Arun Kumar Jain, Jaspreet Sukhija, Ira Chopra, Nishant Sachdev
{"title":"Primary conjunctival herpetic geographic ulcer in an immunocompetent patient.","authors":"Arun Kumar Jain, Jaspreet Sukhija, Ira Chopra, Nishant Sachdev","doi":"10.1007/s12019-007-0009-x","DOIUrl":"https://doi.org/10.1007/s12019-007-0009-x","url":null,"abstract":"<p><p>Herpes simplex virus ocular infections have been recognized as a major cause of corneal blindness in the developed world. The major signs of a primary infection are limited to the lids, conjunctiva, and cornea. Presence of a conjunctival dendrite without corneal involvement has been reported. Although conjunctival ulceration has been associated with recurrent attacks, it has not been documented as a manifestation of primary herpetic infection. We report a case of primary herpetic infection with geographic conjunctival ulcer with multiple corneal dendrites.</p>","PeriodicalId":75729,"journal":{"name":"Comprehensive therapy","volume":"33 1","pages":"36-8"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12019-007-0009-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40741484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aortic stenosis.","authors":"Wilbert S Aronow","doi":"10.1007/s12019-007-8021-8","DOIUrl":"https://doi.org/10.1007/s12019-007-8021-8","url":null,"abstract":"<p><p>Patients with aortic stenosis (AS) have an increased prevalence of coronary risk factors, coronary artery disease, and other atherosclerotic vascular disease and an increased incidence of coronary events and death. Statins may reduce the progression of AS. Angina pectoris, syncope or near syncope, and heart failure are the three classic manifestations of severe AS. Prolonged duration and late peaking of an aortic systolic ejection murmur best differentiate severe AS from mild AS on physical examination. Doppler echocardiography is used to diagnose the presence and severity of AS. Once symptoms develop, aortic valve replacement (AVR) should be performed in patients with severe or moderate AS. Warfarin should be administered indefinitely after AVR in patients with a mechanical aortic valve and in patients with a bioprosthetic aortic valve who have either atrial fibrillation, prior thromboembolism, left ventricular systolic dysfunction, or a hypercoagulable condition. Patients with a bioprosthetic aortic valve without any of these four risk factors should be treated with aspirin 75-100 mg daily.</p>","PeriodicalId":75729,"journal":{"name":"Comprehensive therapy","volume":"33 4","pages":"174-83"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12019-007-8021-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27099647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acute retinal necrosis complicating chickenpox in a healthy adult--a case report and review of literature.","authors":"I Tajunisah, S C Reddy","doi":"10.1007/s12019-007-0008-y","DOIUrl":"https://doi.org/10.1007/s12019-007-0008-y","url":null,"abstract":"<p><p>Acute retinal necrosis (ARN) is known to occur in conjunction with primary varicella or chickenpox infection. The majority of ARN cases reported in the literature were of milder form with mild to moderate vitritis, limited retinitis, and rare occurrence of retinal breaks or detachment that responded well to intravenous acyclovir, with or without oral prednisolone. We report a case of unilateral ARN with marked vitritis and retinal necrosis leading to retinal breaks following chickenpox in a 32-year-old healthy lady. This patient was successfully treated with intravenous acyclovir followed by oral acyclovir and orbital floor triamcinolone injections to contain the inflammation with barrier laser therapy to secure the retinal breaks with good visual outcome. This case is unusual in its severity, and to our knowledge, orbital floor triamcinolone therapy was not used earlier to contain ARN inflammation.</p>","PeriodicalId":75729,"journal":{"name":"Comprehensive therapy","volume":"33 1","pages":"25-31"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12019-007-0008-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41016583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of peripheral arterial disease of the lower extremities.","authors":"Wilbert S Aronow","doi":"10.1007/s12019-007-8013-8","DOIUrl":"https://doi.org/10.1007/s12019-007-8013-8","url":null,"abstract":"<p><p>Smoking should be stopped and hypertension, diabetes mellitus, dyslipidemia, and hypothyroidism treated in patients with peripheral arterial disease (PAD) of the lower extremities. Statins decrease the incidence of intermittent claudication and improve exercise duration until the onset of intermittent claudication in persons with PAD and hypercholesterolemia. Antiplatelet drugs such as aspirin or clopidogrel, especially clopidogrel, angiotensin-converting enzyme inhibitors, and statins should be given to all persons with PAD. Beta blockers should be given if coronary artery disease is present. Exercise rehabilitation programs and cilostazol increase exercise time until intermittent claudication develops. Chelation therapy should be avoided. Indications for lower extremity percutaneous transluminal angioplasty or bypass surgery are (1) incapacitating claudication in persons interfering with work or lifestyle, (2) limb salvage in persons with limb-threatening ischemia as manifested by rest pain, nonhealing ulcers, and/or infection or gangrene, and (3) vasculogenic impotence.</p>","PeriodicalId":75729,"journal":{"name":"Comprehensive therapy","volume":"33 4","pages":"247-56"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12019-007-8013-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27098435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alzheimer's disease.","authors":"Richard J Goldberg","doi":"10.1007/s12019-007-8000-0","DOIUrl":"https://doi.org/10.1007/s12019-007-8000-0","url":null,"abstract":"<p><p>Alzheimer's disease is the most prevalent form of dementia. There are significant efforts underway to elucidate the pathogenesis of this disease and to find ways to lessen the impact of the symptoms. This paper summarizes current knowledge regarding the diagnosis and treatment of the disorder.