American journal of perinatology最新文献

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Evaluating Risk-Adjusted Associations between Prenatal Care Utilization and Obstetric Outcomes in a Commercially Insured Patient Population. 评估商业保险患者群体中产前护理利用率与产科结果之间的风险调整关联。
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-17 DOI: 10.1055/a-2559-7261
Adina Rachel Kern-Goldberger, Natalie E Sheils, Rachell Vinculado, Ana Jane Paderanga, David A Asch, Sindhu Srinivas
{"title":"Evaluating Risk-Adjusted Associations between Prenatal Care Utilization and Obstetric Outcomes in a Commercially Insured Patient Population.","authors":"Adina Rachel Kern-Goldberger, Natalie E Sheils, Rachell Vinculado, Ana Jane Paderanga, David A Asch, Sindhu Srinivas","doi":"10.1055/a-2559-7261","DOIUrl":"10.1055/a-2559-7261","url":null,"abstract":"<p><p>This study examined associations between prenatal care utilization and adverse obstetric outcomes including severe maternal morbidity (SMM), preterm birth, and stillbirth in a large, commercially insured U.S. patient population. This is a retrospective cohort study using an insurance claims database evaluating associations between prenatal care utilization and obstetric outcomes over four years (2017 - 2020). Prenatal care utilization was characterized based on the Adequacy of Prenatal Care Utilization (APNCU) index. The primary outcome was SMM (as per Centers for Disease Control). Secondary outcomes included preterm birth < 37 weeks and stillbirth. Associations between exposure and outcome were investigated using logistic regression models in designated \"low\" and \"medium\" maternal risk groups, defined based on obstetric co-morbidity index (OB-CMI) scores modeled at the time of the first trimester and at delivery. 297,453 patients were included: 78,100 in the sub-group who remained low-risk throughout pregnancy and 49,920 in the sub-group who remained medium-risk. The largest number of patients overall (29.9%) received \"adequate plus\" care, as defined by the APNCU index, while a plurality of low- and medium-risk patients received \"intermediate\" care (35.6% and 29.9%, respectively). 1.77% of patients experienced SMM, 8.63% delivered preterm, and 0.88% had stillbirth. Adjusted analysis comparing volume of prenatal care with these outcomes demonstrated no statistically significant associations, with the exception of preterm birth, which was positively associated with \"adequate\" and \"adequate plus\" care in low- and medium-risk patients. \"Inadequate care\" was not associated with any of the studied outcomes. Overall volume of prenatal care was not associated with a reduction in adverse obstetric outcomes. Clinical quality improvement and health policy efforts to improve prenatal care delivery models may need to bypass adherence to established guidelines in terms of gross visit number as a key metric and instead work to revise practices based on more meaningful clinical outcomes.</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time To Hemorrhage Response After Implementation of Obstetric Hemorrhage Bundle.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-17 DOI: 10.1055/a-2559-1837
Akanksha Srivastava, Michelle Wang, Sara Young, Swetha Tummala, Diana Abbas, Megan Alexander, Lindsey Claus, Ronald Iverson, Ashley Comfort
{"title":"Time To Hemorrhage Response After Implementation of Obstetric Hemorrhage Bundle.","authors":"Akanksha Srivastava, Michelle Wang, Sara Young, Swetha Tummala, Diana Abbas, Megan Alexander, Lindsey Claus, Ronald Iverson, Ashley Comfort","doi":"10.1055/a-2559-1837","DOIUrl":"10.1055/a-2559-1837","url":null,"abstract":"<p><p>Objective To evaluate the time to uterotonic administration before and after the implementation of an obstetric hemorrhage bundle. Study Design This is a retrospective cohort study of deliveries at an urban tertiary care hospital before and after implementation of an obstetric hemorrhage bundle. Two groups were compared on time from delivery to first dose of postpartum uterotonic intervention. Secondary outcomes included total number of uterotonics, transfusion rates, and utilization of non-uterotonic hemorrhage interventions including uterine artery embolization and balloon tamponade. Results Of the 4,275 deliveries of live births included in this study, 1944 occurred pre-intervention and 2,331 occurred post-intervention. Mean time to oxytocin decreased from 12.2 minutes to 5.9 minutes after implementation of the bundle (p<0.01). Post-intervention deliveries received significantly more second line uterotonics when compared to pre-intervention deliveries (p<0.01). Conclusion Implementation of an obstetric hemorrhage bundle was associated with improved management as reflected in faster and increased delivery of uterotonic interventions for hemorrhage. Future studies should continue to explore the effect of hemorrhage bundle protocols on hemorrhage-related process measures.</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrence risk of preterm birth in successive pregnancies based on its subtypes.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-07 DOI: 10.1055/a-2552-9058
