American journal of nuclear medicine and molecular imaging最新文献

{"title":"Comparison of PSMA-based ¹⁸F-DCFPyL PET/CT and Tc-99m MDP bone scan in detection of bone metastasis in prostate cancer.","authors":"Zenus J Wilson,&nbsp;Guofan Xu,&nbsp;Sanjit O Tewari,&nbsp;Yang Lu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>While Tc-99m MDP bone scan (BS) remains the conventional standard for detection of bone metastasis in prostate cancer, newly FDA-approved imaging with PSMA-based ¹⁸F-DCFPyL PET/CT has shown promise for early detection of metastatic disease. However, a paucity of data remains in the diagnostic accuracy of PSMA PET/CT in detecting bone metastasis compared to BS. This retrospective study included 91 patients who received both BS and PSMA PET/CT within a 3-month interval from August 2021 to February 2022. Separate concurrent primary cancer, interval PSA levels greater than a 2-fold difference (or absolute difference >1 ng/ml) between the two studies were excluded. All abnormal bone lesions on either scan were compared. The findings were verified by pathological findings and/or 6-month clinical follow-up. High concordance (78%) was found between modalities with discordant findings (20/91, 22%) demonstrating more false positives (4/20, 20%) and false negatives (3/20, 15%) on BS compared to PET/CT. Additionally, more bone metastases were detected on PSMA PET/CT (13/20, 65%) with all true positive BS lesions also detected PET/CT. The sensitivity, specificity, PPV and NPV for BS were 89%, 91%, 80%, and 95% respectively; and 100%, 97%, 93%, and 100% for ¹⁸F-DCFPyL PET/CT respectively. Our results demonstrate that ¹⁸F-DCFPyL PET/CT identified more bone metastases while also identifying all bone metastases identified on BS. With the added diagnostic value of detecting primary tumor and soft tissue metastasis, ¹⁸F-DCFPyL PET/CT may render BS unnecessary to investigate bone metastases in patients with prostate cancer.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"13 1","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009469/pdf/ajnmmi0013-0001.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9122053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Claudin18.2-targeted cancer theranostics.","authors":"Di Zhang,&nbsp;Gang Huang,&nbsp;Jianjun Liu,&nbsp;Weijun Wei","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Claudin 18.2 (CLDN18.2) is an emerging target for the treatment of CLDN18.2-expressing cancers such as gastric and pancreatic cancers. Cell and antibody therapies targeting CLDN18.2 are under intensive clinical trials. In this setting, how to efficiently and specifically detect CLDN18.2 expression before and after the therapies is a clinical challenge. In recent years, molecular imaging with radiolabeled antibodies or antibody fragments have shown promise in noninvasively annotating antigen expression across the body. In this <i>Perspective</i>, we will bring together the most recent progress on CLDN18.2-targeted imaging and therapy of solid tumors.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"13 2","pages":"64-69"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193197/pdf/ajnmmi0013-0064.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9496438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterine adenosarcoma: a case report and review of the literature.","authors":"Qiyue Wang,&nbsp;Si Sun,&nbsp;Jing Cai,&nbsp;Lu Yang,&nbsp;Gang Lv,&nbsp;Qiang Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Uterine adenosarcoma is a rare gynecological malignancy with no specific symptoms, and the optimal management is still inconclusive. Herein we present a case of uterine adenosarcoma in a 38-year-old woman with a good prognosis and review of literatures. The patient presented with abnormal vaginal bleeding with no special medical history. Sonographic scan revealed a heterogeneous echoic mass in the cavity, indicating a polypus or a submucous myoma. The pathology based on the specimen after the hysteroscopic tumor excision suggested diagnosis of uterine adenosarcoma. Subsequently, the patient received pelvic MRI scan before surgery. MRI identified a patchy lesion at the cervix-lower endometrial cavity with low signal in T1WI and a mixed high T2 signal in T2WI, with no sign of metastasis. Then total abdominal hysterectomy with bilateral salpingo-oopherectomy plus pelvic lymph node dissection was performed and 6 cycles of chemotherapy were administered. The patient remains disease-free on follow-up to date, more than 15 months after chemotherapy.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"13 2","pages":"70-76"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10193199/pdf/ajnmmi0013-0070.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9874581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the correlation between arterial lumen density and its metabolic activity in atherosclerotic patients using ¹⁸F-FDG positron emission tomography/computed tomography.","authors":"Mamdouh S Al-Enezi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Large lipid core (extended into arterial lumen) and high density of macrophages (associated with ¹⁸F-fluorodeoxyglucose \"¹⁸F-FDG\" uptake) in atherosclerotic plaque were shown to be an overt feature of plaque rupture. Nineteen participants were imaged with computed tomography (CT) and positron emission tomography (PET) with ¹⁸F-FDG in a dynamic mode. The mean lumen density in Hounsfield unit (HU) was measured per region of interest (ROI) on CT images and classified as non-calcified and calcified classifications. Calcified group was divided into partially calcified and calcified groups. Metabolic