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[Utilization of chromosomal markers in cancer research]. 染色体标记物在癌症研究中的应用
Acta zoologica et pathologica Antverpiensia Pub Date : 1979-06-01
J R Maisin, A Leonard
{"title":"[Utilization of chromosomal markers in cancer research].","authors":"J R Maisin,&nbsp;A Leonard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The mouse is an unsuitable species for cytogenetical studies to the extent that it has 40 acrocentric chromosomes and the only criterion which could be used to differentiate them is size. We envisaged using in the case of cell grafts donors or recipients of different sex. This technique has, however, been used to a limited extent. Among the other markers which have been utilized, T6T6 of CBA mice must be mentioned. The discovery in 1966 by Léonard and Dekundt of the presence in AKR mice of fusions of the Robertson type (between chromosomes 6 and 15) has generated new interest in experimental work based on the utilisation of chromosome markers. Being interested in the mechanisms of radio-induced leukemia, the authors described how they have introduced the chromosome marker of AKR mice into the C57B1 strain which is very sensitive to the induction of radio-induced leukemias.</p>","PeriodicalId":75428,"journal":{"name":"Acta zoologica et pathologica Antverpiensia","volume":" 72","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"1979-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11700012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Types and quality of animals in cancer research. 癌症研究中动物的种类和质量。
Acta zoologica et pathologica Antverpiensia Pub Date : 1979-06-01
H A Solleveld
{"title":"Types and quality of animals in cancer research.","authors":"H A Solleveld","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In addition to studies in man, animal models may serve as important tools in the detection of the etiology, biology and treatment of certain types of human cancers. Various models have become available by performing life span studies on 2 rat strains, viz WAG/Rij, BN/Bi and (WAG x BN) F1 hybrid and on Praomys natalensis. Several of these models are described. A basic prerequisite for these types of studies is the availability of animals of good quality. After a general description of the quality of laboratory animals the desirable health status of animals in cancer research is discussed.</p>","PeriodicalId":75428,"journal":{"name":"Acta zoologica et pathologica Antverpiensia","volume":" 72","pages":"5-18"},"PeriodicalIF":0.0,"publicationDate":"1979-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11700013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Transplantable carcinoma of the large intestine in BD IX rats: a new model for study of metastatic dissemination and experimental therapeutics]. [BD IX大鼠可移植性大肠癌:转移扩散和实验治疗研究的新模型]。
Acta zoologica et pathologica Antverpiensia Pub Date : 1979-06-01
P Mendes da Costa, V Defleur, F J Lejeune
{"title":"[Transplantable carcinoma of the large intestine in BD IX rats: a new model for study of metastatic dissemination and experimental therapeutics].","authors":"P Mendes da Costa,&nbsp;V Defleur,&nbsp;F J Lejeune","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Using cells in culture of a large intestine carcinoma by the rat BD IX, the authors have produced 5 experimental models of metastases: subcutane, of the lung, the liver and the peritoneum. These metastases have the same properties as the primitive tumor. These four models have the originality to be metastases of a large intestine carcinoma chemically induced in the rat representing situations frequently encountered in human cancerology in the case of generalised cancer. These models allow immunotherapy, immunoprophylaxis, chimotherapy, angiotherapy and biochemical studies and to test the effects of certain substances such as the anticoagulants.</p>","PeriodicalId":75428,"journal":{"name":"Acta zoologica et pathologica Antverpiensia","volume":" 72","pages":"65-76"},"PeriodicalIF":0.0,"publicationDate":"1979-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11700015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induction of malignant and benign tumors with embryonic tissues. 胚胎组织诱导恶性和良性肿瘤。
Acta zoologica et pathologica Antverpiensia Pub Date : 1979-06-01
H Sobis
{"title":"Induction of malignant and benign tumors with embryonic tissues.","authors":"H Sobis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The inoculation of viruses into the placenta of fetectomized rats induces the development of malignant tumors from extraembryonic fetal membranes. The same membrane--visceral yolk sac--gives rise to benign teratomas if displaced outside the uterus after fetectomy. Moreover, the transplantation of 3 to 7 day old embroys under the kidney capsule of adult mice gives rise of malignant teratocarcinoma. The methods to induction of these tumors are described.</p>","PeriodicalId":75428,"journal":{"name":"Acta zoologica et pathologica Antverpiensia","volume":" 72","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"1979-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11700016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[An animal model for tumors of the large intestine]. 大肠肿瘤的动物模型。
Acta zoologica et pathologica Antverpiensia Pub Date : 1979-06-01
A P Maskens
{"title":"[An animal model for tumors of the large intestine].","authors":"A P Maskens","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dimethylhydrazine (DMH) and its derivatives induced in many animal species tumors of the large intestine with a great specificity and reproductibility. Oour personal observations using rats BD IX injected weekly with DMH are summarized in this presentation. The induced tumors appear as invaded tumors already at the microscopic stade. Their growth is best described by a Gompertz function. The number of induced tumors increases with time as a non linear function. This model is very useful for the study of the biology of human tumors with a low development.</p>","PeriodicalId":75428,"journal":{"name":"Acta zoologica et pathologica Antverpiensia","volume":" 72","pages":"53-64"},"PeriodicalIF":0.0,"publicationDate":"1979-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11700014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Methods of identifying carcinogenic factors in medication, food and cosmetics]. 【药品、食品、化妆品中致癌因素的鉴别方法】。
