12"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0141-5425(93)90086-E","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19403056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Raftopoulos , E. Katsamanis , F. Saul , W. Liu , S. Saddemi
{"title":"An intermediate loading rate technique for the determination of mechanical properties of human femoral cortical bone","authors":"D. Raftopoulos , E. Katsamanis , F. Saul , W. Liu , S. Saddemi","doi":"10.1016/0141-5425(93)90095-G","DOIUrl":"10.1016/0141-5425(93)90095-G","url":null,"abstract":"<div><p>An experimental method to evaluate the mechanical properties of human femoral cortical bone under an intermediate strain rate of 4 × 10<sup>−2</sup> s<sup>−1</sup> is presented. The dynamic loading was developed by dropping weights from various heights; results were obtained for Young's modulus and Poisson's ratio when the specimens were loaded along the longitudinal axis of the femur. The results were compared with those under a slow strain rate of 2 × 10<sup>−5</sup> s<sup>−1</sup> and a fast strain rate of 1 × 10<sup>−2</sup> s<sup>−1</sup>. It was found that Young's modulus for the intermediate strain rate is 10.5% higher than for the slow strain rate and 10% lower than for the fast strain rate. Poisson's ratio did not show any significant variation for the above three strain rates. The results were compared with those given previously by other investigators.</p></div>","PeriodicalId":75992,"journal":{"name":"Journal of biomedical engineering","volume":"15 1","pages":"Pages 60-66"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0141-5425(93)90095-G","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19403059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G.S. Friedrichs , D.S. Berger , E. Micheli-Tzanakou
{"title":"Cardiovascular applications of the ALOPEX optimization technique","authors":"G.S. Friedrichs , D.S. Berger , E. Micheli-Tzanakou","doi":"10.1016/0141-5425(93)90097-I","DOIUrl":"10.1016/0141-5425(93)90097-I","url":null,"abstract":"<div><p>ALOPEX is a general optimization process incorporating a cost function containing a large number of parameters which may be simultaneously adjusted until the cost function reaches an optimum (maximum or minimum); local extremes are avoided by introducing random noise into the procedure. In this paper, ALOPEX is incorporated into a simple haemodynamic study in which an electric analogue model of the left ventricle is used to develop equations of myocardial stroke work. Pilot experiments were undertaken in rabbits (<em>n</em> = 5) to gauge the effectiveness of this optimizing technique. In the control state, calculated stroke work for the rabbit was determined to be 50 ± 7 mmHg ml, while ALOPEX predicted a stroke work of 51 ± 7 mmHg ml. ALOPEX is capable of following changing cardiovascular states when pharmacological agents are introduced. For example, after nitroprusside treatment, stroke work was reduced by 38 ± 6% (<em>P</em> < 0.05) while ALOPEX predicted a 42 ± 4% reduction from baseline (<em>P</em> < 0.05). Methoxamine treatment increased stroke work by 74 ± 34%, while ALOPEX predicted a 73 ± 43% increase above control values. There were no statistical differences between calculated and ALOPEX predicted values. Individual model parameters such as maximum left ventricular elastance (<em>E</em><sub><em>max</em></sub>) and left ventricular end diastolic volume (<em>EDV</em>) were also predicted correctly by ALOPEX. We have found that the ALOPEX optimization technique is useful in predicting components of multi-parametric functions. In particular, we have shown it to be adaptable to a simple haemodynamic model.</p></div>","PeriodicalId":75992,"journal":{"name":"Journal of biomedical engineering","volume":"15 1","pages":"Pages 74-78"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0141-5425(93)90097-I","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19404975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Drijber and Finlay (1992) — Universal joint slippage as a cause of Hofmann half-frame external fixator failure. J Biomed Eng 1992; 14: 509-15","authors":"Eur Ing Professor JP Paul FEng","doi":"10.1016/0141-5425(93)90100-D","DOIUrl":"10.1016/0141-5425(93)90100-D","url":null,"abstract":"","PeriodicalId":75992,"journal":{"name":"Journal of biomedical engineering","volume":"15 1","pages":"Page 83"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0141-5425(93)90100-D","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19404978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}