Acta pathologica japonica最新文献_第3页

alpha-Fetoprotein producing gastric carcinomas: a comparative study of three different subtypes. 产生甲胎蛋白的胃癌:三种不同亚型的比较研究。

Acta pathologica japonica Pub Date : 1993-11-01 DOI: 10.1111/j.1440-1827.1993.tb02549.x

T Motoyama, K Aizawa, H Watanabe, M Fukase, K Saito

引用次数: 107

Three-dimensional structural changes of hepatic sinusoids in cirrhosis providing an increase in vascular resistance of portal hypertension. 肝硬化肝窦三维结构改变，门静脉高压症血管阻力增加。

Acta pathologica japonica Pub Date : 1993-11-01 DOI: 10.1111/j.1440-1827.1993.tb02546.x

H Shimizu, T Yokoyama

{"title":"Three-dimensional structural changes of hepatic sinusoids in cirrhosis providing an increase in vascular resistance of portal hypertension.","authors":"H Shimizu, T Yokoyama","doi":"10.1111/j.1440-1827.1993.tb02546.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb02546.x","url":null,"abstract":"A quantitative topological analysis of the three-dimensional sinusoidal structure of five normal human livers and ten cirrhotic livers was performed with the aid of a computer system for reconstruction from serial tissue sections. The mean cycle rank (number of independent cycles) of the sinusoidal network in the examined tissue, 200 x 200 x 80 microns 3 in size, was 181.2 +/- 23.9 in the normal liver and 84.9 +/- 19.1 in the cirrhotic liver. There was a statistically significant difference between the two values (P < 0.001), while there was no significant difference in the sinusoidal volume of the same size tissue between the normal liver and cirrhotic liver. It was found therefore that the sinusoidal network of the cirrhotic liver was more sparsely and coarsely connected in three-dimensional space than that of the normal liver. In addition, there was no significant difference in the mean sinusoidal radius or in the distribution of 1/(radius)4 values between the normal liver and the cirrhotic liver. Resistance changes of the lattice sinusoidal model, where resistance of each sinusoidal branch is proportional only to its length, were then studied. In the lattice model analysis, the resistance between the two endpoints becomes larger as the cycle rank of the network model decreases. This fact suggests that in portal hypertension of cirrhosis the three-dimensional structural change of sinusoids, that is, decrease in the cycle rank, plays a role of increased vascular resistance within regenerative nodules.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 11","pages":"625-34"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb02546.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19297023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Mixed mesodermal tumor of the ovary: immunohistochemical study with histogenetic consideration. 卵巢混合性中胚层肿瘤:免疫组化及组织遗传学研究。

Acta pathologica japonica Pub Date : 1993-11-01 DOI: 10.1111/j.1440-1827.1993.tb02555.x

R Haba, S Kobayashi, H Miki, E Hirakawa, S Mori, M Ohmori, T Handou, A Shiota, Y Ishii

{"title":"Mixed mesodermal tumor of the ovary: immunohistochemical study with histogenetic consideration.","authors":"R Haba, S Kobayashi, H Miki, E Hirakawa, S Mori, M Ohmori, T Handou, A Shiota, Y Ishii","doi":"10.1111/j.1440-1827.1993.tb02555.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb02555.x","url":null,"abstract":"The clinical, histological and immunohistochemical features of three cases of ovarian mixed mesodermal tumor (MMT) were examined. The epithelial component was serous papillary cystadenocarcinoma in case 1 and 3, and endometrioid adenocarcinoma in case 2. In case 1, undifferentiated adenocarcinoma was also seen. The mesenchymal component was fibrosarcomatous and chondrosarcomatous in case 1 and 2. In case 3, only fibrosarcomatous area was seen. No endometriosis was observed. Immunohistochemically, the epithelial component showed positivity for epithelial membrane antigen in all three cases. S-100 protein was positive in two cases with chondrosarcomatous differentiation. The fibrosarcomatous area showed positivity for vimentin in all three cases. However desmin, myosin and myoglobin were negative. The antibodies thought to be epithelial or mesenchymal markers unexpectedly reacted positively in some cells; for example, EMA was positive in fibrosarcomatous and chondrosarcomatous cells. Therefore, it was speculated that because the undifferentiated tumor cells had a biphasic character, MMT might originate from immature multipotential cells of surface epithelium and subcapsular connective tissue of the ovary.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 11","pages":"696-701"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb02555.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19299019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Lung carcinoma mimicking malignant lymphoma: report of three cases. 肺癌模拟恶性淋巴瘤:附3例报告。

Acta pathologica japonica Pub Date : 1993-10-01 DOI: 10.1111/j.1440-1827.1993.tb03238.x

