American journal of nuclear medicine and molecular imaging最新文献

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Erratum: Accuracy of 68Ga-PSMA-11 PET/CT and multiparametric MRI for the detection of local tumor and lymph node metastases in early biochemical recurrence of prostate cancer. 勘误:68Ga-PSMA-11 PET/CT 和多参数 MRI 检测前列腺癌早期生化复发的局部肿瘤和淋巴结转移的准确性。
IF 2
American journal of nuclear medicine and molecular imaging Pub Date : 2024-06-15 eCollection Date: 2024-01-01 DOI: 10.62347/SUNN5303
Maija Radzina, Mara Tirane, Lilita Roznere, Liene Zemniece, Laura Dronka, Marika Kalnina, Edgars Mamis, Juergen Biederer, Vilnis Lietuvietis, Arvis Freimanis, Egils Vjaters
{"title":"Erratum: Accuracy of <sup>68</sup>Ga-PSMA-11 PET/CT and multiparametric MRI for the detection of local tumor and lymph node metastases in early biochemical recurrence of prostate cancer.","authors":"Maija Radzina, Mara Tirane, Lilita Roznere, Liene Zemniece, Laura Dronka, Marika Kalnina, Edgars Mamis, Juergen Biederer, Vilnis Lietuvietis, Arvis Freimanis, Egils Vjaters","doi":"10.62347/SUNN5303","DOIUrl":"https://doi.org/10.62347/SUNN5303","url":null,"abstract":"<p><p>[This corrects the article on p. 106 in vol. 10, PMID: 32419979.].</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11253078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141722862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[18F]FDG PET/CT for identifying the causes of fever of unknown origin (FUO). [18F]FDG正电子发射计算机断层扫描(PET/CT)用于确定不明原因发热(FUO)的病因。
IF 2.5
American journal of nuclear medicine and molecular imaging Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.62347/OQQC6007
Shashi B Singh, Niki Shrestha, Sadikshya Bhandari, Suprita Shrestha, Bijay Shrestha, Neharika Shrestha, Swarnima Rijal, Rajshree Singh, Soren Hess, Thomas J Werner, Abass Alavi, Mona-Elisabeth Revheim
{"title":"[<sup>18</sup>F]FDG PET/CT for identifying the causes of fever of unknown origin (FUO).","authors":"Shashi B Singh, Niki Shrestha, Sadikshya Bhandari, Suprita Shrestha, Bijay Shrestha, Neharika Shrestha, Swarnima Rijal, Rajshree Singh, Soren Hess, Thomas J Werner, Abass Alavi, Mona-Elisabeth Revheim","doi":"10.62347/OQQC6007","DOIUrl":"10.62347/OQQC6007","url":null,"abstract":"<p><p>Fever of unknown origin (FUO) continues to be a challenging diagnosis in clinical medicine. It has more than 200 known causes, including infections, autoimmune diseases, neoplasia, and other miscellaneous disorders. Despite the development of a wide range of diagnostic tools, a specific diagnostic algorithm for FUO is not yet available. However, [<sup>18</sup>F]FDG PET/CT, which yields information on cellular metabolism, in addition to details of organ anatomy, has been shown to be successful in the FUO investigation. This study highlights the uses of [<sup>18</sup>F]FDG PET/CT in diagnosing various causes of FUO. [<sup>18</sup>F]FDG PET/CT has been increasingly used to detect septic infections, sterile inflammatory processes, and malignancies, occupying a significant portion of the known causes of FUO. It has led to a more definitive identification of the etiology of FUO and accurate clinical management. However, more in-depth studies are crucial to understanding if [<sup>18</sup>F]FDG PET/CT can be used in the work-up of FUO.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advancements in 18F-FDG PET/CT for the diagnosis, staging, and treatment management of HIV-related lymphoma. 18F-FDG PET/CT 在艾滋病相关淋巴瘤的诊断、分期和治疗管理方面的最新进展。
IF 2.5
American journal of nuclear medicine and molecular imaging Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.62347/QPAS5990
Ghazaleh Jamalipour Soufi, Ali Hekmatnia, Farzaneh Hekmatnia, Andrew Parviz Zarei, Shamim Shafieyoon, Sara Azizollahi, Mohamad Ghazanfari Hashemi, Farshad Riahi