Iris T Smith, Michael John Fassett, David A Sacks, Nehaa Khadka, Nana Mensah, Morgan Peltier, Vicki Y Chiu, Fagen Xie, Jiaxiao M Shi, Darios Getahun
{"title":"Recurrence risk of preterm birth in successive pregnancies based on its subtypes.","authors":"Iris T Smith, Michael John Fassett, David A Sacks, Nehaa Khadka, Nana Mensah, Morgan Peltier, Vicki Y Chiu, Fagen Xie, Jiaxiao M Shi, Darios Getahun","doi":"10.1055/a-2552-9058","DOIUrl":"https://doi.org/10.1055/a-2552-9058","url":null,"abstract":"<p><strong>Objective: </strong>Preterm birth (PTB) remains one of the biggest public health challenges with both obstetric and perinatal implications. While a prior PTB is a known risk factor for recurrence, the understanding of the influence of factors such as race/ethnicity, gestational age, PTB subtypes, and interpregnancy intervals (IPI) remains limited. This study aimed to assess whether these factors modify PTB recurrence risk.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of singleton pregnancies in Kaiser Permanente Southern California (2009-2022) using electronic health record data from 82,610 women with two pregnancies and 14,925 women with three. PTB subtypes, spontaneous (sPTB) and indicated (iPTB), were identified through natural language processing. Logistic regression was used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI).</p><p><strong>Results: </strong>A first PTB was associated with a 6-fold increased risk of PTB in the second pregnancy compared to an uncomplicated pregnancy (23.29% vs. 4.98%, respectively; aOR, 5.60, 95% CI: 5.23-5.99). Those with a history of sPTB (aOR: 5.32, 95% CI: 4.87, 5.81) and iPTB (aOR: 8.26, 95% CI: 7.18, 9.50) had increased risk for the same respective subtype at their second pregnancy. PTB recurrence risk persisted across race/ethnicity categories. In women with PTB in both prior pregnancies, the risk for PTB in a third pregnancy was significantly higher (aOR 14.59, 95% CI 11.28-18.88). The recurrence of PTB between 1st and 2nd pregnancy was substantially higher for those who delivered at 20-33 weeks of gestation, regardless of PTB subtype. Non-Hispanic Black and Asian/Pacific Islander women had higher recurrence risk compared to non-Hispanic Whites.</p><p><strong>Conclusion: </strong>These findings highlight disparities in PTB recurrence by race/ethnicity and PTB subtype among a large integrated healthcare system in Southern California, underscoring the need for targeted interventions, particularly for sPTB.</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improved Growth Velocity Using a New Liquid Human Milk Fortifier in Very Low Birth Weight Infants: A Multicenter, Retrospective Study.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-06 DOI: 10.1055/a-2527-4638
Fernando Moya, Jennifer Fowler, Adrian Florens, Jennifer Dombrowski, Olivia Davis, Tiffony Blanks, Austin Gratton
{"title":"Improved Growth Velocity Using a New Liquid Human Milk Fortifier in Very Low Birth Weight Infants: A Multicenter, Retrospective Study.","authors":"Fernando Moya, Jennifer Fowler, Adrian Florens, Jennifer Dombrowski, Olivia Davis, Tiffony Blanks, Austin Gratton","doi":"10.1055/a-2527-4638","DOIUrl":"10.1055/a-2527-4638","url":null,"abstract":"<p><p>This study aimed to compare growth outcomes and tolerance among very low birth weight (VLBW) infants receiving a new, liquid human milk fortifier (LHMF-NEW) or a human milk fortifier-acidified liquid (HMF-AL).Retrospective, multicenter study of 515 VLBW infants in three regional neonatal intensive care units. The primary objective was to compare growth velocity (g/kg/d) during fortification between groups by repeated measures regression. Secondary outcomes of interest were feeding tolerance and the incidence of late-onset sepsis, necrotizing enterocolitis, and metabolic acidosis. Student's <i>t</i>, analysis of variance, Wilcoxon, and Kruskal-Wallis tests were used for numeric variables, or chi-squared and Fisher's exact test for categorical variables.No demographic differences were identified between the groups (HMF-AL, <i>n</i> = 242; LHMF-NEW, <i>n</i> = 273). Growth velocity during fortification was significantly higher in the group receiving LHMF-NEW, despite relatively similar total fluid, calorie, or protein intake (<i>p</i> = 0.001). Feeding intolerance was comparable between fortifiers. Necrotizing enterocolitis and late-onset sepsis did not differ between groups and metabolic acidosis was diagnosed less frequently with the LHMF-NEW. Anthropometric measures at discharge and length of