International review of experimental pathology最新文献_第5页

Comparative pathology of recombinant murine interferon-gamma in mice and recombinant human interferon-gamma in cynomolgus monkeys. 重组鼠γ干扰素在小鼠体内与重组人γ干扰素在食蟹猴体内的病理比较。

International review of experimental pathology Pub Date : 1993-01-01 DOI: 10.1016/b978-0-12-364935-5.50011-0

T G Terrell, J D Green

{"title":"Comparative pathology of recombinant murine interferon-gamma in mice and recombinant human interferon-gamma in cynomolgus monkeys.","authors":"T G Terrell, J D Green","doi":"10.1016/b978-0-12-364935-5.50011-0","DOIUrl":"https://doi.org/10.1016/b978-0-12-364935-5.50011-0","url":null,"abstract":"Interferon-gamma is a highly species-specific cytokine and has the most restricted host range of activity of the interferons. Recombinant human IFN-gamma was one of the first species-specific recombinant proteins to be thoroughly assessed in conventional safety models used for xenobiotics. Acute single-dose intravenous toxicity studies with rHuIFN-gamma were performed in rats, marmosets, and squirrel monkeys with no indications of toxicity. A complete series of subchronic toxicity studies and segment I and II reproductive studies in the rat revealed no evidence of toxicity at any of the doses tested. These results suggested that studies conducted in pharmacologically nonresponsive species may not be predictive of clinical toxicity. Human IFN-gamma is active on nonhuman primate cells, though not at the same level as on human cells. Multidose studies in cynomolgus monkeys with rHuIFN-gamma for 28 or 90 days were predictive of many of the dose-limiting clinical toxicities. Qualitative similarity was observed between toxicity studies employing rHuIFN-gamma in the cynomolgus monkey and rMuIFN-gamma in the mouse. The adverse effects seen in toxicity studies with cytokines and growth factors are often exaggerated pharmacological effects of the molecules, and therefore can only be studied in a responsive species. In situations in which a high degree of species specificity is encountered, studies employing a recombinant protein in a homologous species may provide a useful test system for preclinical safety assessment.","PeriodicalId":75947,"journal":{"name":"International review of experimental pathology","volume":"34 Pt B ","pages":"73-101"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19442160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

Cytokines involved in pulmonary fibrosis. 细胞因子参与肺纤维化。

International review of experimental pathology Pub Date : 1993-01-01 DOI: 10.1016/b978-0-12-364935-5.50017-1

P F Piguet

引用次数: 58

TNF receptor distribution in human tissues. TNF受体在人体组织中的分布。

International review of experimental pathology Pub Date : 1993-01-01 DOI: 10.1016/b978-0-12-364935-5.50015-8

B Ryffel, M J Mihatsch

{"title":"TNF receptor distribution in human tissues.","authors":"B Ryffel, M J Mihatsch","doi":"10.1016/b978-0-12-364935-5.50015-8","DOIUrl":"https://doi.org/10.1016/b978-0-12-364935-5.50015-8","url":null,"abstract":"The nature and location of cells responding to tumor necrosis factor-alpha were investigated in situ by immunohistochemistry using monoclonal antibodies directed against the p75 and p55 proteins of the TNF receptor. Receptor expression was found in the thymus and secondary lymphoid tissues. In the thymus, the p75 receptor was confined to medullary lymphoblasts and dendritic cells, which costain with the Tac protein of the interleukin-2 receptor. In lymph nodes and other secondary lymphoid tissues, the p75 receptor was expressed on activated lymphocytes and interdigitating reticulum cells of the T cell areas, whereas the p55 receptor was confined to the germinal center dendritic reticulum cells, which are the main site of TNF-alpha production. TNF receptor proteins were up-regulated in reactive hyperplasia together with increased TNF-alpha expression. Surprisingly, no TNF-R was detectable on nonlymphoid tissues. The species specificity of these TNF-antibodies was high: whereas the antibodies cross-reacted with epitopes in nonhuman primates, no immunoreactivity was detected in lower animal species, e.g., dog, rabbit, and rodents. The data presented suggest that TNF-alpha, which is produced by germinal center DRCs, might regulate an in vivo immune response through autocrine and paracrine pathways, e.g., through the p55 and p75 receptor proteins, which are expressed at different sites on the lymphoid tissue.","PeriodicalId":75947,"journal":{"name":"International review of experimental pathology","volume":"34 Pt B ","pages":"149-56"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/b978-0-12-364935-5.50015-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19370405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53

Pathology induced by hematopoietic growth factors. Introduction. 造血生长因子所致病理。介绍。

International review of experimental pathology Pub Date : 1993-01-01

B Ryffel

引用次数: 0

In vitro and in vivo activity and pathophysiology of human interleukin-8 and related peptides. 人白细胞介素-8及其相关肽的体内外活性及病理生理。

International review of experimental pathology Pub Date : 1993-01-01 DOI: 10.1016/b978-0-12-364935-5.50008-0

R Zwahlen, A Walz, A Rot

引用次数: 81

Pathology of recombinant human transforming growth factor-beta 1 in rats and rabbits. 重组人转化生长因子- β 1在大鼠和家兔体内的病理变化。

International review of experimental pathology Pub Date : 1993-01-01 DOI: 10.1016/b978-0-12-364935-5.50009-2

T G Terrell, P K Working, C P Chow, J D Green

引用次数: 132

Clinical experience with Escherichia coli rHuGM-CSF. 大肠杆菌rHuGM-CSF的临床应用经验。

International review of experimental pathology Pub Date : 1993-01-01 DOI: 10.1016/b978-0-12-364935-5.50020-1

A C Stern, T C Jones

引用次数: 0

The nature and function of the Hodgkin's cell lectin and its role in lymphocyte agglutination. 霍奇金细胞凝集素的性质和功能及其在淋巴细胞凝集中的作用。

International review of experimental pathology Pub Date : 1992-01-01 DOI: 10.1016/b978-0-12-364933-1.50010-2

E Paietta

引用次数: 0

Hodgkin's disease: analysis of cell line data. 何杰金氏病:细胞系数据分析。

International review of experimental pathology Pub Date : 1992-01-01 DOI: 10.1016/b978-0-12-364933-1.50013-8

C von Kalle, V Diehl

引用次数: 5

Diagnosis and grading of nodular sclerosing Hodgkin's disease: a study of 2190 patients. 结节硬化性霍奇金病的诊断和分级:一项2190例患者的研究

International review of experimental pathology Pub Date : 1992-01-01 DOI: 10.1016/b978-0-12-364933-1.50007-2

K A MacLennan, M H Bennett, B Vaughan Hudson, G Vaughan Hudson

引用次数: 14