{"title":"Recent advancements in <sup>18</sup>F-FDG PET/CT for the diagnosis, staging, and treatment management of HIV-related lymphoma.","authors":"Ghazaleh Jamalipour Soufi, Ali Hekmatnia, Farzaneh Hekmatnia, Andrew Parviz Zarei, Shamim Shafieyoon, Sara Azizollahi, Mohamad Ghazanfari Hashemi, Farshad Riahi","doi":"10.62347/QPAS5990","DOIUrl":"10.62347/QPAS5990","url":null,"abstract":"<p><p>Infection with the Human Immunodeficiency Virus (HIV) is one of the most pressing issues facing public health on a worldwide scale. Currently, HIV-related lymphoma is the most common cause of death among people living with HIV, and warrants more attention. The unique challenges associated with HIV-related lymphoma management derive from the underlying HIV infection and its immunosuppressive effects. <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) has gained significant prominence in the past few years as a valuable diagnostic and therapeutic instrument for the treatment of HIV-related lymphoma. This review will start with an overview of the subtypes, risk factors, and therapeutic choices for individuals with HIV-related lymphoma. We will then briefly discuss the current application of <sup>18</sup>F-FDG PET/CT in the medical management of HIV-related lymphoma patients, followed by the initial staging of the disease, the evaluation of therapeutic response, the prediction of prognostic outcomes, the decision-making process for radiotherapy guided by PET findings, and the distinguishing of various diagnoses.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subregion-specific 18F-FDG PET-CT radiomics for the pre-treatment prediction of EGFR mutation status in solid lung adenocarcinoma. 用于治疗前预测实性肺腺癌表皮生长因子受体突变状态的亚区域特异性 18F-FDG PET-CT 放射组学。
IF 2.5
American journal of nuclear medicine and molecular imaging Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.62347/DDRR4923
Yun Wang, Guang Yang, Xinyi Gao, Linfa Li, Hongzhou Zhu, Heqing Yi
{"title":"Subregion-specific <sup>18</sup>F-FDG PET-CT radiomics for the pre-treatment prediction of EGFR mutation status in solid lung adenocarcinoma.","authors":"Yun Wang, Guang Yang, Xinyi Gao, Linfa Li, Hongzhou Zhu, Heqing Yi","doi":"10.62347/DDRR4923","DOIUrl":"10.62347/DDRR4923","url":null,"abstract":"<p><p>This study aimed to assess the efficacy of fluor-18 fluorodeoxyglucose (<sup>18</sup>F-FDG) PET/CT using sub-regional-based radiomics in predicting epidermal growth factor receptor (EGFR) mutation status in pretreatment patients with solid lung adenocarcinoma. A retrospective analysis included 269 patients (134 EGFR+ and 135 EGFR-) who underwent pretreatment <sup>18</sup>F-FDG PET/CT scans and EGFR mutation testing. The most metabolically active intratumoral sub-region was identified, and radiomics features from whole tumors or sub-regional regions were used to build classification models. The dataset was split into a 7:3 ratio for training and independent testing. Feature subsets were determined by Pearson correlation and the Kruskal Wallis test and radiomics classifiers were built with support vector machines or logistic regressions. Evaluation metrics, including accuracy, area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were employed for different classifiers. Results indicated that the sub-region-based classifier outperformed the whole-tumor classifier in terms of accuracy (73.8% vs. 66.2%), AUC (0.768 vs. 0.632), specificity (65.0% vs. 50.0%), PPV (70.2% vs. 62.2%), and NPV (78.8% vs. 74.0%). The clinical classifier exhibited an accuracy of 75.0%, AUC of 0.768, sensitivity of 72.5%, specificity of 77.5%, PPV of 76.3%, and NPV of 73.8%. The combined classifier, incorporating sub-region analysis and clinical parameters, demonstrated further improvement with an accuracy of 77.5%, AUC of 0.807, sensitivity of 77.5%, specificity of 77.5%, and NPV of 77.5%. The study suggests that sub-region-based <sup>18</sup>F-FDG PET/CT radiomics enhances EGFR mutation prediction in solid lung adenocarcinoma, providing a practical and cost-efficient alternative to invasive EGFR testing.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