K Matsui, M Kitagawa, K Wakaki, S Masuda

引用次数: 6

Ileal duplication cyst associated with heterotopic pancreas: report of a case and literature review. 异位胰腺伴回肠重复囊肿1例报告并文献复习。

Acta pathologica japonica Pub Date : 1993-10-01 DOI: 10.1111/j.1440-1827.1993.tb03236.x

T Sato, M Oyamada, H Chiba, S Koide, Y Yuyama, K Watabe, R Denno, D Ueda, N Sato, M Mori

引用次数: 7

Immunohistochemistry of neuronal inclusions in the cerebral cortex and brain-stem in Lewy body disease. 路易体病大脑皮层和脑干神经元包涵体的免疫组化。

Acta pathologica japonica Pub Date : 1993-10-01 DOI: 10.1111/j.1440-1827.1993.tb03230.x

T Fukuda, J Tanaka, K Watabe, R T Numoto, M Minamitani

{"title":"Immunohistochemistry of neuronal inclusions in the cerebral cortex and brain-stem in Lewy body disease.","authors":"T Fukuda, J Tanaka, K Watabe, R T Numoto, M Minamitani","doi":"10.1111/j.1440-1827.1993.tb03230.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb03230.x","url":null,"abstract":"Three cases of Lewy body disease were investigated in order to compare the morphological and immunohistochemical characteristics of the neuronal inclusions in the cerebral cortex (CC) and brain-stem (BS). Ultrastructurally, the CC contained intermediate-sized filaments with variable amounts of granular material and other organelles, whereas the BS consisted of an electron-dense core and an outer area with radially oriented filaments. The cerebral cortex was immuno-reactive with antibodies against tyrosine hydroxylase (TH) and tau protein, and differed from BS. In addition, although the CC were antigenically similar to BS in their neurofilament (70, 160 and 200 kDa) and ubiquitin contents, the localization of neurofilament immunoreactivity differed between them, being confined positively to the core of CC, but to the periphery of the BS. Although Lewy bodies (LB) in idiopathic Parkinson's disease are morphologically similar to BS, they have been reported to differ in their immunoreactivity with antibodies against tau. It has been reported that CC differ from LB with regard to immunoreactivity with antibodies against TH and tropomyosin. It is inferred that these inclusions (CC, BS and LB) differ in morphogenesis.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 10","pages":"545-51"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb03230.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19279696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Epstein-Barr virus related gastric cancer in Japan: a molecular patho-epidemiological study. 日本Epstein-Barr病毒相关胃癌的分子病理流行病学研究

Acta pathologica japonica Pub Date : 1993-10-01 DOI: 10.1111/j.1440-1827.1993.tb03233.x

M Tokunaga, Y Uemura, T Tokudome, T Ishidate, H Masuda, E Okazaki, K Kaneko, S Naoe, M Ito, A Okamura

{"title":"Epstein-Barr virus related gastric cancer in Japan: a molecular patho-epidemiological study.","authors":"M Tokunaga, Y Uemura, T Tokudome, T Ishidate, H Masuda, E Okazaki, K Kaneko, S Naoe, M Ito, A Okamura","doi":"10.1111/j.1440-1827.1993.tb03233.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb03233.x","url":null,"abstract":"Epstein-Barr virus (EBV) involvement in gastric carcinoma has been demonstrated by the presence of EBV genomes and EBV-encoded small RNA (EBER) in the carcinoma cells, monoclonal proliferation of EBV-infected carcinoma cells and elevated antibody titers. The present study was conducted to investigate the prevalence of EBV involvement among gastric carcinomas observed in nine Japanese cities with varying gastric cancer rates. In situ hybridization of EBER-1 was applied to paraffin sections from 1848 carcinomas observed in 1795 cases and EBV involvement was detected based on uniform hybridization in carcinoma cells. Epstein-Barr virus was detected in 6.6% of lesions and 6.7% of cases. The rate of EBV involvement did not vary significantly for each city and there was no correlation with underlying gastric cancer mortality rates. Thus, geographic variation of gastric cancer rates within Japan cannot be explained in terms of EBV involvement. Epstein-Barr virus-related gastric carcinoma is one of the most common EBV-related tumors in Japan. The involvement of EBV was significantly more frequent among males than among females, mainly for cancers occurring in the upper and middle part of the stomach, and exhibited more variation by cell type among males. These observations suggest that other factors yet to be discovered may modulate the causal role of EBV in gastric carcinogenesis.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 10","pages":"574-81"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb03233.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19279699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 126

