Research on Chemical Intermediates最新文献

{"title":"Unveiling the Pd(PPh3)4/CuI-catalyzed efficient synthesis of indole-benzimidazole conjugated β-lactams with antiproliferative profiling","authors":"Rachana Upadhyay,&nbsp;Amit B. Patel","doi":"10.1007/s11164-026-05955-8","DOIUrl":"10.1007/s11164-026-05955-8","url":null,"abstract":"<div><p>A novel series of fifteen indole-benzimidazole conjugated <i>β</i>-lactams (<b>6a–o</b>) was synthesized via a bimetallic Pd(PPh₃)₄/CuI catalyzed alkynylation of 3-chloroazetidine-2-one (<i>β</i>-lactam derivative) with structurally diverse terminal alkynes through tandem C–C bond activation/Sonogashira-type coupling. The synthetic strategy encompasses Schiff base formation between indole-3-carbaldehyde and 2-aminobenzimidazole, followed by cyclization to the <i>β</i>-lactam framework, and sequential C(sp³)–X/C(sp)–H functionalization, enabling efficient formation of C(sp³)–C(sp) bonds, affording yields up to 87%. The mechanistic interplay highlights the synergistic role of Pd and Cu, especially during the transmetallation step, affording broad substrate scope and high functional group tolerance. The synthesized analogs were further screened for antiproliferative activity against A549 and MCF-7 cancer cell lines. Among them, compounds <b>6b</b>, <b>e–g</b>, exhibited pronounced growth inhibition against A549 cells (GI₅₀ =  &lt; 10 µg/mL), while <b>6e–g</b>, <b>6i</b> and <b>6j</b> showed potent activity against MCF-7 cells (GI₅₀ =  &lt; 10–12 µg/mL). Notably, three compounds <b>6e–g</b> bearing electron-withdrawing substituents (Cl, Br, and NO₂, respectively) on the aromatic ring demonstrate strong antiproliferative activity against both cell lines, identifying them as the most active analogs. The structural activity relationship analysis also confirms the critical role of electron-withdrawing substituents in enhancing antiproliferative activity. Overall, these results highlight the indole-benzimidazole conjugated <i>β</i>-lactum hybrids as promising lead scaffolds for future development of anticancer drugs.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 5","pages":"2937 - 2960"},"PeriodicalIF":3.5,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147686588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zr-Bi2WO6 with abundant oxygen vacancy for activation of peroxydisulfate (PDS) to photodegrade RhB","authors":"Wenxuan Dong,&nbsp;Fuqing Zhang,&nbsp;Qian Liu,&nbsp;Yarui Zhang,&nbsp;Jiahe Du","doi":"10.1007/s11164-026-05940-1","DOIUrl":"10.1007/s11164-026-05940-1","url":null,"abstract":"<div><p>Crystal defect engineering, as a key strategy for regulating the performance of semiconductor photocatalysis, has received extensive attention. This study successfully constructed controllable crystal defects and oxygen vacancies in the Bi₂WO₆ lattice by regulating the doping amount of Zr element. Combined with the photocatalytic activation of PDS, this system achieved efficient co-degradation of rhodamine B (RhB). The degradation rate of RhB reached 99.12% after 8 min of light exposure, and its reaction rate constant (0.05242 min⁻¹) was 62.40 times that of pure Bi₂WO₆ under light conditions. The XPS and EPR results jointly confirmed that Zr can replace W⁶⁺ in the Bi₂WO₆ crystal structure and form defects, generating a large number of oxygen vacancies. Further characterization through photoluminescence spectroscopy (PL), photocurrent testing, and electrochemical impedance spectroscopy (EIS) revealed that Zr₃-Bi₂WO₆ has a higher charge migration rate and better carrier separation efficiency, which jointly promoted the improvement of photocatalytic performance. Through careful analysis of the experimental results, the crystal defects and oxygen vacancies mediated by Zr doping played a key role in regulating the photocatalytic performance of Bi₂WO₆, providing important references for the design of efficient solar-driven advanced oxidation systems.