Research on Chemical Intermediates最新文献

{"title":"Study on the support effect and structure–activity relationship of cobalt-based hydrogen production catalysts by ammonia reforming","authors":"Bin Guan,&nbsp;Zhongqi Zhuang,&nbsp;Lei Zhu,&nbsp;Chenyu Zhu,&nbsp;Tiankui Zhu,&nbsp;Shiying Chang,&nbsp;Jiangli Ma,&nbsp;Rong Wang,&nbsp;Dongxia Yang,&nbsp;Hanshi Qu,&nbsp;Bingqian Tan,&nbsp;Zhen Huang","doi":"10.1007/s11164-026-06120-x","DOIUrl":"10.1007/s11164-026-06120-x","url":null,"abstract":"<div><p>To break through the bottleneck in hydrogen storage and transportation and advance the industrial application of the \"ammonia-hydrogen\" energy route, this study focuses on the support effect of cobalt-based non-precious metal ammonia decomposition catalysts. Through the deposition–precipitation method, cobalt-based catalysts loaded on different oxide supports (CeO₂, La₂O₃, SiO₂, etc.) were prepared. Combined with XRD, TEM, XPS, and other methods for characterization, the effect of the physical and chemical properties of the supports on the structure and ammonia decomposition performance of the catalysts was systematically explored, and kinetic analysis and stability tests were carried out. The activity test shows that the chemical effect of the support has a much greater impact on the catalytic efficiency than the physical specific surface area. Nano-sized oxide supports deliver far better catalytic performance than their microsized counterparts, which we attribute to the richer surface structural defects and oxygen vacancies on nano-support; these defects strengthen metal–support interaction and optimize the electronic state of cobalt active sites. The cobalt-based catalyst loaded on CeO₂(N) (Co/CeO₂(N)) performed the best, with an ammonia conversion rate of 46.3% at 450 ℃ and approaching complete decomposition (94.2%) at 550 ℃, significantly superior to traditional Al₂O₃ and TiO₂ support catalysts. This research clarifies the correlation between support properties and the structure–activity relationship of cobalt-based catalysts, and confirms that CeO₂(N) can enhance catalytic performance through electronic regulation and the synergistic effect of basic sites, providing a theoretical foundation and technical support for the design and development of low-cost, high-stability ammonia decomposition catalysts.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 11","pages":"7591 - 7636"},"PeriodicalIF":3.3,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of novel chromane-fused pyrimidine−2-thione and pyrimidine−2-one scaffolds: synthesis, antimicrobial evaluation, SAR interpretation, and molecular docking studies","authors":"Vidhi V. Desai,&nbsp;Yogen H. Talia,&nbsp;Nikhil M. Parekh","doi":"10.1007/s11164-026-06124-7","DOIUrl":"10.1007/s11164-026-06124-7","url":null,"abstract":"<div><p>A series of novel 6-fluorochromane-based pyrimidine derivatives were designed and synthesized via a convenient two-step approach involving chalcone intermediates followed by cyclocondensation with urea or thiourea, affording the corresponding pyrimidin-2-one (<b>6a–6j</b>) and pyrimidin-2-thione <b>(7a–7j</b>) derivatives, respectively. The synthesized compounds were obtained in good yields and characterized by FT-IR, ¹H NMR, ¹³C NMR, and mass spectral analyses. The antimicrobial activity of the synthesized derivatives was evaluated against Gram-positive bacteria (<i>Staphylococcus aureus and Streptococcus pyogenes</i>), Gram-negative bacteria (<i>Escherichia coli and Pseudomonas aeruginosa</i>), and fungal strains (<i>Candida albicans and Aspergillus niger</i>) using the agar diffusion method and Broth dilution method. Among the tested compounds, pyrimidin-2-thione derivatives exhibited comparatively superior antimicrobial activity than the corresponding pyrimidin-2-one analogs. Compounds 7 g and 7f displayed the most promising antibacterial activity. Molecular docking studies against bacterial DNA gyrase B (PDB ID: 7C7N) revealed favorable binding affinities, with compounds 7 g and 6f exhibiting docking scores of −7.71 and −7.35 kcal/mol, respectively, comparable to the reference drug ampicillin (− 7.64 kcal/mol). In silico ADMET and SAR analyses further highlighted favorable drug-like properties and identified structural features associated with enhanced antimicrobial activity. The present study highlights chromane-linked pyrimidine scaffolds as promising candidates for further antimicrobial drug development.