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International journal of clinical pharmacology and biopharmacy最新文献

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Clinical effect of diltiazem on angina of effort in relation to dosage of nitroglycerin. 地尔硫卓治疗心绞痛的临床疗效与硝酸甘油用量的关系。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-09-01
I Nakayama
{"title":"Clinical effect of diltiazem on angina of effort in relation to dosage of nitroglycerin.","authors":"I Nakayama","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 9","pages":"410-5"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11335261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spectrophotometric assay of antipyrine in plasma: a reevaluation. 血浆中安替比林的分光光度测定:再评价。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-09-01
D J Greenblatt, A Locniskar
{"title":"Spectrophotometric assay of antipyrine in plasma: a reevaluation.","authors":"D J Greenblatt,&nbsp;A Locniskar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The linearity, sensitivity, and replicability of the spectrophotometric antipyrine assay were reevaluated. Standard curves are always linear through concentrations of at least 50 microgram/ml, whether prepared in water, dilute acid, or plasma. Sensitivity limits are 1 to 2 microgram of antipyrine per ml of plasma in healthy individuals. Within-day coefficients of variation for identical samples ranged from 12.3% at 2 microgram/ml to 1.2% at 50 microgram/ml. Identical samples assayed two years apart deviated by a mean of 3.8%, indicating high between-day replicability as well as stability during prolonged storage at -20 degrees C. Thus the spectrophotometric assay for antipyrine is suitable for most clinical pharmacokinetic studies.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 9","pages":"401-4"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11705433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Canadian survey to determine the rate of drug resistance to isoniazid, PAS and streptomycin in newly detected untreated tuberculosis patients and retreatment cases. 加拿大调查确定异烟肼，PAS和链霉素的耐药率在新发现的未经治疗的结核病患者和再治疗病例。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-09-01
E S Hershfield, L Eidus, D M Helbecque
{"title":"Canadian survey to determine the rate of drug resistance to isoniazid, PAS and streptomycin in newly detected untreated tuberculosis patients and retreatment cases.","authors":"E S Hershfield,&nbsp;L Eidus,&nbsp;D M Helbecque","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 1975, a survey was carried out in Canada to determine the primary and acquired drug resistance of M. tuberculosis isolates to isoniazid (INH), para-aminosalicylic acid (PAS) and streptomycin. The results of this investigation were compared with those of the primary drug resistant study of Armstrong, undertaken in 1963-64. It revealed that primary drug resistance has increased from 4.9% to 6.3%. The increase is mainly due to immigrants having arrived in this country during the last 12 years. In these newcomers the primary resistance rate was 11.5%. Moreover, 57.8% of the immigrants examined in the survey were of Asian origin, with a drug resistance rate of 11.7%, while 15.6% had arrived from South Europe with a resistant ratio of 16.7%. In retreatment cases, the national average of drug resistance was 26.4%. Among the Canadian provinces, the highest drug resistance rate in retreatment patients (40%) was found in Quebec. While in primary resistance Streptomycin exhibited the highest incidence, in retreatment cases isoniazid resistance proved to be more frequent. In natives, the rates and patterns of primary and acquired resistance were very similar to those observed in other Canadian born patients.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 9","pages":"387-93"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11335260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Absorption of sustained-release and plain papaverine in man. 缓释罂粟碱和普通罂粟碱的人体吸收。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-09-01
J Kanto, E Iisalo, D Manell, R Mäntylä
{"title":"Absorption of sustained-release and plain papaverine in man.","authors":"J Kanto,&nbsp;E Iisalo,&nbsp;D Manell,&nbsp;R Mäntylä","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The concentrations of papaverine in the plasma of healthy volunteers were determined by a GLC-method both after single and repeated oral doses of plain and sustained-release drug formulation. In both experiments the AUC-value after the sustained-release drug form was significantly lower than after the plain papaverine and no maintenance of plasma levels for 12 hours after the sustained-release drug form was observed. Our work demonstrates that the systemic availability or papaverine can be markedly affected by product formulation.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 9","pages":"375-7"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11705429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring adverse drug reactions-the problem of integration of heterogeneous data. 药物不良反应监测——异构数据整合问题。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-09-01
J Venulet
{"title":"Monitoring adverse drug reactions-the problem of integration of heterogeneous data.","authors":"J Venulet","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Effective systems for a meaningful integration and interpretation of data of heterogeneous origin are essential for successful monitoring of adverse drug reactions internationally or in multicenter programs. Particular difficulties are encountered in the area of suspected drug adverse reactions and in the area of drugs. Both problem areas are discussed in the paper.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 9","pages":"383-6"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11705431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics of cefamandole in patients undergoing hemodialysis. 头孢门铎在血液透析患者中的药代动力学。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-09-01
J A Campillo, J M Lanao, A Dominguez-Gil, J M Tabernero, F Rubio