68Ga-labeled TMTP1 radiotracer for PET imaging of cervical cancer. 用于宫颈癌 PET 成像的 68Ga 标记 TMTP1 放射性示踪剂。
IF 2.5
American journal of nuclear medicine and molecular imaging Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.62347/NFDH6303
Xi Chen, Yue Sun, Fei Li, Ling Xi, Jun Dai, Can Zhao, Qingjian Dong
{"title":"<sup>68</sup>Ga-labeled TMTP1 radiotracer for PET imaging of cervical cancer.","authors":"Xi Chen, Yue Sun, Fei Li, Ling Xi, Jun Dai, Can Zhao, Qingjian Dong","doi":"10.62347/NFDH6303","DOIUrl":"10.62347/NFDH6303","url":null,"abstract":"<p><p>Molecular imaging enables visualization and characterization of biological processes that influence tumor behavior and response to therapy. The TMTP1 (NVVRQ) peptide has shown remarkable affinity to highly metastatic tumors and and its potential receptor is aminopeptidase P2. In this study, we have designed and synthesized a <sup>68</sup>Ga-labeled cyclic TMTP1 radiotracer (<sup>68</sup>Ga-DOTA-TMTP1), for PET imaging of cervical cancer. The goal of this study was to investigate the properties of this radiotracer and its tumor diagnostic potential. The radiochemical yield of <sup>68</sup>Ga-DOTA-TMTP1 was high and the radiochemical purity was greater than 95%. The octanol-water partition coefficient for <sup>68</sup>Ga-DOTA-TMTP1 was -2.76 ± 0.08 and <sup>68</sup>Ga-DOTA-TMTP1 has showed excellent stability in in vitro studies. The cellular uptake and efflux of <sup>68</sup>Ga-DOTA-TMTP1 in paired highly metastatic and lowly metastatic cervical cancer cell line HeLa and C-33A as well as normal cervical epithelial cell line End1 were measured in a γ counter. <sup>68</sup>Ga-DOTA-TMTP1 exhibited higher uptake in HeLa cells than in C-33A cells. The binding to HeLa and C-33A cells could be blocked by excess TMTP1. On microPET images, HeLa tumors were clearly visualized within 60 min and the uptake of the radiotracer in HeLa tumors was higher than that of C-33A tumors. After blocking with TMTP1, HeLa tumors uptake was significantly reduced and the specificity <sup>68</sup>Ga-DOTA-TMTP1 was thus validated. Overall, we have successfully synthesized <sup>68</sup>Ga-DOTA-TMTP1 with high yield and high specific activity and have demonstrated its potential role for highly metastatic tumor-targeted diagnosis.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated radiosynthesis of [11C]CPPC for in-human PET imaging applications. 用于人体 PET 成像的 [11C]CPPC 自动放射合成。
IF 2.5
American journal of nuclear medicine and molecular imaging Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.62347/MXKZ6739
Huailei Jiang, Pritam Roy, Yan Guo, Otto Muzik, Eric A Woodcock
{"title":"Automated radiosynthesis of [<sup>11</sup>C]CPPC for in-human PET imaging applications.","authors":"Huailei Jiang, Pritam Roy, Yan Guo, Otto Muzik, Eric A Woodcock","doi":"10.62347/MXKZ6739","DOIUrl":"10.62347/MXKZ6739","url":null,"abstract":"<p><p>The macrophage colony-stimulating factor 1 receptor (CSF1R) is almost exclusively expressed in microglia, representing a biomarker target for imaging of microglia availability. [<sup>11</sup>C]CPPC has specific binding affinity to CSF1R and suitable kinetic properties for <i>in vivo</i> PET imaging of microglia. However, previous studies reported a low radiochemical yield, motivating additional research to optimize [<sup>11</sup>C]CPPC radiochemistry. In this work, we report an automated radiosynthesis of [<sup>11</sup>C]CPPC on a Synthra MeIPlus module with improved radiochemical yield. The final [<sup>11</sup>C]CPPC product was obtained with excellent chemical/radiochemical purities and molecular activity, facilitating high-quality in-human PET imaging applications.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the latest advances in 18F-FDG PET/CT and cardiac magnetic resonance for imaging for cardiac sarcoidosis diagnosis. 探索 18F-FDG PET/CT 和心脏磁共振成像用于心脏肉瘤病诊断的最新进展。
