International review of experimental pathology最新文献_第4页

Clinical and histopathological effects of M-CSF in laboratory animals. M-CSF对实验动物的临床和组织病理学影响。

International review of experimental pathology Pub Date : 1993-01-01

C W Johnson, J P Nachtman, R E Cimprich, H L Moon, S E Mills, J Beckendorf, B S Levine, R C Long, G B Fuller, G Losos

引用次数: 0

Pathogenesis of toxicity with human-derived interleukin-2 in experimental animals. 实验动物中人源性白介素-2毒性的发病机制。

International review of experimental pathology Pub Date : 1993-01-01

Y Harada, I Yahara

{"title":"Pathogenesis of toxicity with human-derived interleukin-2 in experimental animals.","authors":"Y Harada, I Yahara","doi":"","DOIUrl":"","url":null,"abstract":"It should be pointed out that although repeated systemic administration of exogenous rIL-2 in nonphysiological doses to mice, rats, and monkeys produced various toxicity-related exaggerated pharmacodynamic effects in many experimental parameters, pathological findings were substantially similar among all species. Furthermore, because toxicities observed in our studies were identical to those reported in humans dosed with rIL-2, preclinical toxicity using animal models was fully predictive of the pathogenesis of rIL-2 in human. With continuous infusion, which maintained high blood concentrations of the product during the course of the study, rIL-2 constantly stimulated proliferation of lymphoblastoid cells in peripheral blood, subsequently causing vascular leakage, which consists of edema and extravasation of activated lymphoblastoid cells into perivascular areas. The migrating lymphoblastoid cells, identified as cytotoxic T lymphocytes and NK-LAK cells, caused perivascular and hepatocytic necrosis by means of enzymatic secretions from the cells in association with infiltration into parenchymal tissues. In addition to the stimulation of lymphoblastoid cells in peripheral blood, prolonged daily bolus administration of rIL-2 induced extravasation and infiltration of activated macrophages and B cells in tissues of all organs. Eosinophilia, fibrosis in the subcutis, or pseudolobular formations in the liver could be mediated by systemic release of many other cytokines from activated T cells, i.e., CTLs or LAK cells, B cells, and macrophages.","PeriodicalId":75947,"journal":{"name":"International review of experimental pathology","volume":"34 Pt A ","pages":"37-55"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19437143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin-6 in myeloma/plasmacytoma. 白介素-6在骨髓瘤/浆细胞瘤中的作用。

International review of experimental pathology Pub Date : 1993-01-01

S Suematsu, T Matsusaka, T Matsuda, T Hirano, T Kishimoto

引用次数: 0

Cytokine-induced pathology. Part B: inflammatory cytokines, receptors and disease. Workshop. Basel, Switzerland, August 1991. 细胞因子诱导的病理变化。B部分:炎性细胞因子、受体和疾病。车间。瑞士巴塞尔，1991年8月。

International review of experimental pathology Pub Date : 1993-01-01 DOI: 10.1016/c2013-0-10893-8

Caitlyn Phillip

引用次数: 0

Immune-mediated injury in bacterial meningitis. 细菌性脑膜炎的免疫介导损伤。

International review of experimental pathology Pub Date : 1993-01-01 DOI: 10.1016/b978-0-12-364935-5.50018-3

K Frei, D Piani, H W Pfister, A Fontana

引用次数: 28

Pathology induced by inflammatory cytokines. Introduction. 炎症细胞因子引起的病理。介绍。

International review of experimental pathology Pub Date : 1993-01-01

B Ryffel

引用次数: 0

Comparative toxicity and pathology associated with administration of recombinant IL-2 to animals. 重组白介素-2给药对动物的比较毒性和病理学。

International review of experimental pathology Pub Date : 1993-01-01

T D Anderson, T J Hayes, G D Powers, M K Gately, R Tudor, A Rushton

引用次数: 0

Pathophysiologic alterations induced by tumor necrosis factor. 肿瘤坏死因子引起的病理生理改变。

International review of experimental pathology Pub Date : 1993-01-01 DOI: 10.1016/b978-0-12-364935-5.50007-9

D G Remick, S L Kunkel

引用次数: 30

Granulocyte colony stimulating factor: animal studies for risk assessment. 粒细胞集落刺激因子:风险评估的动物研究。

International review of experimental pathology Pub Date : 1993-01-01

P Keller, R Smalling

{"title":"Granulocyte colony stimulating factor: animal studies for risk assessment.","authors":"P Keller, R Smalling","doi":"","DOIUrl":"","url":null,"abstract":"In mice, rats, hamsters, dogs, and monkeys, doses of > or = 1.1 microgram/kg/day of r-metHuG-CSF stimulated neutrophil production in bone marrow. There was a resulting rapid release of mature neutrophils from the marrow storage pool into circulation and a distinct neutrophilia maintained for the dosing period in each study. R-metHuG-CSF corrected cyclic hemopoiesis in dogs, established sustained endogenous recovery after lethal bone marrow suppression, and elicited differention and maturation induction and enhanced functional activity of mature neutrophils. Reversible side effects due to an exaggerated pharmacological activity of the growth factor were observed at doses of > or = 115 micrograms/kg/day, with the exception of a rodent-specific osteopathy, which occurred in some animals after 3 months at > or = 5.7 micrograms/kg/day. The only irreversible adverse effect was seen in monkeys at doses of 1150 micrograms/kg/day (equivalent to 200 times the recommended human dose) when leukocyte counts exceeded 100 x 10(9)/liter. It consisted of hyperleukocytosis, leukostasis in terminal capillaries of the brain, followed by tissue hypoxia and intracerebral hemorrhage. Local tolerance of r-metHuG-CSF was good and no hypersensitivity reactions were observed. Antibody formation was minimal in monkeys but occasionally marked in dogs, which is not suprising due to the species difference in the amino acid sequence of the factor. The use of recombinant canine G-CSF, however, did not elicit formation of neutralizing antibodies in dogs. Moreover, relatively few untoward effects were seen in reproductive toxicology except when maternal toxicity or weight loss of dams occurred. In addition, negative results were obtained in all genotoxicity studies performed.","PeriodicalId":75947,"journal":{"name":"International review of experimental pathology","volume":"34 Pt A ","pages":"173-88"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18684616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to cytokine receptors: structure and signal transduction. 细胞因子受体简介:结构和信号转导。

International review of experimental pathology Pub Date : 1993-01-01 DOI: 10.1016/b978-0-12-364935-5.50012-2

B Foxwell, K Barrett

引用次数: 5