Beitrage zur Pathologie最新文献

{"title":"Risk of Periprosthetic Joint Infection after Posttraumatic Hip Arthroplasty following Acetabular Fractures.","authors":"Florian Schmidutz, Anna Janine Schreiner, Marc-Daniel Ahrend, Ulrich Stöckle, Sven Maier, Tina Histing, Philipp Hemmann","doi":"10.1055/a-1810-7379","DOIUrl":"10.1055/a-1810-7379","url":null,"abstract":"<p><strong>Background: </strong>Raised complication rates have been reported for total hip arthroplasty (THA) in posttraumatic hip joints after acetabular fractures with prior open reduction and internal fixation (ORIF). The present study evaluated (I) postoperative surgical site infection and the risk of early infection following THA in posttraumatic hip joints after acetabular fractures and (II) the discriminatory ability of preoperative C-reactive protein (CRP) blood levels for periprosthetic joint infection (PJI).</p><p><strong>Materials and methods: </strong>Patients were included who had undergone THA (2014-2019) after prior ORIF, and nonsurgically treated acetabular fractures. Patients' demographics and the duration between fracture and THA implantation were assessed. Preoperative diagnostic testing (laboratory results, hip aspirations) as well as the results of intraoperative microbiological swabs and sonication were also evaluated. Postoperative complications were recorded.</p><p><strong>Results: </strong>Sixty-seven patients (51 men/16 women) were included, with a mean age of 54.7 ± 14.0 years (range: 18.0-82.9). The mean time between acetabular fracture and THA was 13.5 ± 14.9 years (0.2-53.5). Four subgroups were classified: subgroup I (nonsurgical, n = 15), subgroup II (complete removal of osteosynthesis, n = 8), subgroup III (partial removal of osteosynthesis, n = 15), and subgroup IV (remaining osteosynthesis, n = 29). Preoperative CRP blood levels were normal. CRP levels had no discriminatory ability to predict PJI (AUC: 0.43). Positive microbiological swabs were assessed in subgroups III (n = 1) and IV (n = 2). Complications during follow-up occurred in subgroups I (one aseptic loosening [6.7%]), III (one wound revision [6.7%], two low-grade infections [13.3%]), and IV (three low-grade infections [10.3%]).</p><p><strong>Conclusion: </strong>High infection rates were found in patients with THA after acetabular fracture with remaining implants or partial implant removal. Serum CRP alone seems to be a poor predictor. Therefore, an extensive diagnostic algorithm can help to detect an occult infection, including preoperative hip aspiration (microbiological samples and measurements of synovial CRP, WBC, and alpha-defensin levels). Intraoperative tissue samples and sonication results should be obtained during THA implantation.</p>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"159 1","pages":"671-677"},"PeriodicalIF":1.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77558245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spindle cell lipoma (report of 2 cases and differential diagnosis)","authors":"P. Meister","doi":"10.1016/S0005-8165(77)80138-8","DOIUrl":"10.1016/S0005-8165(77)80138-8","url":null,"abstract":"<div><p>“Spindle Cell Lipoma” is a benign tumor consisting of immature mesenchymal spindle cells with occasional collagen fibers, myxoid areas and lipocytes scattered throughout in varying numbers. Only focally it shows the typical appearance of a lipoma. Therefore it may be confused with liposarcoma, fibrosing lipoma, furthermore with areas of fibrous histiocytoma or nodular fasciitis showing fat infiltration.</p></div>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"161 4","pages":"Pages 376-384"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80138-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11420487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the lysosomal function of juxtaglomerular granules","authors":"M. Cantin ,&nbsp;Y. Desormeaux,&nbsp;S. Benchimol","doi":"10.1016/S0005-8165(77)80134-0","DOIUrl":"10.1016/S0005-8165(77)80134-0","url":null,"abstract":"<div><p>The presence of acid phosphatase, β-glucuronidase and aryl sulfatase in juxtaglomerular cell granules (JGG) as well as the uptake and concentration of certain low molecular weight dyes by these granules have repeatedly suggested that they are akin to lysosomes. In the present experiments, rats were injected with three substances of widely different molecular weight and physicochemical properties - sucrose, iron sorbitol-citric acid complex (Jectofer) and horseradish peroxidase - that are well known to selectively concentrate in renal tubular cell lysosomes. None of these substances was found to enter the JGG to any significant degree, although both sucrose and Jectofer were evident in juxtaglomerular cells. Contrary to previous reports, thorium dioxide (Thorotrast) particles were not detected in the JGG after parenteral injection. These results indicate that JGG do not possess any significant lysosomal function and raise the question of the role of hydrolytic enzymes in the physiology of these granules.