Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology最新文献

{"title":"Exploring <i>Bifidobacterium</i> species community and functional variations with human gut microbiome structure and health beyond infancy.","authors":"Ruben Ladeira, Julien Tap, Muriel Derrien","doi":"10.20517/mrr.2023.01","DOIUrl":"10.20517/mrr.2023.01","url":null,"abstract":"<p><p><b>Aim:</b> The human gut <i>Bifidobacterium</i> community has been studied in detail in infants and following dietary interventions in adults. However, the variability of the distribution of <i>Bifidobacterium</i> species and intra-species functions have been little studied, particularly beyond infancy. Here, we explore the ecology of <i>Bifidobacterium</i> communities in a large public dataset of human gut metagenomes, mostly corresponding to adults. <b>Methods:</b> We selected 9.515 unique gut metagenomes from curatedMetagenomicData. Samples were partitioned by applying Dirichlet's multinomial mixture to <i>Bifidobacterium</i> species. A functional analysis was performed on > 2.000 human-associated <i>Bifidobacterium</i> metagenome-assembled genomes (MAGs) paired with participant gut microbiome and health features. <b>Results:</b> We identified several <i>Bifidobacterium</i>-based partitions in the human gut microbiome differing in terms of the presence and abundance of <i>Bifidobacterium</i> species. The partitions enriched in both <i>B. longum</i> and <i>B. adolescentis</i> were associated with gut microbiome diversity and a higher abundance of butyrate producers and were more prevalent in healthy individuals. <i>B. bifidum</i> MAGs harboring a set of genes potentially related to phages were more prevalent in partitions associated with a lower gut microbiome diversity and were genetically more closely related. <b>Conclusion:</b> This study expands our knowledge of the ecology and variability of the <i>Bifidobacterium</i> community, particularly in adults, and its specific association with the gut microbiota and health. Its findings may guide the rational selection of <i>Bifidobacterium</i> strains for gut microbiome complementation according to the individual's endogenous <i>Bifidobacterium</i> community. Our results also suggest that gut microbiome stratification for particular genera may be relevant for studies of variations of species and associations with the gut microbiome and health.</p>","PeriodicalId":75465,"journal":{"name":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology","volume":"258 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89709234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum and resistance in bacterial infections of the ocular surface in a German tertiary referral center 2009-2019.","authors":"Mathias Roth, Paul Goerke, Christoph Holtmann, Andreas Frings, Colin R MacKenzie, Gerd Geerling","doi":"10.1007/s00417-022-05721-7","DOIUrl":"10.1007/s00417-022-05721-7","url":null,"abstract":"<p><strong>Purpose: </strong>Aim of this study was to evaluate the frequencies, trends, and antibiotic resistance of bacteria collected from ocular surface or contact lens material in a German tertiary referral center from 2009 to 2019.</p><p><strong>Methods: </strong>Microbiological data from 2009 to 2019 was analyzed. Culture-dependent microbial identification and analysis of antibiotic sensitivity was completed by the Institute of Microbiology. Statistical analysis of age- and sex-specific differences as well as changes in the microbial spectrum and resistance over the study period was performed with GraphPad Prism 9.0 applying nonparametric tests (level of significance: p ≦ 0.05).</p><p><strong>Results: </strong>A total of 6361 specimens were analyzed. Positivity rate was 18.6%. Sixty-three percent (n = 680) of the bacterial isolates were derived from ocular surface and 37% (n = 399) from contact lens material. The ratio of gram-negative bacteria was significantly higher in contact lens material. Multiresistant bacteria showed a significant increase with patient age (p < 0.0001). An overall increase in resistance to levofloxacin (p = 0.0239) was detected. Only 2.4% and 3.1% isolates were resistant to a combination of moxifloxacin and gentamicin, respectively, levofloxacin and gentamicin.