</p>","PeriodicalId":75729,"journal":{"name":"Comprehensive therapy","volume":"33 2","pages":"58-64"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12019-007-8000-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27077620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Women's reactions to partner's ejaculation problems.","authors":"Domeena C Renshaw","doi":"10.1007/s12019-007-8002-y","DOIUrl":"https://doi.org/10.1007/s12019-007-8002-y","url":null,"abstract":"<p><p>Ejaculation problems--too rapid, too slow, or absent--may be as ancient as man himself but less researched than erectile difficulties. This article gives attention at long last to the woman partner who struggles to understand and react to recurrence of the ejaculation dysfunction. Some women may be wrongly blamed while others may berate him for his inability to overcome the symptom. Today, it is essential to gain more knowledge with added understanding of how his partner is impacted if the ejaculation problem persists. There are usually two patients when a sexual problem presents.</p>","PeriodicalId":75729,"journal":{"name":"Comprehensive therapy","volume":"33 2","pages":"94-8"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12019-007-8002-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27079679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Graciana Fuentes-Páez, Maria C Mendez, Javier Montañez, Jose M Herreras, Maria A Saornil, Margarita Calonge
{"title":"Conjunctival pigmentation in Stevens-Johnson syndrome.","authors":"Graciana Fuentes-Páez, Maria C Mendez, Javier Montañez, Jose M Herreras, Maria A Saornil, Margarita Calonge","doi":"10.1007/s12019-007-8009-4","DOIUrl":"https://doi.org/10.1007/s12019-007-8009-4","url":null,"abstract":"<p><p>We report a 29-year-old white female with conjunctival pigmentation after a Stevens-Johnson syndrome (SJS) episode triggered by sulfasalazine. The patient developed bilateral tarsal and forniceal conjunctiva and black pigmentation. Diagnostic biopsy showed stromal monocyte infiltration consistent with chronic phase SJS and conjunctival pigment of melanic origin and not due to drug deposition. Treatment with topical steroids and unpreserved artificial tears resulted in improvement of clinical symptoms; however, pigmentation was unchanged after 2 years.</p>","PeriodicalId":75729,"journal":{"name":"Comprehensive therapy","volume":"33 2","pages":"99-103"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12019-007-8009-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27079680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of postmenopausal osteoporosis.","authors":"Gayatri Gupta, Wilbert S Aronow","doi":"10.1007/s12019-007-0017-x","DOIUrl":"https://doi.org/10.1007/s12019-007-0017-x","url":null,"abstract":"<p><p>Osteoporosis is a skeletal disease characterized by low bone mass and microarchitectural deterioration with a resulting increase in bone fragility and hence susceptibility to fracture. Calcium and vitamin D are the most commonly used therapies for osteoporosis, although their efficacy in osteoporotic fracture prevention remains uncertain. Biphosphonates are the most frequently prescribed medication for treatment of osteoporosis and are often considered as first-line therapy for the treatment of osteoporosis. Currently, hormone replacement therapy is only approved by the Food and Drug Administration (FDA) for short-term treatment of severe postmenopausal symptoms with the lowest dose used for the shortest time. In view of its lack of effect on the prevention of nonvertebral fractures, the use of raloxifene should be limited to women with spinal osteoporosis. Most experts agree that it is preferable to treat osteoporosis with a more potent agent than calcitonin and manage the pain separately. Currently, the FDA recommends the use of parathyroid hormone for treatment of osteoporosis for a maximum of 2 years because of the concern of development of osteosarcoma.</p>","PeriodicalId":75729,"journal":{"name":"Comprehensive therapy","volume":"33 3","pages":"114-9"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12019-007-0017-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27079682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyhmus Ari, Uğur Keklíkçí, Ihsan Caça, Kaan Unlü, Hasan Kayabaşi
{"title":"Wolfram syndrome: case report and review of the literature.","authors":"Seyhmus Ari, Uğur Keklíkçí, Ihsan Caça, Kaan Unlü, Hasan Kayabaşi","doi":"10.1007/s12019-007-0007-z","DOIUrl":"https://doi.org/10.1007/s12019-007-0007-z","url":null,"abstract":"<p><p>Wolfram syndrome (WFS) is a rare diffuse neurodegenerative disorder characterized by diabetes insipidus, diabetes mellitus, optic atrophy, deafness, and a wide variety of central nervous system abnormalities. Insulin-dependent diabetes mellitus with optic nerve atrophy is a sufficient criterion for the diagnosis. WFS is a devastating disease for the patients and their families. This study emphasizes the need for careful evaluation of cases having insulin-dependent diabetes mellitus and optic atrophy.</p>","PeriodicalId":75729,"journal":{"name":"Comprehensive therapy","volume":"33 1","pages":"18-20"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12019-007-0007-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41016581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pain in the Neck","authors":"M. Borins","doi":"10.1007/978-1-59745-258-8_4","DOIUrl":"https://doi.org/10.1007/978-1-59745-258-8_4","url":null,"abstract":"","PeriodicalId":75729,"journal":{"name":"Comprehensive therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51061369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}