Investigative & cell pathology最新文献

{"title":"Endomyocardial biopsy.","authors":"E G Olsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cardiac biopsies are being undertaken with increased frequency in recent years. The present review concentrates mainly upon the role of this technique in the more accurate classification and diagnosis of the cardiomyopathies. In addition the quality of biopsy material and the degree to which it represents the overall cardiac pathological changes are presented.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 2","pages":"139-57"},"PeriodicalIF":0.0,"publicationDate":"1978-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11607103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automation and the chemical pathologist.","authors":"T P Whitehead","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 2","pages":"115-7"},"PeriodicalIF":0.0,"publicationDate":"1978-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11608472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanisms of human tumour-induced osteolysis and hypercalcaemia.","authors":"M Dowsett","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This is a brief resume of the current knowledge regarding the mechanisms whereby tumours may cause the breakdown or increase the turnover of bone matrix resulting in hypercalcaemia. The precise mechanisms and agents still remain to be ascertained. This would appear to be an investigative area worthy of significant research effort in view of the potential benefit to patient care which may then ensue.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 2","pages":"159-70"},"PeriodicalIF":0.0,"publicationDate":"1978-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11607105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinico-pathological conference.","authors":"D J Evans","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 2","pages":"119-21"},"PeriodicalIF":0.0,"publicationDate":"1978-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11608475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistence of the Fc cytophilic antibody receptor in macrophage hybrid cells.","authors":"D Parker,&nbsp;J F Watkins","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hybrid cell clones were obtained from mouse macrophase/Ehrlich ascites cell fusions which showed the 'Fc' cytophilic antibody receptor site, phagocytosis and motility typical of macrophages. With continued growth of the clones for 11 weeks, the receptor became undetectable but could be unmasked by dilute trypsin treatment; subsequent remasking of the receptor could be prevented with cycloheximide treatment of the hybrid cells. These hybrids produced cystic anaplastic tumours in neonatal irradiated mice. Chinese hamster/mouse interspecific macrophage hybrid cells did not show macrophage markers. This was probably due to rapid loss of macrophage chromosomes from the hybrid cells.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 2","pages":"123-7"},"PeriodicalIF":0.0,"publicationDate":"1978-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11608478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drugs and the developing skeleton.","authors":"C L Berry","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The skeleton develops from early embryonal stages until the end of the second decade. Normal morphogenesis requires integrated growth, differentiation and morphogenetic movement over prolonged periods of time. The complexity of the processes involved ensures that the potential for drugs to affect the system is very large, and that a number of metabolic pathways may be disturbed. Skeletal abnormalities are thus an important component of many malformation syndromes and are produced by varied genetic mechanisms combined with environmental effects.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 2","pages":"129-37"},"PeriodicalIF":0.0,"publicationDate":"1978-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11607097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Milk proteins and mammary cancer: a review.","authors":"D J Laurence","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Milk proteins are of potential value in characterizing mammary carcinoma from a functional point of view. The major milk proteins are described with special reference to human milk. The caseins, whey proteins and membrane structures in the milk are discussed in terms of their chemical, biological and immunological properties. In vitro culture systems help to define the hormone dependency of normal mammary tissues and mammary carcinomas. The control of proliferation and milk protein production are partially independent, and this becomes especially evident in experimental tumours. Clinical samples of human tumours and plasma from patients with mammary carcinoma show differences in the level of certain milk proteins. These appear to relate to tumour spread, state of differentiation and the presence of hormone receptors.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 1","pages":"5-22"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11608354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The nodular adrenal.","authors":"A M Neville","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nodules commonly occur in the human adrenal gland. They are best regarded as part of the ageing process, produced in response to adrenal vascular changes. Nodules exhibit a wide diversity of size and distribution and are seen not only in subjects with normal adrenal function but also in patients with hypercorticalism (Cushing's and Conn's syndromes). In these disorders, the nodules appear to be a consequence of the diseases, rather than being aetiological.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 1","pages":"99-111"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11608355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intercellular adhesion and its role in epidermal differentiation.","authors":"C J Skerrow","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The differentiation of epidermal keratinocytes is accompanied by a regular sequence of changes in the nature of their adhesive interactions. The basis of these changes is discussed with reference to the more detailed studies of intercellular adhesion of other tissue types. In the early stages, desmosome formation predominates. A sequence of molecular events which may underlie desmosome formation and junctional stability is constructed. At the later stages of differentiation, adhesive interactions between non-junctional membranes are of increasing importance, and cells undergo pronounced flattening. The involvement of the cytoskeleton in these processes is considered. Possibilities for further studies on keratinocyte adhesion in normal and pathological epidermis are suggested.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 1","pages":"23-37"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11608352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teratomas, neoplasia and differentiation: a biological overview. I. The natural history of teratomas.","authors":"M J O'Hare","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this paper I have attempted to outline the natural history of spontaneously occurring teratomas and associated tumours, but without introducing any preconceptions or assumptions as to their histogenesis or mechanisms of internal differentiation. The justification for this omission is that there is presently no direct evidence in respect of either process in human tumours of this type, with the exception of recent work by LINDER et al. (1975a, b). The various histopathological classifications of teratoid lesions have not been discussed in detail either, because for the most part they have been evolved to serve a specific prognostic purpose on either an empirical basis or on certain histogenetic assumptions. In either case there is an inevitable tendency to emphasize extremes of morphological appearance at the expense of possible continuities of structure and behaviour across the spectrum of teratoid lesions. The purpose of this paper, on the contrary, has been to discern features common to these tumours whenever and wherever they occur. Thus, human teratomas are uniquely puritissular lesions composed, potentially at least, of virtually every recognizable (and probably some as yet unrecognizable), type of embryonic, foetal and adult cell and tissue, together with, in some cases, frankly malignant cells of no obvious derivation or differentiation. In spite of the occasional appearance of structures resembling pre-somite embryos (embryoid bodies), there is no compelling evidence that human teratomatous histogenesis recapitulates embryogenesis in any strict fashion. Histologically, the overwhelming impression is of a more or less random association of cells and tissues at different stages of development and differentiation that proceed up to but not beyond organogenesis. Such teratomas are found at a number of well-defined sites, of which the sacrococcyx is the most prominent in infancy and the gonads during adult life. Both gonadal and extragonadal sites are also associated with apparently homogeneous neoplasms containing cells with features reminiscent of early stages of germinal differentiation which evoke, in many cases, a marked stromal and lymphocytic response, the so-called germinomas. In 'mixed' tumours, which are recognized in an increasing proportion of cases, there is karyological evidence of a conjoint rather than separate origin of teratomatous and germinomatous elements in at least some tumours, challenging a long held belief in their invariably separate character (e.g. HALLEY, 1963).</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 1","pages":"39-63"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11608353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}