</p><p><strong>Conclusions: </strong>The reported bacterial spectrum is similar to comparable centers. Our data show that it should not be assumed that the newest classes of antibiotics have the best efficacy or lowest resistance levels. In suspected bacterial conjunctivitis, we propose using gentamicin as first-line therapy. In therapy refractive cases and in involvement of the cornea, we recommend a combination of gentamicin and ofloxacin or moxifloxacin. Overall, the evaluated organisms showed good sensitivity to the regularly used antibiotics.</p>","PeriodicalId":75465,"journal":{"name":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology","volume":"260 1","pages":"3909-3917"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47095830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SriniVas Sadda, Andrew Schachat, Charles Wilkinson, David Hinton, Peter Wiedemann, K. Bailey Freund, David Sarraf (eds): Ryanʼs Retina, 3 Volume Set 7th Edition, Elsevier, 2022 (eBook ISBN: 9780323722148; Hardcover ISBN: 9780323722131)","authors":"B. Kirchhof","doi":"10.1007/s00417-022-05874-5","DOIUrl":"https://doi.org/10.1007/s00417-022-05874-5","url":null,"abstract":"","PeriodicalId":75465,"journal":{"name":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology","volume":"261 1","pages":"599 - 599"},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45663841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macular neovascularization lesion type and vision outcomes in neovascular age-related macular degeneration: post hoc analysis of HARBOR.","authors":"K Bailey Freund, Giovanni Staurenghi, Jesse J Jung, Sandrine A Zweifel, Mariano Cozzi, Lauren Hill, Steven Blotner, Min Tsuboi, Shamika Gune","doi":"10.1007/s00417-022-05586-w","DOIUrl":"10.1007/s00417-022-05586-w","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize relationships between Consensus on Neovascular Age-Related Macular Degeneration Nomenclature (CONAN) Study Group classifications of macular neovascularization (MNV) and visual responses to ranibizumab in patients with neovascular age-related macular degeneration (nAMD).</p><p><strong>Methods: </strong>This was a post hoc analysis of the phase 3 HARBOR trial of ranibizumab in nAMD. Analyses included ranibizumab-treated eyes with baseline multimodal imaging data; baseline MNV; subretinal and/or intraretinal fluid at screening, baseline, or week 1; and spectral-domain optical coherence tomography images through month 24 (n = 700). Mean best-corrected visual acuity (BCVA) over time and mean BCVA change at months 12 and 24 were compared between eyes with type 1, type 2/mixed type 1 and 2 (type 2/M), and any type 3 MNV at baseline.</p><p><strong>Results: </strong>At baseline, 263 (37.6%), 287 (41.0%), and 150 (21.4%) eyes had type 1, type 2/M, and any type 3 lesions, respectively. Type 1 eyes had the best mean BCVA at baseline (59.0 [95% CI: 57.7-60.3] letters) and month 24 (67.7 [65.8-69.6] letters), whereas type 2/M eyes had the worst (50.0 [48.6-51.4] letters and 60.8 [58.7-62.9] letters, respectively). Mean BCVA gains at month 24 were most pronounced for type 2/M eyes (10.8 [8.9-12.7] letters) and similar for type 1 (8.7 [6.9-10.5] letters) and any type 3 eyes (8.3 [6.3-10.3] letters).</p><p><strong>Conclusion: </strong>Differences in BCVA outcomes between CONAN lesion type subgroups support the use of an anatomic classification system to characterize MNV and prognosticate visual responses to anti-vascular endothelial growth factor therapy for nAMD.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT00891735. Date of registration: April 29, 2009.</p>","PeriodicalId":75465,"journal":{"name":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology","volume":"260 1","pages":"2437-2447"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47039033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive factors, diagnosis, and management of injection-related endophthalmitis: a literature review.","authors":"Rupali Singh,&nbsp;Samaneh Davoudi,&nbsp;Steven Ness","doi":"10.1007/s00417-022-05607-8","DOIUrl":"10.1007/s00417-022-05607-8","url":null,"abstract":"<p><strong>Background: </strong>Intravitreal medication injections represent the gold standard treatment for a variety of potentially blinding chorioretinal vascular diseases. Despite their excellent safety profile, they are associated with the feared complication of injection-related endophthalmitis (IRE). Though the overall incidence of IRE is low, due to the ever-increasing number of injections being performed, it is a complication that all retina specialists are likely to encounter. This article reviews various factors that could potentially influence the risk of IRE and discusses evidence-based strategies for management.