Beitrage zur Pathologie最新文献

{"title":"Completing Remarkers Regarding the Postgraduate Training in Pathology in the Federal Republic of Germany","authors":"F.W. Bückmann","doi":"10.1016/S0005-8165(77)80025-5","DOIUrl":"10.1016/S0005-8165(77)80025-5","url":null,"abstract":"","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"160 2","pages":"Pages 195-197"},"PeriodicalIF":0.0,"publicationDate":"1977-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80025-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12074541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphopenia and Lymph Node Histology Following Repetitive Extracorporeal Irradiation of Blood in Normal and Thymectomized Calves","authors":"H. Buerki ,&nbsp;B. Massner,&nbsp;H. Cottier,&nbsp;A.D. Chanana,&nbsp;D.D. Joel,&nbsp;E.P. Cronkite","doi":"10.1016/S0005-8165(77)80004-8","DOIUrl":"10.1016/S0005-8165(77)80004-8","url":null,"abstract":"<div><p>Repetitive extracorporeal irradiation of the circulating blood (RECIB) in normal or thymectomized calves and RECIB plus Imuran were used for comparative studies on the depletion of blood and lymph node lymphocytes. Elimination of the easily mobilizable pool of lymphocytes was almost complete within approximately 6 days after commencing RECIB and was reflected by a reduction of approximately 50% in the numbers of paracortical lymphocytes. Blood lymphocyte counts were reduced to approximately ⅓ to ¼ of the pre-irradiation values. Thymectomized calves had lower pre-irradiation blood lymphocyte counts than non-operated controls, however, the reduction in the number of blood lymphocytes was proportionally similar. Continuation of RECIB beyond one week did not result in a further depletion of blood lymphocytes. The lymphocyte counts in the follicular cortex and in the medulla of lymph nodes were not significantly changed by the various procedures. RECIB of 8–16 days duration did not alter the number of germinal centers in non-thymectomized calves, however, in thymectomized animals treated with RECIB, the number of germinal centers was reduced.</p></div><div><p>Mit Hilfe der wiederholten extrakorporellen Bestrahlung des peripheren Blutes (RECIB, repetitive extracorporeal irradiation of the circulating blood) läßt sich ohne Gewebeschädigung und ohne Hämolyse der mobilisierbare Anteil der Lymphozyten zerstören. Diese Technik wurde — allein oder in Kombination mit Thymektomie bzw. Imuran-Behandlung — zu Vergleichszwecken bei Kälbern angewandt. Innerhalb der ersten sechs Tage nach Beginn der RECIB war fast der ganze leicht mobilisierbare Anteil der Lymphozyten ausgeschaltet. Dies zeigte sich u. a. in einem Absinken der Lymphozytenzahl auf ungefähr die Hälfte im Bereich der parakortikalen Zone der Lymphknoten sowie auf ein Drittel bis ein Viertel der Ausgangswerte im peripheren Blut. Thymektomierte Tiere wiesen schon vor der RECIB tiefere Blutlymphozytenwerte auf als die nicht operierten Kontrolltiere, zeigten aber eine proportional entsprechende Abnahme dieser Werte nach RECIB. Eine Fortsetzung der RECIB über eine Woche hinaus bewirkte keine weitere Verstärkung der Blutlymphopenie mehr. Die Lymphozytenzahl im Bereich des follikulären Kortex und der Medulla von Lymphknoten wurde durch die verschiedenen Behandlungsmethoden nicht nennenswert beeinflußt. Die Zahl der Keimzentren veränderte sich trotz 8–16tägiger RECIB bei den nicht thymektomierten Tieren nicht wesentlich, im Gegensatz zu thymektomierten, RECIB-behandelten Kälbern.</p></div>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"160 1","pages":"Pages 38-49"},"PeriodicalIF":0.0,"publicationDate":"1977-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80004-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12057128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucopolysaccharidosis III A (Sanfilippo Disease Type A). Histochemical, Electron Microscopical and Biochemical Findings","authors":"H. Cain ,&nbsp;E. Egner ,&nbsp;H. Kresse","doi":"10.1016/S0005-8165(77)80006-1","DOIUrl":"10.1016/S0005-8165(77)80006-1","url":null,"abstract":"<div><p>This is a report of two brothers with mucopolysaccharidosis. The 8- and 10-year-old boys presented the characteristic clinical symptoms of the syndrome in their entirety. Both had a highly increased excretion of heparan sulfate in urine. The elder boy died and was autopsied and diagnosed as having Sanfilippo disease Typ A by a drastic reduction of heparan sulfate sulfamidase activity in organ extracts. Histochemically, highly water-soluble, sulfated acid mucopolysaccharides were demonstrated in liver, spleen, and cerebrum of the deceased child. Chemical analyses revealed a 12-fold increase of sulfated mucopolysaccharide in the patients liver and a 4.5-fold increase in the cerebrum when compared with normal controls. The sulfated polysaccharide consisted mainly of heparan sulfate, which was of low molecular size, heterogeneous in charge, and rich in its sulfamino hexose content. In addition, the gangliocytes of cerebrum and cerebellum had accumulated glycolipids. Electron microscopically the storage cells were overloaded with lysosomal residual bodies. The mitral valve was also involved in the storage process, which is a rare manifestation of the Sanfilippo syndrome. Acid mucopolysaccharides were deposited intracellularly as well as extracellularly in the mitral valve tissue. Polarisation microscopically there was found a change from normally positive to negative birefringence in the connective tissue ground substance of the mitral valve when containing stored mucopolysaccharides.