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International journal of nuclear medicine and biology最新文献

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[Detection of endotoxins in radiopharmaceutical preparations--II. Comparison of the sensitivity of methods using the rabbit and the Limulus amoebocyte lysate for the detection of endotoxins]. 放射性药物制剂中内毒素的检测——ⅱ。兔法与鲎试剂法检测内毒素的灵敏度比较。
International journal of nuclear medicine and biology Pub Date : 1986-01-01
J Bruneau, Y Cohen, L Merlin, S Peysson
{"title":"[Detection of endotoxins in radiopharmaceutical preparations--II. Comparison of the sensitivity of methods using the rabbit and the Limulus amoebocyte lysate for the detection of endotoxins].","authors":"J Bruneau,&nbsp;Y Cohen,&nbsp;L Merlin,&nbsp;S Peysson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The rise of the rabbit internal temperature after i.v. injection of an endotoxin solution is proportional to concentration. Gelation of Limulus amoebocyte, when in presence of an endotoxin solution, is also related to concentration. We compared the sensitivity of these two methods. With our experimental procedure, the rabbit is sensitive to a 0.40 ng/mL solution and the Limulus amoebocyte lysate to a 0.14 ng/mL solution. The rabbit sensitivity increase is related to the per kilogramme injected volume, whereas sensitivity is not related to the volume to check in the case of the lysate.</p>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"471-6"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14642267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
La recherche des endotoxines dans les préparations radiopharmaceutiques—II. Comparaison de la sensibilité des methodes utilisant le lapin et le lysat d’Amoebocytes de Limule pour la détection d’Endotoxines 放射性药物制剂中内毒素的研究-二。用兔子和Limule变形虫细胞裂解液检测内毒素的敏感性比较
International journal of nuclear medicine and biology Pub Date : 1986-01-01 DOI: 10.1016/S0047-0740(86)80010-9
J. Bruneau, Y. Cohen, L. Merlin, S. Peysson
{"title":"La recherche des endotoxines dans les préparations radiopharmaceutiques—II. Comparaison de la sensibilité des methodes utilisant le lapin et le lysat d’Amoebocytes de Limule pour la détection d’Endotoxines","authors":"J. Bruneau,&nbsp;Y. Cohen,&nbsp;L. Merlin,&nbsp;S. Peysson","doi":"10.1016/S0047-0740(86)80010-9","DOIUrl":"10.1016/S0047-0740(86)80010-9","url":null,"abstract":"<div><p>L’élévation de la température interne du lapin après injection intraveineuse d’une solution d’endotoxine est proportionnelle à la concentration. La coagulation d’un lysat d’amoebocytes de <em>Limule</em> lorsqu'il est placé en présence d’une solution d’endotoxine a aussi pour facteur la concentration. Nous avons comparé la sensibilité des deux réactions. Dans nos conditions expérimentales, le lapin se montre sensible à une solution contenant 0,40 ng/mL et le lysat d’amoebocytes de <em>Limule</em>, à une solution contenant 0,14 ng/mL. La sensibilité du lapin croît avec le volume injecté par kilogramme alors que pour le lysat cette sensibilité n'est pas liée directement au volume de solution à contrôler.</p></div><div><p>The rise of the rabbit internal temperature after i.v. injection of an endotoxin solution is proportional to concentration. Gelation of <em>Limulus</em> amoebocyte, when in presence of an endotoxin solution, is also related to concentration. We compared the sensitivity of these two methods. With our experimental procedure, the rabbit is sensitive to a 0.40 ng/mL solution and the <em>Limulus</em> amoebocyte lysate to a 0.14 ng/mL solution. The rabbit sensitivity increase is related to the per kilogramme injected volume, whereas sensitivity is not related to the volume to check in the case of the lysate.</p></div>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Pages 471-476"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80010-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55874409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Detection of endotoxins in radiopharmaceutical preparations--I. Comparison of rabbit hyperthermia after intravenous or intrathecal administration of reference endotoxin preparations]. 放射性药物制剂中内毒素的检测——ⅰ。兔热疗后静脉或鞘内给药参考内毒素制剂的比较[j]。
