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International journal of clinical pharmacology and biopharmacy最新文献

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Systemic thermotherapy (whole body hyperthermia). 全身热疗(全身热疗)。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-08-01
D R Cole, J Pung, Y D Kim, R A Berman, D F Cole
{"title":"Systemic thermotherapy (whole body hyperthermia).","authors":"D R Cole,&nbsp;J Pung,&nbsp;Y D Kim,&nbsp;R A Berman,&nbsp;D F Cole","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This is an article reviewing the literature and our experience to date (six months) in the treatment of cancer using whole body hyperthermia in the first 60 patients. WBHT is an effective method of treating cancer. Patients were treated for a total of eight hours, 180 degrees F for two hours. WBHT was induced by means of two high-flow water filled blankets. Toxicity included fatigue, nausea, diarrhea and first degree burns. There was no evidence of visceral damage. There were no mortalities during the procedure. Objective responses were 50%, subjective responses were 65%. The literature demonstrates and our study confirms that under closely monitored conditions, WBHT is a feasible, safe and active anti-cancer therapy. WBHT may be safely used as an adjunct to other active cancer therapies including X-ray therapy and chemotherapy.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 8","pages":"329-333"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11694391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenacetin concentrations in portal and hepatic venous blood in man. 非那西丁在人门静脉和肝静脉血中的浓度。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-08-01
T Inaba, W A Mahon, R M Stone
{"title":"Phenacetin concentrations in portal and hepatic venous blood in man.","authors":"T Inaba,&nbsp;W A Mahon,&nbsp;R M Stone","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>After intra-gastric or intra-duodenal administration of phenacetin (200 mg in solution), concentrations of phenacetin and its 0-dealkylated metabolite, acetaminophen, in portal and hepatic veins and in peripheral blood were monitored. A sharp increase in the portal concentration of phenacetin indicated rapid absorption. The concentration ratio of acetaminophen to phenacetin in early portal blood was 0.01--0.11 and lower than the ratio in hepatic vein. The hepatic extraction ratio of phenacetin was calculated to be 0.59--0.78. It is concluded that 0-dealkylation occurs mainly in the liver and only to a limited extent in the gastrointestinal wall.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 8","pages":"371-4"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11693098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of metoprolol on hemodynamics and respiratory function in asthmatic patients. 美托洛尔对哮喘患者血液动力学和呼吸功能的影响。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-08-01
S Mue, T Sasaki, S Shibahara, M Takahashi, T Ohmi, K Yamauchi, S Suzuki, W Hida, T Takishima
{"title":"Influence of metoprolol on hemodynamics and respiratory function in asthmatic patients.","authors":"S Mue,&nbsp;T Sasaki,&nbsp;S Shibahara,&nbsp;M Takahashi,&nbsp;T Ohmi,&nbsp;K Yamauchi,&nbsp;S Suzuki,&nbsp;W Hida,&nbsp;T Takishima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Studies of metoprolol in asthmatic patients showed beta 1-selective blocking properties on the adrenergic receptor. Metoprolol in a dose of 40 mg given orally to 9 asthmatic patients significantly decreased the pulse rate at 60 and 120 minutes and the systolic blood pressure at 120 minutes but did not cause any increase of respiratory impedance, measured by the forced oscillation technique. A double-blind test was carried out to compare the effects of metoprolol and inactive placebo on the respiratory response to isoproterenol in 24 asthmatic patients. In the metoprolol group, systolic blood pressure decreased significantly and pulse rate at rest also tended to decrease. There was no significant difference between the metoprolol and placebo groups in the respiratory response to an isoproterenol aerosol.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 8","pages":"346-50"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11694392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemodynamic changes in hypertensive patients at rest and during physical exercise before and after acute i.v. administration of bufuralol-HCl or propranolol. 急性静脉注射盐酸布呋喃洛尔或心得安前后高血压患者静息和运动时血流动力学的变化
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-08-01
D Magometschnigg, J Bonelli, G Kaik, H Rameis
{"title":"Hemodynamic changes in hypertensive patients at rest and during physical exercise before and after acute i.v. administration of bufuralol-HCl or propranolol.","authors":"D Magometschnigg,&nbsp;J Bonelli,&nbsp;G Kaik,&nbsp;H Rameis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The hemodynamic effects of 20 mg Bufuralol-HCl and of 15 mg Propranolol given to hypertensives i.v. at rest and under physical exercise conditions were examined. It could be shown that Bufuralol-HCl lowered the diastolic BP and PR at rest already in the acute experiment, contrary to Propranolol. Under physical exercise conditions the diastolic BP is lowered, the PR remains unchanged in spite of reduced CO. After exclusion of other possible explanations, Bufuralol-HCl may lower the diastolic BP acutely at least partly by inhibition of cerebral beta-receptors. A faster and better liquor diffusion could be the reason for these results. It can be assumed that the acute BP lowering effect is mediated by the same mechanism as the chronic effect of the other beta-receptor blocking drugs.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 8","pages":"334-40"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11262870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug interactions and side effects of hypolipidemic drugs. 降血脂药物的相互作用和副作用。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-08-01
P Schwandt
{"title":"Drug interactions and side effects of hypolipidemic drugs.","authors":"P Schwandt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The side effects and drug interactions of clofibrate, cholestyramine and nicotinic acid are reviewed because these hypolipidemic drugs are given for preventive and only rarely curative reasons and because these drugs have been given for many years and often concomitantly with other drugs.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 8","pages":"351-6"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11694393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics of amikacin (BB-K8) in patients undergoing hemodialysis. 阿米卡星(BB-K8)在血液透析患者中的药代动力学。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-08-01
J M Lanao, A Dominguez-Gil, J M Tabernero, J A Sanchez Tomero
