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International journal of clinical pharmacology and biopharmacy最新文献

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Pharmacokinetics of carbamazepine in the neonate and in the child. 卡马西平在新生儿和儿童体内的药代动力学。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-02-01
E Rey, P d'Athis, D de Lauture, O Dulac, J Aicardi, G Olive
{"title":"Pharmacokinetics of carbamazepine in the neonate and in the child.","authors":"E Rey,&nbsp;P d'Athis,&nbsp;D de Lauture,&nbsp;O Dulac,&nbsp;J Aicardi,&nbsp;G Olive","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>1. Pharmacokinetic of carbamazepine were made in 7 new-borns and in 5 children. They were hospitalized for epilepsy and were receiving drugs such as phenobarbital alone or in association with other antiepileptic drugs, but not with carbamazepine. 2. The drug was given by oral route with a mean dose of 17.2 mg.kg-1. 3. The determination of carbamazepine concentration in serum was made by gas liquid chromatography on a 50 microliter sample. 4. A one compartment body model was used to determine the pharmacokinetic constants with first order rate constants for absorption and elimination. 5. Absorption was generally delayed by about half an hour, the maximum concentrations ranging from 3.14 to 10 microgram.ml-1 at 2 and 9 hr after administration. The mean half-life for absorption was 1.42 +/- 0.34 hr. The mean half-life for elimination was 8.76 +/- 0.85 hr. The half-life for elimination was much shorter than those already described even in multiple dosing epileptic adult patients. The pharmacokinetic parameters were used to predict blood levels in chronic treatment in 3 children. The predicted steady state concentrations disagreed with the concentrations measured.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 2","pages":"90-6"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11629134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cephapirin concentrations in prostatic and seminal vesicle tissues. 前列腺和精囊组织中的头孢匹林浓度。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-02-01
R Rubi, H M Galan
{"title":"Cephapirin concentrations in prostatic and seminal vesicle tissues.","authors":"R Rubi,&nbsp;H M Galan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 15 min i.v. infusion supplying either 1 or 2 g of sodium cephapirin was administered preoperatively to patients about to undergo either retropubic or transvesical prostatectomy. Tissue samples were obtained 30 min after the end of the infusion. Blood samples were obtained immediately before the start of the infusion and 30 min after the end of it. Cephapirin levels in the blood averaged 25.9 +/- 4.0 microgram/ml after the 1 g dose and 47.5 +/- 5.6 microgram/ml after the 2 g dose. Drug levels in prostatic tissue averaged 24.5 +/- 7.1 and 25.8 +/- 4.4 microgram/g for the 1 and 2 g doses, respectively. Levels in tissue taken from the seminal vesicle, often the focus of infection in bacterial prostatitis, averaged 12.5 +/- 2.3 and 44.8 +/- 14.9 microgram/g for the 1 and 2 g doses, respectively. These results suggest that bactericidal levels of cephapirin against sensitive organisms can readily be achieved in the prostate and seminal vesicles.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 2","pages":"87-9"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11629133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of intravenous canrenoate on the determination of digoxin in serum by radio- and enzyme-immunoassay. 静脉注射canrenate对放射和酶免疫法测定血清地高辛的影响。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-02-01
J Lichey, N Rietbrock, K Borner
{"title":"The influence of intravenous canrenoate on the determination of digoxin in serum by radio- and enzyme-immunoassay.","authors":"J Lichey,&nbsp;N Rietbrock,&nbsp;K Borner","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 2","pages":"61-3"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11579235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placental transfer of digoxin (beta-methyl-digoxin) in man. 地高辛(β -甲基地高辛)在人胎盘中的转移。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-02-01
L Padeletti, M C Porciani, G Scimone
{"title":"Placental transfer of digoxin (beta-methyl-digoxin) in man.","authors":"L Padeletti,&nbsp;M C Porciani,&nbsp;G Scimone","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The dynamics of placental transfer of digoxin (beta-methyl-digoxin) has been studied in 20 pregnant women. The drug was administered in a single dose, intravenously, during labor. The samples drawn within the first hour after administration showed significantly lower fetal serum digoxin concentrations (SDC) than in the mother. No significant difference appeared in specimens collected after the first hour.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 2","pages":"82-3"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11629132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DI patient refractory to vasopressin and dDAVP: absence of antibodies to AVP and dDAVP and inactivating factor in blood serum. 抗利尿激素和dDAVP难治性DI患者:血清中无AVP和dDAVP抗体及灭活因子。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-02-01
J Slaninová, J Skopková, T Barth, B Lichardus, O Földes
{"title":"DI patient refractory to vasopressin and dDAVP: absence of antibodies to AVP and dDAVP and inactivating factor in blood serum.","authors":"J Slaninová,&nbsp;J Skopková,&nbsp;T Barth,&nbsp;B Lichardus,&nbsp;O Földes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antibodies to either AVP or dDAVP were sought in the serum of a patient suffering from diabetes insipidus and treated with Adiuretin (Spofa) to which the patient had become refractory. Neither the antibodies nor the presence of enzymes inactivating LVP was detected in the serum.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 2","pages":"84-6"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11774768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative effects of metformin and indanorex in the treatment of reactive hypoglycemia. 二甲双胍与依地诺雷治疗反应性低血糖的疗效比较。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-02-01
D Giugliano, A Luyckx, D Binder, P Lefebvre
