American journal of perinatology最新文献

{"title":"Association between induction start time and labor duration in nulliparous women undergoing elective induction of labor.","authors":"Francesca Lucia Facco, Cora MacPherson, Uma Reddy, Alan Tita, Robert M Silver, Yasser El-Sayed, Ronald Wapner, Dwight J Rouse, George Saade, John M Thorp, Suneet P Chauhan, Maged M Costantine, Edward Chien, Kent Heyborne, Sindhu K Srinivas, Geeta K Swamy, William A Grobman","doi":"10.1055/a-2547-4196","DOIUrl":"https://doi.org/10.1055/a-2547-4196","url":null,"abstract":"<p><strong>Objective: </strong>To examine the association between elective induction of labor (EIOL) start time and labor duration among nulliparous women Methods: The ARRIVE trial was a multi-center randomized controlled trial of induction of labor at 39 weeks 0 days to 39 weeks 4 days versus expectant management in low-risk nulliparous women. In this secondary analysis, we included participants randomized to the induction group who had an EIOL without spontaneous labor or rupture of membranes prior to the induction start. Start time of EIOL was categorized as: early AM (midnight to 5:59 AM), late AM (6 AM-11:59 AM), early PM (noon-5:59 PM), or late PM (6 PM-11:59 PM). The primary outcome was labor duration. Cesarean delivery rates by induction start time were also examined. Multivariable analysis was conducted controlling for age, body mass index, insurance status, and modified Bishop score on admission (< 5 or ≥5).</p><p><strong>Results: </strong>Of 3,062 women randomized to EIOL, 2,197 were included in this analysis. EIOL occurred in the early AM in 13%, in late AM in 28%, in early PM in 13%, and in late PM in 45%. Participants induced in the late AM had the shortest mean labor durations (21.5 ±11.3 hours) and the highest frequency of delivery at < 24 hours (68%). In adjusted analyses, induction in the late AM (vs. grouped other time periods) remained significantly associated with shorter labor duration (-1.5 hrs, 95% CI -2.5, -0.4, p=0.006), and there was no interaction between Bishop score and time of EIOL. Cesarean delivery rates did not differ by start time.</p><p><strong>Conclusions: </strong>Induction of labor starting between 6AM and 11:59 AM was associated with shorter labor durations, independent of baseline maternal characteristics including cervical status on admission.</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Placental Inflammation Is Associated with Reduced Progesterone Receptor Density in the Basal Decidua in Spontaneous Preterm Birth.","authors":"Sunitha Suresh, Alexa Freedman, Emmet Hirsch, Linda M Ernst","doi":"10.1055/a-2524-4053","DOIUrl":"https://doi.org/10.1055/a-2524-4053","url":null,"abstract":"<p><strong>Objective: </strong> A functional progesterone withdrawal has been thought to contribute to the pathophysiology of spontaneous preterm birth (PTB). The density of the progesterone receptor (PR) in gestational tissues could play a role in functional progesterone withdrawal. We sought to understand the relationship between placental pathology and the density of PR in the basal decidua in the setting of spontaneous preterm delivery.</p><p><strong>Study design: </strong> This is a secondary analysis of a retrospective cohort study of 40 patients with spontaneous PTB < 37 weeks from a prior study at NorthShore University HealthSystem previously described. Placental pathology was categorized according to the Amsterdam criteria into acute inflammation (AI), chronic inflammation (CI), maternal vascular malperfusion (MVM), and fetal vascular malperfusion (FVM). Slides containing basal decidua were stained for PR. Ten distinct images were obtained from the basal plate of each placenta. The positive cell detection program in QuPath image analysis software was used to estimate the percentage of cells positive for PR (%PR + ). The mean %PR+ cells were calculated from the ten representative images and were correlated with patterns of placental injury using <i>t</i>-tests. Models were adjusted for gestational age at delivery.</p><p><strong>Results: </strong> The median gestational age at delivery was 32.5 weeks (interquartile range: 30.5, 34.1). There was a lower density of %PR+ cells among those with AI (12.9%PR+ without AI vs. 9.1%PR +  with AI, <i>p</i> = 0.03). There were no differences in the percent of %PR+ cells based on CI, MVM, or FVM. Models adjusted for gestational at delivery demonstrated persistent association with PR density and AI and no difference in the other pathologies.