GABAergic and dopaminergic systems of the substantia nigra and amygdaloid kindling in cats.

Abstract

It has been reported that the nigral GABAergic system intervenes in inhibition of epileptic seizures in various experimental models of epilepsy.' Our previous study showed that a bilateral injection of ?-vinyl GABA (GVG), a GABA-elevating agent, in the substantia nigra (SN) of rats strongly reduced the afterdischarge duration without a significant modification of motor manifestations of seizures in the amygdaloid kindling.3 * The present study demonstrates the effects of GVG injected in the SN on the amygdaloid kindling in cats. In addition, we report the effects of selective lesions of nigral dopaminergic neurons on the amygdaloid kindling produced by the bilateral injection of 6-hydroxydopamine (6-OHDA) in the substantia nigra of cats.