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[Behavior of blood folate in children with thalassemia major under transfusion therapy and in thalassemia trait]. 输血治疗对地中海贫血儿童血叶酸的影响[j]。
Acta vitaminologica et enzymologica Pub Date : 1984-01-01
P C Castagna, F Fedeli, A M Fusco, L Montani, F Radaelli, R Tartara
{"title":"[Behavior of blood folate in children with thalassemia major under transfusion therapy and in thalassemia trait].","authors":"P C Castagna,&nbsp;F Fedeli,&nbsp;A M Fusco,&nbsp;L Montani,&nbsp;F Radaelli,&nbsp;R Tartara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The folic acid plasma level in 12 out of 13 children with thalassemia major was lower than 3 ng/ml. This deficiency is not due to intestinal malabsorption. Folate deficiency should then be provoked by an increased allowance due to the compensatory erythropoiesis and to the lack of. Folic acid level less then 3 ng/ml in 24% and not more then 6 ng/ml in 50% of thalassemic heterozygotic children has been found. Therefore the necessity of folic acid treatment in thalassemic children with a low blood transfusional therapy and in beta-thalassemic heterozygotic children has been recommended.</p>","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17581117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The metabolism of [3H] pteroylglutamic acid in rat liver during regeneration after partial hepatectomy. 大鼠肝部分切除后肝脏再生过程中[3H]翼酰谷氨酸的代谢。
Acta vitaminologica et enzymologica Pub Date : 1984-01-01
C Bovina, G Formiggini, B Tolomelli, M Marchetti
{"title":"The metabolism of [3H] pteroylglutamic acid in rat liver during regeneration after partial hepatectomy.","authors":"C Bovina,&nbsp;G Formiggini,&nbsp;B Tolomelli,&nbsp;M Marchetti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The rate of [3H] PteGlu uptake and of its incorporation into pteroylpolyglutamate derivatives at different times after label administration, was studied in the regenerating liver of rats 36 hr after partial hepatectomy. While 1 hr after administration of labelled PteGlu the radioactivity levels in regenerating livers are quite similar to controls, they are markedly higher 6, 12, 24 hr after label injection, which is mostly due to the high polyglutamate content. If the regenerating process, on the one hand does not modify the folate uptake rate, it does, on the other, increase the capacity for retaining folates, thanks to a more powerful ability to convert them into pteroylpolyglutamates.</p>","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17590334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of different vitamin D treatments on serum vitamin D levels in early postmenopausal women. 不同维生素D治疗对早期绝经后妇女血清维生素D水平的影响。
Acta vitaminologica et enzymologica Pub Date : 1984-01-01
B Riis, C Christiansen, P Rodbro
{"title":"The effect of different vitamin D treatments on serum vitamin D levels in early postmenopausal women.","authors":"B Riis,&nbsp;C Christiansen,&nbsp;P Rodbro","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of vitamin D3 and 1,25 (OH)2D3 or l alpha-OHD3 on vitamin D metabolism were studied in a 12 month placebo controlled clinical study. 29 healthy women in their early menopause were randomized for treatment with either vitamin D3 (2000 IU/day, or 1,25(OH)2D3/l alpha-OHD3(0.25 micrograms/day), or placebo for 12 months. All participants were given a calcium supplement of 0.5 g/day throughout the study. Serum and urinary calcium increased in both vitamin D groups, whereas the posttreatment values in the placebo group were exactly the same as before treatment. Changes in the vitamin D metabolites only occurred in the vitamin D3 group, where 24,25(OH)2D and 25OHD3 were significantly increased, whereas the serum concentration of 1,25(OH)2D was unchanged. In the 1,25(OH)2D3/l alpha-OHD3 group no change in the serum vitamin D was found. The present data indicate that 1,25(OH)2D is subject to a tight feedback regulation; that 1,25(OH)2D is not the only vitamin D metabolite responsible for calcium absorption from the gut, and that 1,25(OH)2D given in physiological doses does not alter the metabolism of the other vitamin D metabolites.</p>","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17160593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Separate determination of anticoccidial thiamine analogs by high-performance liquid chromatography. 高效液相色谱法分离测定抗球虫硫胺素类似物。
Acta vitaminologica et enzymologica Pub Date : 1984-01-01
K Nosaka, H Nishimura, A Iwashima
{"title":"Separate determination of anticoccidial thiamine analogs by high-performance liquid chromatography.","authors":"K Nosaka,&nbsp;H Nishimura,&nbsp;A Iwashima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The separate determination of anticoccidial thiamine analogs such as chloroethylthiamine and dimethialium, and thiamine was achieved by reversed-phase high-performance liquid chromatography after conversion to the corresponding thiochromes by alkaline oxidation. Using this method, it was demonstrated that chloroethylthiamine is accumulated in nonproliferating cells of Saccharomyces cerevisiae by the same transport mechanism as for thiamine and dimethialium.</p>","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17448303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purification and some properties of a thermostable alpha-amylase from Bacillus apiarius CBML 152. 蜜蜂芽孢杆菌CBML 152中耐热α -淀粉酶的纯化及其性质研究。
Acta vitaminologica et enzymologica Pub Date : 1984-01-01
S B Ghosh, A K Chandra