</p><p><strong>Conclusion: </strong> The presence of AI is associated with the lower density of PR expression in the basal decidua by quantitative immunohistochemical analysis. Further research is needed to investigate these findings in the context of spontaneous PTL and the prevention of PTB.</p><p><strong>Key points: </strong>· AI is associated with a lower density of PR expression.. · PR is expressed in the basal decidua in the placenta.. · Further research is needed to investigate findings in the context of PTB..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transvaginal Cervical Screening in Individuals with Previous Late Preterm Birth.","authors":"Diana Aboukhater, Amira Elzarea, Shaida Campbell, Wave Hatton, Tracey DeYoung, Jerri Waller, Tetsuya Kawakita","doi":"10.1055/a-2526-5492","DOIUrl":"https://doi.org/10.1055/a-2526-5492","url":null,"abstract":"<p><strong>Objective: </strong> This study aimed to assess the effectiveness of ultrasound cervical length (CL) screening in reducing preterm births among individuals with various preterm birth histories, aiming to optimize prevention strategies.</p><p><strong>Study design: </strong> This retrospective cohort study included 576 pregnant individuals with singleton pregnancies and a history of preterm birth, who underwent transvaginal ultrasound CL screening between January 2014 and December 2020. The primary outcome was the detection of a short cervix (≤2.5 cm). We compared outcomes among individuals with a previous gestational age (GA) of 34 to 36, 28 to 33, 24 to 27, and <24 weeks. Adjusted relative risks (aRRs) with 95% confidence intervals (95% CIs) were calculated using modified Poisson's regression with robust variance, controlling for predefined confounders.</p><p><strong>Results: </strong> Of 576 (35%), 139 (24.1%) had a previous birth at 34 to 36 weeks, 129 (22.4%) had a previous birth at 28 to 33 weeks, 90 (15.6%) had a previous birth at 24 to 27 weeks, and 218 (37.8%) had a previous birth <24 weeks. Compared with individuals with a previous GA 34 to 36 weeks, the risk of short cervix was higher in those with a previous <24 weeks (21.6 vs. 52.8%, aRR = 2.56, 95% CI: 1.81-3.62) and GA 24 to 27 weeks (40.0%, aRR = 1.80, 95% CI: 1.20-2.71), but no difference was found with those with previous GA 28 to 33 weeks (24.8%, aRR = 1.12, 95% CI: 0.72-1.72). Compared with individuals with previous GA 28 to 33 weeks, individuals with prior GA 34 to 36 weeks had the same risk of cerclage placement and preterm birth <34 weeks, but a lower risk of composite neonatal outcomes.</p><p><strong>Conclusion: </strong> Based on our results of similar incidence of the short cervix between individuals with previous GA 34 to 36 weeks and those with previous GA 28 to 33 weeks, individuals with a history of late preterm birth should receive CL screening in a similar manner.</p><p><strong>Key points: </strong>· Similar short cervix for prior 34 to 36 versus 28 to 33 weeks.. · Lower risk of neonatal outcomes in the prior 34 to 36 weeks of birth.. · Screening is warranted for any prior preterm birth..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 1 Diabetes Mellitus and Thromboembolism in Pregnancy.","authors":"Jacob Thomas, Charles Brewerton, Calla Holmgren, Rachel Harrison","doi":"10.1055/a-2515-2602","DOIUrl":"10.1055/a-2515-2602","url":null,"abstract":"<p><strong>Objective: </strong> The impact of type 1 DM (T1DM) on thromboembolism in pregnancy is uncertain. We hypothesized that T1DM is associated with higher rates of thrombotic events during pregnancy and the postpartum period.</p><p><strong>Study design: </strong> This is a retrospective cohort study utilizing the National Inpatient Sample database from HCUP/AHRQ for 2017-2019. Pregnant and postpartum patients with a history of T1DM were compared to those without. The primary outcome was a composite diagnosis of any thrombotic disease (pulmonary embolism [PE], deep vein thrombosis [DVT], cerebral vascular thrombosis [CVT], or other thromboses). Secondary outcomes were the diagnosis of each individual type of thromboembolic event. Groups were compared via student's test, chi-squared, and logistic regression analyses, controlling for confounders including age, race, obesity, tobacco use, cHTN, asthma, anemia, and cesarean section.