International journal of nuclear medicine and biology Pub Date : 1986-01-01
L Merlin, J Bruneau, Y Cohen, T Michaud
{"title":"[Detection of endotoxins in radiopharmaceutical preparations--I. Comparison of rabbit hyperthermia after intravenous or intrathecal administration of reference endotoxin preparations].","authors":"L Merlin,&nbsp;J Bruneau,&nbsp;Y Cohen,&nbsp;T Michaud","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The rise of the rabbit internal temperature after endotoxin injection is related to the route of administration. A rise of 1.71 +/- 0.411 degrees C is obtained after i.v. injection of 1 ng/kg Escherichia coli 0111.B.4 endotoxin. An increase of 1.93 +/- 0.236 degrees C is obtained after suboccipital intrathecal injection of 0.1 ng/kg of the same endotoxin; with the intrathecal route, the hyperthermia is induced by E. coli endotoxin after a dose ten times lower than with i.v. injection as shown by statistical analysis.</p>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"467-70"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14642266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
99mTc bone scanning agents—III. Preparation and gel chromatography of 99mTc(Sn)MDP complexes 99mTc骨扫描剂- iii。99mTc(Sn)MDP配合物的制备及凝胶层析
International journal of nuclear medicine and biology Pub Date : 1986-01-01 DOI: 10.1016/S0047-0740(86)80002-X
J. Kroesbergen, W.J. Gelsema, C.L. De Ligny
{"title":"99mTc bone scanning agents—III. Preparation and gel chromatography of 99mTc(Sn)MDP complexes","authors":"J. Kroesbergen,&nbsp;W.J. Gelsema,&nbsp;C.L. De Ligny","doi":"10.1016/S0047-0740(86)80002-X","DOIUrl":"10.1016/S0047-0740(86)80002-X","url":null,"abstract":"<div><p>The preparation of <sup>99m</sup>Tc(Sn)MDP was investigated as a function of pH, MDP concentration and Sn(II) concentration. The labeling efficiency was over 90% in the majority of the experiments and remained constant over the range pH 2–9. The MDP concentration had little effect, while the Sn(II) concentration had a significant positive influence. The complex formation appeared to be partly reversible.</p><p>The formation of different complexes was investigated by means of gel chromatography under various experimental conditions. Altogether six complexes were found. At acid conditions two major complexes were found and at neutral pH one major complex. The presence or absence of a particular complex was mainly determined by the pH and by the MDP concentration. The Sn(II) concentration had very little effect.</p><p>The results are compared with previous results of similar experiments with <sup>99m</sup>Tc(Sn)pyrophosphate.(1)</p></div>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Pages 419-424"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80002-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14829938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Radiation synovectomy with 165Dy-FHMA: Lymph node uptake and radiation dosimetry calculations 放射滑膜切除术与165Dy-FHMA:淋巴结摄取和辐射剂量计算
International journal of nuclear medicine and biology Pub Date : 1986-01-01 DOI: 10.1016/S0047-0740(86)80008-0
M.R. Zalutsky, P.P. Venkatesan, R.J. English, S. Shortkroff, C.B. Sledge, S.J. Adelstein
