[Transplantable carcinoma of the large intestine in BD IX rats: a new model for study of metastatic dissemination and experimental therapeutics].

Abstract

Using cells in culture of a large intestine carcinoma by the rat BD IX, the authors have produced 5 experimental models of metastases: subcutane, of the lung, the liver and the peritoneum. These metastases have the same properties as the primitive tumor. These four models have the originality to be metastases of a large intestine carcinoma chemically induced in the rat representing situations frequently encountered in human cancerology in the case of generalised cancer. These models allow immunotherapy, immunoprophylaxis, chimotherapy, angiotherapy and biochemical studies and to test the effects of certain substances such as the anticoagulants.