rate of glucose (MRG) was computed per ROI on PET dynamic images using modified 2-tissue compartmental model that is independent of partial volume effect. Data is clustered using Automatic Hierarchical K-means algorithm (AKH) with silhouette-coefficient. Arterial segments of 1180 ROIs for Aorta and iliac arteries were classified as non-calcified and calcified segments and clustered using AHK with respect to the mean of intravascular attenuation (in HU). There was a statistical difference in MRG corresponded to low intravascular attenuation cluster compared to higher intravascular attenuation clusters (P<0.05), but not within higher clusters (P>0.05), for both non-calcified and calcified classes. In partially calcified segments, same pattern was observed as the low intravascular attenuation cluster was accompanied with significant metabolic activity but not for calcified segments. Low intravascular attenuation is associated with high MRG measured on ¹⁸F-FDG PET images, which may reflect the instability of atherosclerotic plaque. Partially calcified plaque is metabolically active compared to calcified plaque.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"13 1","pages":"18-25"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10009471/pdf/ajnmmi0013-0018.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9122055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Single-center developing country analysis of radium-223 therapy in prostate cancer-preliminary results.","authors":"Thaís B Minekawa,&nbsp;Allan O Santos,&nbsp;André G Moraes,&nbsp;André Sasse,&nbsp;Cleide A Silva,&nbsp;Marcelo T Lima,&nbsp;Mariana Camacho,&nbsp;Mariana C Lima,&nbsp;Elba Etchebehere","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>[This corrects the article on p. 352 in vol. 11, PMID: 34754606.].</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"13 3","pages":"126"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349289/pdf/ajnmmi0013-0126.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9816657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic efficacy of SPECT/CT MPI and CMR in children with myocarditis caused by different infection sources.","authors":"Luxi Yang, Jicheng Li, Kai Zhang, Kexin Zhao, Yahong Liu, Yongjun Luo, Lele Huang, Xiaowei Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study aimed to analyze the diagnostic efficacy of ^99mTc-methoxy isobutyl isonitrile (MIBI) single photon emission tomography (SPECT/CT) myocardial perfusion imaging (MPI) and cardiac magnetic resonance imaging (CMR) in children with myocarditis caused by different infection sources and provide an imaging reference basis for clinical diagnosis and treatment. In total, 232 children diagnosed with myocarditis were retrospectively divided into five groups according to the different infection sources: viral infection (group A), bacterial infection (group B), viral combined with bacterial infection (group C), viral combined with mycoplasma infection (group D), and bacterial combined with mycoplasma infection (group E). A chi-square test and ANOVA were used to analyze the difference between SPECT/CT MPI and CMR in the diagnosis of myocarditis in children according to their categorical infection source group, including the impact of the average daily hospital costs (a=0.05). The positive rates of SPECT/CT in groups A and D were higher than those of CMR, and the positive rates of SPECT/CT in groups C and E were lower than those of CMR, with statistically significant differences (P < 0.05). The SPECT/CT ischemic lesions were located in the anterior wall, or the anterior wall combined with other walls of the left ventricle in 69.5% of patients. SPECT/CT MPI had no effect on the average daily hospitalization cost (P > 0.05); however, the average daily hospitalization cost of CMR-negative patients in group D was higher than that of CMR-positive patients, and it was statistically significant in groups C and E (P < 0.05). In groups A and D, the use of ^99mTc-MIBI SPECT/CT MPI was preferred for diagnosing myocarditis. The detection rate of CMR was higher in groups C and E. SPECT/CT MPI findings of ischemic segments were mostly found in the anterior wall. The results of CMR diagnosis affected the average daily hospitalization cost among patients with different infection sources; however, SPECT/CT had no such effect. These findings denote a potential targeted approach to myocarditis diagnosis in pediatric patients based on source of infection.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 6","pages":"180-187"},"PeriodicalIF":2.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831860/pdf/ajnmmi0012-0180.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9076387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel tetrapeptide for chelator-free radiolabeling in optimized preparation of ^99mTc-radiolabeled oligonucleotides.","authors":"Zhao Chen,&nbsp;Qi Yang,&nbsp;Lele Song,&nbsp;Yongkang Qiu,&nbsp;Sitong Wu,&nbsp;Wenpeng Huang,&nbsp;Qiao Jiang,&nbsp;Shengnan Wu,&nbsp;Lei Kang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antisense imaging uses radionuclide labeled antisense oligonucleotides to hybridize with nucleic acids in vivo, display the expression of target genes, and directly quantify biological processes at the cellular and subcellular levels. The anti-miRNA oligonucleotides (AMOs) are a series of single-stranded DNA oligonucleotides that are widely used in gene imaging and gene therapy. However, due to the negative charge and high molecular weight, the permeability through the membrane of AMOs is generally low so that most AMOs cannot enter the cells. Based on the ^99mTc-labeled