IF 2.5
American journal of nuclear medicine and molecular imaging Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.62347/GIKK5707
Seyedeh Nooshin Miratashi Yazdi, Farshad Riahi, Sara Azizollahi, Seyed Hamed Tooyserkani, Shahin Fesharaki, Maryam Alaei, Mohamad Ghazanfari Hashemi, Milad Vakili Zarch, Azad Mojahedi
{"title":"Exploring the latest advances in <sup>18</sup>F-FDG PET/CT and cardiac magnetic resonance for imaging for cardiac sarcoidosis diagnosis.","authors":"Seyedeh Nooshin Miratashi Yazdi, Farshad Riahi, Sara Azizollahi, Seyed Hamed Tooyserkani, Shahin Fesharaki, Maryam Alaei, Mohamad Ghazanfari Hashemi, Milad Vakili Zarch, Azad Mojahedi","doi":"10.62347/GIKK5707","DOIUrl":"10.62347/GIKK5707","url":null,"abstract":"<p><p>Sarcoidosis is a systemic inflammatory disease that affects multiple organs. Various clinical signs are associated with cardiac sarcoidosis (CS), and the diagnosis process is complicated because any organ could be involved. Despite the critical clinical importance of early and precise diagnosis of CS, there is currently no gold-standard method for CS evaluation. The non-invasive imaging modalities of <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) and cardiac magnetic resonance (CMR) imaging have demonstrated the potential for identifying various histological characteristics of CS. Recently, the development of hybrid FDG-PET/CMR scanners has enabled the simultaneous acquisition of these attributes. Compared to just one imaging modality, these scanners detect CS and stratify risk more accurately and with higher sensitivity. Analyzing the potential role of concurrent FDG-PET/CMR in enhancing the diagnosis of CS, the present review concentrates on the advantages of this technique in light of recent technological developments.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiodifluoromethylation of well-functionalized molecules. 功能良好的分子的放射性二氟甲基化。
IF 2
American journal of nuclear medicine and molecular imaging Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.62347/IIOG5660
Wei Zhang, Yinlong Li, Steven H Liang
{"title":"Radiodifluoromethylation of well-functionalized molecules.","authors":"Wei Zhang, Yinlong Li, Steven H Liang","doi":"10.62347/IIOG5660","DOIUrl":"10.62347/IIOG5660","url":null,"abstract":"<p><p>The strategic installation of a [<sup>18</sup>F]fluorine atom at the specific position of the lead molecule is a never-ending challenge for radiochemists in their endeavour to develop novel positron emission tomography (PET) imaging applications. Although the radiosynthesis of [<sup>18</sup>F]CF<sub>2</sub>H-containing molecules has been explored in the past decade, more methods need to be explored for various well-functionalized compounds. Recently, two novel strategies of radiodifluoromethylation were reported, namely the utilization of [<sup>18</sup>F]difluorocarbene building block and frustrated Lewis pair-mediated C-<sup>18</sup>F bond formation, respectively. These methods provide an efficient radiofunctionalization of complex CF<sub>2</sub>H-containing molecules for drug discovery and PET ligand development.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[99mTc]Tc-labeled cyc-DX600-HYNIC as a SPECT probe for ACE2-specific pancreatic cancer imaging. 将[99mTc]Tc标记的cyc-DX600-HYNIC作为SPECT探针,用于ACE2特异性胰腺癌成像。
IF 2.5
American journal of nuclear medicine and molecular imaging Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.62347/VFHT4078
Pan Zhou, Zheng Li, Danni Li, Shuai Xue, Rou Li, Lan Zhang, Qingyun Bai, Xiao Li