</p><p><strong>Results: </strong> A total of 2,361,711 subjects met the criteria. Patients with T1DM encompassed 0.4% of subjects (<i>n</i> = 9,983). T1DM subjects were more likely to be younger, non-Hispanic white, obese, tobacco users, chronic hypertensive, asthmatic, and have a history of cesarean (all <i>p</i> < 0.001). They were less likely to be in the top income quartile. Thromboembolic events occurred more frequently in those with T1DM (0.45% vs. 0.20%, <i>p</i> < 0.001). DVT was the most common event (0.25%). After controlling for confounders, T1DM remained independently associated with any thromboembolic event in pregnancy (adjusted odds ratio [aOR] = 2.19, 95% confidence interval [CI]: 1.49-3.23), PE (aOR = 3.59, 95% CI: 1.65-7.82), and DVT (aOR = 2.43, 95% CI: 1.43-4.14).</p><p><strong>Conclusion: </strong> T1DM is associated with an increased risk of thromboembolic events in pregnancy.</p><p><strong>Key points: </strong>· T1DM is independently associated with VTE.. · PE and DVT are the most common events.. · T1DM has an impact on VTE similar to obesity..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Skincubator: A Novel Incubator for Skin-to-Skin Care (SSC) of Premature Neonates, Enables SSC within Humidified Environment and may Improve Thermoregulation during SSC.","authors":"Itamar Nitzan, Yair Kasirer, Francis B Mimouni, Tehilla Kagan, Alona Bin Nun, Tali B Weiss, Robert D White, Cathy Hammerman","doi":"10.1055/a-2526-5064","DOIUrl":"10.1055/a-2526-5064","url":null,"abstract":"<p><strong>Objective: </strong> This study aimed to assess thermoregulation and humidity within the Skincubator-a novel, wearable skin-to-skin incubator designed to attach to the caregiver.</p><p><strong>Study design: </strong> Preterm neonates (PN; born between 24 and 33 weeks gestational age [GA]) received skin-to-skin care (SSC) either via the Skincubator or traditional SSC (t-SSC) with continuous axillary temperature monitoring.</p><p><strong>Results: </strong> Twenty PN were enrolled in the study and treated in the Skincubator. One couple who consented to Skincubator care during delivery subsequently revoked their consent and the baby was excluded from further analysis. Fifty-four paired sessions of Skincubator and t-SCC were performed and compared for 19 babies. The average GA was 29 weeks (range: 26-32), the average weight was -1,296 ± 271 g, and the average day of life was 5 ± 2. The temperature drop after transfer to Skincubator care was smaller than in t-SSC (0.2°C [0.2-0.3] vs. 0.4°C [0.3-0.6]; Wilcoxon's signed rank test [WSRT], <i>p</i> < 0.001). The average hypothermia time per session was a median (25th-75th%) of 8.2 minutes (0-9) for Skincubator, compared to 27.8 minutes (0-56) for t-SSC, respectively (WSRT, <i>p</i> = 0.002). No baby had moderate hypothermia (35.5-35.9°C) during Skincubator care as compared with eight babies who experienced moderate hypothermia during t-SSC (Fisher's exact test <i>p</i> = 0.003). The average Skincubator humidity was 85 ± 7% and was above 70% during 93% of the time.</p><p><strong>Conclusion: </strong> Skincubator SSC was superior to t-SSC in maintaining PN temperature while also maintaining an optimally humidified environment. The Skincubator may promote early SSC in very and extremely PN. (Trial registration number MOH_2021-12-13_010470 registration date 24/10/21.) KEY POINTS: · Early prolonged SSC improves preterm infants' outcomes but may be challenging to perform.. · To mitigate several SSC barriers we invented the Skincubator, a wearable incubator for SSC.. · We have shown that the Skincubator reduces transient moderate hypothermia at SSC initiation.. · Average Skincubator humidity was 85 ± 7% and above 70% during 93% of SSC time..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Septo-Optic Dysplasia in Neonates with Absent Cavum Septi Pellucidi Identified during Routine Prenatal Imaging.","authors":"Michael A Phillipi, Sheevaun Khaki, Amanda J H Kim, Michael F Regner, Ladawna Gievers","doi":"10.1055/a-2521-1020","DOIUrl":"10.1055/a-2521-1020","url":null,"abstract":"<p><strong>Objective: </strong> This study aimed to determine the prevalence of septo-optic dysplasia (SOD) in patients with prenatally identified absent cavum septi pellucidi (CSP), agenesis of the corpus callosum (ACC), or dysgenesis of the corpus callosum (DCC).