Zoonoses (Burlington, Mass.)最新文献_第2页

Klebsiella, a Hitherto Underappreciated Zoonotic Pathogen of Importance to One Health: A Short Review 克雷伯氏菌，一种迄今未被充分认识的对人类健康至关重要的人畜共患病原体:简要综述

Zoonoses (Burlington, Mass.) Pub Date : 2023-01-01 DOI: 10.15212/zoonoses-2023-0016

Katie Wall, Guerrino Macori, Leonard Koolman, Fengqin Li, Séamus Fanning

引用次数: 0

Yersinia pestis and Plague: some knowns and unknowns. 鼠疫耶尔森菌和鼠疫：一些已知和未知。

Zoonoses (Burlington, Mass.) Pub Date : 2023-01-01 Epub Date: 2023-01-19 DOI: 10.15212/zoonoses-2022-0040

Ruifu Yang, Steve Atkinson, Ziqi Chen, Yujun Cui, Zongmin Du, Yanping Han, Florent Sebbane, Philip Slavin, Yajun Song, Yanfeng Yan, Yarong Wu, Lei Xu, Chutian Zhang, Yun Zhang, B Joseph Hinnebusch, Nils Chr Stenseth, Vladimir L Motin

{"title":"Yersinia pestis and Plague: some knowns and unknowns.","authors":"Ruifu Yang, Steve Atkinson, Ziqi Chen, Yujun Cui, Zongmin Du, Yanping Han, Florent Sebbane, Philip Slavin, Yajun Song, Yanfeng Yan, Yarong Wu, Lei Xu, Chutian Zhang, Yun Zhang, B Joseph Hinnebusch, Nils Chr Stenseth, Vladimir L Motin","doi":"10.15212/zoonoses-2022-0040","DOIUrl":"10.15212/zoonoses-2022-0040","url":null,"abstract":"Since its first identification in 1894 during the third pandemic in Hong Kong, there has been significant progress of understanding the lifestyle of Yersinia pestis, the pathogen that is responsible for plague. Although we now have some understanding of the pathogen's physiology, genetics, genomics, evolution, gene regulation, pathogenesis and immunity, there are many unknown aspects of the pathogen and its disease development. Here, we focus on some of the knowns and unknowns relating to Y. pestis and plague. We notably focus on some key Y. pestis physiological and virulence traits that are important for its mammal-flea-mammal life cycle but also its emergence from the enteropathogen Yersinia pseudotuberculosis. Some aspects of the genetic diversity of Y. pestis, the distribution and ecology of plague as well as the medical countermeasures to protect our population are also provided. Lastly, we present some biosafety and biosecurity information related to Y. pestis and plague.","PeriodicalId":75363,"journal":{"name":"Zoonoses (Burlington, Mass.)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438918/pdf/nihms-1866885.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10052714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eight years' advances on Bourbon virus, a tick-born Thogotovirus of the Orthomyxovirus family. 波旁病毒的8年研究进展，波旁病毒是一种蜱传的正粘病毒科的Thogotovirus。

Zoonoses (Burlington, Mass.) Pub Date : 2022-01-06 Epub Date: 2022-06-14 DOI: 10.15212/zoonoses-2022-0012

Siyuan Hao, Kang Ning, Çağla Aksu Küz, Shane McFarlin, Fang Cheng, Jianming Qiu

引用次数: 2

Review: Protective Immunity and Immunopathology of Ehrlichiosis. 综述:埃利希体病的保护性免疫和免疫病理学。

Zoonoses (Burlington, Mass.) Pub Date : 2022-01-06 DOI: 10.15212/zoonoses-2022-0009