{"title":"[<sup>99m</sup>Tc]Tc-labeled cyc-DX600-HYNIC as a SPECT probe for ACE2-specific pancreatic cancer imaging.","authors":"Pan Zhou, Zheng Li, Danni Li, Shuai Xue, Rou Li, Lan Zhang, Qingyun Bai, Xiao Li","doi":"10.62347/VFHT4078","DOIUrl":"10.62347/VFHT4078","url":null,"abstract":"<p><p>As a regulator in renin-angiotensin-aldosterone system, angiotensin-converting enzyme 2 (ACE2) closely correlated with tumor progression of pancreatic cancer, meantime, was easily affected by a variety of factors. [<sup>99m</sup>Tc]Tc-cyc-DX600 SPECT was established as an ACE2-specific imaging protocol to figure out the ACE2 status in pancreatic tumor. BALB/C-NU mice were used to prepare the subcutaneous cell derived xenograft (CDX) models with HEK-293T or HEK-293T/hACE2 cells to validate ACE2 specificity of [<sup>99m</sup>Tc]Tc-cyc-DX600 SPECT and establish SPECT imaging protocol. On the basis of [<sup>99m</sup>Tc]Tc-cyc-DX600 SPECT and [<sup>18</sup>F]F-FDG PET/CT, ACE2-dependence on tumor size and tumor metabolism were further verified on orthotopic pancreatic cancer model with KPC cells. Immunohistochemical analysis was used to demonstrate the findings on ACE2 SPECT. [<sup>99m</sup>Tc]Tc-cyc-DX600 was of superior tumor uptake in HEK-293T/hACE2 CDX than wild type (6.74 ± 0.31 %ID/mL vs 1.83 ± 0.26 %ID/mL at 1.5 h post injection (p.i.); 3.14 ± 0.31 %ID/mL vs 1.16 ± 0.15 %ID/mL at 4.5 h p.i.). For the CDX models with PANC-1 cells, a significant negative correlation between the slope of tumor volume and tumor uptake was observed (r = -0.382 for the 1-4th day; r = -0.146 for the 1-5th day; r = -0.114 for the 1-6th day; r = -0.152 for the 1-7th day; but <i>P > 0.05</i> for all). For orthotopic pancreatic cancer model, the linear correlation between FDG PET and ACE2 SPECT of the pancreatic lesions was negative (r = -0.878), the quantitative values of ACE2 SPCET was positively correlated with the volume of primary lesions (r = 0.752) and also positively correlated with the quantitative values of ACE2 immunohistochemical analysis (r = 0.991). Conclusively, [<sup>99m</sup>Tc]Tc-cyc-DX600 SPECT is an ACE2-specific imaging protocol with clinical translational potential, adding multidimensional information on the disease progression of pancreatic cancer.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report: [18F]FAPI-42 PET/CT visualize primary adenoid cystic carcinoma not detected by [18F]FDG. 病例报告:[18F]FAPI-42正电子发射计算机断层成像(PET/CT)显示[18F]FDG检测不到的原发性腺样囊性癌。
IF 2.5
American journal of nuclear medicine and molecular imaging Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI: 10.62347/WSUV5599
Zehao Wang, Zheng Liu, Lulu Zhuang, Weihua Yin, Yongsheng Zhao, Mengjie Dong
{"title":"Case report: [<sup>18</sup>F]FAPI-42 PET/CT visualize primary adenoid cystic carcinoma not detected by [<sup>18</sup>F]FDG.","authors":"Zehao Wang, Zheng Liu, Lulu Zhuang, Weihua Yin, Yongsheng Zhao, Mengjie Dong","doi":"10.62347/WSUV5599","DOIUrl":"10.62347/WSUV5599","url":null,"abstract":"<p><p>Adenoid cystic carcinoma (ACC) is a rare salivary gland cancer. Still, its growth and invasion progress is slow, and its hematogenous metastasis is ACC's most common distant metastasis. Because of the broad expression and low background uptake of fibroblast activation protein (FAP) in tumor stroma, FAPI is considered another potential tracer of ACC in addition to FDG. In this case, we report a patient who was diagnosed with metastatic ACC liver cancer by fine needle aspiration biopsy (FNAB) and underwent PET/CT examination of [<sup>18</sup>F]FDG and [<sup>18</sup>F]FAPI-42 to find the primary cancer lesion. Finally, the primary cancer lesion was found in the left submandibular gland and was pathologically confirmed as ACC after resection.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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