</p><p><strong>Study design: </strong> This retrospective chart review investigated neonates prenatally diagnosed with an absent CSP, ACC, or DCC who were admitted to a single quaternary academic medical center in the Pacific Northwest between 2016 and 2023. This prenatal diagnosis prompted a routine and protocolized postnatal workup for SOD including laboratory evaluation, imaging, and specialty consultation. Sociodemographic and clinical data were collected for eligible neonates and their birthing persons. The prevalence of SOD in patients with midline callososeptal anomalies was calculated.</p><p><strong>Results: </strong> Of the 86 patients prenatally diagnosed with absent CSP, ACC, and/or DCC, 36.0% (<i>n</i> = 31) were diagnosed postnatally with SOD. Of those diagnosed with SOD, 71.0% (<i>n</i> = 22) had isolated optic nerve hypoplasia, 9.7% (<i>n</i> = 3) had pituitary hormone abnormalities, and 19.4% (<i>n</i> = 6) had both. Seven patients required maintenance hydrocortisone, one required thyroid hormone replacement, and one required thyroid and growth hormones. Of the 26 patients with SOD who underwent genetic testing, 9 (34.6%) had one or more genetic differences detected.</p><p><strong>Conclusion: </strong> SOD was diagnosed in 36.0% of cases of prenatally diagnosed midline callososeptal anomalies. For patients with prenatally diagnosed midline callososeptal anomalies, a standardized, postnatal SOD evaluation allows timely diagnosis and prompts early intervention and hormone replacement, thus avoiding the consequences of a delayed diagnosis.</p><p><strong>Key points: </strong>· Thirty-six percent of patients with midline callososeptal anomalies were diagnosed with SOD.. · Most patients (71.0%) diagnosed with SOD had optic nerve hypoplasia without pituitary abnormalities.. · Although most patients received genetic testing, no findings were linked to SOD..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing Home Oxygen and Nasogastric Feeds Post-NICU Discharge: PCP Practices and Perspectives.","authors":"Lauren A Beard, Blair W Weikel, Kathleen E Hannan, Amanda I Messinger, Stephanie L Bourque","doi":"10.1055/a-2522-1708","DOIUrl":"10.1055/a-2522-1708","url":null,"abstract":"<p><strong>Objective: </strong> NICU graduates are frequently technology dependent including home oxygen, pulse oximetry, and/or nasogastric (NG) feedings. Primary care provider (PCP) perceptions, practices, and barriers to managing these infants are not well described, especially at altitude. We sought to 1) describe PCP comfort and 2) determine practices and barriers in managing this technology at higher altitudes.</p><p><strong>Study design: </strong> This cross-sectional survey assessed Colorado and Wyoming PCP perceptions and practices surrounding technology in NICU graduates. We explored bivariate analysis between clinic altitude, location, and provider's experience with comfort caring for infants discharged with technology using chi-squared or Fisher's exact tests. Significant relationships were modeled using logistic regression for odds ratios and 95% confidence intervals.</p><p><strong>Results: </strong> Among 203 respondents, 82% were pediatricians, and 86% practiced in urban/suburban environments. Clinic altitude ranged 2,500-9,000 ft. PCPs endorsed comfort managing oxygen in term (92%) and moderately/late preterm infants (82%), versus 52% comfort in very/extremely preterm infants. 62% utilized an oxygen-weaning algorithm. Comfort managing oxygen was greater in suburban versus urban locations (odds ratio [OR] = 4.4, 95% confidence interval [CI]: 1.6-11.7) and providers practicing for >10 versus <5 years (OR = 3.5, 95% CI: 1.5, 8.4). 60% found pulse oximetry useful, though 70% perceived caregiver stress. 69% accepted infants on NG feeds, though 61% endorsed discomfort with management.</p><p><strong>Conclusion: </strong> PCPs are comfortable managing home oxygen in moderately preterm to term infants but find caring for most preterm infants challenging. Discomfort in managing NG feeds is prevalent. This highlights peridischarge barriers and improvement opportunities for high-risk, technology-dependent infants.