</p><h3>Graphic Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 11","pages":"7785 - 7816"},"PeriodicalIF":3.3,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvent-free manual grinding and a recyclable metal- and halogen-free organocatalyst for the gram-scale synthesis of various 5-aryl-1,2,4-triazolidine-3-thiones","authors":"Mamduhah Mohamad,&nbsp;Nader Ghaffari Khaligh","doi":"10.1007/s11164-026-06112-x","DOIUrl":"10.1007/s11164-026-06112-x","url":null,"abstract":"<div><p>The development of facile and cost-effective processes for product and catalyst separation and the use of highly recyclable organocatalysts aligns with the core principles of Green Chemistry. These systems address environmental and economic constraints by reducing waste, improving safety, and enabling efficient product isolation. Piperazinium dihydrogen phosphate (PzH₂P) is a metal- and halogen-free organocatalyst, bearing numerous acceptor and donor sites for hydrogen bonding. This organic salt is exclusively soluble in water and insoluble in organic solvents, including ethanol. It exhibited high catalytic activity and high recyclability in the preparation of a library of twelve 1,2,4-triazolidine-3-thione derivatives through a solvent-free manual grinding process under mild conditions. Combining this uniquely soluble organocatalyst with manual grinding at ambient pressure and temperature enabled rapid reaction, high yields, and direct product isolation from the reactor. Notably, PzH₂P was reused over 10 consecutive cycles with negligible loss of activity. This protocol features excellent scalability and was successfully implemented on a gram scale for the synthesis of 5-(4-hydroxyphenyl)-1,2,4-triazolidine-3-thione without relying on traditional, tedious purification procedures such as distillation or column chromatography.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 11","pages":"7529 - 7545"},"PeriodicalIF":3.3,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green-engineered CoFe2O4/rGO NCs: applications in photocatalytic RhB degradation and anticancer performance against A549 cells","authors":"ZabnAllah M. Alaizeri","doi":"10.1007/s11164-026-06116-7","DOIUrl":"10.1007/s11164-026-06116-7","url":null,"abstract":"<div><p>The sustainable synthesis of multifunctional nanocomposites for environmental remediation and biomedical applications remains an important challenge. In the present work, the green co-precipitation method has been applied to prepare CoFe₂O₄/rGO NCs using an aqueous extract of Thymus vulgaris as a novel approach. XRD, TEM, FESEM, EDX, XPS, Raman, FTIR, UV–Vis, PL, and DLS were used to investigate the properties of the prepared samples. XRD results confirm the formation of a cubic spinel structure with a decrease in crystallite size values after the addition of Co and rGO sheets. TEM and FESEM images show the morphology with uniformly anchored onto wrinkled rGO sheets and a reduced average particle size from 90.4 ± 18.1 to 80.2 ± 16.5 nm. XPS and EDX analyses revealed the states and elemental composition of the prepared CoFe₂O₄/rGO NCs. UV–Vis and PL investigations showed that the optical properties of Fe₃O₄ NPs improved by the addition of Co and rGO. DLS results showed that the synthesized CoFe₂O₄/rGO NCs have good stability. In environmental remediation applications, the CoFe₂O₄/rGO NCs exhibited enhanced photocatalytic degradation of RhB under UV irradiation, achieving 80.1% degradation at pH = 9 and 91.2% at pH = 11 after 120 min. In the biological response, the prepared CoFe₂O₄/rGO NCs induced high cytotoxicity toward human lung cancer cell lines (A549) using the MTT assay for 48 h due to the high surface area and the generation of reactive oxygen species facilitated by rGO integration. The IC₅₀ value of pre-prepared CoFe₂O₄/rGO NCs was 73.2 ± 7.3 µg/mL after 48 h. This result showed that the presence of rGO has enhanced cytotoxicity toward cancer cells. Further, this study recommends applying these NCs in vivo applications.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 11","pages":"7637 - 7673"},"PeriodicalIF":3.