stay were comparable.Infants receiving human milk fortified with the LHMF-NEW had faster growth velocity during fortification, similar tolerance, and less metabolic acidosis compared with an earlier cohort of infants who received human milk fortified with an HMF-AL. · Among VLBW infants, using an LHMF-NEW resulted in a faster growth velocity in weight during several weeks of fortification than using the previous HMF-AL.. · The incidence of feeding intolerance (stopping feeds >8 hour) in any given week of fortification was low and not different between groups. Also, late-onset sepsis and necrotizing enterocolitis were uncommon with no differences between groups, whereas the incidence of metabolic acidosis was lower in infants receiving the LHMF-NEW.. · No differences in length of stay or anthropometrics at discharge were identified..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Coronavirus Disease 2019 on the Incidence of No Prenatal Care.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-06 DOI: 10.1055/a-2535-8309
Takaki Tanamoto, Misa Hayasaka, Lindsay Robbins, George Saade, Tetsuya Kawakita
{"title":"Impact of Coronavirus Disease 2019 on the Incidence of No Prenatal Care.","authors":"Takaki Tanamoto, Misa Hayasaka, Lindsay Robbins, George Saade, Tetsuya Kawakita","doi":"10.1055/a-2535-8309","DOIUrl":"10.1055/a-2535-8309","url":null,"abstract":"<p><p>This study aimed to examine the impact of coronavirus disease 2019 (COVID-19) on the racial disparity in prenatal care utilization in the United States before and during the pandemic.This was a cross-sectional study using the National Vital Statistics Data from 2018 to 2022. Our focus was on low-risk individuals who delivered singleton pregnancies at term. The analysis was restricted to Black and White individuals to explore racial disparities. The study periods based on the last menstrual period (LMP) were prepandemic (March 2018-February 2020) and pandemic (March 2020-February 2022). The primary outcome was the rate of no prenatal care. We employed interrupted time series analysis, negative binomial regression models, adjusting for confounders, seasonality, and autocorrelation. We conducted postestimation analyses to calculate the counterfactual and actual incidences of outcomes for individuals with an LMP in March 2020 and February 2022. Difference-in-difference (DID) with 95% confidence intervals (95% CI) was estimated.The analysis included 3,511,813 individuals in the prepandemic period and 5,163,486 in the pandemic period. For individuals with LMP in March 2020, the actual incidences of no prenatal care per 100 births were 3.2 (95% CI: 3.0, 3.3) for Black individuals and 1.6 (95% CI: 1.2, 2.0) for White individuals. The difference between counterfactual and actual no prenatal care rates per 100 births for Black individuals was 0.4 (95% CI: 0.2, 0.5), indicating a significant increase in no prenatal care. Conversely, there was no significant difference for White individuals. DID analysis further demonstrated that this increase was greater in Black individuals compared with White individuals (DID per 100 births 0.3 [95% CI: 0.1, 0.5]). For individuals with LMP in February 2022, this difference in disparity further worsened (DID per 100 births 0.8 [95% CI: 0.4, 1.2]).The COVID-19 pandemic increased the incidence of no prenatal care, which disproportionately affected Black individuals. · The COVID-19 pandemic increased racial disparities.. · The increase in no prenatal care among Black individuals.. · White individuals are lower affected during this period..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving First-Attempt Intubation Success Rate in a Level IV Neonatal Intensive Care Unit Through the Use of a Video Laryngoscope: A Quality Improvement Initiative.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-06 DOI: 10.1055/a-2533-2465
Stephanie Martinez, Monika Bhola, Nori Mercuri Minich, Charlene Nauman, Kathleen Deakins, Allison Oliverio, Gulgun Yalcinkaya
{"title":"Improving First-Attempt Intubation Success Rate in a Level IV Neonatal Intensive Care Unit Through the Use of a Video Laryngoscope: A Quality Improvement Initiative.","authors":"Stephanie Martinez, Monika Bhola, Nori Mercuri Minich, Charlene Nauman, Kathleen Deakins, Allison Oliverio, Gulgun Yalcinkaya","doi":"10.1055/a-2533-2465","DOIUrl":"https://doi.org/10.1055/a-2533-2465","url":null,"abstract":"<p><p>There is increasing evidence that the use of a video laryngoscope improves first-attempt intubation rates in neonates. The goal of this quality improvement initiative was to improve the first-attempt intubation success rate from 45 to 65% in 2.5 years through the introduction and increased use of a video laryngoscope in a level IV neonatal intensive care unit (NICU).We utilized the Model for Improvement with plan-do-study-act cycles