</p><p><strong>Key points: </strong>· PCPs are uncomfortable managing very/extremely preterm infants on home oxygen after NICU discharge.. · PCPs perceive frequent commercial pulse oximetry use in NICU graduates.. · Most PCPs are uncomfortable managing home NG feedings..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143035735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dose-Dependent Effect of Obesity on Adverse Maternal and Neonatal Outcomes in a Hispanic Population.","authors":"Sara I Jones, Elise A Rosenthal, Jessica E Pruszynski, F Gary Cunningham","doi":"10.1055/a-2515-2673","DOIUrl":"10.1055/a-2515-2673","url":null,"abstract":"<p><strong>Objective: </strong> This study aimed to evaluate the frequency of adverse maternal and neonatal outcomes associated with maternal obesity in a Hispanic population. We hypothesized that obesity confers a dose-dependent risk associated with these outcomes.</p><p><strong>Study design: </strong> This was a retrospective cohort study of singleton pregnancies delivered between 24 and 42 weeks gestation at an urban county hospital between 2013 and 2021. Body mass index (BMI) at the first prenatal visit was used as a proxy for prepregnancy weight. Patients were excluded if their first-trimester BMI was not available. Trends in adverse outcomes across increasing obesity classes were assessed.</p><p><strong>Results: </strong> During the study period, 58,497 patients delivered a singleton infant, of which 12,365 (21.1%), 5,429 (9.3%), and 3,482 (6.0%) were in class I, II, and III obesity, respectively. Compared with nonobese patients, obese patients were more likely to be younger and nulliparous with a higher incidence of hypertension and pregestational diabetes. Higher BMI was associated with a significant dose-dependent increase in cesarean delivery (27% for nonobese, 34% for class I, 39% for class II, and 46% for class III obesity); severe preeclampsia (8% in nonobese and 19% for class III obesity); and gestational diabetes (5% in nonobese and 15% in class III obesity). There were significant trends in increasing morbidity for infants born to patients with correspondingly higher obesity classes. Some of these adverse outcomes included respiratory distress syndrome, neonatal intensive care unit admission, fetal anomalies, and sepsis (all <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong> Increasing body mass index is associated with a significant dose-dependent increase in multiple adverse perinatal outcomes in a Hispanic population. Associated adverse maternal outcomes include severe preeclampsia, gestational diabetes, and cesarean delivery. Infants born to patients with correspondingly higher BMI class have significantly increased associated morbidity. Often, only higher BMI classes are significantly associated with these adverse outcomes.</p><p><strong>Key points: </strong>· As BMI increases, pregnant patients are more likely to experience adverse maternal and neonatal outcomes.. · Many adverse pregnancy outcomes are associated only with a BMI greater than 40 kg/m2.. · Obesity is associated with cesarean delivery, likely due to an increase in labor dystocia..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Antibiotics on Latency When Given at the Time of Membrane Rupture Before Viability.","authors":"Katherine A Lambert, Jennifer Cate, Anne West Honart, Matthew R Grace, Sarah K Dotters-Katz","doi":"10.1055/a-2516-1911","DOIUrl":"10.1055/a-2516-1911","url":null,"abstract":"<p><strong>Objective: </strong> It is well established that antibiotics administered in preterm prelabor rupture of membranes increase latency to delivery. While data are limited for membrane rupture prior to viability, antibiotics may also increase latency in this population. This study aimed to assess the effect of prophylactic antibiotics on the duration of latency in individuals with previable prelabor rupture of membranes.