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Self-Contempt as a Predictor of Suicidality: A Longitudinal Study. 作为自杀预兆的自责：纵向研究
IF 1.9
International journal of nuclear medicine and biology Pub Date : 2019-12-01 DOI: 10.1097/NMD.0000000000001079
Nicolas Rüsch, Nathalie Oexle, Graham Thornicroft, Johannes Keller, Christiane Waller, Ines Germann, Christina A Regelmann, Michael Noll-Hussong, Roland Zahn
{"title":"Self-Contempt as a Predictor of Suicidality: A Longitudinal Study.","authors":"Nicolas Rüsch, Nathalie Oexle, Graham Thornicroft, Johannes Keller, Christiane Waller, Ines Germann, Christina A Regelmann, Michael Noll-Hussong, Roland Zahn","doi":"10.1097/NMD.0000000000001079","DOIUrl":"10.1097/NMD.0000000000001079","url":null,"abstract":"<p><p>People with mental illness can internalize public prejudice and negative emotional reactions to their group, leading to self-contempt. This study examined self-contempt related to having a mental illness as predictor of suicidality among 77 people with mental illness in Southern Germany. Self-contempt, depressive symptoms, hopelessness, and suicidality were assessed at baseline; suicidality was measured again 3 months later. High self-contempt at baseline predicted increased suicidality at follow-up, adjusting for baseline suicidality, symptoms, diagnosis, age, sex, and hopelessness. These results suggest that self-contempt may be a risk factor for suicidality and call for specific interventions targeting self-stigma and its emotional consequences.</p>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"9 1","pages":"1056-1057"},"PeriodicalIF":1.9,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75142587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and evaluation of a new bifunctional chelating agent for 99mTc labeling proteins: p-carboxyethylphenylglyoxal-di(N-methylthiosemicarbazone) 新型99mTc标记蛋白双功能螯合剂对羧基乙基苯基乙二醛-二(n -甲基硫代氨基脲)的合成与评价
International journal of nuclear medicine and biology Pub Date : 1986-01-01 DOI: 10.1016/S0047-0740(86)80003-1
Yasushi Arano , Akira Yokoyama , Yasuhiro Magata , Hideo Saji , Kazuko Horiuchi , Kanji Torizuka
{"title":"Synthesis and evaluation of a new bifunctional chelating agent for 99mTc labeling proteins: p-carboxyethylphenylglyoxal-di(N-methylthiosemicarbazone)","authors":"Yasushi Arano ,&nbsp;Akira Yokoyama ,&nbsp;Yasuhiro Magata ,&nbsp;Hideo Saji ,&nbsp;Kazuko Horiuchi ,&nbsp;Kanji Torizuka","doi":"10.1016/S0047-0740(86)80003-1","DOIUrl":"10.1016/S0047-0740(86)80003-1","url":null,"abstract":"<div><p>A new bifunctional chelating agent, <em>p</em>-carboxyethylphenylglyoxal-di(N-methylthiosemicarbazone) (CE-DTS), containing a di(N-methylthiosemicarbazone) as the technetium coordinating site and an aralkyl carboxylate site for the protein conjugation was synthesized. Coupling to human serum albumin (HSA), selected as a model protein was carried out by the phosphorylazide method using diphenylphosphoryl azide (DPPA). The conjugation level of CE-DTS to HSA played a critical role in its biological evaluation. A <sup>99m</sup>Tc-CE-DTS-HSA with high <em>in vivo</em> stability was obtained when CE-DTS was coupled to HSA at 1:1 molar ratio. This compound showed similar <em>in vivo</em> stability to <sup>131</sup>I labeled HSA in mice and rabbits.</p></div>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Pages 425-430"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80003-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14829939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
New patents 新专利
International journal of nuclear medicine and biology Pub Date : 1986-01-01 DOI: 10.1016/S0047-0740(86)80016-X