{"title":"Pharmacokinetics of amikacin (BB-K8) in patients undergoing hemodialysis.","authors":"J M Lanao,&nbsp;A Dominguez-Gil,&nbsp;J M Tabernero,&nbsp;J A Sanchez Tomero","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The pharmacokinetics of Amikacin (BB-K8) was studied after administration in an i.v. bolus injection of 7.5 mg/kg to 10 patients with terminal renal impairment undergoing dialysis sessions of 6 hours. A two-compartment kinetic model has been used to describe the bi-phasic decrease of the plasma concentrations of the antibiotic thus establishing the amounts of the antibiotic in the central and peripheral compartments, its elimination being principally through the kidney. During the hemodialysis sessions the average pharmacokinetic parameters of the Amikacin were: alpha = 3.422 h-1 beta = 0.176 h-1 K12 = 1.820 h-1 K21 = 1.327 H-1, K13 = 0.450 h-1, Vc = 9.242 l Vp = 11.455 l Vdss = 20.697 l and delta = 0.377 l/kg. A dosage regimen as a function of the pharmacokinetic parameters is established for patients with terminal renal impairment which guarantees safe and efficient concentrations of the antibiotic.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 8","pages":"357-60"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11693095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of DDAVP on plasma renin activity in man. DDAVP对人血浆肾素活性的影响。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-07-01
J P Radó, P Boer
{"title":"Effect of DDAVP on plasma renin activity in man.","authors":"J P Radó,&nbsp;P Boer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have investigated in eight healthy persons the effect of a single intranasal dose of 40 microgram DDAVP on plasma renin activity (PRA) in the upright posture. During normal sodium intake there were no differences in the PRA values between the time-control and DDAVP studies. However, during sodium restriction in four subjects with higher initial PRA, DDAVP induced a 40% decrease, lasting no longer than 45 minutes. There was no change in PRA after DDAVP in the other four subjects with much lower initial levels. Although no major or consistent suppressive influence could be demonstrated in the present study, in certain persons with highly stimulated initial PRA levels a transitory slight depression may be expected after a pharmacological dose of DDAVP.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 7","pages":"307-10"},"PeriodicalIF":0.0,"publicationDate":"1979-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11694388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of tricyclic antidepressants (TA) on the circulatory system in primary arterial hypertension. 三环抗抑郁药(TA)对原发性动脉高血压循环系统的影响。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-07-01
A Chodera, B Konkiewicz, E Nowakowska, J Godlewski
{"title":"The effect of tricyclic antidepressants (TA) on the circulatory system in primary arterial hypertension.","authors":"A Chodera,&nbsp;B Konkiewicz,&nbsp;E Nowakowska,&nbsp;J Godlewski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The cardio-vascular reactions after i.m. application of 0.4 mg/kg of TA (imipramine, amitryptyline and nortryptyline) were compared in normotonics and patients suffering from essential hypertonia. It was found, that systolic blood pressure decreased significantly after the drugs only in hypertonic patients, whereas diastolic blood pressure fall was marked more in the normotonic group. In both groups, no apparent changes in heart action were noticed after the drugs. The TA caused a stronger increase of urine excretion of NE, E, VMA and NMN and MN in hypertonics than in normotonics.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 7","pages":"299-302"},"PeriodicalIF":0.0,"publicationDate":"1979-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11694386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on kinetics of anturan excretion in man. 人排泄安图兰的动力学研究。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-07-01
W Seńczuk, J Jodynis-Liebert
{"title":"Studies on kinetics of anturan excretion in man.","authors":"W Seńczuk,&nbsp;J Jodynis-Liebert","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The kinetics of anturan excretion was studied. Experiments were carried out on ten healthy volunteers. The drug was given orally once applying three different doses: 100, 200, 400 mg. The contents of the drug in urine were determined by means of the modified method worked out by Wallace. It was found about 42 per cent of the dose was excreted with urine in an unchanged form. The process of anturan excretion may be described according to the one-compartment open kinetic model. The half-life of excretion is 3.5 hours, the excretion constant is 0.20. The formula showing the course of anturan excretion in time has been given. Five examples of the quantitative exposure test have been proposed; they allow the calculation of the absorbed drug dose and thus the degree of poisoning. The test can be also helpful in controlled therapy.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 7","pages":"303-6"},"PeriodicalIF":0.0,"publicationDate":"1979-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11694387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The cardiac electrophysiological effects of nifedipine. 硝苯地平对心脏电生理的影响。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-07-01
L Padeletti, F Franchi, A Brat, R P Dabizzi, A Michelucci
{"title":"The cardiac electrophysiological effects of nifedipine.","authors":"L Padeletti,&nbsp;F Franchi,&nbsp;A Brat,&nbsp;R P Dabizzi,&nbsp;A Michelucci","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A study was carried out on the electrophysiological effects of a sublingually administered antianginal drug: nifedipine (20 mg). The results show a significant shortening of sinus cycle length from 925 +/- 249 msec to 810 +/- 245 msec, (p less than 0.005) and the disappearance of some interpolation and echo zones. There are no significant effects on the other evaluated parameters of sino-atrial and AV-node function. In one case, during atrial pacing, a second-degree, Wenckebach type, A-V block was present only before nifedipine. The following conclusions were reached: 1. nifedipine has no significant electrophysiological effect on the human heart; 2. the electrophysiological effects observed are probably indirect and related to the vasodilating effect of the drug; 3. the absence of direct cardiac electrophysiological actions may be useful in patients suffering from coronary artery disease and presenting disturbances in the formation and/or conduction of the cardiac impulse.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 7","pages":"290-3"},"PeriodicalIF":0.0,"publicationDate":"1979-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11694384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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