发布求助
文献互助 智能选刊 最新文献

Investigative & cell pathology最新文献

筛选
英文 中文
The lung at high altitude. 高海拔地区的肺。
Investigative & cell pathology Pub Date : 1979-01-01 DOI: 10.1007/978-1-4684-3971-7_26
D. Heath, D. Williams
{"title":"The lung at high altitude.","authors":"D. Heath, D. Williams","doi":"10.1007/978-1-4684-3971-7_26","DOIUrl":"https://doi.org/10.1007/978-1-4684-3971-7_26","url":null,"abstract":"","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"40 4","pages":"147-56"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51018126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cytochemical characterization of cultured adult, guinea pig glomerular cells. 培养成人豚鼠肾小球细胞的细胞化学特性。
Investigative & cell pathology Pub Date : 1979-01-01
T D Oberley, P M Burkholder, T A Barber, C C Hwang
{"title":"Cytochemical characterization of cultured adult, guinea pig glomerular cells.","authors":"T D Oberley,&nbsp;P M Burkholder,&nbsp;T A Barber,&nbsp;C C Hwang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Methods are described for culture of intact or trypsin-digested adult guinea pig glomeruli. Cell types grown from intact glomeruli were distinctly different from those which dominated cultures of trypsin dissociated glomerular cells as determined by transmission and scanning electron microscopy as well as by fluorescence or enzyme cytochemical reaction with lectins and immunofluorescence cytochemical staining for actin or fibronectin. Cells with long cytoplasmic extensions (glomerular epithelial cells), cultured from intact glomeruli, have strong affinity for concanavalin-A and soybean agglutinin which react with glucose and galactose residues respectively. Rectangular cells (glomerular mesangial cells), cultured as the predominant cell from trypsinized glomeruli, have strong affinity for wheat germ agglutinin which reacts with N-acetyl glucosamine. Both of these cell types stained immunocytochemically for fibronectin and actin although the intracellular patterns were somewhat different. These two types of cells are able to secrete extracellular basement membrane material.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"2 1","pages":"27-43"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11715397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Motor neuron diseases in man and animals. 人和动物的运动神经元疾病。
Investigative & cell pathology Pub Date : 1978-07-01
L W Duchen
{"title":"Motor neuron diseases in man and animals.","authors":"L W Duchen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Aspects of motor neuron diseases in man are described and compared with a series of animal models for these disorders. Such models provide new approaches to understanding many features of abnormalities of the central and peripheral nervous system.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 3","pages":"249-62"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11314351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic potential of malignant tumours. 恶性肿瘤的转移潜力。
Investigative & cell pathology Pub Date : 1978-07-01
R L Carter
{"title":"Metastatic potential of malignant tumours.","authors":"R L Carter","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The term 'metastatic potential' is examined, together with some of the factors that may contribute to it. The evidence is drawn from clinical and experimental sources. Morphological factors include the site of the tumour, its size, histological appearances and pattern of local spread. The scope and limitations of each are discussed and the potential application of newer morphological techniques is noted. Certain non-morphological factors are considered: these are (1) the functional heterogeneity of tumour cell populations with resepct to the metastatic capacity; (2) the elaboration of certain tumour-associated products which may potentiate tumour spread; and (3) immunological factors in the form of local host cell infiltrates in and around primary tumours. The tumour-associated products include collagenases, prostaglandins and angiogenesis factor; their likely origin from tumour and host cells is stressed, together with their implications in physiological and pathological processes other than neoplasia. It is concluded that the metastatic potential of tumours cannot be assessed in the terms of conventional tumour pathology alone. A more functional approach is needed before the term 'metastatic potential' acquires solid conceptual or practical value.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 3","pages":"275-86"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11598145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dvelopment of the Harderian gland in the chicken: light and electron microscopic investigations. 鸡哈德氏腺的发育:光镜和电镜观察。
Investigative & cell pathology Pub Date : 1978-07-01
H R Niedorf, B Wolters
{"title":"Dvelopment of the Harderian gland in the chicken: light and electron microscopic investigations.","authors":"H R Niedorf,&nbsp;B Wolters","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Harderian gland of the chcken develops from epithelial cones of the conjunctiva between the 11th and 12th day of embryonal life. The development of the organ proceeds in two phases. During the stage of epithelial development (days 13 to 17 of embryonal life) the acinar epithelium differentiates into a lumen-adjacent glandular epithelium, and a separate layer of basal epithelial cells. This basal layer is initially compact but later forms a loose meshwork. The basal cells differ from the myoepithelial cells found in the Harderian gland of rodents by virtue of their smaller number of myofilaments; and they resemble the reticuloepithelial cells in the Bursa of Fabricius. On days 17 and 18 of embryonal life the interstitial tissue is invaded by eosinophils and by small 'blasts', up to 4 microns in diameter, both of vascular origin. Between days 17 and 20 the glandular epithelium undergoes secretory transformation. At the time of hatching (day 21), the secretory function is fully developed. The mode of secretion is partly apocrine, partly merocrine. During the following phase of plasmacellular development (from day 17 of prenatal until day thirty of postnatal life) interstitial plasma cells are formed from the immigrant small 'blasts'. Their number increases until the fourth week after hatching; thereafter the plasma cell population remains stable.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 3","pages":"205-15"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11955961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An ultrahistochemical study of the placental content of respiratory enzymes in normal and prolonged pregnancies. 正常妊娠和延长妊娠胎盘呼吸酶含量的超组织化学研究。