{"title":"New patents","authors":"","doi":"10.1016/S0047-0740(86)80016-X","DOIUrl":"https://doi.org/10.1016/S0047-0740(86)80016-X","url":null,"abstract":"","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Pages I-II"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80016-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91590490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Detection of endotoxins in radiopharmaceutical preparations--III. Limulus test assessment using radiopharmaceutical preparations; correlation with the rabbit pyrogen test]. 放射性药物制剂中内毒素的检测——ⅲ。放射性药物制剂的鲎试验评价;[与兔热原试验的相关性]。
International journal of nuclear medicine and biology Pub Date : 1986-01-01
Y Cohen, F Bahri, J Bruneau, M Dubuis, N Dubuis, L Merlin, T Michaud, S Peysson
{"title":"[Detection of endotoxins in radiopharmaceutical preparations--III. Limulus test assessment using radiopharmaceutical preparations; correlation with the rabbit pyrogen test].","authors":"Y Cohen,&nbsp;F Bahri,&nbsp;J Bruneau,&nbsp;M Dubuis,&nbsp;N Dubuis,&nbsp;L Merlin,&nbsp;T Michaud,&nbsp;S Peysson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Experiments using 17 radiopharmaceuticals containing known amounts of added endotoxin show that none of them inhibits the pyrogenic reaction of the rabbit. Gelation of the Limulus amoebocyte lysate (LAL) is inhibited by 4 of them: colloidal erbium 169Er citrate, colloidal rhenium 186Re sulfide, colloidal technetium 99mTc (Re) sulfide for liver scintigraphy and the colloidal technetium 99mTc (Re) sulfide for lymphography. This inhibition is cancelled, either by dilution or after neutral pH adjustment. Both controls were performed on 313 batches of various radiopharmaceuticals, 95% of results were identical (93% negative, 2% positive). The remaining 5% correspond to positive LAL tests vs negative rabbit tests on the same batches. No negative LAL test vs positive rabbit test was observed.</p>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"477-81"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14642268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
62Zn-EDDA: A radiopharmaceutical for pancreatic functional diagnosis 62Zn-EDDA:用于胰腺功能诊断的放射性药物
International journal of nuclear medicine and biology Pub Date : 1986-01-01 DOI: 10.1016/S0047-0740(86)80005-5
Y. Fujibayashi , H. Saji , I. Yomoda , K. Kawai , K. Horiuchi , H. Adachi , K. Torizuka , A. Yokoyama
{"title":"62Zn-EDDA: A radiopharmaceutical for pancreatic functional diagnosis","authors":"Y. Fujibayashi ,&nbsp;H. Saji ,&nbsp;I. Yomoda ,&nbsp;K. Kawai ,&nbsp;K. Horiuchi ,&nbsp;H. Adachi ,&nbsp;K. Torizuka ,&nbsp;A. Yokoyama","doi":"10.1016/S0047-0740(86)80005-5","DOIUrl":"10.1016/S0047-0740(86)80005-5","url":null,"abstract":"<div><p>As Zn is closely associated with the exocrine and endocrine functions of the pancreas, exploitation of Zn metabolism for anatomical and functional diagnosis was conceived, namely with the recent availability of positron emitting <sup>62</sup>Zn (<em>t</em>½ = 9 h). In the present paper, response changes in Zn biodistribution (mice) and Zn excretion through the pancreatic duct (rats) due to the stimulation of gastro-intestinal hormones like secretin, CCK-PZ (exocrine stimulation) and glucose (endocrine stimulation) were studied. Under these stimuli, the pancreatic secretion of radioactive Zn through cannulated pancreatic duct showed increased Zn secretion only under the CCK-PZ effect, 3 h post <sup>65</sup>Zn (<em>t</em>½ = 270 d) injection. Tissue biodistribution in mice pre-injected with <sup>65</sup>Zn showed pancreas specific decrease of radioactive Zn whenever a gastro-intestinal hormone was post-administered, whereas the glucose effect was negligible. Thus, the effective mobilization of the injected radioactive Zn, upon exocrine stimulation, represented by CCK-PZ, favored the exploration of a functional study of the pancreas with the positron computed tomograph (PCT) using short lived nuclide labeled <sup>62</sup>Zn-EDDA in dog. Evidence of the applicability of this system in regional function studies of the pancreas was obtained. Demonstration of Zn participation in the exocrine function of the pancreas <em>in-vivo</em> holds considerable promise for diagnosis of pancreatic diseases.</p></div>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Pages 439-446"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80005-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14217596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
