Yersinia pestis and Plague: some knowns and unknowns.

Zoonoses (Burlington, Mass.) Pub Date : 2023-01-01 Epub Date: 2023-01-19 DOI:10.15212/zoonoses-2022-0040

Ruifu Yang, Steve Atkinson, Ziqi Chen, Yujun Cui, Zongmin Du, Yanping Han, Florent Sebbane, Philip Slavin, Yajun Song, Yanfeng Yan, Yarong Wu, Lei Xu, Chutian Zhang, Yun Zhang, B Joseph Hinnebusch, Nils Chr Stenseth, Vladimir L Motin

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引用次数: 0

Abstract

Since its first identification in 1894 during the third pandemic in Hong Kong, there has been significant progress of understanding the lifestyle of Yersinia pestis, the pathogen that is responsible for plague. Although we now have some understanding of the pathogen's physiology, genetics, genomics, evolution, gene regulation, pathogenesis and immunity, there are many unknown aspects of the pathogen and its disease development. Here, we focus on some of the knowns and unknowns relating to Y. pestis and plague. We notably focus on some key Y. pestis physiological and virulence traits that are important for its mammal-flea-mammal life cycle but also its emergence from the enteropathogen Yersinia pseudotuberculosis. Some aspects of the genetic diversity of Y. pestis, the distribution and ecology of plague as well as the medical countermeasures to protect our population are also provided. Lastly, we present some biosafety and biosecurity information related to Y. pestis and plague.

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鼠疫耶尔森菌和鼠疫：一些已知和未知。

自1894年在香港第三次鼠疫大流行期间首次发现鼠疫耶尔森氏菌以来，对鼠疫病原体鼠疫菌的生活方式的了解取得了重大进展。虽然我们现在对病原体的生理、遗传学、基因组学、进化、基因调控、发病机制和免疫有了一定的了解，但对病原体及其疾病发展仍有许多未知的方面。在这里，我们将重点关注与鼠疫杆菌和鼠疫有关的一些已知和未知情况。我们特别关注鼠疫杆菌的一些关键生理和毒力特征，这些特征对其哺乳动物-跳蚤-哺乳动物的生命周期很重要，但也对其从肠病原菌假结核耶尔森菌中出现很重要。并就鼠疫菌的遗传多样性、鼠疫的分布和生态以及保护我国人群的医学对策等方面进行了探讨。最后，我们介绍了一些与鼠疫菌和鼠疫有关的生物安全和生物安全信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zoonoses (Burlington, Mass.)

CiteScore

2.30

自引率

0.00%

发文量