targeted at increasing buy-in and comfort with the use of a video laryngoscope. Data on 418 intubations were collected from November 2021 to April 2024.Through increasing routine use of the video laryngoscope, achieved via a staggered introduction of the device, creation of reference materials, and coaching workshops, we improved the overall first-attempt intubation success rate from 45 to 57% during the intervention period.We increased the first-attempt success rate of intubations in the NICU by effectively implementing the use of a video laryngoscope into daily practice. · Neonatal intubations have low success rates, but video laryngoscopy improves success especially for those with less experience.. · This study shows that video laryngoscopy adoption in a neonatal ICU improved first-attempt intubation rates.. · This study contributes to neonatal intubation and video laryngoscopy literature from a quality improvement perspective..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plain Language Summary of Publication: Design of the Phase 3 AZALEA Trial of Nipocalimab in Severe Hemolytic Disease of the Fetus and Newborn.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-06 DOI: 10.1055/a-2529-4150
Yosuke Komatsu, Victor Olusajo, Leona E Ling, Shumyla Saeed-Khawaja, May Lee Tjoa, Trishan Vaikunthanathan, Arpana Mirza, Kenneth J Moise
{"title":"Plain Language Summary of Publication: Design of the Phase 3 AZALEA Trial of Nipocalimab in Severe Hemolytic Disease of the Fetus and Newborn.","authors":"Yosuke Komatsu, Victor Olusajo, Leona E Ling, Shumyla Saeed-Khawaja, May Lee Tjoa, Trishan Vaikunthanathan, Arpana Mirza, Kenneth J Moise","doi":"10.1055/a-2529-4150","DOIUrl":"https://doi.org/10.1055/a-2529-4150","url":null,"abstract":"<p><p>This article is a plain language summary of publication (PLSP) of the following article: Design of a phase 3, global, multicenter, randomized, placebo-controlled, double-blind study of nipocalimab in pregnancies at risk for severe hemolytic disease of the fetus and newborn by Komatsu et al published in <i>American Journal of Perinatology</i> on September 17, 2024 (doi:10.1055/a-2404-8089). This PLSP describes the design of the phase 3 AZALEA clinical trial in pregnant participants at risk for developing severe hemolytic disease of the fetus and newborn (HDFN). In this study, researchers will determine if an investigational treatment called nipocalimab can be used safely and effectively to treat pregnant individuals who are at risk for severe HDFN. This PLSP will help members of the public, including individuals and families affected by HDFN, understand the study. It may also be helpful for health care professionals. An infographic summary of this article is available in the Supplementary Material. · Severe HDFN causes serious health issues for babies. · IUTs carry risks of complications and fetal loss. · Nipocalimab reduces fetal anemia and IUTs in HDFN. · AZALEA is testing nipocalimab for severe HDFN.</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk and Causes of Early Mortality among Extremely Preterm Infants Born Small for Gestational Age.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-06 DOI: 10.1055/a-2533-2533
Olasunkanmi Kehinde, Dmitry Tumin, Uduak S Akpan, Martha Naylor
{"title":"Risk and Causes of Early Mortality among Extremely Preterm Infants Born Small for Gestational Age.","authors":"Olasunkanmi Kehinde, Dmitry Tumin, Uduak S Akpan, Martha Naylor","doi":"10.1055/a-2533-2533","DOIUrl":"10.1055/a-2533-2533","url":null,"abstract":"<p><p>Extreme preterm (EPT) delivery, occurring before 28 weeks of gestation, carries high morbidity and mortality risks. Small for gestational age (SGA) infants, approximately 8 to 20% of EPT neonates, face increased risks. Mortality risk varies with gestational age and birth weight, with mixed reports on specific morbidities. This study aims to determine mortality rates and common causes of death among EPT SGA infants.The study used data from the CDC National Vital Statistics System, covering births and deaths from 2016 to 2021, with follow-up through 2022. It included infants born between 22 and 27 weeks gestation who were admitted to the neonatal intensive care unit. The outcome was all-cause in-hospital mortality within 30 days of birth, with causes of mortality classified based on the International Classification of Diseases, 10th revision codes. SGA was the primary independent variable.Based on a sample of <i>n</i> = 96,134 infants, we estimated 13% were born SGA and 30-day mortality rates were higher among SGA compared with non-SGA infants (31 vs. 13%). On multivariable analysis, SGA infants had higher 30-day mortality than non-SGA (odds ratio: 3.82; confidence interval 95% [CI]: 3.64, 4.01; <i>p</i> < 0.001), and were more likely to have death ascribed to complications of short gestation rather than other causes of death (relative risk ratio: 1.42; 95% CI: 1.27, 1.59; <i>p</i> < 0.001).SGA infants receiving intensive care have a high mortality risk, especially due to complications of short gestation and low birth weight complications. · EPT infants face high mortality risk.. · Mortality risk is increased for infants born SGA.. · Mortality in SGA EPT infants is frequently attributed to complications of prematurity and small size..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sinopharm COVID-19 Vaccination during Pregnancy Triggers Thyroid Stimulating Hormone Levels in Newborns.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-06 DOI: 10.1055/a-2526-5326
