Annales de medecine interne最新文献

{"title":"[EGF receptors in urological cancer. Molecular basis and therapeutic involvements].","authors":"Bernard Paule,&nbsp;Nathalie Brion","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Many epithelial cancers have been found to overexpress the receptor to epidermal growth factor (EGFR) including head and neck, breast, colon, lung, prostate, kidney, ovary, brain, pancreas and bladder cancer. Because of the association of EGFR overexpression with overall poor prognosis in patients with cancer, a number of strategies to block or downregulate EGFR have been developed to inhibit tumor proliferation and improve clinical outcome. These include monoclonal antibodies directed against the EGFR such as IMC-C225 which specifically targets EGFR and ZD 1839 (Iressa) capable of inhibiting EGFR tyrosine-kinase in vitro. This report will focus on antibodies that target EGFR in renal cell carcinoma, prostate cancer and bladder cancer.</p>","PeriodicalId":75505,"journal":{"name":"Annales de medecine interne","volume":"154 7","pages":"448-56"},"PeriodicalIF":0.0,"publicationDate":"2003-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24171934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Sports practices and violent behaviors in 14-16 year-olds: analysis based on the ESPAD 99 survey data].","authors":"Marie Choquet,&nbsp;Philippe Arvers","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To date, there has been little research into the relationship between violent behavior and the practice of sport in young adolescents (both girls and boys) in the general population. Indeed, sport is often recommended as a means of prevention and an alternative to violence in adolescence. For this reason, we studied this issue in a representative sample of 14-16 year-olds (ESPAD 99). Among this sample, boys practised some form of extra-curricular sport more than girls (75% vs. 57%), this practice being more intensive (13% boys vs. 4% girls practising sport more than 8 hours per week outside of school) and more \"competitive\" (14% vs. 4% taking part in national and/or international events). Boys also exhibited more violent behavior than girls, including stealing (mean 0.91 for boys vs. 0.49 in girls), fighting (mean 1.71 in boys vs. 0.49 in girls) or serious offences (mean 0.66 in boys vs. 0.34 in girls). Taking part in competitions was found to be highly associated with violent behavior. In particular, competition at a national or international level was associated (in decreasing order of significance) with fighting (OR=2.35), serious offences (OR=1.78) and stealing (OR=1.58), after adjustment for age, gender, father's educational level and type of school attended. The practical implications of this study are that it is important to moderate one's judgment about the positive effects of sport in reducing youth violence, to be attentive to violent acts perpetrated in stadiums and to better analyze the eventual beneficial effects of sports clubs.</p>","PeriodicalId":75505,"journal":{"name":"Annales de medecine interne","volume":"154 Spec No 2 ","pages":"S15-22"},"PeriodicalIF":0.0,"publicationDate":"2003-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24197827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Development of diagnosis criteria for physical activity abuse and dependence: a qualitative study].","authors":"Eric Mangon,&nbsp;Serge Simon,&nbsp;Pascale Franques-Rénéric,&nbsp;Marc Auriacombe","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>The purpose of this work was to search for criteria of physical activity abuse and dependence, patterned after abuse and dependence criteria for psychoactive substances described in DSM IV and CIM10, and to determine whether these criteria could be found in individuals practising sports. This preliminary work was designed as the first step in the search for a possible physical activity dependence syndrome.</p><p><strong>Methods: </strong>Operational criteria for physical activity abuse and dependence were defined by using the DSM IV and CIM 10 criteria for psychoactive substances abuse and dependence as a pattern. We searched for these criteria among a group of 8 persons (4 men and 4 women, aged 17-25 years) who practised 7 different sports. The subjects participated in a qualitative interview during which the defined criteria were not mentioned directly. The script of the interview was analyzed with a pre-established grid in order to search for the operational diagnostic criteria.</p><p><strong>Results: </strong>All of the defined operational criteria except two concerning physical activity abuse were identified in the interview scripts. All of the participants fulfilled at least one of the defined criteria. The importance of physical activity dependence criteria spontaneously mentioned by the participants was notable; abuse criteria were found less often.</p><p><strong>Discussion: </strong>Based on the findings of this qualitative study, the development of diagnostic criteria for physical activity abuse or dependence patterned after psychoactive abuse and dependence criteria appears to be a realistic possibility. The operational criteria we defined were found in all of the participants in this study, irrespective of the sports they practised. Although a large number of dependence criteria were found for each participant, this study was not designed to determine the number of participants for whom the diagnosis of physical activity dependence could be retained. This would require search for notions such as duration of the manifestations, changing functional behavior, or clinically significant suffering in order to identify the pathological nature of the behavior. Other studies are now needed to determine whether individual subjects who present a sufficient number of criteria simultaneously can be identified as presenting physical activity abuse or dependence.