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Advances in clinical pharmacology最新文献

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Relationship between adrenergic blocking and antihypertensive effects of beta receptor antagonists. 受体拮抗剂肾上腺素能阻断与降压作用的关系
Advances in clinical pharmacology Pub Date : 1976-01-01
K H Rahn
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引用次数: 0
The significance of beta1-beta2-selectivity and intrinsic sympathomimetic activity in beta-blockers, with particular reference to antihypertensive treatment. β受体阻滞剂β 1- β 2选择性和内在拟交感神经活性的意义，特别是在抗高血压治疗方面。
Advances in clinical pharmacology Pub Date : 1976-01-01
P Imhof
{"title":"The significance of beta1-beta2-selectivity and intrinsic sympathomimetic activity in beta-blockers, with particular reference to antihypertensive treatment.","authors":"P Imhof","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>From the findings described in the already fairly copious literature on antihypertensive therapy with beta-blockers, as well as on the basis of theoretical considerations, it may be concluded that neither cardio-selectivity nor intrinsic sympathomimetic activity is of decisive importance with regard to the blood-pressure-lowering action of these these compounds. As far as hypotensive potency alone is concerned, none of the known beta-blocking agents is fundamentally superior to the others. There are, however, considerable differences between them in respect of their safety in use, tolerability and side effects, and during long-term treatment especially these must be taken into account.</p>","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"11 ","pages":"26-32"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11249274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hemodynamic long-term effects of a beta-receptor blockader (Pindolol) in primary essential hypertension]. [β受体阻滞剂(品多洛尔)对原发性原发性高血压的长期血流动力学影响]。
Advances in clinical pharmacology Pub Date : 1976-01-01
W W Klein, D Brandt, N Fluch, R Goebel, H Holzer, G Pöch
{"title":"[Hemodynamic long-term effects of a beta-receptor blockader (Pindolol) in primary essential hypertension].","authors":"W W Klein,&nbsp;D Brandt,&nbsp;N Fluch,&nbsp;R Goebel,&nbsp;H Holzer,&nbsp;G Pöch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>1. Pindolol lowers blood pressure both, immediately after administration by a reduction of cardiac output and heart rate and after long-term administration by reducing peripheral resistance. Cardiac index, initially decreased, reached the control value after 8 weeks of treatment. 2. The persistent reduction in heart rate and increase of the cardiac index during exercise after prolonged treatment together with the increase of right and left heart filling pressures seems to be due to augmentation of the Starling mechanism. The increase of the stroke volume at rest and during exercise diminished the blood-pressure lowering effect of the drug. 4. The exercise-induced increase of noradrenalin was abolished by acute administration of pindolol. After long-term treatment, however, we found a consistent and significant elevation of the plasma-catecholamines. This may reflect the development of heart failure [1], a tyramin- or cocain-like action of pindolol [2] or an indirect sympathicomimetic effect of this drug at low doses (10--15 mg/day orally ) [3]. 5. The elevation of plasma-noradrenalin reflects increased sympathetic tone and may be responsible for the increase in stroke volume and plasma renin activity observed by several authors. 6. Since there was no evidence for a hemodynamic mode of action, the lowering of blood rpessure by pindolol may be a central effect.</p>","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"11 ","pages":"79-85"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies with a new cardioselective beta-blocker, metoprolol. 一种新的心脏选择性受体阻滞剂美托洛尔的研究。
Advances in clinical pharmacology Pub Date : 1976-01-01
L Werkö, M Aurell, G Johnsson, R Sannerstedt, N Svedmyr
{"title":"Studies with a new cardioselective beta-blocker, metoprolol.","authors":"L Werkö,&nbsp;M Aurell,&nbsp;G Johnsson,&nbsp;R Sannerstedt,&nbsp;N Svedmyr","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>These studies indicate that the cardioselective beta-adrenergic blocking drug metoprolol might be expected to be at least as effective for the treatment of arterial hypertension as propranolol. The difference in effect on the peripheral vascular bed may be of importance when acute increase of the blood adrenaline level occur, as in severe anxiety states. Experience in long-term studies in all kinds of patients with raised arterial pressure has confirmed that metoprolol is an active antihypertensive agent of similar potency to other beta-blocking agents.</p>","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"11 ","pages":"19-25"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hemodynamics following a 14-day propranolol therapy]. [14天心得安治疗后的血流动力学]。
Advances in clinical pharmacology Pub Date : 1976-01-01
J Bonelli, D Magometschnigg, G Hitzenberger, A Korn
{"title":"[Hemodynamics following a 14-day propranolol therapy].","authors":"J Bonelli,&nbsp;D Magometschnigg,&nbsp;G Hitzenberger,&nbsp;A Korn","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"11 ","pages":"87-93"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The combined effect of propranolol with bethanidine or methyldopa in hypertension. 心得安与伯他啶或甲基多巴联合治疗高血压的疗效观察。
Advances in clinical pharmacology Pub Date : 1976-01-01
B N Prichard
{"title":"The combined effect of propranolol with bethanidine or methyldopa in hypertension.","authors":"B N Prichard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"11 ","pages":"107-13"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12212721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Renin and age, determinants of the beta-blocker effect in essential hypertension]. [肾素和年龄:原发性高血压β受体阻滞剂作用的决定因素]。
Advances in clinical pharmacology Pub Date : 1976-01-01
F R Bühler
{"title":"[Renin and age, determinants of the beta-blocker effect in essential hypertension].","authors":"F R Bühler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"11 ","pages":"42-53"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11249275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Blood pressure, renin, angiotension II and catecholamines in the plasma of healthy subjects and patients with essential hypertension before and after beta blockade]. [β阻断前后健康人及原发性高血压患者血浆血压、肾素、血管紧张素II和儿茶酚胺的变化]。
Advances in clinical pharmacology Pub Date : 1976-01-01
J Schuchard, W Wober, H Dahlheim, K Thurau, H Lydtin
{"title":"[Blood pressure, renin, angiotension II and catecholamines in the plasma of healthy subjects and patients with essential hypertension before and after beta blockade].","authors":"J Schuchard,&nbsp;W Wober,&nbsp;H Dahlheim,&nbsp;K Thurau,&nbsp;H Lydtin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"11 ","pages":"61-5"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11249276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro antibacterial activity of amoxicillin alone and in combination with other antibiotics. 阿莫西林单用及与其他抗生素联用的体外抗菌活性。
Advances in clinical pharmacology Pub Date : 1974-01-01
R Sutherland
{"title":"In vitro antibacterial activity of amoxicillin alone and in combination with other antibiotics.","authors":"R Sutherland","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"7 ","pages":"7-15"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15572478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The clinical effects of amoxicillin in the management of chronic bronchitis]. 阿莫西林治疗慢性支气管炎的临床疗效分析。
Advances in clinical pharmacology Pub Date : 1974-01-01
H Bürgi
{"title":"[The clinical effects of amoxicillin in the management of chronic bronchitis].","authors":"H Bürgi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"7 ","pages":"91-3"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15572480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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