Aylar Vatanparast, Faeze Daghigh, Hossein Akbari
{"title":"Sinopharm COVID-19 Vaccination during Pregnancy Triggers Thyroid Stimulating Hormone Levels in Newborns.","authors":"Aylar Vatanparast, Faeze Daghigh, Hossein Akbari","doi":"10.1055/a-2526-5326","DOIUrl":"https://doi.org/10.1055/a-2526-5326","url":null,"abstract":"<p><p>The effects of covid vaccination on the fetus and placenta make pregnant women a special group in the vaccination series. Coronavirus vaccines are associated with endocrine complications such as thyroid disease.The study included pregnant women who received the corona virus disease 2019 (COVID-19) vaccine. Pregnant women were divided into three study groups; group A (who have not received the COVID-19 vaccine), group B (who received the Sinopharm vaccine during pregnancy), and group C (who received the Sinopharm vaccine before pregnancy). Blood samples were taken to measure thyroid stimulating hormone (TSH) levels in infants 3 to 5 days old. Neonatal TSH values below 5 mU/L are considered normal.Sinopharm/BBIBP-CorV during and/or before pregnancy was associated with a slight increase in mean TSH in newborns.Vaccination with Sinopharm/BBIBP-CorV during or before pregnancy may slightly increase neonatal TSH levels, but this is not clinically significant. · COVID-19 vaccines linked to endocrine disruption.. · Sinopharm CorV during pregnancy triggers TSH in infants.. · Sinopharm vaccination in pregnancy increases neonatal TSH levels..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preterm Births and Maternal-Fetal Medicine Physician Workforce Location in the United States.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-06 DOI: 10.1055/a-2531-2783
Andrea L Greiner, Sina Haeri, Nichole L Nidey
{"title":"Preterm Births and Maternal-Fetal Medicine Physician Workforce Location in the United States.","authors":"Andrea L Greiner, Sina Haeri, Nichole L Nidey","doi":"10.1055/a-2531-2783","DOIUrl":"https://doi.org/10.1055/a-2531-2783","url":null,"abstract":"<p><p>Examine for association between geographic disparity in the national maternal-fetal medicine (MFM) physician workforce distribution and preterm birth (PTB) rate in counties without MFM presence.Cohort study of PTBs in the United States from 2015 to 2019, utilizing National Center for Health Statistics natality data. The independent risk factor is the presence of an MFM physician in the county or county equivalent where the pregnant woman resides. Bivariate logistic regression analysis estimated the odds of county-level PTB rates higher than the national average (10.2%, March of Dimes 2019 national data) by MFM physician location.The Northeast, Southeast, and Pacific Coast regions of the United States had the highest density of physician practice locations whereas regions in the Midwest and Western United States had the lowest density. Of the 2,981 counties with PTB rates available, 90.3% (<i>n</i> = 2,691) did not have a practicing MFM physician. U.S. counties without an MFM physician are more likely to have a PTB rate higher than the national average, operating room (OR) = 1.56 (95% confidence interval [CI], 1.22-1.99), compared with a county with at least one MFM physician.Counties with no practicing MFM physician had a 56% increase in the odds of having PTB rates higher than the national average. The lack of proximate high-risk obstetric care is a geographic health disparity associated with PTB. The location of the MFM workforce has implications for both clinical care and health policy. These data suggest that attention should be directed toward where physicians practice and to increase access to care for at-risk pregnant women. · U.S. regions with the highest concentration of MFM physicians remain unchanged from prior publications.. · Only 9.7% of counties reporting PTB data have practicing MFM physicians.. · Counties without an MFM physician have 56% higher odds of exceeding national PTB rates.. · Regional disparities in MFM physician distribution may impact maternal and neonatal outcomes..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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