</p>","PeriodicalId":75505,"journal":{"name":"Annales de medecine interne","volume":"154 Spec No 2 ","pages":"S33-42"},"PeriodicalIF":0.0,"publicationDate":"2003-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24195829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Psychological aspects of MDMA (ecstasy) users].","authors":"Isabelle Varescon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We reviewed the literature on the psychological aspects of MDMA consumption. The present paper examined the characteristics, psychological and psychopathological consequences of synthetic drug use (MDMA). The most frequent features are depression, anxiety, cognitive disorders and sensation seeking. Longer-term, higher dosage, and use of other substances are correlated with higher risk of developing psychopathological disorders. Care should be taken in cross-sectional studies in interpreting signs and symptoms of mental disorder merely as a consequence of MDMA use, because the use of ecstasy may be associated with use of multiple substances from which the mental disorder might be more likely to precede. The consumption pattern of ecstasy and related substances must be carefully analyzed. Knowledge of the MDMA consumption profile is an important for understanding the psychological characteristics of synthetic drug users.</p>","PeriodicalId":75505,"journal":{"name":"Annales de medecine interne","volume":"154 Spec No 2 ","pages":"S81-5"},"PeriodicalIF":0.0,"publicationDate":"2003-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24194087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Abdominal and digestive manifestations in systemic vasculitides].","authors":"Christian Pagnoux,&nbsp;Alfred Mahr,&nbsp;Loïc Guillevin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Digestive involvement is frequent during the course of systemic small and medium-sized vessel vasculitides. Clinical manifestations range from rapidly regressive abdominal pain to surgical manifestations associated with poor prognosis. These are usually associated with extra-abdominal signs, reflecting vasculitis activity. Isolated gastrointestinal involvement is observed in only 16% of these patients. The main clinical manifestations are common to all vasculitides (ischemia, bowel infarction and perforations, gastrointestinal hemorrhage due to mucosal ulcerations or aneurysmal ruptures), but some are more specific to one type (granulomatous ileo-colitis during Wegener's granulomatosis, eosinophilic colitis during Churg-Strauss syndrome). Gastrointestinal arteriography can be helpful for diagnosis, but has no prognostic value, likewise for the presence of ANCA. As there are no identified factors predictive of a surgical abdomen, therapy must be adapted individually, using steroids and immunosuppressive agents, generally cyclophosphamide. Prompt surgical and medical care of these seriously ill patients has lowered mortality from nearly 100% twenty years ago to approximately 23 to 56% currently.</p>","PeriodicalId":75505,"journal":{"name":"Annales de medecine interne","volume":"154 7","pages":"457-67"},"PeriodicalIF":0.0,"publicationDate":"2003-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24171936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cluster headache].","authors":"Anne Ducros,&nbsp;Marie-Germaine Bousser","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cluster headache is characterized by recurrent unilateral attacks of headache of great intensity and brief duration (15-180 minutes), accompanied by local signs and symptoms of autonomic dysfunction including conjunctival injection, lacrimation, nasal congestion, rhinnorrhea, forehead and facial sweating, miosis, ptosis or eyelid edema. Attacks occur in so-called cluster periods lasting for weeks or months. About 10% of patients have chronic symptoms with no period of remission. There are only two abortive treatments with proven efficacy: subcutaneous sumatriptan and nasal oxygen inhalation. Prophylactic treatment is often needed to reduce the daily frequency of attacks: verapamil in episodic cluster headache and lithium in chronic cluster headache.</p>","PeriodicalId":75505,"journal":{"name":"Annales de medecine interne","volume":"154 7","pages":"468-74"},"PeriodicalIF":0.0,"publicationDate":"2003-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24171939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Opioid tolerance: what if it was just a question of receptor internalization?].","authors":"Nicolas Marie,&nbsp;Philippe Jauzac,&nbsp;Stéphane Allouche","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Despite side effects which appear upon chronic administration of opioid agonists, these drugs remain widely used and effective for pain relief. Among these side effects, tolerance is the major factor limiting the effectiveness of these drugs. Desensitization, defined by a decrease of opioid receptor transduction, would be a crucial step in the development of tolerance. Molecular mechanisms of opioid receptor desensitization have been extensively studied on cellular models and have been found to involve various proteins and different steps such as receptor phosphorylation, internalization, and recycling or degradation into intracellular compartments. In the present review, we discuss the role of opioid receptor internalization and sorting in desensitization and tolerance processes.