Nahed Ismail, Aditya Sharma, Lynn Soong, David H Walker

{"title":"Review: Protective Immunity and Immunopathology of Ehrlichiosis.","authors":"Nahed Ismail, Aditya Sharma, Lynn Soong, David H Walker","doi":"10.15212/zoonoses-2022-0009","DOIUrl":"https://doi.org/10.15212/zoonoses-2022-0009","url":null,"abstract":"Human monocytic ehrlichiosis, a tick transmitted infection, ranges in severity from apparently subclinical to a fatal toxic shock-like fatal disease. Models in immunocompetent mice range from an abortive infection to uniformly lethal depending on the infecting Ehrlichia species, dose of inoculum, and route of inoculation. Effective immunity is mediated by CD4+ T lymphocytes and gamma interferon. Lethal infection occurs with early overproduction of proinflammatory cytokines and overproduction of TNF alpha and IL-10 by CD8+ T lymphocytes. Furthermore, fatal ehrlichiosis is associated with signaling via TLR 9/MyD88 with upregulation of several inflammasome complexes and secretion of IL-1 beta, IL-1 alpha, and IL-18 by hepatic mononuclear cells, suggesting activation of canonical and noncanonical inflammasome pathways, a deleterious role for IL-18, and the protective role for caspase 1. Autophagy promotes ehrlichial infection, and MyD88 signaling hinders ehrlichial infection by inhibiting autophagy induction and flux. Activation of caspase 11 during infection of hepatocytes by the lethal ehrlichial species after interferon alpha receptor signaling results in the production of inflammasome-dependent IL-1 beta, extracellular secretion of HMGB1, and pyroptosis. The high level of HMGB1 in lethal ehrlichiosis suggests a role in toxic shock. Studies of primary bone marrow-derived macrophages infected by highly avirulent or mildly avirulent ehrlichiae reveal divergent M1 and M2 macrophage polarization that links with generation of pathogenic CD8 T cells, neutrophils, and excessive inflammation or with strong expansion of protective Th1 and NKT cells, resolution of inflammation and clearance of infection, respectively.","PeriodicalId":75363,"journal":{"name":"Zoonoses (Burlington, Mass.)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300479/pdf/nihms-1824000.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9808863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

In silico Design of a Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Multi-Epitope Antigen for Vaccine Development. 用于疫苗研制的克里米亚-刚果出血热病毒糖蛋白多表位抗原的计算机设计。

Zoonoses (Burlington, Mass.) Pub Date : 2022-01-01 DOI: 10.15212/zoonoses-2022-0029

Megan C Mears, Dennis A Bente

{"title":"In silico Design of a Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Multi-Epitope Antigen for Vaccine Development.","authors":"Megan C Mears, Dennis A Bente","doi":"10.15212/zoonoses-2022-0029","DOIUrl":"https://doi.org/10.15212/zoonoses-2022-0029","url":null,"abstract":"Objective: There is no licensed vaccine available to prevent the severe tick-borne disease Crimean-Congo hemorrhagic fever (CCHF), caused by the CCHF virus (CCHFV). This study sought to show that a combination of computational methods and data from published literature can inform the design of a multi-epitope antigen for CCHFV that has the potential to be immunogenic.Methods: Cytotoxic and helper T-cell epitopes were evaluated on the CCHFV GPC using bioinformatic servers, and this data was combined with work from previous studies to identify potentially immunodominant regions of the GPC. Regions of the GPC were selected for generation of a model multi-epitope antigen in silico, and the percent residue identity and similarity of each region was compared across sequences representing the widespread geographical and ecological distribution of CCHFV.Results: Eleven multi-epitope regions were joined together with flexible linkers in silico to generate a model multi-epitope antigen, termed EPIC, which included 812 (75.7%) of all predicted epitopes. EPIC was predicted to be antigenic by two independent bioinformatic servers, suggesting that multi-epitope antigens should be explored further for CCHFV vaccine development.Conclusion: The results presented within this manuscript provide information for potential targets within the CCHFV GPC for guiding future vaccine development.","PeriodicalId":75363,"journal":{"name":"Zoonoses (Burlington, Mass.)","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195060/pdf/nihms-1849223.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9502294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pattern Recognition Receptors in Innate Immunity to Obligate Intracellular Bacteria. 专性细胞内细菌先天免疫中的模式识别受体。