{"title":"Radiation synovectomy with 165Dy-FHMA: Lymph node uptake and radiation dosimetry calculations","authors":"M.R. Zalutsky,&nbsp;P.P. Venkatesan,&nbsp;R.J. English,&nbsp;S. Shortkroff,&nbsp;C.B. Sledge,&nbsp;S.J. Adelstein","doi":"10.1016/S0047-0740(86)80008-0","DOIUrl":"10.1016/S0047-0740(86)80008-0","url":null,"abstract":"<div><p>The lymph node uptake of <sup>165</sup>Dy was measured in 25 patients treated by radiation synovectomy via intra-articular injection of <sup>l65</sup>Dy-ferric hydroxide macroaggregates (FHMA). An average of 0.12% of the injected dose was found in the inguinal lymph nodes 19h post injection. This results in a lymph node of 16.6 rad (166mGy), a dose significantly less than that reported following radiation synovectomy with other radiocolloids. Dosimetry calculations for the intra-articular injection of <sup>165</sup>Dy-FHMA are provided in the appendix.</p></div>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Pages 457-465"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80008-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14829942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
[Iodo carboxamidino-1 phenyl-4 piperazine, a new adrenomedullary imaging agent: comparison with metaiodobenzylguanidine]. 一种新的肾上腺髓显像剂——碘羧氨基-1苯基-4哌嗪:与甲氧苄胍的比较。
International journal of nuclear medicine and biology Pub Date : 1986-01-01
A Letiec, D Guilloteau, F Huguet, J L Baulieu, J C Besnard, C Viel
{"title":"[Iodo carboxamidino-1 phenyl-4 piperazine, a new adrenomedullary imaging agent: comparison with metaiodobenzylguanidine].","authors":"A Letiec,&nbsp;D Guilloteau,&nbsp;F Huguet,&nbsp;J L Baulieu,&nbsp;J C Besnard,&nbsp;C Viel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This report describes the comparison between two adrenal medulla imaging agents, mIBG and I-CPP. Biodistribution demonstrated an early and preferential uptake by both adrenal glands and heart and then storage in the adrenal gland of both agents, however I-CPP is less stable in vivo than mIBG. Reserpine depletion study in rat indicated that the I-CPP and mIBG uptake mechanisms are not similar.</p>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"495-6"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14829943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
La recherche des endotoxines dans les préparations radiopharmaceutiques—I. Comparaison de l’Hyperthermie du lapin après administration intraveineuse ou intrathécale d’Endotoxine de référence 放射性药物制剂中内毒素的研究- I。兔静脉或鞘内注射参考内毒素后的热疗比较
International journal of nuclear medicine and biology Pub Date : 1986-01-01 DOI: 10.1016/S0047-0740(86)80009-2
L. Merlin, J. Bruneau, Y. Cohen, T. Michaud
{"title":"La recherche des endotoxines dans les préparations radiopharmaceutiques—I. Comparaison de l’Hyperthermie du lapin après administration intraveineuse ou intrathécale d’Endotoxine de référence","authors":"L. Merlin,&nbsp;J. Bruneau,&nbsp;Y. Cohen,&nbsp;T. Michaud","doi":"10.1016/S0047-0740(86)80009-2","DOIUrl":"10.1016/S0047-0740(86)80009-2","url":null,"abstract":"<div><p>L’élévation de la température interne du lapin après injection d’endotoxine varie en fonction de la voie utilisée. Une élévation de température de 1,71 ± 0,411°C est obtenue après injection intraveineuse de 1 ng/kg d’endotoxine d’<em>Escherichia coli</em> 0111.B.4. L’injection intrathécale par la voie sous occipitale de 0,1 ng/kg entraîne une élévation de 1,93 ± 0,236°C; l’analyse statistique des résultats montre que la réaction hyperthermique du lapin est dix fois plus intense lorsque l’endotoxine est injectée par cette voie.</p></div><div><p>The rise of the rabbit internal temperature after endotoxin injection is related to the route of administration. A rise of 1.71 ±0.411°C is obtained after i.v. injection of 1 ng/kg <em>Escherichia coli</em> 0111.B.4 endotoxin. An increase of 1.93 ±0.236°C is obtained after suboccipital intrathecal injection of 0.1 ng/kg of the same endotoxin; with the intrathecal route, the hyperthermia is induced by <em>E. coli</em> endotoxin after a dose ten times lower than with i.v. injection as shown by statistical analysis.</p></div>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Pages 467-470"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80009-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55874403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