{"title":"Comparative effects of metformin and indanorex in the treatment of reactive hypoglycemia.","authors":"D Giugliano,&nbsp;A Luyckx,&nbsp;D Binder,&nbsp;P Lefebvre","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 2","pages":"76-81"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11629131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of adrenergic receptor blockade on cortisol and GH response to insulin-induced hypoglycemia in man. 肾上腺素能受体阻断对人胰岛素诱导低血糖时皮质醇和生长激素反应的影响。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-02-01
D Jezová-Repceková, I Klimes, J Jurcovicová, M Vigas
{"title":"Effect of adrenergic receptor blockade on cortisol and GH response to insulin-induced hypoglycemia in man.","authors":"D Jezová-Repceková,&nbsp;I Klimes,&nbsp;J Jurcovicová,&nbsp;M Vigas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of several drugs presumably influencing central catecholaminergic receptors on plasma cortisol and GH response to insulin-induced hypoglycemia was studied in healthy adult males. The intravenous infusion of alpha-adrenergic blocking agents tolazoline or phentolamine supressed plasma cortisol and GH response to insulin-induced hypoglycemia. After an infusion of beta-adrenergic antagonist propranolol both hypoglycemia and rise in plasma cortisol and GH were prolonged. Finally, the administration of dopaminergic blocker pimozide failed to affect the plasma cortisol response, but slightly suppressed the enhancement of GH release during hypoglycemia. Caution is recommended before making suggestions about neuroendocrine regulations from the data obtained after systemic administration of drugs. Nevertheless, it may be concluded that the hypothesis on the inhibitory role of the central alpha-adrenergic system on ACTH secretion suggested in rats and dogs was not confirmed by our results obtained in man.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 2","pages":"64-7"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11629129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics of l-carnitine in man following intravenous infusion of dl-carnitine. 静脉输注左旋肉碱后左旋肉碱在人体内的药代动力学。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-02-01
P G Welling, J H Thomsen, A L Shug, F L Tse
{"title":"Pharmacokinetics of l-carnitine in man following intravenous infusion of dl-carnitine.","authors":"P G Welling,&nbsp;J H Thomsen,&nbsp;A L Shug,&nbsp;F L Tse","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The pharmacokinetics of l-carnitine were studied in adult male patients following intravenous infusion of dl-carnitine hydrochloride-L-Carnitine appears to distribute into a rapidly perfused and then a more slowly perfused body space following administration. The overall apparent distribution volume Vd (ss) is consistent with extracellular body water. Serum levels of l-carnitine, from two different dose levels were adequately described by a two-compartment model. 80% of the administered dose was recovered in 24 hour post dose urine.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 2","pages":"56-60"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11629128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antihypertensive effect and plasma levels of labetalol. A comparison with propranolol and dihydrallazine. 拉贝他洛尔的降压作用和血浆水平。心得安与二羟嗪的比较。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-02-01
A Lehtonen, H Allonen, T Kleimola
{"title":"Antihypertensive effect and plasma levels of labetalol. A comparison with propranolol and dihydrallazine.","authors":"A Lehtonen,&nbsp;H Allonen,&nbsp;T Kleimola","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Seventeen outpatients suffering from essential hypertension were treated in a double-blind cross-over study with labetalol or with a combination of propranolol and dihydrallazine. The doses were increased depending on the response during the six week treatment periods. Both treatments reduced the blood pressure significantly as compared to the placebo, and the combination more than labetalol with the doses used, apparently because of a higher degree of the beta-blockade. Positive linear correlations were found between the dose of labetalol and the concentration in plasma as well as the concentration of labetalol in plasma and the decrease of standing blood pressures.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 2","pages":"71-5"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11629130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lidocaine plasma concentrations during and after endoscopic procedures. 内窥镜手术前后利多卡因血药浓度。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-02-01
J le Lorier, P Larochelle, P Bolduc, R Clermont, J Gratton, L Knight, J F Letendre, P Nadeau
{"title":"Lidocaine plasma concentrations during and after endoscopic procedures.","authors":"J le Lorier,&nbsp;P Larochelle,&nbsp;P Bolduc,&nbsp;R Clermont,&nbsp;J Gratton,&nbsp;L Knight,&nbsp;J F Letendre,&nbsp;P Nadeau","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Plasma lidocaine concentrations were intermittently measured in 8 upper gastrointestinal endoscopy and 12 bronchoscopy patients. The highest individual concentration was 0.98 microgram/ml in the upper gastrointestinal endoscopy patients and 3.79 microgram/ml in the bronchoscopy patients. Highest concentrations were reached at 15 minutes in the gastrointestinal endoscopy patients and at 30 or 60 minutes in the bronchoscopy patients. Thus, since lidocaine does not produce toxic effects at concentrations inferior to 6 microgram/ml, doses of this topical anaesthetic up to 16 mg/kg can be safely given during endoscopic procedures to patients with normal hepatic and cardiovascular functions. However, patients with liver metastases should be considered at high risk even if their liver function tests are normal. Patients at high risk of developing lidocaine toxicity should receive lower doses and be closely watched for at least 60 minutes after the end of the procedure.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 2","pages":"53-5"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11629127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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