</p><p><strong>Method: </strong>PubMed was searched for keywords \"intravitreal injection\" and \"endophthalmitis\" from the period of 1995-2021. Relevant articles were reviewed and selected articles were analyzed with respect to the incidence, potential preventive factors, clinical presentation, microbial profile, management, and outcomes for IRE.</p><p><strong>Results: </strong>There is strong consensus supporting the use of povidone iodine topical antiseptic, eyelid retraction away from the injection site, and avoiding treatment of eyes with active surface or eyelid disease, but there is less agreement on the use of face masks versus \"no-talking\" policies and optimal anesthetic technique. Current evidence comparing tap and inject or early vitrectomy for treatment of IRE is inadequate to determine an optimal treatment strategy.</p><p><strong>Conclusion: </strong>Intravitreal injections are sight saving, but even using established prophylactic measures there remains a small but real risk of infectious injection-related complications. Further investigations comparing tap and inject versus vitrectomy may help to establish optimal treatment, although the rarity of IRE makes designing adequately powered prospective trials a difficult task.</p>","PeriodicalId":75465,"journal":{"name":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology","volume":"260 1","pages":"2399-2416"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45509482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-year outcomes of episcleral brachytherapy adjunct to anti-VEGF therapy for treatment-resistant nAMD","authors":"J. Chhablani, R. Jager, J. Ong, Ryan Lohrenz, R. Hamilton, Baldassare Stea, M. Drew, G. Kokame, Muneeswar Sophiana Swetha Bindu Ayesha Gupta Nittala Lindenberg Velaga Karamat, Muneeswar Gupta Nittala, Sophiana Lindenberg, S. Velaga, Ayesha Karamat","doi":"10.1007/s00417-022-05736-0","DOIUrl":"https://doi.org/10.1007/s00417-022-05736-0","url":null,"abstract":"","PeriodicalId":75465,"journal":{"name":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology","volume":"260 1","pages":"3791 - 3798"},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44586033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cataract surgery astigmatism incisional management. Manual relaxing incision versus femtosecond laser-assisted arcuate keratotomy. A systematic review","authors":"T. González-Cruces, A. Cano-Ortiz, M. C. Sánchez-González, J. Sánchez-González","doi":"10.1007/s00417-022-05728-0","DOIUrl":"https://doi.org/10.1007/s00417-022-05728-0","url":null,"abstract":"","PeriodicalId":75465,"journal":{"name":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology","volume":"260 1","pages":"3437 - 3452"},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48791784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraocular muscle enlargement","authors":"Khizar Rana, V. Juniat, Sandy Patel, D. Selva","doi":"10.1007/s00417-022-05727-1","DOIUrl":"https://doi.org/10.1007/s00417-022-05727-1","url":null,"abstract":"","PeriodicalId":75465,"journal":{"name":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology","volume":"260 1","pages":"3419 - 3435"},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49130014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of subjective cyclofusion ranges and objective ocular torsion in normal participants according to age","authors":"Manami Kawai, T. Goseki, Takashi Okano, H. Ishikawa","doi":"10.1007/s00417-022-05734-2","DOIUrl":"https://doi.org/10.1007/s00417-022-05734-2","url":null,"abstract":"","PeriodicalId":75465,"journal":{"name":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology","volume":"260 1","pages":"3675 - 3681"},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43385664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iridian anterior segment OCT in rubella uveitis syndrome and cytomegalovirus anterior uveitis: a comparative study","authors":"Patricia Escribano López, J. G. Gonzalez Guijarro","doi":"10.1007/s00417-022-05733-3","DOIUrl":"https://doi.org/10.1007/s00417-022-05733-3","url":null,"abstract":"","PeriodicalId":75465,"journal":{"name":"Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology","volume":"260 1","pages":"3647 - 3655"},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47545370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}