Clinical and experimental pharmacology & physiology. Supplement最新文献_第5页

Ocular fundus changes in malignant or precocious stroke-prone spontaneously hypertensive rats after administration of antihypertensive drugs. 抗高血压药物对恶性或早发性卒中的自发性高血压大鼠眼底的影响。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02851.x

Y Hamada, E Niisato, T Otori, T A Chikugo, Y Ohta, T Suzuki, K Okamoto

{"title":"Ocular fundus changes in malignant or precocious stroke-prone spontaneously hypertensive rats after administration of antihypertensive drugs.","authors":"Y Hamada, E Niisato, T Otori, T A Chikugo, Y Ohta, T Suzuki, K Okamoto","doi":"10.1111/j.1440-1681.1995.tb02851.x","DOIUrl":"https://doi.org/10.1111/j.1440-1681.1995.tb02851.x","url":null,"abstract":"1. Malignant or precocious stroke-prone spontaneously hypertensive rats (M-SHRSP) showed hypertensive ocular fundus changes with severe hypertension, but various anti-hypertensive drugs given over a proper period improved funduscopic findings. 2. We treated a M-SHRSP with SQ29,852 (an angiotensin converting enzyme inhibitor, ACEI) or manidipine (a calcium antagonist) and observed hypertensive vascular changes in the fundus. 3. The M-SHRSP treated with anti-hypertensive drugs lived longer and the hypertensive fundic changes improved in both groups. But there were some differences of histochemical staining reaction on the endothelial cell-surface and mucopolysaccharides accumulations between the treated group of ACEI and the group treated with the calcium antagonist. 4. In the treated group with calcium antagonist, the anionic ion functions of the endothelial cell-surface were impaired and organic retinal or choroidal damages appeared to have deteriorated.","PeriodicalId":75710,"journal":{"name":"Clinical and experimental pharmacology & physiology. Supplement","volume":"22 1","pages":"S132-3"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1681.1995.tb02851.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20026280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Glial endothelin/nitric oxide system participates in hippocampus CA1 neuronal death of SHRSP following transient forebrain ischaemia. 神经胶质内皮素/一氧化氮系统参与短暂性前脑缺血后SHRSP海马CA1神经元死亡。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02915.x

K Yamashita, Y Kataoka, Y S Yamashita, A Himeno, K Tsutsumi, M Niwa, K Taniyama

引用次数: 21

Noradrenergic hyperinnervation in the heart of stroke-prone spontaneously hypertensive rats. 卒中易发自发性高血压大鼠心脏的去甲肾上腺素能亢进神经支配。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02977.x

M Kondo, M Terada, T Fujiwara, N Arita, A Yano, R Tabei

{"title":"Noradrenergic hyperinnervation in the heart of stroke-prone spontaneously hypertensive rats.","authors":"M Kondo, M Terada, T Fujiwara, N Arita, A Yano, R Tabei","doi":"10.1111/j.1440-1681.1995.tb02977.x","DOIUrl":"https://doi.org/10.1111/j.1440-1681.1995.tb02977.x","url":null,"abstract":"1. Noradrenergic (NA) nerve fibre distribution was investigated in the epicardium and myocardium of the heart in stroke-prone spontaneously hypertensive rats (SHRSP) and was compared to that in normotensive Wistar-Kyoto (WKY) rats. Fluorescent NA nerve fibres in the left and right epicardium of both strains aged 10, 30, 60, 90 and 180 days, and in the myocardium of left and right ventricles and the ventricular septum of both strains aged 30, 90 and 180 days were examined by the glyoxylic acid method. The distribution densities of NA nerve fibres were measured by quantitative image analysis. 2. The distribution pattern of NA nerve fibres in the epicardium of both strains showed a constant meshwork pattern throughout the entire examination period. 3. In the myocardium, NA nerve fibres were distributed irregularly between myocytes of both strains in all ages examined. 4. The densities of NA nerve fibres in the epicardium of SHRSP were significantly higher (P < 0.01 and 0.05; Student's t-test, 6 d.f.) than those of WKY at all ages examined except left epicardium at 90 days of age. 5. The densities in the right myocardium in 30 and 90 day old SHRSP were significantly higher (P < 0.05; Student's t-test, 6 d.f.) than those of WKY. 6. NA hyperinnervation in the epicardium and the myocardium of SHRSP may be assumed to be caused by the hyperfunction of the stellate ganglia which innervate the heart and may give rise to hypertrophy of the heart in SHRSP by a trophic effect of NA nerve fibre.","PeriodicalId":75710,"journal":{"name":"Clinical and experimental pharmacology & physiology. Supplement","volume":"22 1","pages":"S75-6"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1681.1995.tb02977.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20026293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Development of hypertension in spontaneously hypertensive rats: role of milk electrolytes. 自发性高血压大鼠高血压的发展:乳电解质的作用。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02888.x

R McCarty, H Tong

引用次数: 10

Comparative study on free radical injury in the endothelium of SHR and WKY aorta. SHR和WKY大鼠主动脉内皮自由基损伤的比较研究。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02862.x