International journal of nuclear medicine and biology Pub Date : 1986-01-01 DOI: 10.1016/S0047-0740(86)80015-8
Dr Fred Rapp
{"title":"","authors":"Dr Fred Rapp","doi":"10.1016/S0047-0740(86)80015-8","DOIUrl":"https://doi.org/10.1016/S0047-0740(86)80015-8","url":null,"abstract":"","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Page 497"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80015-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91590491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The binding of plutonium to transferrin in the presence of tri-n-butyl phosphate or nitrate and its release by diethylenetriaminepenta-acetate and the tetrameric catechoylamide ligand LICAMC(C) 在磷酸三丁酯或硝酸盐存在的情况下，钚与转铁蛋白的结合以及二乙烯三胺五乙酸酯和四聚儿茶酚酰胺配体LICAMC的释放(C)
International journal of nuclear medicine and biology Pub Date : 1986-01-01 DOI: 10.1016/S0047-0740(86)80012-2
J.R. Duffield, D.M. Taylor, S.A. Proctor
{"title":"The binding of plutonium to transferrin in the presence of tri-n-butyl phosphate or nitrate and its release by diethylenetriaminepenta-acetate and the tetrameric catechoylamide ligand LICAMC(C)","authors":"J.R. Duffield,&nbsp;D.M. Taylor,&nbsp;S.A. Proctor","doi":"10.1016/S0047-0740(86)80012-2","DOIUrl":"10.1016/S0047-0740(86)80012-2","url":null,"abstract":"<div><p>The binding of plutonium to human apo-transferrin and to rat serum was investigated following delivery of the metal to the protein either as the plutonium-tri-n-butyl phosphate (Pu-TBP) complex in n-dodecane or as plutonium nitrate. Chromatographic behaviour, the failure to bind to iron-saturated transferrin and the release of plutonium by the chelating agents CaNa<sub>3</sub>DTPA and 3,4,3-LICAM(C) suggest that the transferrin complexes formed from the two plutonium compounds are similar. The tetracatechoylamide ligand LICAM(C) was found to be about 500 times more effective than DTPA, on a molar basis, for the release of plutonium from transferrin in rat serum.</p></div>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Pages 483-487"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80012-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14872738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
99mTc bone scanning agents—II. Adsorption of 99mTc(Sn)pyrophosphate complexes on the mineral phase of bone 99mTc骨扫描剂- ii。99mTc(Sn)焦磷酸盐配合物在骨矿物相上的吸附
International journal of nuclear medicine and biology Pub Date : 1986-01-01 DOI: 10.1016/S0047-0740(86)80001-8
J. Kroesbergen, A.M.P. Van Steijn, W.J. Gelsema, C.L. De Ligny
{"title":"99mTc bone scanning agents—II. Adsorption of 99mTc(Sn)pyrophosphate complexes on the mineral phase of bone","authors":"J. Kroesbergen,&nbsp;A.M.P. Van Steijn,&nbsp;W.J. Gelsema,&nbsp;C.L. De Ligny","doi":"10.1016/S0047-0740(86)80001-8","DOIUrl":"10.1016/S0047-0740(86)80001-8","url":null,"abstract":"<div><p>The adsorption of pyrophosphate, tin-pyrophosphate and 99mTc(Sn)pyrophosphate on Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> was investigated at pH 4.0 and pH 7.4. All components were radioactively labeled.</p><p>Tin and reduced technetium were in most cases almost completely bound. The adsorption of pyrophosphate, tin(II) and technetium-99m at pH 4.0 was higher than at pH 7.4. The presence of tin gave rise to an increase of the pyrophosphate adsorption that was much larger than can be accounted for by a stoichiometric adsorption of tin-pyrophosphate.</p><p>It is concluded that tin and technetium are bound as negatively charged complexes with pyrophosphate.</p><p>Finally it is argued that the fraction of the bone scanning agent that reaches the bone surface is adsorbed completely by the mineral phase.</p></div>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 6","pages":"Pages 411-417"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0047-0740(86)80001-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14145841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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