{"title":"Purification and some properties of a thermostable alpha-amylase from Bacillus apiarius CBML 152.","authors":"S B Ghosh,&nbsp;A K Chandra","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A thermostable alpha-amylase was purified from Bacillus apiarius CBML 152 by ethanol precipitation, starchamylase complex formation and by ion-exchange chromatography using DEAE-cellulose at pH 8.6, eluted with 0.2 to 0.3 M NaCl in the starting buffer (0.5 M tris-HCl, pH 8.6). The purified enzyme was homogeneous in polyacrylamide gel electrophoresis. The molecular weight of the enzyme was found to be about 65,000 dalton by gel electrophoresis in the presence of SDS. Characteristically the enzyme was an acidic protein, highly pH stable and thermostable, retaining 100% activity after being exposed to 60 degrees C for 1 hr and to pH 6.0-9.0 for 48 hr. Some divalent cations, as Ca2+, Fe2+, Mn2+ and Zn2+, stimulated the enzyme activity at different molar concentrations.</p>","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17396017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transient lipoprotein deficiency at birth: a cause of low levels of vitamin E in the newborn. 出生时短暂性脂蛋白缺乏:新生儿维生素E水平低的原因。
Acta vitaminologica et enzymologica Pub Date : 1984-01-01
I D Desai, F E Martinez, J E Dos Santos, J E Dutra de Oliveria
{"title":"Transient lipoprotein deficiency at birth: a cause of low levels of vitamin E in the newborn.","authors":"I D Desai,&nbsp;F E Martinez,&nbsp;J E Dos Santos,&nbsp;J E Dutra de Oliveria","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In newborns, the level of vitamin E in blood is very low as compared to that of placental intervillous blood and maternal blood. In our attempt to investigate the role of placenta in the transfer of vitamin E from the maternal to the newborn circulation, we have discovered that vitamin E is able to enter placental blood but is not being efficiently transferred from the placental to the newborn circulation. It appears from our preliminary study that the most limiting factor in the transfer of vitamin E from the placental to the newborn circulation is the transient deficiency of prebeta lipoprotein in the newborn blood at birth. A transient lipoprotein deficiency is implicated as a cause of low levels of vitamin E in the newborn.</p>","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17553891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ascorbic acid supplementation and five year survival rates in women with early breast cancer. 抗坏血酸补充与早期乳腺癌妇女的5年生存率。
Acta vitaminologica et enzymologica Pub Date : 1984-01-01
J M Poulter, W F White, J W Dickerson
{"title":"Ascorbic acid supplementation and five year survival rates in women with early breast cancer.","authors":"J M Poulter,&nbsp;W F White,&nbsp;J W Dickerson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of long term ascorbic acid (AA) supplementation (3g per day) on 27 women with early breast cancer has been investigated. For comparison a similar but limited study was carried out in patients with benign breast disease. The responses of leucocyte levels of AA to supplementation provided some evidence to suggest that the metabolism and utilisation of the vitamin may be different in these patients. In addition longitudinal measurements of urinary hydroxyproline/creatinine (OHPro/Cr) ratio were carried out in these patients. The long term ingestion of AA did not appear to affect the prognosis of the disease in the early breast cancer group. Similar 5 year survival rates were seen in the unsupplemented and supplemented cancer groups.</p>","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17581116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of provitamin A carotenoids in reversing vitamin A deficiency induced lesions in brain lipids of chicks. 维生素A原类胡萝卜素对逆转维生素A缺乏引起的雏鸡脑脂质损伤的作用。
Acta vitaminologica et enzymologica Pub Date : 1984-01-01
N Srivastava, K C Goyal, Y K Sharma, U K Misra
{"title":"Efficacy of provitamin A carotenoids in reversing vitamin A deficiency induced lesions in brain lipids of chicks.","authors":"N Srivastava,&nbsp;K C Goyal,&nbsp;Y K Sharma,&nbsp;U K Misra","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17581121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Use of preparations of group B vitamins also at high dosage and by the parenteral route in a population of hospitalized patients]. [B族维生素制剂在住院病人中的高剂量和肠外应用]。
Acta vitaminologica et enzymologica Pub Date : 1984-01-01
V Paoletti, P Strazzera, V Katsarou, A Mammarella, M Barlattani
{"title":"[Use of preparations of group B vitamins also at high dosage and by the parenteral route in a population of hospitalized patients].","authors":"V Paoletti,&nbsp;P Strazzera,&nbsp;V Katsarou,&nbsp;A Mammarella,&nbsp;M Barlattani","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17590201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thiamin absorption by small intestine. 小肠对硫胺素的吸收
Acta vitaminologica et enzymologica Pub Date : 1984-01-01
G Rindi
{"title":"Thiamin absorption by small intestine.","authors":"G Rindi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In different animal species, including man, thiamin is absorbed in vivo from the small intestine by means of two mechanism: at low intraluminal concentrations (less than 1.5 microM), absorption shows a saturation kinetics; at higher concentrations, passive transport (diffusion) takes place. The absorption is maximal in the duodenum, its rate decreasing caudally along the small intestine. In vitro at low concentrations, the transcellular transport system of thiamin shows the following general features: it takes place against a chemical concentration gradient, is easily saturable (Km = 0.16-0.63 microM; Vmax = 5.2 mumol X g-1 X h-1), is blocked by cellular metabolic inhibitors, anoxia, low temperature and thiamin structural analogues. It is Na+-dependent and operates mainly from mucosa to serosa. In contrast, distinctive features of the thiamin transfer are the following: entry in the enterocyte in the free form (sodium-independent); pyrophosphorylation by means of a cytoplasm thiamin-pyrophosphokinase; the dephosphorylation of thiamin-pyrophosphate by means of particulate intracellular phosphatases; the cellular exit mainly in the free form, through the action of the controluminal Na-K activated ATPase. A working scheme for thiamin intestinal transport is proposed and discussed.</p>","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17521958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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