</p></div>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"161 4","pages":"Pages 310-327"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80134-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11812729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological alterations and focal deficiency of the histochemical activity of acid and alkaline nucleases in rat liver after chronic administration of phenobarbital","authors":"L. Fort ,&nbsp;H.S. Taper,&nbsp;J.M. Brucher","doi":"10.1016/S0005-8165(77)80137-6","DOIUrl":"10.1016/S0005-8165(77)80137-6","url":null,"abstract":"<div><p>Chronic oral administration of phenobarbital (up to 16 months) did not produce any neoplastic foci or nodules in the liver of male Wistar rats. Decrease of glycogen content and cytoplasmic alterations probably indicating S.E.R. hypertrophy were observed in the hepatocytes localized predominantly in the centrilobular areas of rats after chronic phenobarbital treatment. This treatment induced small foci of alkaline DNAse and RNAse deficient liver cells in the initial stages of the experiment. Acid DNAse and RNAse deficient zones increased in liver parenchyma since the third month of chronic administration of phenobarbital. At later stages of the experiment (7 to 16 months) they concerned in some cases more than 50% of liver parenchyma. The hyperbasophilia and the intensity of methylgreen-pyronin staining which, most probably, indicated the accumulation of nucleic acids also increased progressively with phenobarbital administration in similarly distributed irregular zones. These zones had predominant centrilobular localization.</p><p>It was suggested that such zonal deficiency of acid nuclease activity might be involved in tumor-promoting action of phenobarbital when separately administered in rats after hepatocarcinogen treatment.</p></div>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"161 4","pages":"Pages 363-375"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80137-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11812731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Technique of Death Masks Making","authors":"H.H. Jansen ,&nbsp;P. Leist","doi":"10.1016/S0005-8165(77)80139-X","DOIUrl":"10.1016/S0005-8165(77)80139-X","url":null,"abstract":"<div><p>In taking death-masks two different techniques are used. In the technique using a plaster matrix the plaster mash is brought on the face. When the plaster-cast has dried it is filled with plaster mash. Later the matrix is removed in order to lay open the mask. In the technique using a plastic matrix the plastic powder Palgat is brought on the face after mixing it rapidly with icewater until it appears pappy. After that a layer of several centimeters of plaster mash follows in order to stabilize the delicate plastic matrix. Likewise the matrix is filled with plaster mash. The mask can be furnished with a collar and a fixation and the surface can be prepared. The skin relief of the face is reproduced finer using the cast of a plastic matrix.</p></div>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"161 4","pages":"Pages 385-390"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80139-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11812732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of hemoglobin loads on the function and morphology of ischémic kidneys in the rat","authors":"G.E. Schubert ,&nbsp;R. Ochs,&nbsp;A. Haupt","doi":"10.1016/S0005-8165(77)80135-2","DOIUrl":"https://doi.org/10.1016/S0005-8165(77)80135-2","url":null,"abstract":"<div><p>Male Wistar rats were used to investigate the effects of stromafree hemoglobin (200 mg Hb/100 g body weights, i.v. as a 16.4% solution) on kidney function and morphology.</p><p>Ischemia of the kidney was induced by bilateral clamping of the renal pedicle. The most severe disturbances of kidney function occurred in kidneys damaged by ischemia during the peak of Hb excretion; endogenous creatinine clearance decreased to 5%) of control values, serum creatinine concentration rose 6 times as high as control values, and Hb excretion in the urine was reduced. Kidney damage after Hb loading and ischemia was more severe than damage caused by ischemia alone. These results demonstrate that the vulnerability of kidneys to damage by ischemia is increased by Hb loading.</p></div>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"161 4","pages":"Pages 328-341"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80135-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91979181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Form and structure of cell nuclei in growing and hypertrophied human hearts","authors":"C.P. Adler ,&nbsp;A. Hartz,&nbsp;W. Sandritter","doi":"10.1016/S0005-8165(77)80136-4","DOIUrl":"10.1016/S0005-8165(77)80136-4","url":null,"abstract":"<div><p>Tissue portions were taken from eight different places in the right and left ventricle from 17 autopsied human hearts (fetuses, children, adults, hypertrophied and atrophic hearts), and sectioned and smear preparations were obtained and stained after Feulgen. Twenty-eight light microscopic features of heart muscle nuclei were identified, and their percent frequency in individual hearts was obtained.</p><p>The studies showed:</p><ul><li><span>1.</span><span><p>Heart muscle nuclei in fetal hearts and in hearts soon after birth show a compact, rounded form in <em>cross section</em>. During childhood heart growth, the nuclei become more and more angular and develop pointed or bizarre projections. In marked heart hypertrophy, almost all heart muscle nuclei assume a bizarre shape and have pointed projections. Compact nuclei are encountered only very occasionally.</p></span></li><li><span>2.</span><span><p>In <em>longitudinal section</em>, 80% of heart muscle nuclei in fetal hearts have an oval shape, 20%) are rectangular with rounded corners. During childhood heart growth, the nuclei are angular, and the corners frequently form a point. The smaller edges of the nuclei are cleft. Hypertrophied hearts again show more rounded nuclei.</p></span></li><li><span>3.</span><span><p>The external <em>nuclear membrane</em> during childhood heart growth is either smooth or mildly wavy, in contrast to adult heart nuclei which are grooved. Heart hypertrophy again shows predominantly smooth nuclear membranes.</p></span></li><li><span>4.