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile one-pot synthesis of an efficient MoO3/g-C3N4 heterojunction for enhanced visible-light photodegradation of Reactive Orange 16 and Tetracycline","authors":"Wiphawadee Jantawong,&nbsp;Thitima Rujiralai,&nbsp;Kanokon Srijan,&nbsp;Uraiwan Sirimahachai","doi":"10.1007/s11164-026-06121-w","DOIUrl":"10.1007/s11164-026-06121-w","url":null,"abstract":"<div><p>This research presents the facile one-pot synthesis of a Z-scheme heterojunction photocatalyst, composed of molybdenum trioxide supported on graphitic carbon nitride (MoO₃/g-C₃N₄, MCN), using a simple one-pot polycondensation method. Characterization analysis confirms the formation of the MCN composite structure and demonstrates that the inclusion of MoO₃ significantly enhances the visible-light absorption capabilities of g-C₃N₄. The photocatalytic activity of the synthesized MCN was systematically evaluated for the degradation of two common pollutants: Reactive Orange 16 (RO16) dye and tetracycline hydrochloride (TC) antibiotics. The MCN catalyst demonstrated remarkable efficiency, achieving a degradation rate of 0.1129 and 0.0689 min⁻¹ for RO16 (60 min) and TC (90 min), respectively, under visible-light irradiation (55W Xe lamp). In reactive species scavenging experiments, superoxide radical (^•O₂⁻) and holes (h⁺) are the main active species in the photocatalytic process. The enhanced performance is attributed to the efficient charge separation and improved electron transfer facilitated by the Z-scheme heterojunction, which reduces the recombination of electron–hole pairs. This study highlights the potential of the MCN composite as a highly effective and environmentally friendly photocatalyst for the removal of organic pollutants from wastewater under a low-power light source.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 11","pages":"7763 - 7784"},"PeriodicalIF":3.3,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic polyvinylpyridine-based acidic ionic liquid catalyst: preparation of 1-amidoalkyl-2-naphthols through Betti-type condensation","authors":"Athar Heydari,&nbsp;Soheila Ghasemi","doi":"10.1007/s11164-026-06108-7","DOIUrl":"10.1007/s11164-026-06108-7","url":null,"abstract":"<div><p>In this study, an efficient magnetic polyvinylpyridine-based acidic ionic liquid catalyst (Fe₃O₄@SiO₂@PVPBr–COOH) was synthesized by reacting bromoacetic acid with a polyvinylpyridine-grafted Fe₃O₄@SiO₂ nanostructure. The resulting catalyst was thoroughly characterized using various analytical techniques. Its catalytic performance was evaluated in the production of 1-amidoalkyl-2-naphthols through a three-component Betti-type condensation of benzaldehyde derivatives, 2-naphthol, and different amides (acetamide, acrylamide, benzamide, and 2-hydroxybenzamide). The catalyst exhibited high efficiency, enabling rapid formation of the target products with excellent yields and reduced reaction times while operating under green, solvent-free reaction conditions. The approach provides high yields, convenient work-up, easy magnetic separation, and efficient catalyst reuse with minimal loss of activity, demonstrating its potential for sustainable synthesis.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 11","pages":"7399 - 7420"},"PeriodicalIF":3.3,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of citric acid complexation on the structure and NH3-SCR performance of CuCe/ZSM-5 catalysts","authors":"Zhi-Hao Wei,&nbsp;Xu-Long Li,&nbsp;Shu-Feng Wu,&nbsp;Xiao-Tong Feng,&nbsp;Jun-Qiang Liu,&nbsp;Xing-Yu Liu,&nbsp;Zhang Zhang","doi":"10.1007/s11164-026-06122-9","DOIUrl":"10.1007/s11164-026-06122-9","url":null,"abstract":"<div><p>Citric acid-assisted CuCe/ZSM-5 catalysts with different Ce loadings were prepared by an incipient wetness impregnation method and evaluated for the selective catalytic reduction of NO_x with NH₃ (NH₃-SCR). Among the prepared catalysts, the sample containing 1.5 wt% Ce exhibited the highest NO conversion over a broad temperature window, while citric acid modification further enhanced the low-temperature catalytic activity<b>.</b> Characterization results revealed that Ce incorporation regulated the textural properties and the distribution of active species while preserving the ZSM-5 framework. XPS, UV–vis DRS, and H₂-TPR analyses indicate the coexistence of Cu²⁺/Cu⁺ and Ce⁴⁺/Ce³⁺ species and support a strong redox interaction between Cu and Ce, which contributes to the enhanced redox capability of the catalysts. Meanwhile, NH₃-TPD and NO-TPD results confirmed that Ce addition and citric acid modification enhanced NH₃ adsorption and NO activation, thereby promoting the NH₃-SCR reaction. Moreover, the optimized catalyst exhibited excellent resistance to H₂O and SO₂ poisoning and maintained stable catalytic performance during a 120 h continuous stability test. The superior catalytic performance is mainly attributed to the synergistic interaction between Cu and Ce species together with the dispersion regulation induced by citric acid, which contributes to enhanced redox properties, suitable surface acidity, and improved accessibility of active sites.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 11","pages":"7745 - 7761"},"PeriodicalIF":3.