Advances in lipid research最新文献_第4页

Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A. 神经酰胺活化蛋白磷酸酶:部分纯化及其与蛋白磷酸酶2A的关系。

Advances in lipid research Pub Date : 1993-01-01

R T Dobrowsky, Y A Hannun

引用次数: 0

Ceramidases: enzymology and metabolic roles. 神经酰胺酶:酶学和代谢作用。

Advances in lipid research Pub Date : 1993-01-01

D F Hassler, R M Bell

引用次数: 0

Chemistry and function of mammalian sebaceous lipids. 哺乳动物皮脂脂的化学和功能。

Advances in lipid research Pub Date : 1991-01-01 DOI: 10.1016/b978-0-12-024924-4.50013-4

M E Stewart, D T Downing

引用次数: 77

The biochemistry and function of stratum corneum lipids. 角质层脂质的生物化学及功能。

Advances in lipid research Pub Date : 1991-01-01 DOI: 10.1016/b978-0-12-024924-4.50006-7

N Y Schurer, P M Elias

引用次数: 265

Lipid metabolism in cultured keratinocytes. 培养角质形成细胞的脂质代谢。

Advances in lipid research Pub Date : 1991-01-01 DOI: 10.1016/b978-0-12-024924-4.50008-0

M Ponec

引用次数: 34

Integumental lipids of plants and animals: comparative function and biochemistry. 动植物被皮脂:比较功能与生物化学。

Advances in lipid research Pub Date : 1991-01-01 DOI: 10.1016/b978-0-12-024924-4.50014-6

N F Hadley

引用次数: 27

The regulation and role of epidermal lipid synthesis. 表皮脂质合成的调控及作用。

Advances in lipid research Pub Date : 1991-01-01 DOI: 10.1016/b978-0-12-024924-4.50007-9

K R Feingold

{"title":"The regulation and role of epidermal lipid synthesis.","authors":"K R Feingold","doi":"10.1016/b978-0-12-024924-4.50007-9","DOIUrl":"https://doi.org/10.1016/b978-0-12-024924-4.50007-9","url":null,"abstract":"<p><p>One of the key functions of the epidermis is to form a barrier between the organism and the outside world. As shown in Fig. 3, disruptions of the barrier result in a cascade of events that ultimately leads to barrier repair. The initial signal that initiates this repair response is unknown. The exocytosis of preformed lipid-enriched lamellar bodies is the first step in this response, which is followed by an increase in lipid synthesis in the epidermis. Our studies demonstrate that this increase in epidermal lipid synthesis is required for the synthesis of new lamellar bodies and repair of the barrier. Inhibition of epidermal lipid synthesis by artificial membranes or drugs impairs barrier recovery by preventing the reformation of lamellar bodies and the continued secretion of lipid. Whether the stimulation of lipid synthesis is primarily regulated by disturbances in barrier function or secondarily by decreases in the lipid content of the cells due to the utilization of lipid for the formation of lamellar bodies is unknown. Additionally, the precise mechanisms by which lipid synthesis is increased (enzyme activation, transcriptional regulation, etc.) remain to be elucidated. The secretion of lipid-containing lamellar bodies results in the reaccumulation of lipid in the intercellular spaces of the stratum corneum and the recovery of normal barrier function. Epidermal lipid synthesis also is probably required to provide lipid for new cell membrane formation to allow for the increase in epidermal cell proliferation, which is stimulated following barrier disruption. Additionally, epidermal lipid synthesis may provide regulatory molecules or crucial substrates that are required for DNA synthesis. Thus, epidermal lipid synthesis plays a key role in the major biological functions of the epidermis, the cutaneous permeability barrier, and cell proliferation.</p>","PeriodicalId":75444,"journal":{"name":"Advances in lipid research","volume":"24 ","pages":"57-82"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12927568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 178

Structural and lipid biochemical correlates of the epidermal permeability barrier. 表皮通透性屏障的结构和脂质生化相关。

Advances in lipid research Pub Date : 1991-01-01 DOI: 10.1016/b978-0-12-024924-4.50005-5

P M Elias, G K Menon

引用次数: 648

Epidermal vitamin D metabolism, function, and regulation. 表皮维生素D代谢、功能及调控。

Advances in lipid research Pub Date : 1991-01-01 DOI: 10.1016/b978-0-12-024924-4.50015-8

S Pillai, D D Bikle

引用次数: 16

Lipids in normal and pathological desquamation. 正常和病理性脱屑中的脂质。

Advances in lipid research Pub Date : 1991-01-01 DOI: 10.1016/b978-0-12-024924-4.50012-2

M L Williams

引用次数: 81