A radiopharmaceutical for pancreatic exocrine functional diagnosis: 62Zn-EDDA metabolism in pancreas. 胰脏外分泌功能诊断的放射性药物:胰脏62Zn-EDDA代谢。
International journal of nuclear medicine and biology Pub Date : 1986-01-01
Y Fujibayashi, H Saji, K Kawai, Y Unuma, S Miyata, T Okuno, R Hosotani, K Inoue, H Adachi, K Horiuchi
{"title":"A radiopharmaceutical for pancreatic exocrine functional diagnosis: 62Zn-EDDA metabolism in pancreas.","authors":"Y Fujibayashi,&nbsp;H Saji,&nbsp;K Kawai,&nbsp;Y Unuma,&nbsp;S Miyata,&nbsp;T Okuno,&nbsp;R Hosotani,&nbsp;K Inoue,&nbsp;H Adachi,&nbsp;K Horiuchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The metabolic pathway of radioactive 62Zn-EDDA (ethylenediamine-N,N'-diacetic acid), in the exocrine pancreas was studied with respect to that of endogenous Zn. In pancreatic duct cannulated dog, the secretion of intravenously injected exogenous 62Zn into pancreatic juice increased under the stimulation of CCK-PZ (pancreatic protein secretion stimulating hormone), which closely correlated to endogenous Zn. Moreover, in pancreatic juice, 62Zn as well as endogenous Zn was selectively bound to Zn-metalloenzymes, carboxypeptidase A and B. These results demonstrated the close correlation between the endogenous and the exogenously-administered Zn (62Zn-EDDA), as well as the high availability of 62Zn-EDDA as a marker of pancreatic function for the follow up of carboxypeptidase metabolism.</p>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"447-51"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14217597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In the procurement of a neutral and compact monomeric complex of dithiosemicarbazone (DTS) derivative: 99mTc-KTS 在采购中性和紧凑的二硫代氨基脲(DTS)衍生物的单体配合物:99mTc-KTS
International journal of nuclear medicine and biology Pub Date : 1986-01-01 DOI: 10.1016/S0047-0740(86)80004-3
Takeo Hosotani , Akira Yokoyama , Yasushi Arano , Kazuko Horiuchi , Hiroko Wasaki , Hideo Saji , Kanji Torizuka
{"title":"In the procurement of a neutral and compact monomeric complex of dithiosemicarbazone (DTS) derivative: 99mTc-KTS","authors":"Takeo Hosotani ,&nbsp;Akira Yokoyama ,&nbsp;Yasushi Arano ,&nbsp;Kazuko Horiuchi ,&nbsp;Hiroko Wasaki ,&nbsp;Hideo Saji ,&nbsp;Kanji Torizuka","doi":"10.1016/S0047-0740(86)80004-3","DOIUrl":"10.1016/S0047-0740(86)80004-3","url":null,"abstract":"<div><p>As a basic structure of a bifunctional radiopharmaceutical (BR), dithiosemicarbazone (DTS) enables the formation of a small conjugated chelating ring with divalent metals (Cu<sup>2+</sup>, Zn<sup>2+</sup>, Ni<sup>2+</sup>), yielding stable and compact complexes.</p><p>In the development of a neutral and compact monomelic DTS complex of technetium (<sup>99m</sup>Tc), a DTS containing ligand, kethoxal-bis(thiosemicarbazone) (KTS) was selected. A well known monomelic Cu-KTS complex (or <sup>64</sup>Cu-KTS) is taken as a model compound, and <em>in vitro</em> (TLC, EP, HPLC) and <em>in vivo</em> (mice biodistribution) studies were compared. Using the stannous chloride method, under conditions to avoid the hydrolytic polynucleation of technetium, a good yield of <sup>99m</sup>Tc-KTS with characteristics resembling the non-charged, compact and stable Cu-KTS is obtained, in <em>in vitro</em> as well as <em>in vivo</em> studies. The importance of DTS as the constituent of a BR is discussed.</p></div>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Pages 431-437"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80004-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14829940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