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 5","pages":"3371 - 3391"},"PeriodicalIF":3.5,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147686567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boosted Fe(III)–porphyrin catalysis for eco-friendly synthesis of tetrazolopyrimidine–chromone derivatives by water-powered chemistry","authors":"Thomas Nady A. Eskander,&nbsp;Omar M. Elhady,&nbsp;Abdullah Yahya Abdullah Alzahrani,&nbsp;Mohammed H. AL Mughram,&nbsp;Ahmed D. H. Deeb,&nbsp;Mahmoud Abd El Aleem Ali Ali El-Remaily","doi":"10.1007/s11164-026-05937-w","DOIUrl":"10.1007/s11164-026-05937-w","url":null,"abstract":"<div><p>A green, efficient, and highly sustainable one-pot three-component synthetic protocol has been established for the preparation of novel (4,5-dihydro-tetrazolo[1,5-a]pyrimidin-7-yl)-chromen-2-one derivatives through the condensation of 3-acetyl-chromen-2-one, 5-aminotetrazole and various aromatic aldehydes catalyzed by a recyclable Fe(III)–porphyrin complex. The optimized reaction system, operating in an ethanol: water (1:3, v/v) medium at 80 °C, afforded the desired heterocycles in excellent yields (91–96%) within short reaction times (15–30 min). Systematic optimization revealed that increasing the catalyst loading from 3 to 10 mmol% significantly enhanced both product yield and reaction rate, with 10 mmol% identified as the optimal dosage. Comparative catalytic screening demonstrated that the Fe(III)–porphyrin complex markedly outperformed other Lewis acid, basic, and ionic liquid catalysts—including FeCl₃·6H₂O, Fe(OTf)₃, Mg(OTf)₂, and ZnBr₂ by achieving superior conversion efficiency and selectivity under mild, eco-friendly conditions. Hot filtration experiments confirmed that the reaction predominantly proceeds through a homogeneous catalytic pathway. The Fe(III)–porphyrin complex exhibited excellent structural stability and could be efficiently reused for at least five consecutive cycles without notable loss of activity. This environmentally benign and high-yielding strategy underscores the potential of Fe(III)–porphyrin complexes as robust, recyclable, and green catalysts for the sustainable synthesis of pharmacologically valuable heterocyclic scaffolds.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 5","pages":"2851 - 2877"},"PeriodicalIF":3.5,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147686607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalytic H2 generation influenced by cations: a comparative study of MFe2O4 (M = Mn, Ni and Cu)","authors":"Khaled Derkaoui,&nbsp;Ismail Bencherifa,&nbsp;Khadidja Boukhouidem,&nbsp;Amira Djaibet,&nbsp;Hadil Laiche,&nbsp;Amal Elfiad,&nbsp;Yamina Mebdoua,&nbsp;Toufik Hadjersi,&nbsp;Mohamed Kechouane,&nbsp;Mohamed Mehdi Kaci","doi":"10.1007/s11164-025-05902-z","DOIUrl":"10.1007/s11164-025-05902-z","url":null,"abstract":"<div><p>The development of efficient and sustainable photocatalysts for hydrogen generation is a key step in addressing the global energy and environmental crises. In this study, spinel ferrite nanoparticles with the general formula MFe₂O₄ (M = Mn, Ni, Cu) were synthesized via a facile co-precipitation route followed by thermal treatment, and their physicochemical and photocatalytic properties were systematically investigated. Structural analysis by X-ray diffraction confirmed the successful formation of phase-pure spinel ferrites, whereas SEM and EDX revealed distinct morphological features and uniform elemental distributions in the manufactured samples. Raman spectroscopy provided evidence of cation-dependent lattice ordering, and UV–Vis diffuse reflectance measurements showed band gap values of 1.32 eV (MnFe₂O₄), 1.43 eV (CuFe₂O₄), and 1.78 eV (NiFe₂O₄). Photocatalytic H₂ evolution experiments under visible-light irradiation demonstrated that MnFe₂O₄ exhibited a superior capability, reaching nearly 150 μmol of H₂ within 25 min, outperforming NiFe₂O₄ by 1.36 times and CuFe₂O₄ by 2.14 times. The superior photocatalytic ability of MnFe₂O₄ can be attributed to its narrower band gap, porous morphology, and enhanced structural order, which synergistically promote visible light absorption, charge segregation, and surface redox reactions. This comparative study highlights the pivotal role of cation substitution in tailoring the electronic and structural properties of spinel ferrites and establishes MnFe₂O₄ as a highly promising photocatalyst for cost-effective and environmentally friendly hydrogen production.