AMOs imaging in previous studies, this study developed a novel tetrapeptide Glycine-Alanine-Glycine-Lysine (Gly-Ala-Gly-Lys, GAGK) for one-step labeling AMO with ^99mTc. The labeling conditions were optimized by changing the number of stannous ions, the reaction time, and the temperature, respectively. The labeled products were identified by gel electrophoresis and their serum stability was evaluated. The optimal labeling condition in this study was using 1 mg/mL SnCl₂·2H₂O and heating for 30 min at 100°C. Gel electrophoresis confirmed the verification of successful labeling of ^99mTc-GAGK-AMO. After being incubated with human fresh serum for 12 h, ^99mTc-GAGK-AMO showed good stability and no obvious degradation. Therefore, this labeling method has high labeling efficiency and stable labeling, which provides an effective method for the application of miRNA-targeted imaging.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 5","pages":"143-151"},"PeriodicalIF":2.5,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677136/pdf/ajnmmi0012-0143.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40721585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare pulmonary metastases of atypical meningioma diagnosed on total-body ¹⁸F-FDG PET/CT.","authors":"Qing Wang,&nbsp;Weijun Wei,&nbsp;Min Cao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Here we reported a 59-year-old male who had undergone brain surgery three times and the pathological results showed atypical meningioma (2015, WHO grade I; 2018, WHO grade II; 2019, WHO grade II-III), with multiple pulmonary nodules, which arose during follow-up. A total-body ¹⁸F-FDG PET/CT showed multiple solid nodules with increased ¹⁸F-FDG metabolism (SUVmax = 8.6). The patient underwent a CT-guided lung biopsy and the histopathological study showed positive staining of epithelial membrane antigen (EMA), vimentin (VIM), SSTR2, Ki67 (20%), and negative staining of CK, TTF-1, CD34, SY, PR, P40, respectively. Based on the history and immunohistology results, multiple pulmonary metastases from atypical meningioma were finally diagnosed, since double positive staining of EMA and VIM supported the diagnosis of meningioma and negative staining excluded primary lung cancers. The patient has given up any treatment because of personal reasons. Pulmonary metastasis from meningioma is rare, accurate diagnosis should be based on medical history, imaging characteristics, and histopathological findings.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 5","pages":"163-165"},"PeriodicalIF":2.5,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677137/pdf/ajnmmi0012-0163.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40721586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[⁶⁸Ga]Ga-DOTATATE-avid tumor volume, uptake and inflammation-based index correlate with survival in neuroendocrine tumor patients treated with [¹⁷⁷Lu]Lu-DOTATATE PRRT.","authors":"Elin Pauwels,&nbsp;Jeroen Dekervel,&nbsp;Chris Verslype,&nbsp;Paul M Clement,&nbsp;Christophe Dooms,&nbsp;Kristof Baete,&nbsp;Karolien Goffin,&nbsp;Sander Jentjens,&nbsp;Koen Van Laere,&nbsp;Eric Van Cutsem,&nbsp;Christophe M Deroose","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To meet the increasing demand for PRRT in the treatment of patients with inoperable/disseminated well-differentiated neuroendocrine tumors (NETs) and to guide optimization strategies, adequate and accessible predictive tools that allow to stratify patients who will benefit from treatment from those who will not are becoming indispensable. Previously, we have investigated the role of baseline [⁶⁸Ga]Ga-DOTATOC PET tumor uptake and volumetric parameters and a blood-derived inflammatory biomarker, the inflammation-based index (IBI), for outcome prediction in NET patients treated with [⁹⁰Y]Y-DOTATOC. In this retrospective study in 83 NET patients treated with [¹⁷⁷Lu]Lu-DOTATATE in a routine clinical setting, we aimed to evaluate the generalizability of our previous findings to [¹⁷⁷Lu]Lu-DOTATATE treatment combined with a pre-therapeutic [⁶⁸Ga]Ga-DOTATATE PET. A semi-automatic customized SUV threshold-based approach was used for tumor delineation. The previously identified SUV_mean cut-off of 13.7 for better survival could not be applied to this patient cohort. Instead, a more optimal cut-off could be identified: an SUV_mean lower or equal than 11.2 was associated with worse overall survival (OS) (hazard ratio (HR) 2.28; P = 0.008). Also in line with our previous study, a [⁶⁸Ga]Ga-DOTATATE-avid tumor volume (TV) higher than 672 mL and an elevated baseline IBI were correlated with worse OS (HR 3.13 (P = 0.0001) and HR 2.00 (P = 0.034), respectively). Multivariate analysis confirmed independent associations between OS and baseline IBI (P = 0.032), SUV_mean (P = 0.027) and [⁶⁸Ga]Ga-DOTATATE-avid TV (P = 0.001). Taking baseline IBI, [⁶⁸Ga]Ga-DOTATATE-avid TV and [⁶⁸Ga]Ga-DOTATATE uptake into account may help guide PRRT treatment decisions.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 5","pages":"152-162"},"PeriodicalIF":2.5,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677135/pdf/ajnmmi0012-0152.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40721584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescent intraoperative navigation: trends and beyond.","authors":"Lixia Feng, Dawei Jiang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"12 4","pages":"138-142"},"PeriodicalIF":2.0,"publicationDate":"2022-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441924/pdf/ajnmmi0012-0138.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33448968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}