{"title":"Pharmacokinetics of cefamandole in patients undergoing hemodialysis.","authors":"J A Campillo,&nbsp;J M Lanao,&nbsp;A Dominguez-Gil,&nbsp;J M Tabernero,&nbsp;F Rubio","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The pharmacokinetics of Cefamandole was studied in 17 patients with terminal renal impairment, 10 of which were undergoing sessions of hemodialysis while 7 were in the period between dialysis sessions. An open two-compartment kinetic model was used to describe the bi-phasic decrease of the plasma concentrations of Cefamandole thus establishing the amounts of the antibiotic in the peripheral and central compartments together with the amount eliminated. All patients received an i.v. bolus injections of 15 mg/kg body weight. During the hemodialysis sessions, the pharmacokinetic parameters of Cefamandole were the following: alpha = 5.006 hr-1 beta = 0.182 hr-1 K12 = 2.598 hr-1 K21 = 2.147 hr-1 K13 = 0.441 hr-1 Vc = 5.700 l Vp = 6.190 l Vdss = 11.94 l It may be seen that there is a decrease in the overall elimination constant compared with that obtained during the periods between the dialysis sessions. A dosage regimen of multiple doses is established as a function of the pharmacokinetic parameters of the antibiotic for patients with terminal renal impairment undergoing periodic sessions of hemodialysis.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 9","pages":"416-20"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11705435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of metoprolol and propranolol on lipid metabolism. 美托洛尔和心得安对脂质代谢的影响。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-09-01
P Bielmann, G Leduc
{"title":"Effects of metoprolol and propranolol on lipid metabolism.","authors":"P Bielmann,&nbsp;G Leduc","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Treatment of five hypertriglyceridemic and one normolipemic patients with propranolol, a non-selective beta-blocking agent, and metoprolol, which is generally considered to be a cardioselective beta-adrenoceptor antagonist, was observed to produce a further elevation in their triglyceride levels. The subjects were followed for 20 weeks, during which they received propranolol for eight weeks, a placebo for four weeks and metoprolol for eight weeks in a crossover design. The analysis suggested that the increase in triglyceride levels was less pronounced with the more cardioselective agent. Moreover, alpha-cholesterol decreased significantly after propranolol but remained constant while on metoprolol. Both drugs decreased beta-cholesterol whereas chylo- and pre- beta-cholesterol increased, particularly with propranolol. Considering the contradictory evidence regarding the clinical importance of chronic elevation of plasma triglyceride and decreased alpha- und beta-cholesterol concentrations, it is suggested that a cardioselective drug would be presently preferable in hyperlipidemic subjects.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 9","pages":"378-82"},"PeriodicalIF":0.0,"publicationDate":"1979-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11705430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A double-blind study of melperone and placebo in hospitalized chronic alcoholics in postintoxication phase. melperone和安慰剂治疗住院慢性酒精中毒后期的双盲研究。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-08-01
C Carlsson, B Gullberg, U Höstery, E Christensson
{"title":"A double-blind study of melperone and placebo in hospitalized chronic alcoholics in postintoxication phase.","authors":"C Carlsson,&nbsp;B Gullberg,&nbsp;U Höstery,&nbsp;E Christensson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a double-blind study in chronic alcoholics melperone (Buronil) was shown to significantly improve muscular and nervous tension, emotional lability, somatization, ability to sleep, anxiety, depression, paranoid ideation and presumed ability to work, but had no effect on alcoholic craving. The results received from three rating scales, and the theoretical aspects of alcoholism are discussed.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 8","pages":"341-5"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11261881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical pharmacology studies with acenocoumarol. 阿替诺香豆醇的临床药理学研究。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-08-01
J Hirtz, Y Le Roux, A Jaouen, J Richard, C Blatrix, J J Thébault, J P Schoeller
{"title":"Clinical pharmacology studies with acenocoumarol.","authors":"J Hirtz,&nbsp;Y Le Roux,&nbsp;A Jaouen,&nbsp;J Richard,&nbsp;C Blatrix,&nbsp;J J Thébault,&nbsp;J P Schoeller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In two different studies, the relation between plasma concentrations of acenocoumarol and apparent prothrombin levels (Quick test) was investigated, using a new specific analytical method for the assay of the drug. The prothrombin level appeared independent of the plasma concentration of the drug, which is higher in old patients (over 70 years) than in younger patients (under 51 years).</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 8","pages":"361-5"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11693096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacokinetics of cefoxitin in patients undergoing hemodialysis. 头孢西丁在血液透析患者体内的药代动力学。
International journal of clinical pharmacology and biopharmacy Pub Date : 1979-08-01
M J Garcia, A Dominguez-Gil, J M Tabernero, A Bondia Román
{"title":"Pharmacokinetics of cefoxitin in patients undergoing hemodialysis.","authors":"M J Garcia,&nbsp;A Dominguez-Gil,&nbsp;J M Tabernero,&nbsp;A Bondia Román","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The parmacokinetics of Cefoxitin were studied after an i.v. administration of 15 mg/kg body weight in 17 patients with terminal renal impairment, 10 of which were undergoing 6 hr hemodialysis sessions. The average pharmokinetic parameters obtained from this kind of patient were the following: alpha = 2.88 hr-1 beta = 0.18 hr-1 K12 = 1.43 hr-1 K21 = 1.04 hr-1 K13 = 0.53 hr-1 Vc = 8.23 l Vp = 11.61 l Vdss = 19.84 l. The amounts of the antibiotic in the central and peripheric compartments are established together with the amount of the antibiotic eliminated as a function of time. The pharmacokinetic parameters are significantly different from those established in the period between dialysis sessions, and thus, the elimination constant reaches a value of 0.28 h-1. The degree of plasma protein binding of Cefoxitin is 41.46% during the hemodialysis sessions. A dosage regimen is programmed as a function of the pharmacokinetic parameters established for this kind of patient. It is recommended that an i.v. dose of 15 mg/kg body weight should be administered at the beginning and end of each dialysis session lasting 6 hours, when the periods between the sessions are 48 hours.</p>","PeriodicalId":75937,"journal":{"name":"International journal of clinical pharmacology and biopharmacy","volume":"17 8","pages":"366-70"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11693097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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