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 4","pages":"2029 - 2051"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147558903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green synthesis of CuO–ZnO nanoparticles and study of their activity as an efficient catalyst for the synthesis of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitrile derivatives","authors":"Parul Yadav,&nbsp;Ram Singh","doi":"10.1007/s11164-026-05958-5","DOIUrl":"10.1007/s11164-026-05958-5","url":null,"abstract":"<div><p>In this study, the CuO–ZnO nanoparticles were synthesized via a green approach using aqueous extract of fallen neem leaves. This nanoparticle was used as an effective heterogenous catalyst for the synthesis of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitrile derivatives through one-pot three-component reaction using aryl aldehydes, malononitrile, and resorcinol in ethanol: water under reflux condition. This study offers 70–90% yield of chromene derivatives, reaction in green solvents, value addition to biomass, and adherence to principles of green chemistry. The catalyst and products were characterized using XRD, TGA, ICP-OES, FESEM, FTIR, and ¹H NMR spectral data.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 5","pages":"2985 - 2996"},"PeriodicalIF":3.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147686616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-inspired synthesis and characterization of ZnO–NiO nanocomposites as recyclable catalysts for environmentally friendly synthesis of pyranopyrazole compounds","authors":"Ashwini More,&nbsp;Avdhut Kadam,&nbsp;Prakash Kokare,&nbsp;Prasad Mane,&nbsp;Nilesh Pandit,&nbsp;Santosh Kamble,&nbsp;Balu Ajalkar","doi":"10.1007/s11164-026-05947-8","DOIUrl":"10.1007/s11164-026-05947-8","url":null,"abstract":"<div><p>In the current work, we report the <i>Moringa oleifera</i> leaves-mediated synthesis of ZnO-NiO nanocomposite and utilization of it for synthesis of pyranopyrazole derivatives by using aromatic aldehyde, malononitrile, hydrazine hydrate, and ethyl acetoacetate in a 1:1 EtOH: H₂O solvent system. Under the optimized conditions, the protocol afforded isolated product yields in the range of 86–97% within 25 min. The prepared nanocomposite was confirmed by different characterization techniques via XRD, SEM, EDS, UV, FTIR, and TGA. ZnO-NiO nanocomposite shows excellent catalytic activity for the synthesis of pyranopyrazole; the catalyst was recycled up to several cycles and exhibited good TON and TOF. This study demonstrates a cost-effective and eco-friendly strategy for the bio-inspired fabrication of metal-oxide nanoparticles and their application as heterogeneous catalysts in the green synthesis of pyranopyrazole heterocycles, fully aligned with the core principles of green chemistry and sustainable nanotechnology.</p><h3>Graphical abstract</h3><p>The graphical abstract illustrates the synthesis of pyranopyrazole derivatives via a one-pot reaction involving benzaldehyde, ethyl acetoacetate, hydrazine hydrate, and malononitrile, with the ZnO–NiO nanocomposite serving as a heterogeneous catalyst under ambient conditions. The ZnO–NiO nanocomposite was synthesized using an environmentally benign approach employing <i>Moringa oleifera</i> leaf extract, highlighting the green and sustainable nature of the catalytic system.</p>\u0000<div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 5","pages":"2879 - 2905"},"PeriodicalIF":3.5,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147686604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Material to synthetic efficiency: Novel AMP modified g-C3N4·SO3H catalyst for the green and scalable synthesis of xanthene-1,8-diones","authors":"Shivani Soni,&nbsp;Sunita Teli,&nbsp;Shikha Agarwal","doi":"10.1007/s11164-026-05952-x","DOIUrl":"10.1007/s11164-026-05952-x","url":null,"abstract":"<div><p>Catalysis plays a crucial role in promoting efficient methodologies for organic synthesis. In this study, a novel heterogeneous catalyst AMP (2-amino-2-methyl-1-propanol) modified graphitic carbon nitride sulphonic acid (AMP@CNSA) was developed and applied for the green synthesis of xanthene-1,8-dione