Folia psychiatrica et neurologica japonica最新文献_第2页

Endocrinological function in schizophrenic patients under haloperidol treatment: plasma PRL, HGH and 5HT levels after L-5HTP loading. 氟哌啶醇治疗精神分裂症患者的内分泌功能:L-5HTP负荷后血浆PRL、HGH和5HT水平

Folia psychiatrica et neurologica japonica Pub Date : 1985-01-01 DOI: 10.1111/j.1440-1819.1985.tb01941.x

Y Hoshino, M Kaneko, H Kumashiro, R Tachibana

{"title":"Endocrinological function in schizophrenic patients under haloperidol treatment: plasma PRL, HGH and 5HT levels after L-5HTP loading.","authors":"Y Hoshino, M Kaneko, H Kumashiro, R Tachibana","doi":"10.1111/j.1440-1819.1985.tb01941.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1985.tb01941.x","url":null,"abstract":"In order to examine 5HT metabolism in the hypothalamo-pituitary (HP) system of chronic schizophrenic patients taking haloperidol for a short or long period, chronological changes of blood 5HT, PRL and HGH were measured after an oral loading dose of L-5hydroxytryptophan (L-5HTP), a precursor of 5HT. The subjects consisted of 8 male patients with chronic schizophrenia, who were divided into the following two groups. The 1st group--4 patients taking haloperidol (5.6 mg/day) for 8 months on an average (short-term treatment). The 2nd group--4 patients taking haloperidol (4.8 mg/day) for 7.5 years on an average (long-term treatment). The control group was made up of 9 healthy male volunteers. As a result, the basal level of blood 5HT in the 1st group was significantly higher than that in the control group. The blood 5HT levels in the 1st and 2nd groups showed an equally remarkable increase as compared with the control group. The basal level of plasma PRL in the 2nd group was significantly lowe than that in the control group. Moreover, in the 2nd group, an increase in the plasma PRL level after the loading was suppressed, but it showed less suppression in the 1st group. There was no significant difference in the basal HGH levels among the control, 1st and 2nd groups. After the loading, an increase in the plasma HGH was suppressed in the 2nd group, but the suppression was less in the 1st group.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":75857,"journal":{"name":"Folia psychiatrica et neurologica japonica","volume":"39 1","pages":"25-31"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1985.tb01941.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14992116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

The prophylactic and anticonvulsant effects of a TRH analog (DN-1417) on amygdaloid kindling model of epilepsy. TRH类似物DN-1417对癫痫杏仁核点燃模型的预防和抗惊厥作用。

Folia psychiatrica et neurologica japonica Pub Date : 1985-01-01 DOI: 10.1111/j.1440-1819.1985.tb02008.x

M Okamoto, M Sato, T Moriwake, K Morimoto, T Ogawa, K Morita, T Nakatsu, N Ogawa

{"title":"The prophylactic and anticonvulsant effects of a TRH analog (DN-1417) on amygdaloid kindling model of epilepsy.","authors":"M Okamoto, M Sato, T Moriwake, K Morimoto, T Ogawa, K Morita, T Nakatsu, N Ogawa","doi":"10.1111/j.1440-1819.1985.tb02008.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1985.tb02008.x","url":null,"abstract":"Thyrotropin-releasing hormone (TRH) is a neuropeptide that is widely distributed throughout the CNS in addition to the hypothalamus and has a variety of CNS actions unrelated to its endocrine action via the pituitary-thyroid axis. A TRH analog, y -butyrolactone-y -carbanyl-L-histidyl-L-prolinamide citrate (DN-1417), has been reported3 to have a more profound CNS action with a Iess TSH-releasing activity than TRHtartrate (TRH-T). Recently, a therapeutic effect of DN14 17 on myoclonus epilepsy and Lennox syndrome has been reported.2 Our previous study showed that an intravenous administration of TRH-T and DN1417 has a short-lived anticonvulsant effect on kindled amygdaloid (AM) seizures in cats, although the effect had considerable individual variations and no dose-related responses.s A short-lived effect without doserelated responses appears to depend upon the degradation or less penetration through BBB after a systemic administration. In this study, we examined the prophylactic and anticonvulsant effects of intracerebroventricularly (ICV) administered DN-1417 on the AM kindling model of rats. Male Sprague-Dawley (SD) rats were ~~","PeriodicalId":75857,"journal":{"name":"Folia psychiatrica et neurologica japonica","volume":"39 3","pages":"313-6"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1985.tb02008.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15054489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

GABAergic and dopaminergic systems of the substantia nigra and amygdaloid kindling in cats. 猫黑质和杏仁核的gaba能和多巴胺能系统的激活。

Folia psychiatrica et neurologica japonica Pub Date : 1985-01-01 DOI: 10.1111/j.1440-1819.1985.tb02009.x

M Kaijima, G Le Gal La Salle, T Tanaka, Y Yonemasu

引用次数: 1

L-dopa-induced asterixis. L-dopa-induced扑翼样震颤。

Folia psychiatrica et neurologica japonica Pub Date : 1985-01-01 DOI: 10.1111/j.1440-1819.1985.tb00804.x

