Acta obstetricia et gynecologica Scandinavica. Supplement最新文献_第4页

Clinical aspects on the use of preimplantation genetic diagnosis in couples at risk. 胚胎植入前遗传学诊断在高危夫妇中的临床应用。

Acta obstetricia et gynecologica Scandinavica. Supplement Pub Date : 1997-01-01

C Hanson, L Hamberger

{"title":"Clinical aspects on the use of preimplantation genetic diagnosis in couples at risk.","authors":"C Hanson, L Hamberger","doi":"","DOIUrl":"","url":null,"abstract":"Background: Preimplantation genetic diagnosis (PGD) is a new technique which may become an attractive alternative to traditional prenatal diagnosis for couples at risk of getting children with severe genetic diseases. We here report our experience after the first trials in Sweden.Methods: On day three after fertilization by intracytoplasmic sperm injection (ICSI) one or two blastomeres were biopsied and diagnosed by fluorescence in situ hybridization (FISH). Gender determination was done in two cases where the female in the couples were carrier of a severe X-chromosome bound disease (Wiskott-Aldrich disease or ornithine transcarbamylase deficiency).Results: The first couple got an embryo transfer in each of their two treatment cycles. Two female embryos were transferred in the first cycle and one in the second cycle. The second couple did not get any embryo transfer in their two cycles. No clinical pregnancy occurred.Conclusion: With the rapidly improving knowledge about inherited disease and refinement of the IVF techniques, PGD will play an important clinical role in high risk groups within a decade for both mono- and polygenic disorders. Both technical as well as legal and ethical problems have however to be solved before these new techniques can be applied on large scale.","PeriodicalId":75400,"journal":{"name":"Acta obstetricia et gynecologica Scandinavica. Supplement","volume":"164 ","pages":"19-21"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20169663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-medical prevention of pre-eclampsia. 非医学预防先兆子痫。

Acta obstetricia et gynecologica Scandinavica. Supplement Pub Date : 1997-01-01

A Ehrenberg

引用次数: 0

Diagnosis of infections due to Chlamydia trachomatis. 沙眼衣原体感染的诊断。

Acta obstetricia et gynecologica Scandinavica. Supplement Pub Date : 1997-01-01

M Domeika

引用次数: 0

The changing face of prostitution in the Baltic sea area. 波罗的海地区卖淫业面貌的变化。

Acta obstetricia et gynecologica Scandinavica. Supplement Pub Date : 1997-01-01

P A Mårdh

引用次数: 0

Pregnancy termination--situation in Finland. 终止妊娠——芬兰的情况。

Acta obstetricia et gynecologica Scandinavica. Supplement Pub Date : 1997-01-01

M A Mandelin

引用次数: 0

Hemodynamic measures in prediction of pre-eclampsia. 血流动力学指标预测先兆子痫。

Acta obstetricia et gynecologica Scandinavica. Supplement Pub Date : 1997-01-01

E Ekholm

引用次数: 0

The Scandinavian opinion on assessment of female urinary incontinence. Proceedings of a meeting. Copenhagen, Denmark, 1995. 斯堪的纳维亚对女性尿失禁评估的看法。会议记录。哥本哈根，丹麦，1995年。

Acta obstetricia et gynecologica Scandinavica. Supplement Pub Date : 1997-01-01

引用次数: 0

Home environment and cognitive abilities in infants born small-for-gestational-age. 家庭环境与小胎龄儿认知能力的关系。

Acta obstetricia et gynecologica Scandinavica. Supplement Pub Date : 1997-01-01

H W Andersson, S J Gotlieb, K G Nelson

{"title":"Home environment and cognitive abilities in infants born small-for-gestational-age.","authors":"H W Andersson, S J Gotlieb, K G Nelson","doi":"","DOIUrl":"","url":null,"abstract":"Background: In the present study we analyzed the relationship between home environment and cognitive abilities in small-for-gestational-age infants.Method: A group of 142 small-for-gestational-age infants and a control group of 172 appropriate-for-gestational-age infants were tested on the Fagan Test of Infant Intelligence at 7 months. The Home Screening Questionnaire was completed by the mothers when their infants were 13 months.Results: The group of small-for-gestational age infants had significantly lower scores on both the Fagan test (p < 0.05) and on the Home Screening Questionnaire (p < 0.01). A significant relation between the Fagan test score and the home score was found for the small-for-gestational-age group (p < 0.05). When the home score was controlled for, the difference in mean Fagan score between the two groups of infants disappeared.Conclusions: It is suggested that small-for-gestational-age infants may be more vulnerable to adverse social conditions that infants born with a normal birthweight for gestational age. Results also suggest that cognitive impairments among small-for-gestational-age infants may be an effect of their social environments and their parents' general intelligence. Possible physical and neurological effects of intrauterine growth retardation may be less important for cognitive functioning.","PeriodicalId":75400,"journal":{"name":"Acta obstetricia et gynecologica Scandinavica. Supplement","volume":"165 ","pages":"82-6"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20164244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consensus of basic assessment of female incontinence. 女性尿失禁基本评估的共识。

Acta obstetricia et gynecologica Scandinavica. Supplement Pub Date : 1997-01-01

L Mouritsen, G Lose, U Ulmsten, K Ludviksson, H Siltberg, S Kulseng-Hanssen, E Kujansuu

引用次数: 0

Prediction of fetal growth based on maternal serum concentrations of human chorionic gonadotropin, human placental lactogen and estriol. 基于母体绒毛膜促性腺激素、胎盘乳原和雌三醇浓度的胎儿生长预测。

Acta obstetricia et gynecologica Scandinavica. Supplement Pub Date : 1997-01-01

T Markestad, P Bergsjø, A Aakvaag, R T Lie, G Jacobsen, H J Hoffman, L S Bakketeig

{"title":"Prediction of fetal growth based on maternal serum concentrations of human chorionic gonadotropin, human placental lactogen and estriol.","authors":"T Markestad, P Bergsjø, A Aakvaag, R T Lie, G Jacobsen, H J Hoffman, L S Bakketeig","doi":"","DOIUrl":"","url":null,"abstract":"Background: The purpose was to determine the usefulness of maternal serum concentrations of human chorionic gonadotropin (hCG), human placental lactogen (hPL) and estriol as predictors of fetal growth.Method: From a large cohort serum obtained serially at 17, 25, 33 and 37 weeks of gestation were analyzed for randomly selected pregnancies resulting in small for gestational age (SGA, n = 102) and non-SGA (n = 112) infants.Results: There were no significant correlations between birthweight ratio (ratio of birthweight to mean weight for gestational age) and hCG, but between birthweight ratio on one hand and estriol for all stages of pregnancy (r = 0.19-0.38, p < 0.01 - p < 0.001) and hCL except at 33 weeks (r = 0.11-0.40, p ns-p < 0.001) on the other. There were statistically significant, but small median differences and substantial overlaps between the SGA and non-SGA infants for hCG at 17 and 37 weeks, for hPL at 17, 33 and 37 weeks, and for estriol at all the stages of pregnancy. The sensitivity and positive predictive value of low hormone concentrations (below the 10th percentile) in predicting the birth of an SGA infant were in the range of 6-26% and 17-39%, respectively. The corresponding specificity and prediction of a non-SGA infant from normal levels were 91-93% and 85-88%.Conclusions: HPL and estriol, but not hCG concentrations, are positively related to the size of the fetus, but the relationships are too weak to be of predictive value in an unselected population.","PeriodicalId":75400,"journal":{"name":"Acta obstetricia et gynecologica Scandinavica. Supplement","volume":"165 ","pages":"50-5"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20164238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0