derivatives. The catalyst was synthesized through a simple procedure and was thoroughly characterized using FTIR, XRD, SEM–EDX, BET, and TGA, confirming its successful synthesis and excellent thermal stability and reusability over six consecutive cycles with minimal loss of activity. A series of fourteen xanthene-1,8-dione derivatives were synthesized under optimized conditions; 15 mg catalyst in water at reflux, in excellent yields (86–99%) within short reaction times (10–45 min). Notably, seven of these derivatives are reported as new, further underscoring the significance of this work. The method demonstrated excellent green chemistry metrics and was successfully scaled up to gram-scale synthesis, highlighting its industrial relevance.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 5","pages":"2907 - 2936"},"PeriodicalIF":3.5,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147686627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoinduced morphological changes induced by photochemistry of organic compounds in self-assembled thin film","authors":"Osamu Ohtani,&nbsp;Ryo Sasai","doi":"10.1007/s11164-026-05946-9","DOIUrl":"10.1007/s11164-026-05946-9","url":null,"abstract":"<div><p>In this article, we review the photoinduced morphological changes of self-assembled thin films composed of amphiphilic organic compounds. Amphiphilic compounds are known to consist of both hydrophilic and hydrophobic groups and form a variety of self-assembling structures on glass substrates, including micelles, lamellae, vesicles, and lamellar layers. These structures play an important role in regulating the photochemical reaction process of encapsulated guest molecules. This mini-review focuses on the photochemical transformation of guest molecules within these self-assembled films and their subsequent effects on the morphology of the films. We found that these reactions are affected by the structure of molecular assemblies and the free volume and intermolecular distance available for molecular rotation. The findings highlight the importance of understanding the interaction between self-assembling structures and photochemical reactions for the development of advanced photofunctional materials.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 in","pages":"1659 - 1677"},"PeriodicalIF":3.5,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147342079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Insights into the promising heterogeneous catalysis of eco‑friendly synthesized spinel CuFe2O4 nanoparticles for Biginelli reaction","authors":"Dnyaneshwar Sanap,&nbsp;Lata Avhad,&nbsp;Satish Ahire,&nbsp;Mahmoud Mirzaei,&nbsp;Deepak Kumar,&nbsp;Suresh Ghotekar,&nbsp;Nitin D. Gaikwad","doi":"10.1007/s11164-026-05913-4","DOIUrl":"10.1007/s11164-026-05913-4","url":null,"abstract":"","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 4","pages":"2803 - 2804"},"PeriodicalIF":3.5,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147560930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical determination of the asymmetric interface continuous photogeneration charge transfer rate under bias conditions","authors":"Kun Jia,&nbsp;Peng Jia","doi":"10.1007/s11164-026-05935-y","DOIUrl":"10.1007/s11164-026-05935-y","url":null,"abstract":"<div><p>This paper optimizes the interface charge transfer rate model and combines it with the interface to determine the charge transfer rate under continuous polarization conditions and in non-aqueous systems. The order of magnitude of the net interface charge transfer rate is found to be 10⁻¹⁶ cm⁴/s, which meets the upper limit of the interface charge transfer rate and aligns with the range of different electrolyte ions within the double-layer scale. Compared with previous errors in semiconductor interface charge transfer rates (10³ ~ 10⁴), the magnitude of the error is reduced by 10⁰ ~ 10¹. Additionally, the time scale of the interface charge transfer is determined using the dual-channel method.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"52 5","pages":"3357 - 3370"},"PeriodicalIF":3.5,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147686586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}