Advances in lipid research最新文献

Molecular approaches to studying the intracellular trafficking of glycosphingolipids. 研究鞘糖脂细胞内转运的分子方法。

Advances in lipid research Pub Date : 1993-01-01

W W Young

引用次数: 0

Sphingolipid-like molecule linked to CD45, a protein tyrosine phosphatase. 鞘脂样分子与CD45，一种蛋白酪氨酸磷酸酶相连。

Advances in lipid research Pub Date : 1993-01-01

A Takeda

引用次数: 0

Sphingomyelinases. Sphingomyelinases .

Advances in lipid research Pub Date : 1993-01-01

M W Spence

引用次数: 0

Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling. 神经节苷脂和鞘糖脂作为细胞生长、粘附和跨膜信号的调节剂。

Advances in lipid research Pub Date : 1993-01-01

S Hakomori, Y Igarashi

引用次数: 0

Gangliosides as receptors for bacterial enterotoxins. 神经节苷作为细菌肠毒素的受体。

Advances in lipid research Pub Date : 1993-01-01

P H Fishman, T Pacuszka, P A Orlandi

引用次数: 0

Neutral sphingomyelinase. 中性鞘磷脂酶。

Advances in lipid research Pub Date : 1993-01-01

S Chatterjee

{"title":"Neutral sphingomyelinase.","authors":"S Chatterjee","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although we have accumulated few data that would definitely designate the role of N-SMase in modern cell biology, current evidence indicates that N-SMase may play a central role in signal transduction (Fig. 7). Biomodulators such as hormones, antibiotics, drugs, growth factors, and lipoproteins may interact with N-SMase either directly or in combination with other components (receptors) on the cell surface. The cell surface topology would provide easy access for such interactions. According to our hypothetical model shown in Fig. 7, activation of N-SMase via biomodulators, e.g., TNF-alpha, leads to the mobilization of cell surface cholesterol to the interior of the cell. We speculate that this process may be facilitated by sterol carrier proteins. This phenomenon may alter the lipid bilayer and make N-SMase accessible to its substrate, sphingomyelin. Ceramide released as a consequence of N-SMase reaction would then carry out various biological phenomena, such as cell proliferation and differentiation. Cholesterol on the other hand, may undergo oxidation and inhibit HMG-CoA reductase activity; it may also be utilized by ACAT to form cholesteryl esters. A decrease in cell membrane cholesterol levels may stimulate LDL receptor activity and LDL receptor recycling and/or synthesis. In contrast, inactivation or decreased activity of N-SMase, as in the case of gentamicin-treated cells, may have the opposite effect, i.e., decreased LDL receptor activity and decreased cholesteryl ester synthesis. Thus, N-SMase may indirectly modulate cholesterol metabolism in cells independent of LDL. It can also modify LDL, allowing its rapid uptake and foam cell formation in macrophages. We can safely conclude that N-SMase action may be required to carry out a myriad of important cellular functions either directly or by cholesterol mobilization, or generation of ceramide, ceramide-1-phosphate, and sphingoid bases. The present data support the view that N-SMase action may initiate signal transduction for such biomodulators as growth factors, lipoprotein, and hormones.</p>","PeriodicalId":75444,"journal":{"name":"Advances in lipid research","volume":"26 ","pages":"25-48"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19365195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Verotoxins and their glycolipid receptors. 维罗毒素及其糖脂受体。

Advances in lipid research Pub Date : 1993-01-01

C A Lingwood

引用次数: 0

Protection by gangliosides against glutamate excitotoxicity. 神经节苷对谷氨酸兴奋毒性的保护作用。

Advances in lipid research Pub Date : 1993-01-01

H Manev, A Guidotti, E Costa

引用次数: 0

The sphingomyelin cycle: a prototypic sphingolipid signaling pathway. 鞘磷脂循环:一个典型的鞘脂信号通路。

Advances in lipid research Pub Date : 1993-01-01

Y A Hannun, R M Bell