The role of detergent in labeling of Erysipelothrix rhusiopathiae bacteria 洗涤剂在红唇丹毒细菌标记中的作用
International journal of nuclear medicine and biology Pub Date : 1986-01-01 DOI: 10.1016/S0047-0740(86)80007-9
G.-F. Gerlach, K. Petzoldt
{"title":"The role of detergent in labeling of Erysipelothrix rhusiopathiae bacteria","authors":"G.-F. Gerlach,&nbsp;K. Petzoldt","doi":"10.1016/S0047-0740(86)80007-9","DOIUrl":"10.1016/S0047-0740(86)80007-9","url":null,"abstract":"<div><p>The chelating agents oxine, acetylacetone, tropolone, and 2-mercaptopyridine 1-oxide were analysed for their suitability in labeling the bacterium <em>Erysipelothrix rhusiopathiae</em> (E.r.), strain BIO, with <sup>111</sup>In and <sup>67</sup>Ga. The labeling conditions were improved. The bactericidal activity of the labeling process was investigated. The different chelates did not result in a significant difference in labeling yield. The addition of 0.01% detergent to the labeling buffer doubled the labeling yield up to 45%. Labeled bacteria were injected intravenously into rats. The percentage organ distribution was determined and compared with a control group.</p></div>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Pages 453-456"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80007-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55874392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement of visual resolution in fluorescent scanning by a new subtraction procedure for backscatter 用一种新的后向散射减法提高荧光扫描的视觉分辨率
International journal of nuclear medicine and biology Pub Date : 1986-01-01 DOI: 10.1016/S0047-0740(86)80013-4
Yoshiaki Nose, Motoomi Nakamura, Atsushi Yoshimura, Tetsuji Cho, Shuzo Uehara, Yoshihiko Oshiumi
{"title":"Improvement of visual resolution in fluorescent scanning by a new subtraction procedure for backscatter","authors":"Yoshiaki Nose,&nbsp;Motoomi Nakamura,&nbsp;Atsushi Yoshimura,&nbsp;Tetsuji Cho,&nbsp;Shuzo Uehara,&nbsp;Yoshihiko Oshiumi","doi":"10.1016/S0047-0740(86)80013-4","DOIUrl":"10.1016/S0047-0740(86)80013-4","url":null,"abstract":"","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Pages 489-494"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80013-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14642269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of detergent in labeling of Erysipelothrix rhusiopathiae bacteria. 洗涤剂在红唇丹毒细菌标记中的作用。
International journal of nuclear medicine and biology Pub Date : 1986-01-01
G F Gerlach, K Petzoldt
{"title":"The role of detergent in labeling of Erysipelothrix rhusiopathiae bacteria.","authors":"G F Gerlach,&nbsp;K Petzoldt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The chelating agents oxine, acetylacetone, tropolone, and 2-mercaptopyridine 1-oxide were analysed for their suitability in labeling the bacterium Erysipelothrix rhusiopathiae (E.r.), strain B10, with 111In and 67Ga. The labeling conditions were improved. The bactericidal activity of the labeling process was investigated. The different chelates did not result in a significant difference in labeling yield. The addition of 0.01% detergent to the labeling buffer doubled the labeling yield up to 45%. Labeled bacteria were injected intravenously into rats. The percentage organ distribution was determined and compared with a control group.</p>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"453-6"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14829941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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