H Ito, M Torii, T Suzuki

引用次数: 18

Inflammatory cytokines and rat vascular tone. 炎症因子与大鼠血管张力。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02867.x

F Ohkawa, U Ikeda, T Kanbe, K Kawasaki, K Shimada

{"title":"Inflammatory cytokines and rat vascular tone.","authors":"F Ohkawa, U Ikeda, T Kanbe, K Kawasaki, K Shimada","doi":"10.1111/j.1440-1681.1995.tb02867.x","DOIUrl":"https://doi.org/10.1111/j.1440-1681.1995.tb02867.x","url":null,"abstract":"1. Experiments were performed to examine the effect of inflammatory cytokines, interleukin-2 (IL-2), IL-6 and IL-8, on the contractility of rat aorta. 2. Pretreatment of the endothelium-denuded aortic ring with IL-6 for 3 h caused a significant inhibition of its contraction (58.9 +/- 7.8%, n = 9, P < 0.01) when induced by 10(-6) mol/L phenylephrine. 3. On the other hand, IL-2 and IL-8 failed to show significant effects on the contractility of the aorta. 4. This inhibitory effect of IL-6 on phenylephrine-induced contraction showed dose-dependency, and completely disappeared in the presence of 10(-5) mol/L indomethacin. 5. In cultured rat vascular smooth muscle cells (VSMC), the release of 6-keto-prostaglandin F1alpha into the extracellular medium was significantly increased by exposure to IL-6, but not by exposure to IL-2 or IL-8. 6. IL-2, IL-6 and IL-8 showed no effects on the release of nitrite, a stable metabolite of nitric oxide (NO), from VSMC. 7. These results indicate that IL-6, not IL-2 or IL-8, is a potent inhibitor of the alpha-adrenergic-stimulated contraction of vascular smooth muscle and its action is mediated by the increased synthesis of prostacyclin rather than NO.","PeriodicalId":75710,"journal":{"name":"Clinical and experimental pharmacology & physiology. Supplement","volume":"22 1","pages":"S169-71"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1681.1995.tb02867.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20026708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparative haemodynamic studies of endothelin-1, -2 and -3 on conscious SHRSP and WKY. 内皮素-1、-2和-3在有意识SHRSP和WKY中的血流动力学比较研究。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02880.x

H Higashino, K Simeonova, I Lambev, A Suzuki

引用次数: 0

Suppressive effects of benidipine on the development of hypertension and renal lesions in salt-loaded stroke-prone spontaneously hypertensive rats. 苯尼地平对盐负荷卒中易发自发性高血压大鼠高血压及肾损害的抑制作用。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02944.x

M Nito, H Sato, T Hara, A Karasawa, K Yamada, Y Ohta

引用次数: 4

Effect of angiotensin-converting enzyme inhibitors on fructose induced hypertension and hyperinsulinaemia in rats. 血管紧张素转换酶抑制剂对果糖诱导大鼠高血压和高胰岛素血症的影响。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02949.x

Y Erlich, T Rosenthal

引用次数: 32

Baroreceptors in the carotid sinus contribute to arterial baroreceptor reflexes in normotensive rats. 正常血压大鼠颈动脉窦压力感受器参与动脉压力感受器反射。

Clinical and experimental pharmacology & physiology. Supplement Pub Date : 1995-12-01 DOI: 10.1111/j.1440-1681.1995.tb02971.x

H Ohta, W T Talman

{"title":"Baroreceptors in the carotid sinus contribute to arterial baroreceptor reflexes in normotensive rats.","authors":"H Ohta, W T Talman","doi":"10.1111/j.1440-1681.1995.tb02971.x","DOIUrl":"https://doi.org/10.1111/j.1440-1681.1995.tb02971.x","url":null,"abstract":"1. Baroreceptor reflex influences on renal sympathetic nerve activity (RSNA) were estimated with non-linear regression analysis (sigmoidal curve fitting) before and after transection of carotid sinus nerves (CSN) and aortic depressor nerves (ADN) in rats. 2. Transection of ADN reduced the gain of the reflex to 42% of basal levels with increases in arterial pressure (MAP) and RSNA. Subsequent transection of CSN eliminated the remaining sigmoidal correlation between MAP and RSNA without further changes in resting MAP and RSNA. 3. By comparison, the transection of CSN reduced the gain of the reflex to 53% of basal levels without affecting other variables. Additional transection of both ADN eliminated the remaining sigmoidal correlation between MAP and RSNA with further increases in resting MAP and RSNA. 4. These results indicate that carotid sinus baroreceptors exist in rats. They contribute to baroreceptor-mediated reflex changes in RSNA as do aortic baroreceptors, although the working range of MAP may increase with transection of the latter.","PeriodicalId":75710,"journal":{"name":"Clinical and experimental pharmacology & physiology. Supplement","volume":"22 1","pages":"S62-3"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1681.1995.tb02971.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20027652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7