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Advances in clinical pharmacology最新文献

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[The effect of mexiletine, ajmaline and aprindine on ventricular arrhythmias]. 美西汀、ajmaline和aprindine对室性心律失常的影响。
Advances in clinical pharmacology Pub Date : 1978-01-01
H Pozenel
{"title":"[The effect of mexiletine, ajmaline and aprindine on ventricular arrhythmias].","authors":"H Pozenel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"16 ","pages":"125-37"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11566004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pharmacokinetic studies with mexiletine in patients with renal insufficiency]. [美西汀在肾功能不全患者中的药代动力学研究]。
Advances in clinical pharmacology Pub Date : 1978-01-01
W Herbinger, R Kramar, M Fridrik, V Häselbarth, W P Pollmann
{"title":"[Pharmacokinetic studies with mexiletine in patients with renal insufficiency].","authors":"W Herbinger, R Kramar, M Fridrik, V Häselbarth, W P Pollmann","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"16 ","pages":"17-27"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11886835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Microbiology and pharmacokinetics of gentamicin, sisomicin, netilmicin and amikacin]. [庆大霉素、西索霉素、奈替米星和阿米卡星的微生物学和药代动力学]。
Advances in clinical pharmacology Pub Date : 1978-01-01
P Naumann, H Rosin
{"title":"[Microbiology and pharmacokinetics of gentamicin, sisomicin, netilmicin and amikacin].","authors":"P Naumann, H Rosin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"15 ","pages":"23-34"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11877976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Modern anti-arrhythmia agents with special regard to potassium metabolism]. [现代抗心律失常药物，特别是钾代谢]。
Advances in clinical pharmacology Pub Date : 1978-01-01
W Gaube, W Griendl
{"title":"[Modern anti-arrhythmia agents with special regard to potassium metabolism].","authors":"W Gaube, W Griendl","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"16 ","pages":"139-61"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11301375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical pharmacology of adrenergic beta receptor blockade with sotalol (MJ 1999)]. 索他洛尔阻断肾上腺素能受体的临床药理学研究[j]。
Advances in clinical pharmacology Pub Date : 1978-01-01
K Schnelle
{"title":"[Clinical pharmacology of adrenergic beta receptor blockade with sotalol (MJ 1999)].","authors":"K Schnelle","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"18 ","pages":"1-111"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11428627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Microbiological aspects of new aminoglycoside antibiotics]. [新型氨基糖苷类抗生素的微生物学研究]。
Advances in clinical pharmacology Pub Date : 1978-01-01
H Knothe
{"title":"[Microbiological aspects of new aminoglycoside antibiotics].","authors":"H Knothe","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"15 ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11877967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of aminoglycosides on the proximal tubules in man]. 氨基糖苷类药物对人体近端小管的影响。
Advances in clinical pharmacology Pub Date : 1978-01-01
A W Mondorf, J Breier, M Zegelman, H Müller
{"title":"[The effect of aminoglycosides on the proximal tubules in man].","authors":"A W Mondorf, J Breier, M Zegelman, H Müller","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"15 ","pages":"101-10"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11877968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The question of ototoxicity of gentamycin therapy in children]. [儿童庆大霉素治疗的耳毒性问题]。
Advances in clinical pharmacology Pub Date : 1978-01-01
J Innitzer, G Moser, A Rosenkranz
{"title":"[The question of ototoxicity of gentamycin therapy in children].","authors":"J Innitzer, G Moser, A Rosenkranz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"15 ","pages":"149-55"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11877974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pharmacologic studies or aminoglycoside antibiotics (amikacin, gentamicin, sisomicin, tobramycin)]. [氨基糖苷类抗生素(阿米卡星、庆大霉素、西索霉素、妥布霉素)的药理学研究]。
Advances in clinical pharmacology Pub Date : 1978-01-01
H Lode, K Grunert, B Kemmerich, P Koeppe
{"title":"[Pharmacologic studies or aminoglycoside antibiotics (amikacin, gentamicin, sisomicin, tobramycin)].","authors":"H Lode,&nbsp;K Grunert,&nbsp;B Kemmerich,&nbsp;P Koeppe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a randomized study of 12 healthy subjects, the pharmacokinetics of gentamicin, sisomicin and tobramycin were determined after a one-hour infusion of each drug (1.0 mg/kg body-weight). There were no pharmacokinetic differences of therapeutic significance between the three drugs. The mean serum concentrations at the end of infusion were 3.85 microgram/ml for gentamicin and 4.66 microgram/ml for sisomicin, falling to 0.12 and 0.26 microgram/ml, respectively, after eight hours. The biological half-life varied between 96 and 122 min and the apparent volumes of distribution corresponded closely to the size of the extracellular space.--The pharmacokinetic data of amikacin were determined after a one-hour constant infusion, the mean amikacin serum concentration was 37.5 microgram/ml and, 8 hours later, decreased to an average of 1.3 microgram/ml. The biological half-life amounted to a mean of 114.2 +/- 16.7 min, and the apparent volume of distribution could be calculated with 18.1 +/- 1.81/100 kg body weight.</p>","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"15 ","pages":"35-44"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11877977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparative studies on the nephrotoxicity of aminoglycoside antibiotics using renal enzyme elimination in rats as a model]. [以肾酶消除模型大鼠氨基糖苷类抗生素肾毒性的比较研究]。
Advances in clinical pharmacology Pub Date : 1978-01-01
W Raab
{"title":"[Comparative studies on the nephrotoxicity of aminoglycoside antibiotics using renal enzyme elimination in rats as a model].","authors":"W Raab","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Determinations of renal enzyme excretion in rats inform on the relative nephrotoxicity of drugs. The data obtained in such studies are of clinical relevance. For the screening of new aminoglycosides, the renal enzyme excretion technique is a rather simple, but valuable model. New compounds can easily be compared to well-known ones about which clinical cata are available already.--Comparative investigations with netilmicin, a semi-synthetic sisomicin derivative, and with gentamicin are reported. Netilmicin in three different doses provoked significantly less increase in urinary alkaline phosphatase and \"leucine aminopeptidase\" activities.</p>","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"15 ","pages":"91-7"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11877979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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