Investigative & cell pathology Pub Date : 1978-07-01
C J Jones, H Fox
{"title":"An ultrahistochemical study of the placental content of respiratory enzymes in normal and prolonged pregnancies.","authors":"C J Jones,&nbsp;H Fox","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The placental content of malate dehydrogenase and lactate dehydrogenase has been studied at the ultrastructural level. In the trophoblast both enzymes have a predominantly mitochondrial localization although occasional membrane-bound extra-mitochondrial activity is also seen. As compared with the first trimester placenta, there is a highly significant decrease in the activity of both enzymes within the trophoblast at term; this may represent an adaptative change to reduce placental oxygen consumption and increase the amount of oxygen available to the fetus. In prolonged pregnancies, there is a continued decline in trophoblastic malate dehydrogenase activity but the lactate dehydrogenase activity tends to increase, these changes suggesting that there is a switch from oxidative pohosphorylation to anaerobic glycolysis. It is not clear whether this change to a less efficient mode of energy generation is due to an intrinsic ageing change within the trophoblast or is secondary to placental ischaemia.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 3","pages":"217-25"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11955962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer and the medical schools. 癌症和医学院
Investigative & cell pathology Pub Date : 1978-07-01
{"title":"Cancer and the medical schools.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 3","pages":"203"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11957569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro tests of cellular immunity in man. 人体细胞免疫的体外试验
Investigative & cell pathology Pub Date : 1978-07-01
R B Herberman
{"title":"In vitro tests of cellular immunity in man.","authors":"R B Herberman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There has been a recent rapid increase in the number of assays for cellular immunity in man and in information related to the mechanisms underlying the observed reactions. These tests have been applied clinically for three main purposes: (a) Evaluation of cell-mediated immune competence of patients with primary immune deficiencies and of possible immunological depression associated with cancer or other diseases. (b) Determination of major differences in histocompatibility antigens which might be important in rejection of organ transplants. Some cellular immune assays have become part of the routine battery of assays used for immunological evaluation of potential donors and recipients. (c) Measurement of specific immune reactivity against antigens associated with a variety of diseases, including infectious diseases, autoimmune diseases and cancer.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 3","pages":"227-48"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11378285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer: a challenge to clinicians and biomedical scientists. 癌症:对临床医生和生物医学科学家的挑战。
Investigative & cell pathology Pub Date : 1978-07-01
T Symington
{"title":"Cancer: a challenge to clinicians and biomedical scientists.","authors":"T Symington","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The multidisciplinary study of cancer by clinical and scientific oncologists is discussed. This approach is proposed as the optimal method of improving our understanding of the disease. The future role of general hospitals and of University Medical Schools in creating the appropriate environment for such work is outlined.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 3","pages":"263-74"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11955959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The pathogenesis of essential hypertension. 原发性高血压的发病机制。
Investigative & cell pathology Pub Date : 1978-04-01
J B Ferriss
{"title":"The pathogenesis of essential hypertension.","authors":"J B Ferriss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Essential hypertension is a quantitative abnormality, the pathological effects and risks increasing with the blood pressure level. In Western countries blood pressure rises with age in most individuals, so essential hypertension is more frequent in middle and older age groups. It is likely that an individual's blood pressure level is determined by many interacting factors. These include heredity, which probably acts multifactorially, and many environment influences, including psychological stress and obesity. Specific factors may be of varying importance in different individuals and in different populations. Several physiological mechanisms control the blood pressure level and may be altered in essential hypertension. In early hypertension sympathetic nervous activity is sometimes increased, although in long-standing hypertension this is less marked. Cardiac output may be increased in borderline hypertension but is normal in established hypertension, when total peripheral resistance is increased. Total exchangeable sodium is normal, while the renal pressure-natriuresis balance is altered, so that for a given pressure the hypertension kidney excretes less sodium. In some patients, plasma renin is low, probably as a result of renal adaption to prolonged hypertension. The pathogenic sequence in essential hypertension is uncertain. Increased autonomic activity may cause vasoconstriction in renal and other arterioles and increase cardiac output, leading to a rise in blood pressure. Elevated pressure itself produces structural changes in the resistance vessels, including those of the kidney, which eventually maintain the hypertension even when the initiating stimulus is removed. The way in which heredity and environment influence pathogenic mechanism is also uncertain. Heredity might, for example, influence the autonomic response to stress or the liability to irreversible changes in the resistance vessels or in the kidney. Environmental factors may also increase autonomic activity, enhance vascular reactivity or alter renal function.</p>","PeriodicalId":75950,"journal":{"name":"Investigative & cell pathology","volume":"1 2","pages":"171-97"},"PeriodicalIF":0.0,"publicationDate":"1978-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11607102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信