</p>","PeriodicalId":75505,"journal":{"name":"Annales de medecine interne","volume":"154 Spec No 2 ","pages":"S73-80"},"PeriodicalIF":0.0,"publicationDate":"2003-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24194086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[French nationwide survey of abstinence-oriented treatments in opiate-addicted patients. Results at 12 months].","authors":"Jean Vignau,&nbsp;Alain Boissonnas,&nbsp;Jean Tignol,&nbsp;Yannick Millot,&nbsp;Alain Mucchielli","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Unlabelled: </strong>Over the last few years, general practitioners and pharmacists in France have become more directly involved in the treatment of opiate-addicted patients with the rapid development of office-based buprenorphine and methadone maintenance programs. At the same time, demand for abstinence-oriented interventions outside established maintenance programs continues to be addressed to the primary care system.</p><p><strong>Method: </strong>Our prospective and multicentric survey was conducted to monitor the follow-up of such abstinence-oriented interventions during a 12 months period, by means of questionnaires investigating the psychosocial, medical and addictive status of the patients recruited.</p><p><strong>Results: </strong>One hundred and sixty five general practitioners have accepted to participate in the survey. Initially, they recruited 414 patients (51% terminating a buprenorphine maintenance treatment, 5% a methadone treatment and 36% withdrawing from heroin). Naltrexone chlorhydrate was prescribed for 50% early after entry in the survey. During the 12-month follow-up period: four data collections were proposed at 1, 3, 6, and 12 months. In all, data were collected for 158 patients. No data could be collected for 63 patients who were excluded from follow-up analysis. Out of the 351 patients who attended at least one follow-up visit, 137 (one third) moved to an opiate agonist maintenance program. When naltrexone was prescribed, total duration of treatment averaged 4785 days with no significant difference in terms of heroin relapse and attendance to follow-up visits. Between the first and the last data collection, out of the 113 HCV-positive patients, 13 received/started an anti-viral treatment. No significant difference was noted according to indicators of social outcome.</p><p><strong>Conclusion: </strong>Our survey shows that office-base abstinence-oriented interventions in opiate-addicted patients can produce a moderate benefit. Research concerning alternative formulations for opiate antagonists (e.g., long-acting naltrexone) could be helpfully in developing new options for treatment.</p>","PeriodicalId":75505,"journal":{"name":"Annales de medecine interne","volume":"154 Spec No 2 ","pages":"S23-32"},"PeriodicalIF":0.0,"publicationDate":"2003-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24195828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Misuse of tianeptine: five cases of abuse].","authors":"Loïc Leterme,&nbsp;Yves-Stéphane Singlan,&nbsp;Valérie Auclair,&nbsp;Reynald Le Boisselier,&nbsp;Vincent Frimas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Five cases of excessive consumption of tianeptine suggest possible drug-abuse of this substance. This side effect is unknown in animals and humans. According to DSM IV, CIM 10 criteria and the French public health code, these five patients had pathological profiles of psychoactive drug abusers. Tianeptine dosage was always used higher than recommended and the drug was taken in association with other psychotropes. Withdrawal was difficult and induced anxiety and other disorders which led to relapse in most of the patients.</p>","PeriodicalId":75505,"journal":{"name":"Annales de medecine interne","volume":"154 Spec No 2 ","pages":"S58-63"},"PeriodicalIF":0.0,"publicationDate":"2003-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24195833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extra-anatomic bypass shunting in aorto-iliac occlusive disease. Clinical results and risk factors in a Belgian population.","authors":"Serge Gabin Tueche","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present a retrospective study of 38 patients undergoing axillofemoral bypass shunting (AXF, n=42, including 29 axillobifemoral (AXBF) and 9 axillo-unifemoral (AXUF)) from 1988 to 1998, for aorto-iliac occlusive disease (AOD). Six were excluded from the study as they did not meet entry criteria; the remaining 32 patients were retained. All patients had histories of failed medical treatment. Indications for grafting were limb salvage (n=19), pain at rest (n=10), and high grade claudication (n=9). There were 28 males. Mean age was 73 years (range: 56-86). Preoperative assessment, risk factors and early outcome were considered. Knitted Dacron and Gore-Tex prostheses were used. Indications for AXF was poor general status, locally hostile or septic abdomen. All the patients were symptom-free early after surgery, with disappearance of pain at rest, improvement in trophic necrotic, and gangrenous lesions of the limbs, and better independence in walking ability. One patient died during the first 30 days (3% operative mortality). Most deaths occurred within 6 months due to causes unrelated to surgery, mainly in patients with comorbid conditions. AXF bypass is an acceptable procedure for high risk AOD patients or when conventional anatomic in situ repair is contraindicated.</p>","PeriodicalId":75505,"journal":{"name":"Annales de medecine interne","volume":"154 7","pages":"489-92"},"PeriodicalIF":0.0,"publicationDate":"2003-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24173575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}