Acta zoologica et pathologica Antverpiensia Pub Date : 1979-06-01
L Griciute
{"title":"[Methods of identifying carcinogenic factors in medication, food and cosmetics].","authors":"L Griciute","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The removal of carconogenic factors would be a most efficient measure to prevent cancer. As far as known chemicals are concerned, every effort is made to avert them, or at least to reduce the exposure to such compounds, but is necessary to detect unknown chemicals, especially those, drugs and foodstuffs for example, to which large populations are exposed. Giving suspected chemicals to laboratory animals is a standard carcinogenicity test. Studies of the carcinogenicity of unknown chemicals in animals are time consuming, expensive and cumbersome. This is why other means of establishing carcinogenicity are sought for. Several rapid tests are available to-day to select suspected carcinogens. These methods aim primarily at determining with chemicals--at the cell or tissue level--certain changes that would appear essential to trigger the carcinogenic process, such as somatic mutations. Studies are used on the mutagenicity of chemicals for bacteria of the Salmonella type, for yeast and cultured mammalian cells, together with the induction of recessive lethal mutations in Drosophila and of the unscheduled repair synthesis of DNA and the transformation of mammalian cells in vitro. Although there is an unequivocal correlation between the activity of chemicals in such tests and their carcinogenicity, discrepancies are found. Thus, the in vivo tests on laboratory animals remain the most reliable method to determine carcinogenicity. Whereas direct extrapolation of experimental data to human pathology is impossible, the experimental evidence of the carcinogenicity of any chemical should allow us to draw constructive conclusions. We shall never be able to reject drugs which produce the expected results and cannot be replaced by other drugs. But we can must the drugs whose beneficial effects are not exceptional and which can be replaced by other chemicals. As for the chemicals used in food additives and cosmetics, and recognized as carcinogenic in animals, they should be totally given up. Any decision made should be based on animal studies.</p>","PeriodicalId":75428,"journal":{"name":"Acta zoologica et pathologica Antverpiensia","volume":" 72","pages":"19-34"},"PeriodicalIF":0.0,"publicationDate":"1979-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11700225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cryptococcus neoformans (Sanfelice) Vuillemin 1894 and the epidemiology of cryptococcosis]. [新型隐球菌(Sanfelice) Vuillemin 1894与隐球菌病的流行病学]。
Acta zoologica et pathologica Antverpiensia Pub Date : 1979-01-01
D Swinne
{"title":"[Cryptococcus neoformans (Sanfelice) Vuillemin 1894 and the epidemiology of cryptococcosis].","authors":"D Swinne","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75428,"journal":{"name":"Acta zoologica et pathologica Antverpiensia","volume":" 74","pages":"5-134"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11593324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemotherapy of helminthiasis among wild mammals. IV. Efficacy of flubendazole 5% (R17889) against Trichuris trichiura infection of baboons, Papio hamadryas L. 野生哺乳动物蛔虫病的化疗。四、5%氟苯达唑(R17889)对狒狒毛癣菌感染的防治效果。
Acta zoologica et pathologica Antverpiensia Pub Date : 1978-11-01
V Kumar, F Ceulemans, W De Meurichy
{"title":"Chemotherapy of helminthiasis among wild mammals. IV. Efficacy of flubendazole 5% (R17889) against Trichuris trichiura infection of baboons, Papio hamadryas L.","authors":"V Kumar,&nbsp;F Ceulemans,&nbsp;W De Meurichy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Flubendazole 5%, a parafluor analog of benzimidazole derivative, mebendazole, was found efficient in eliminating Trichuris trichiura infection of baboons when administered orally at a dose rate of 27 to 50 mg of the active ingredient per kg body weight twice daily for five days. The drug was found safe, without toxic effects and its palatability was excellent.</p>","PeriodicalId":75428,"journal":{"name":"Acta zoologica et pathologica Antverpiensia","volume":" 73","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"1978-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11955800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International okapi symposium, Antwerp, 25-27 August 1977. 国际霍加皮研讨会，安特卫普，1977年8月25-27日。
Acta zoologica et pathologica Antverpiensia Pub Date : 1978-03-01
{"title":"International okapi symposium, Antwerp, 25-27 August 1977.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75428,"journal":{"name":"Acta zoologica et pathologica Antverpiensia","volume":" 71","pages":"1-134"},"PeriodicalIF":0.0,"publicationDate":"1978-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11955613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anaesthesia in okapis. 霍加狓的麻醉。
Acta zoologica et pathologica Antverpiensia Pub Date : 1978-03-01
J Mortelmans
{"title":"Anaesthesia in okapis.","authors":"J Mortelmans","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75428,"journal":{"name":"Acta zoologica et pathologica Antverpiensia","volume":" 71","pages":"41-4"},"PeriodicalIF":0.0,"publicationDate":"1978-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11955616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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