Zoonoses (Burlington, Mass.) Pub Date : 2021-01-01 DOI: 10.15212/zoonoses-2021-0011

James R Fisher, Zachary D Chroust, Florence Onyoni, Lynn Soong

{"title":"Pattern Recognition Receptors in Innate Immunity to Obligate Intracellular Bacteria.","authors":"James R Fisher, Zachary D Chroust, Florence Onyoni, Lynn Soong","doi":"10.15212/zoonoses-2021-0011","DOIUrl":"https://doi.org/10.15212/zoonoses-2021-0011","url":null,"abstract":"Host pattern recognition receptors (PRRs) are crucial for sensing pathogenic microorganisms, launching innate responses, and shaping pathogen-specific adaptive immunity during infection. Rickettsia spp., Orientia tsutsugamushi, Anaplasma spp., Ehrlichia spp., and Coxiella burnetii are obligate intracellular bacteria, which can only replicate within host cells and must evade immune detection to successfully propagate. These five bacterial species are zoonotic pathogens of clinical or agricultural importance, yet, uncovering how immune recognition occurs has remained challenging. Recent evidence from in-vitro studies and animal models has offered new insights into the types and kinetics of PRR activation during infection with Rickettsia spp., A. phagocytophilum, E. chaffeensis, and C. burnetii, respectively. However, much less is known in these regards for O. tsutsugamushi infection, until the recent discovery for the role of the C-type lectin receptor Mincle during lethal infection in mice and in primary macrophage cultures. This review gives a brief summary for clinical and epidemiologic features of these five bacterial infections, focuses on fundamental biologic facets of infection, and recent advances in host recognition. In addition, we discuss knowledge gaps for innate recognition of these bacteria in the context of disease pathogenesis.","PeriodicalId":75363,"journal":{"name":"Zoonoses (Burlington, Mass.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909792/pdf/nihms-1759910.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9412512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Zika Virus Overview: Transmission, Origin, Pathogenesis, Animal Model and Diagnosis. 寨卡病毒概述：传播、起源、发病机制、动物模型和诊断。

Zoonoses (Burlington, Mass.) Pub Date : 2021-01-01 Epub Date: 2021-12-07 DOI: 10.15212/zoonoses-2021-0017

Dallas Vue, Qiyi Tang

{"title":"Zika Virus Overview: Transmission, Origin, Pathogenesis, Animal Model and Diagnosis.","authors":"Dallas Vue, Qiyi Tang","doi":"10.15212/zoonoses-2021-0017","DOIUrl":"10.15212/zoonoses-2021-0017","url":null,"abstract":"Zika virus (ZIKV) was first discovered in 1947 in Uganda. ZIKV did not entice much attention until Brazil hosted the 2016 Summer Olympics Game, where ZIKV attracted a global audience. ZIKV is a flavivirus that can be transmitted chiefly through the biting of the mosquito or sexually or by breastfeeding at a lower scale. As time passed, the recent discovery of how the ZIKV causes congenital neurodevelopmental defects, including microcephaly, makes us reevaluate the importance of ZIKV interaction with centrosome organization because centrosome plays an important role in cell division. When the ZIKV disrupts centrosome organization and mitotic abnormalities, this will alter neural progenitor differentiation. Altering the neural progenitor differentiation will lead to cell cycle arrest, increase apoptosis, and inhibit the neural progenitor cell differentiation, as this can lead to abnormalities in neural cell development resulting in microcephaly. Understanding the importance of ZIKV infection throughout the years, this review article gives an overview of the history, transmission routes, pathogenesis, animal models, and diagnosis.","PeriodicalId":75363,"journal":{"name":"Zoonoses (Burlington, Mass.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698461/pdf/nihms-1761776.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39765672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0