</p><p><strong>Study design: </strong> Retrospective cohort of pregnancies with previable prelabor rupture of membranes prior to 23^0/7 weeks in a single health system (2013-2022). Patients opting for termination or with a contraindication to expectant management were excluded. The primary outcome was latency from previable prelabor rupture of membranes diagnosis to delivery. Secondary outcomes included subanalysis by gestational age as well as maternal and neonatal morbidity and mortality. Bivariate statistics compared patients who did and did not receive antibiotics (ampicillin, gentamicin). Kaplan-Meier/Cox proportional hazards ratios using significant covariates (<i>p</i> < 0.1) in bivariate analysis models examined antibiotic impact on latency.</p><p><strong>Results: </strong> Of 115 patients, 46 (40%) met inclusion criteria, of whom 34 (74%) received latency antibiotics. Median latency did not differ with antibiotic receipt (1 [0.4, 2.6] vs. 0.6 weeks [0.3, 0.9], <i>p</i> = 0.27). When adjusted for gestational age at rupture of membranes, antibiotics were not associated with longer latency (hazard ratio = 1.33 [0.91, 1.93]). Antibiotic receipt was associated with lower rates of previable delivery (23.0, [22.7, 24.0] vs. 21.3 weeks [20.5, 23.1], <i>p</i> = 0.006). Adjusted odds of previable delivery remained lower with receipt of antibiotics (adjusted odds ratio = 0.20, [0.04, 0.90]). Antibiotics were associated with longer latency in patients with rupture of membranes at less than 22 weeks gestation (2.4 [1.3,4.4] vs. 0.6 weeks [0.1,0.9], <i>p</i> = 0.02).</p><p><strong>Conclusion: </strong> Antibiotic administration at the time of previable prelabor rupture of membranes was associated with longer latency prior to 22 weeks gestation. Antibiotic administration increased the odds of delivering after viability. Further study should address optimal antibiotic strategies for this unique population.</p><p><strong>Key points: </strong>· No significant increase in latency after antibiotics with rupture of membranes prior to 23 weeks.. · Significantly longer latency after antibiotics with rupture of membranes before 22 weeks.. · Antibiotic receipt associated with increased likelihood of delivering after viability..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Premedication for Intubating Very Low Birth Weight Infants in the Neonatal Intensive Care Unit: Results of a National Survey.","authors":"Cassandra DeMartino, Sara Neches, Megan M Gray, Taylor Sawyer, Lindsay Johnston","doi":"10.1055/a-2521-1118","DOIUrl":"10.1055/a-2521-1118","url":null,"abstract":"<p><strong>Objective: </strong> This study aimed to explore barriers and perspectives of premedication use for non-emergent intubations of very low birth weight (VLBW) infants (<1,500 g).</p><p><strong>Study design: </strong> A cross-sectional, online survey was distributed from January to April 2023 to members of the American Academy of Pediatrics Section on Neonatal-Perinatal Medicine. Data was analyzed using descriptive statistics and chi-square tests.</p><p><strong>Results: </strong> Of the 521 respondents, the majority (81%, <i>n</i> = 415) were neonatologists. Over half of respondents (69%, <i>n</i> = 359) consider patient weight when selecting premedication. Most providers (78%, <i>n</i> = 407) agreed that premedication should be used for non-emergent intubation of VLBW infants, while only 41% (<i>n</i> = 216) felt similarly that muscle relaxants should be used. For infants over 1,500 g, 43% (<i>n</i> = 153) reported frequent or regular muscle relaxant use compared with 28% (<i>n</i> = 101) for VLBW infants. The most cited barrier to muscle relaxant use was surfactant delivery with a planned return to non-invasive support. Unit guidelines were associated with significantly more premedication and muscle relaxant use (56 vs. 44%; odds ratio [OR] = 5.2, 95% confidence interval [CI]: 3.4-7.7, <i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong> Most neonatal providers favor premedication for non-emergent intubation but are hesitant to use muscle relaxants for VLBW infants. Premedication guidelines may facilitate the use of both premedication and muscle relaxants for this population.</p><p><strong>Key points: </strong>· Study of intubation premedication perceptions and practices for VLBW infants.. · Premedication is used less for intubation of VLBW infants compared to their larger peers.. · Unit premedication guidelines and available intubation backup may facilitate premedication use..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}