</p></div>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"160 1","pages":"Pages 58-72"},"PeriodicalIF":0.0,"publicationDate":"1977-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80006-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73823806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzyme Histochemistry of Rat Folic Acid Nephropathy","authors":"A. Pataki ,&nbsp;W. Meier-Ruge,&nbsp;P. Sandoz,&nbsp;K.H. Wiederhold","doi":"10.1016/S0005-8165(77)80008-5","DOIUrl":"10.1016/S0005-8165(77)80008-5","url":null,"abstract":"<div><p>One hour after a single i.v. dose of 250 mg/kg folic acid, the straight portion of distal tubules in the outer medulla of rat kidneys showed a distinct reduction in succinate dehydrogenase, NADH₂-diaphorase, glutamate dehydrogenase, cytochrome oxydase, Na⁺/K⁺-ATPase, and acid phosphatase activity. In contrast, the proximal tubules exhibited only a reduction in glutamate dehydrogenase and alkaline phosphatase activity. At this time the straight portion of the distal tubules, whose enzyme activity had changed, showed partly regressive epithelial changes.</p><p>24 hours after folic acid administration an even greater reduction in enzyme activity had occurred in the straight portion of distal tubules; these structures also became dilated.</p><p>The adjacent collecting tubules and the corresponding proximal tubules were also severely dilated, the proximal tubules showing a loss in enzyme acitivities similar to those observed in the distal tubules.</p><p>48 hours after folic acid administration the changes largely resembled those observed after 24 hours, but were more pronounced. At this time a tubular regeneration was observed.</p><p>72 hours after folic acid administration, extensive normalization of the histological and histochemical changes had occured.</p><p>It ist postulated that a disturbance of the hairpin counter-current mechanism occurs as a result of a direct, concentration-dependent effect of folic acid on the enzymes of the energy supplying metabolism. A dilatation in the region of the loop of Henle and the collecting tubules occurs subsequently.</p></div><div><p>Eine Stunde nach einer einmaligen Verabreichung von 250 mg/kg Folsäure i.v. zeigten die gestreckten Mittelstücke des Markinnenstreifens der Rattenniere eine deutliche Aktivitätsabnahme der Succinat-Dehydrogenase, NADH₂-Diaphorase, Glutamat-Dehydrogenase, Cytochrom-Oxidase, Na⁺/K⁺ATPase und sauren Phosphatase. Im Gegensatz dazu ließen die Hauptstücke lediglich eine Abnahme der Glutamat-Dehydrogenase- und der alkalischen Phosphatase-Aktivität erkennen. Zu diesem Zeitpunkt zeigte ein Teil der Tubuli mit veränderter Enzymaktivität regressive Epithelveränderungen.</p><p>24 Stunden nach der Folsäureverabreichung beobachtete man in den gestreckten Mittelstücken eine noch stärkere Enzymaktivitätsabnahme, zusammen mit einer Dilatation. Die benachbarten Sammelröhren sowie die zugehörigen Hauptstücke waren ebenfalls stark dilatiert, wobei die letzteren einen den Mittelstücken entsprechenden Aktivitätsverlust zeigten.</p><p>48 Stunden nach der Folsäureverabreichung entsprachen die Veränderungen im wesentlichen denjenigen nach 24 Stunden, waren aber stärker ausgeprägt. Zu diesem Zeitpunkt beobachtete man eine Tubulusregeneration.</p><p>72 Stunden nach der Folsäureverabreichung kam es zu einer weitgehenden Normalisierung der histologischen und histochemischen Veränderungen.</p><p>Es wird angenommen, daß es durch eine dire","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"160 1","pages":"Pages 82-92"},"PeriodicalIF":0.0,"publicationDate":"1977-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80008-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11410341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloidosis of the isletes of Langerhans in relation to diabetes mellitus and aging.","authors":"M. Melato, G. Antonutto, E. Ferronato","doi":"10.1016/S0005-8165(77)80007-3","DOIUrl":"https://doi.org/10.1016/S0005-8165(77)80007-3","url":null,"abstract":"","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"35 1","pages":"73-81"},"PeriodicalIF":0.0,"publicationDate":"1977-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76951172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloidosis of the isletes of Langerhans in relation to diabetes mellitus and aging.","authors":"M Melato,&nbsp;G Antonutto,&nbsp;E Ferronato","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors, after presenting a review of research work on amyloidosis of the islets of Langerhans,, provide the information obtained from their study of a random sample of 200 autopsies. Special attention was paid to the correlation between amyloidosis of the islets of Langerhans, diabetes mellitus and aging. The analysis of the sample would show there is a close relationship between the general process of aging and insular amyloid deposits; diabetes mellitus would then occur, increasing the amount of the above-mentioned deposits only in patients of a more advanced aged.