Recurred Castleman's disease containing a fibrohistiocytic nodular lesion with vascular occlusion. 复发Castleman病伴纤维组织细胞结节病变伴血管闭塞。

Acta pathologica japonica Pub Date : 1993-10-01 DOI: 10.1111/j.1440-1827.1993.tb03237.x

H Kurotaki, M Kaimori, K Nagai

引用次数: 12

Morphologic variations of dense deposit disease: light and electron microscopic, immunohistochemical and clinical findings in 10 patients. 致密沉积病的形态学变化:10例患者的光镜、电镜、免疫组织化学和临床表现

Acta pathologica japonica Pub Date : 1993-10-01 DOI: 10.1111/j.1440-1827.1993.tb03231.x

K Joh, S Aizawa, N Matsuyama, Y Yamaguchi, T Kitajima, O Sakai, H Mochizuki, N Usui, K Hamaguchi, T Mitarai

{"title":"Morphologic variations of dense deposit disease: light and electron microscopic, immunohistochemical and clinical findings in 10 patients.","authors":"K Joh, S Aizawa, N Matsuyama, Y Yamaguchi, T Kitajima, O Sakai, H Mochizuki, N Usui, K Hamaguchi, T Mitarai","doi":"10.1111/j.1440-1827.1993.tb03231.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb03231.x","url":null,"abstract":"Twenty-one renal biopsy specimens obtained from 10 patients with dense deposit disease (DDD) were investigated using light microscopy, electron microscopy and immunohistochemistry. The patients included four females and six males aged 6 to 35 years (mean 16.1 years). A morphological diagnosis of DDD was made following the ultrastructural detection of continuous intramembranous dense deposits (CIMDD) in some capillary loops of at least one of the series of the repeated biopsies from each patient. With light microscopy, six patients showed membranoproliferative glomerulonephritis (MPGN). The other four patients showed diffuse proliferative glomerulonephritis (DPGN) with acute lesions showing intraglomerular neutrophilic infiltration, hump formation and endothelial swelling in three and minor glomerular abnormalities in one. Follow-up biopsies were obtained in six patients. Two patients progressed from DPGN to MPGN within 7 months, whereas three patients with MPGN showed morphologic improvement that featured increased capillary patency and regional disappearance of dense deposits along with the reduction of proteinuria. Dense deposit disease did not always feature typical amorphous and osmiophilic CIMDD spreading across the whole width of the lamina densa. This classical ultrastructural manifestation was mainly found in the patients with histologic non-MPGN and a linear peripheral pattern of complement component (C3) deposition. The MPGN patients with a granular peripheral pattern of C3 deposition also had CIMDD, but also additionally featured less dense subepithelial deposits superimposed on the CIMDD to produce an appearance simulating membranous transformation.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 10","pages":"552-65"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb03231.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19279697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Relationships between nodal status and cell kinetics, DNA ploidy pattern and histopathology of the deeply infiltrating sites in colorectal adenocarcinoma. 结直肠癌深浸润部位淋巴结状态与细胞动力学、DNA倍体模式及组织病理学的关系。

Acta pathologica japonica Pub Date : 1993-10-01 DOI: 10.1111/j.1440-1827.1993.tb03235.x

K Taniyama, H Suzuki, M Matsumoto, K Hakamada, K Toyama, E Tahara

{"title":"Relationships between nodal status and cell kinetics, DNA ploidy pattern and histopathology of the deeply infiltrating sites in colorectal adenocarcinoma.","authors":"K Taniyama, H Suzuki, M Matsumoto, K Hakamada, K Toyama, E Tahara","doi":"10.1111/j.1440-1827.1993.tb03235.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb03235.x","url":null,"abstract":"Tumor cell kinetics and DNA contents were investigated by in vitro labeling with bromodeoxyuridine (BrdU) and flow cytometry using paraffin-embedded specimens in both superficially (Sup) and deeply (Deep) infiltrating sites of 28 colorectal adenocarcinomas. Eleven were well differentiated and 17 were moderately differentiated adenocarcinomas. In moderately differentiated adenocarcinoma, histologic low grade types of Deep were frequently associated with lymph node metastasis, but the BrdU labeling indices (LI) or tumor DNA ploidy pattern did not correlate with nodal status. Among the seven aneuploid tumors of moderately differentiated adenocarcinoma, the BrdU LI and histology of Deep tended to correlate with nodal status. These findings suggest that the histology of Deep should have a greater significance than tumor cell kinetics or DNA contents. They also suggest that the tumor DNA ploidy pattern may be heterogeneous and divided into subgroups according to its cell kinetics or histology of Deep in relation to lymph node metastasis.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 10","pages":"590-6"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb03235.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19279701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6