Advances in lipid research最新文献_第2页

Bioactive gangliosides: differentiation inducers for hematopoietic cells and their mechanism(s) of actions. 生物活性神经节苷:造血细胞分化诱导剂及其作用机制。

Advances in lipid research Pub Date : 1993-01-01

M Saito

引用次数: 0

Fumonisins and other inhibitors of de novo sphingolipid biosynthesis. 伏马菌素和其他新生鞘脂生物合成抑制剂。

Advances in lipid research Pub Date : 1993-01-01

A H Merrill, E Wang, D G Gilchrist, R T Riley

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Extracellular sialidases. 细胞外唾液酸酶。

Advances in lipid research Pub Date : 1993-01-01

C C Sweeley

引用次数: 0

Glycosphingolipids of the invertebrata as exemplified by a cestode platyhelminth, Taenia crassiceps, and a dipteran insect, Calliphora vicina. 无脊椎动物的鞘糖脂，例如一种半纲扁形蠕虫，带绦虫，和一种双翅目昆虫，栉虫。

Advances in lipid research Pub Date : 1993-01-01

R D Dennis, H Wiegandt

引用次数: 0

Introduction: sphingolipids and their metabolites in cell regulation. 鞘脂及其代谢物在细胞中的调节作用。

Advances in lipid research Pub Date : 1993-01-01

A H Merrill, Y A Hannun, R M Bell

引用次数: 0

The role of sphingosine in cell growth regulation and transmembrane signaling. 鞘氨醇在细胞生长调控和跨膜信号传导中的作用。

Advances in lipid research Pub Date : 1993-01-01

S Spiegel, A Olivera, R O Carlson

引用次数: 0

Glycosphingolipid tumor antigens. 鞘糖脂肿瘤抗原。

Advances in lipid research Pub Date : 1993-01-01

P Fredman

{"title":"Glycosphingolipid tumor antigens.","authors":"P Fredman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tumor-associated glycosphingolipids are a common finding in human tumors, and monoclonal antibodies directed to defined carbohydrate epitopes of these structures have been developed. A majority of the glycosphingolipid antigens are of the lacto series, types 1 and 2, and these epitopes are often also found on glycoproteins. The tumor-associated gangliosides of the ganglio series, preferentially found in tumors of neuroectodermal origin, have binding epitopes that have not been detected in glycoproteins. A large number of monoclonal antibodies, mainly murine but some human, have been produced, and their epitope specificity defined. These antibodies have been used for investigation of the role of tumor-associated glycosphingolipids in tumor cells. Some antibodies have been shown to inhibit the growth of tumor cell lines in vitro and in vivo and to influence the adhesion properties of tumor cells, and some antibodies have been shown to give a clinical response. Tumor cell lines are commonly used in tumor biology studies, but the expression of tumor-associated glycosphingolipids in tumor cell lines does not always reflect their expression in the tumor tissue from which the cell line originates. The expression of tumor-associated glycosphingolipids has also been shown to be different in cells grown in vitro or as solid tumors in nude mice or rats. In conclusion, monoclonal antibodies specific for tumor-associated glycosphingolipids may be valuable tools in diagnosis and, in addition, in therapy, glycosphingolipids may also be used in active immunotherapy. The availability of these antibodies also opens the possibility of studying the biological function of glycosphingolipids and may then lead to new approaches for the improved diagnosis and therapy of human tumors.</p>","PeriodicalId":75444,"journal":{"name":"Advances in lipid research","volume":"25 ","pages":"213-34"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19354768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ganglioside metabolism--topology and regulation. 神经节苷脂代谢——拓扑和调控。

Advances in lipid research Pub Date : 1993-01-01

K Sandhoff, G van Echten

引用次数: 0

Developmental changes of glycosphingolipid composition of epithelia of rat digestive tract. 大鼠消化道上皮鞘糖脂组成的发育变化。

Advances in lipid research Pub Date : 1993-01-01

J F Bouhours, D Bouhours, G C Hansson

引用次数: 0

Sphingomyelinase D: a pathogenic agent produced by bacteria and arthropods. 鞘磷脂酶D:由细菌和节肢动物产生的致病菌。

Advances in lipid research Pub Date : 1993-01-01

A P Truett, L E King

引用次数: 0