</span><span><p>The <em>internal structure</em> of myocardial nuclei (heterochromatin) is granular in the fetal and perinatal periods, whereas it is predominantly netlike in structure during childhood growth phase. Heterochromatin is exclusively coarsely granular in normal, adult hearts, but again finely distributed in a net-like fashion in hypertrophied hearts. Myocardial nuclei from fetuses and children typically show <em>large, round bodies</em>, representing compact DNA aggregates (chromocenters). These are encountered only as isolated findings in normal, adult hearts and in hypertrophied hearts.</p></span></li><li><span>5.</span><span><p>The <em>length of heart muscle nuclei</em> remains constant at 9.8 μm during physiologic heart growth, and increases during heart hypertrophy to a mean of 19.2 μm.</p></span></li><li><span>6.</span><span><p>Approximately 10% of heart muscle cells from all hearts contain <em>double nuclei</em> and <em>nuclear sequences</em>. The morphological findings of these multinucleate heart muscle cells suggest amitotic nuclear division and nuclear increase.</p></span></li></ul><p>Shape and structural alterations in heart muscle nuclei permit conclusions to be drawn on the one hand regarding the functional status of the heart muscle, and on the other hand regarding the growth process of the myocardium in physiological heart growth and in pathologic heart hypertrophy. Morphologic evidence is given for a","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"161 4","pages":"Pages 342-362"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80136-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11366873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies on the tubular ferritin-uptake in the kidneys of Goldblatt-hypertensive rats","authors":"M. Szokol ,&nbsp;M.B. Soltész","doi":"10.1016/S0005-8165(77)80133-9","DOIUrl":"10.1016/S0005-8165(77)80133-9","url":null,"abstract":"<div><p>Ferritin deposition in the tubular epithelial cells developing after intravenous ferritin injection was investigated in the kidneys of 25 Goldblatt hypertensive rats and of 10 normotensive controls. The phenomenon was detected only in the hypertensive animals. Light microscopic and planimetric data indicate an increased permeability of the glomerular filter and contradict a degenerative damage of the tubular epithelial cells as a primary cause. Ferritin after having crossed the glomerular filter is partly reabsorbed by the tubular epithelium and partly excreted by the urine. The high iron content of the urine and the ferritin detected electrophoretically in it also proves this explanation.</p></div>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"161 4","pages":"Pages 297-309"},"PeriodicalIF":0.0,"publicationDate":"1977-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80133-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11812728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphology of Mouse Epidermal Cells in Vitro: A Scanning Electron Microscopy Study","authors":"K. Elgjo ,&nbsp;R. Fölling Elgjo ,&nbsp;H. Hennings","doi":"10.1016/S0005-8165(77)80091-7","DOIUrl":"10.1016/S0005-8165(77)80091-7","url":null,"abstract":"<div><p>Scanning electron microscopy of isolated epidermal cells from newborn mice grown in vitro showed that the cultures consisted of several morphologically different types of cells. Young cultures had many smooth, round cells while older cultures contained more cells with rough or ruffled surface and a varying number of flat, irregular cells. Probably, the various cell types corresponded to different stages of differentation (keratinization). Cultures that were grown in the presence of retinyl acetate (12.5 μg/ml) had more round and smooth cells after several days in vitro than the controls. This could indicate that retinyl acetate delayed or altered cell differentiation. Scanning electron microscopy of the cultures consistently showed that the cells were situated at different layers. The apparent monolayer seen by phase contrast microscopy therefore seems to be an optical phenomenon due to projection of the cells onto the same plane.</p></div>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"161 2","pages":"Pages 122-130"},"PeriodicalIF":0.0,"publicationDate":"1977-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80091-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11800419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of Myofibroblasts in the Different Phases of Morbus Dupuytren (Dupuytren's Contracture)","authors":"J.M. Gokel ,&nbsp;G. Hübner","doi":"10.1016/S0005-8165(77)80095-4","DOIUrl":"10.1016/S0005-8165(77)80095-4","url":null,"abstract":"<div><p>Twenty-one surgically removed specimens of Morbus Dupuytren (M. D.) were studied by light and electron microscopy. The cell type observed in the <em>proliferative phase</em> shows the basic ultrastructural features of fibroblasts, while the majority of the cells in the <em>involutional phase</em> resemble myofibroblasts. Myofibroblasts exhibit ultrastructural characteristics of both smooth muscle cells and fibroblasts and are said to behave functionally like smooth muscle cells. In the <em>residual phase</em>, typical fibrocytes of connective tissue are found. These findings confirm the concept that fibroblasts are capable of converting into myofibroblasts and demonstrate that myofibroblasts represent an intermediate cell type of transitional cellular differentiation. The significance of myofibroblasts for the development of the contracture in M. D. is discussed.</p></div>","PeriodicalId":75583,"journal":{"name":"Beitrage zur Pathologie","volume":"161 2","pages":"Pages 166-175"},"PeriodicalIF":0.0,"publicationDate":"1977-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0005-8165(77)80095-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11800422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}