The significance of beta1-beta2-selectivity and intrinsic sympathomimetic activity in beta-blockers, with particular reference to antihypertensive treatment.

Abstract

From the findings described in the already fairly copious literature on antihypertensive therapy with beta-blockers, as well as on the basis of theoretical considerations, it may be concluded that neither cardio-selectivity nor intrinsic sympathomimetic activity is of decisive importance with regard to the blood-pressure-lowering action of these these compounds. As far as hypotensive potency alone is concerned, none of the known beta-blocking agents is fundamentally superior to the others. There are, however, considerable differences between them in respect of their safety in use, tolerability and side effects, and during long-term treatment especially these must be taken into account.