</p>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"160 1","pages":"73-81"},"PeriodicalIF":0.0,"publicationDate":"1977-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11537075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bursa-independent Plasma Cells in the Harderian Gland of the Chicken (Gallus domesticus) Histomorphometrical Investigations","authors":"B. Wolters ,&nbsp;E. Hultsch ,&nbsp;H.R. Niedorf","doi":"10.1016/S0005-8165(77)80005-X","DOIUrl":"10.1016/S0005-8165(77)80005-X","url":null,"abstract":"<div><p>Morphometric investigations of the Harderian gland in normal and bursectomized chickens at the 16th, 30th, and 60th day after hatching, show a significant suppressive effect of bursectomy on the volume of the plasma cell compartment in this organ. However, the suppression of the plasma cell population in the Harderian gland is not complete. The plasma cells remaining in the Harderian gland after bursectomy are probably components of a bursa-independent B cell population.</p></div><div><p>Morphometrische Untersuchungen an der Harderschen Drüse normaler und bursektomierter Hühnchen am 16., 30. und 60. Lebenstag zeigen einen signifikanten suppressiven Effekt der Bursektomie auf den Plasmazellgehalt dieses Organs. Die Unterdrückung der Plasmazell-Population in der Harderschen Drüse ist allerdings nicht total. Die nach der Bursektomie in der Harderschen Drüse verbliebenen Plasmazellen sind wahrscheinlich Bestandteile einer bursaunabhängigen B-Zell-Population.</p></div>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"160 1","pages":"Pages 50-57"},"PeriodicalIF":0.0,"publicationDate":"1977-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80005-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12043839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personal Remarks to the Situation in German Pathology","authors":"H.-W. Altmann","doi":"10.1016/S0005-8165(77)80010-3","DOIUrl":"10.1016/S0005-8165(77)80010-3","url":null,"abstract":"","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"160 1","pages":"Pages 97-103"},"PeriodicalIF":0.0,"publicationDate":"1977-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80010-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12043841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloidosis of the Islets of Langerhans in Relation to Diabetes mellitus and Aging","authors":"M. Melato ,&nbsp;G. Antonutto,&nbsp;E. Ferronato","doi":"10.1016/S0005-8165(77)80007-3","DOIUrl":"https://doi.org/10.1016/S0005-8165(77)80007-3","url":null,"abstract":"<div><p>The authors, after presenting a review of research work on amyloidosis of the islets of Langerhans, provide the information obtained from their study of a random sample of 200 autopsies. Special attention was paid to the correlation between amyloidosis of the islets of Langerhans, diabetes mellitus and aging. The analysis of the sample would show there is a close relationship between the general process of aging and insular amyloid deposits; diabetes mellitus would then occur, increasing the amount of the above-mentioned deposits only in patients of a more advanced age.</p></div>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"160 1","pages":"Pages 73-81"},"PeriodicalIF":0.0,"publicationDate":"1977-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80007-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92021744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Issue of Professional Discretion for Pathologists","authors":"W. Braun","doi":"10.1016/S0005-8165(77)80009-7","DOIUrl":"https://doi.org/10.1016/S0005-8165(77)80009-7","url":null,"abstract":"<div><p>According to German law the physician shall not disclose secrets that were confided or made known to him.</p><p>The definition reads: physician is who practises the healing art (including medicine and surgery).</p><p>When considering this definition part of the jurisprudence is of the opinion, therefore, that subject of such healing is exclusively the living human being and the pathologist acting as post-mortem examiner makes solely statements concerning the dead body and thus is not to be considered as physician.</p><p>This opinion does not do justice to the real tasks of the pathologist.</p><p>The basic idea of the tasks of the pathologist is the consultation and assistance of the physician practising the healing art. Hence the post- mortem examinations serve indirectly as healing treatment.</p><p>Consequently the pathologist acts as physician and is bound to professional discretion. This result corresponds with the law enforce according to which secrets are subject to protection beyond death.</p></div>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"160 1","pages":"Pages 93-96"},"PeriodicalIF":0.0,"publicationDate":"1977-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80009-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92130754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}