I Kobayashi, M Osawa, K Ohta, S Maruyama

引用次数: 2

Clinicopathologic studies on neuro-Behçet's disease. 神经behaperet病的临床病理研究。

Folia psychiatrica et neurologica japonica Pub Date : 1985-01-01 DOI: 10.1111/j.1440-1819.1985.tb02899.x

S Totsuka, T Hattori, M Yazaki, K Nagao, S Mizushima

引用次数: 20

Epstein-Barr virus antibodies in neurological diseases. 爱泼斯坦-巴尔病毒抗体在神经系统疾病中的应用

Folia psychiatrica et neurologica japonica Pub Date : 1985-01-01 DOI: 10.1111/j.1440-1819.1985.tb01947.x

S Yabuki, Y Kazahaya, I Kubonishi

引用次数: 11

Electron microscopic morphometric studies on synaptic vesicles of long-term CPZ-administered rat striatum. 长期给药cpz大鼠纹状体突触囊泡的电镜形态学研究。

Folia psychiatrica et neurologica japonica Pub Date : 1985-01-01 DOI: 10.1111/j.1440-1819.1985.tb02902.x

M Takeichi

{"title":"Electron microscopic morphometric studies on synaptic vesicles of long-term CPZ-administered rat striatum.","authors":"M Takeichi","doi":"10.1111/j.1440-1819.1985.tb02902.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1985.tb02902.x","url":null,"abstract":"The effect of chronic administration of chlorpromazine (CPZ) on the striatal synaptic vesicles was quantitatively investigated with an electron microscope. Six rats, three controls and three experimentals, which received 20 mg/kg b.wt. of CPZ daily for 15 months, were sacrificed and a total of 300 axo-dendritic spine synapses (50 synapses per animal) were randomly taken and divided into three zones with a width of 160-467 nm on electron micrographs (final magnification 60,000). The first zone was adjacent to the presynaptic membrane in the region of the synaptic cleft. The second and third were farther away from the first zone. In these zones we measured the vesicle density, vesicle size and vesicle elongation ratio (the shortest diameter/the longest diameter) with the following results: In both the CPZ-administered rats and the controls the vesicle number per unit area of axoplasm (vesicle density) was smaller in Zone III than in Zones I and II, while those in the latter two zones did not differ from each other. However, there was no significant difference in the vesicle number in any zone between the control and experimental animals. The vesicles in every zone were significantly larger in the CPZ-administered animals than in the controls. There were no conclusive findings on the vesicle elongation ratio (vesicle shape).","PeriodicalId":75857,"journal":{"name":"Folia psychiatrica et neurologica japonica","volume":"39 2","pages":"185-91"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1985.tb02902.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15177596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Suppression of amygdaloid kindled seizure and regional brain GABA content. 抑制杏仁核点燃癫痫发作和脑区域GABA含量。

Folia psychiatrica et neurologica japonica Pub Date : 1985-01-01 DOI: 10.1111/j.1440-1819.1985.tb02005.x

T Ogawa, T Moriwake, K Morita, K Morimoto, M Okamoto, M Sato

{"title":"Suppression of amygdaloid kindled seizure and regional brain GABA content.","authors":"T Ogawa, T Moriwake, K Morita, K Morimoto, M Okamoto, M Sato","doi":"10.1111/j.1440-1819.1985.tb02005.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1985.tb02005.x","url":null,"abstract":"Gamma-aminobutyric acid (GABA) has been known to be an inhibitory neurotransmitter in the mammalian brain. There are several reports indicating anticonvulsant effects of GABA-agonists on kindled seizures.2 5 t i Recently, Tuff et a1.O lo reported an increase in GABA-mediated inhibition of the dentate gyrus following kindling. To examine a possible role of hippocampal GABA on kindled convulsions, gabaculine, a GABA-transaminase inhibitor, was microinjected into the bilateral hippocampi of rats kindled from the amygdala in this study (Experiment 1 1. Moreover, the regional GABA content in the rat brains after an intra-hippocampal administration of gabaculine was measured (Experiment 2). In Experiment 1, 12 male Sprague-Dawley rats, weighing 280-320 g, were used. Bipolar electrodes were implanted stereotaxically into the left amygdala for EEG recording and electrical stimulation. Each rat had an electrical stimulation at the left amygdala with one second trains of 60 Hz sine wave, at an intensity of 300pA, once a day. Motor","PeriodicalId":75857,"journal":{"name":"Folia psychiatrica et neurologica japonica","volume":"39 3","pages":"301-4"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1985.tb02005.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14949475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study of EEG activities during sleep-wakefulness states in rabbits by autocorrelation and power spectrum analyses. 用自相关和功率谱分析研究兔睡眠-觉醒状态的脑电图活动。

Folia psychiatrica et neurologica japonica Pub Date : 1985-01-01 DOI: 10.1111/j.1440-1819.1985.tb00812.x

T Miyara

引用次数: 4

GABA levels in cerebrospinal fluid of patients with epilepsy. 癫痫患者脑脊液中GABA水平的变化。

Folia psychiatrica et neurologica japonica Pub Date : 1985-01-01 DOI: 10.1111/j.1440-1819.1985.tb00805.x

M Yamamoto, S Takahashi, S Otsuki, T Kugoh, K Hosokawa, N Ogawa

引用次数: 7