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of biological potency of 2-(cyclohexyloxy)acetohydrazide based diorganotin(IV) complexes: synthesis, spectral characterization, crystallographic and computational studies","authors":"Shikha Poonia,&nbsp;Sonika Asija,&nbsp;C. P. Kaushik,&nbsp;Bajrang Lal,&nbsp;Ram Kumar Tittal","doi":"10.1007/s11164-026-06115-8","DOIUrl":"10.1007/s11164-026-06115-8","url":null,"abstract":"<div><p>Recent study focuses on the synthesis, characterization and assessment of biological potency of nine newly prepared diorganotin(IV) complexes from three ligands, which were synthesized from 2-(cyclohexyloxy)acetohydrazide and varying salicylaldehyde derivatives. The compounds were characterized with different techniques such as (¹H, ¹³C, ¹¹⁹Sn) NMR, FT-IR, mass spectrometry to get knowledge of their structural and geometric aspects. To further support the findings of spectral techniques, single crystal diffraction study was also performed for the complex 10 [Me₂SnL³], suggesting distorted octahedral geometry around tin metal center in solid state, while penta-coordinated geometry was observed in solution sate. Furthermore, microbial inhibition and antioxidant ability of all the newly synthesized compounds were also evaluated, indicating that complex 9 [Bu₂SnL²] having MIC value of 0.0093 µmol/mL displayed superior inhibition potential against <i>E. coli</i> and <i>A. niger</i>, while complex 12 [Bu₂SnL³] with IC₅₀ value of 4.21 ± 0.04 µM showed highest antioxidant behavior. Additionally, to support the experimental findings, DFT calculations were performed for ligand 2 and its diorganotin(IV) complexes (7–9). It provides insights into structural, electronic features of the compounds and also helps to assess various descriptors that help to determine their stability and reactivity order. Molecular docking analysis was also conducted for ligand 2 against PDB ID: 7AB4, while that of compound 9 was performed against PDB ID: 7AB4 and 7BLY to know the binding affinity of compound and protein.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 11","pages":"7721 - 7744"},"PeriodicalIF":3.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Theoretical determination of the asymmetric interface continuous photogeneration charge transfer rate under bias conditions","authors":"Kun Jia,&nbsp;Peng Jia","doi":"10.1007/s11164-026-06118-5","DOIUrl":"10.1007/s11164-026-06118-5","url":null,"abstract":"","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 11","pages":"7953 - 7953"},"PeriodicalIF":3.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An efficient synthesis of amalgamated spiro heterocycles catalyzed by acid-functionalized Bi-doped CeO2 nanoparticles","authors":"Snehal Purohit,&nbsp;Ashok Kumar,&nbsp;Gajendra Kumar Inwati,&nbsp;Pratibha Sharma","doi":"10.1007/s11164-026-06109-6","DOIUrl":"10.1007/s11164-026-06109-6","url":null,"abstract":"<div><p>The present work presents the design and synthesis of bismuth-doped cerium oxide nanoparticles, followed by functionalization with sulfonic acid to introduce acidic sites on the surface. CeO₂:Bi@SO₃H was employed as an effective heterogeneous catalyst for the synthesis of spiro[imidazolidine−2,11′-indeno[1,2-b]quinoxalin]− 5-one derivatives. The spirocyclic hybrids were prepared through a one-pot multicomponent reaction under ultrasonic irradiation. This novel procedure generates an imidazole ring linked to indeno[1,2-b]quinoxaline via a spirocarbon, achieving yields ranging from good to excellent. The synthesis of the catalyst and spiroheterocycles was achieved using sustainable energy resources, leaving no hazardous residues. In the presence of the catalyst, a decrease in reaction time and an increase in product yield were observed, along with recyclability and reusability (up to 5 runs). Furthermore, the structure of the synthesized heterocycles was corroborated by FT-IR, ¹H NMR, ¹³C NMR, mass, and elemental composition. The catalyst was also characterized through various techniques, viz. energy-dispersive X-ray (EDX), field-emission scanning electron microscopy (FESEM), powder X-ray diffraction (XRD), BET surface area analysis, and Fourier transform infrared (FT-IR) spectroscopy.</p><h3>Graphical abstract</h3><p>A sustainable and effective multicomponent synthesis of spiroheterocycles has been accomplished using the recyclable CeO₂:Bi@SO₃H nanocatalyst.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 11","pages":"7421 - 7440"},"PeriodicalIF":3.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149189779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}