World journal of clinical pediatrics最新文献

{"title":"Diet fortification for mild and moderate picky eating in typically developed children: Opinion review of Middle East consensus.","authors":"Mohammed Al-Beltagi, Elie Choueiry, Najat Alahmadi, Zeinab Demerdash, Wafaa Helmi Ayesh, Khoula Al-Said, Fatima Al-Haddad, Sanaa Y Shaaban, Eslam Tawfik","doi":"10.5409/wjcp.v14.i1.101769","DOIUrl":"10.5409/wjcp.v14.i1.101769","url":null,"abstract":"<p><strong>Background: </strong>Picky eating is a commonly observed behavior among children globally, negatively impacting their physical and mental growth. Although common characteristics distinguish peaky eaters, including food selectivity, food neophobia, and food avoidance, there is no clear definition to assess this behavior. Due to the unavailability of data regarding picky eating, it wasn't easy to estimate its prevalence.</p><p><strong>Aim: </strong>To develop a regional protocol to help healthcare professionals identify and manage mild and moderate picky eating cases.</p><p><strong>Methods: </strong>A virtual roundtable discussion was held in April 2021 to gather the opinions of seven pediatricians and two pediatric dietitians from eight Middle Eastern countries who had great experience in the management of picky eating. The discussion covered different topics, including clearly defining mild and moderate picky eating, identifying the role of diet fortification in these cases, and the possibility of developing a systematic approach to diet fortification.</p><p><strong>Results: </strong>The panel identified picky eating as consuming an inadequate amount and variety of foods by rejecting familiar and unfamiliar food. Most of the time, moderate picky eating cases had micronutrient deficiencies with over- or undernutrition; the mild cases only showed inadequate food consumption and/or poor diet quality. Paying attention to the organic red flags like growth faltering and development delay and behavioral red flags, including food fixation and anticipatory gagging, will help healthcare professionals evaluate the picky eaters and the caregivers to care for their children. Although dietary supplementation and commercial food fortification play an important role in picky eating, they were no benefit in the Middle East.</p><p><strong>Conclusion: </strong>The panel agreed that food fortification through a food-first approach and oral nutritional supplements would be the best for Middle Eastern children. These recommendations would facilitate identifying and managing picky-eating children in the Middle East.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"14 1","pages":"101769"},"PeriodicalIF":0.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of neonatal screening: A case study of sickle cell disease and cystic fibrosis coexistence.","authors":"Nathalia Noyma Sampaio Magalhães, Lucas Barra Mathiasi, Daniela de Oliveira Werneck Rodrigues","doi":"10.5409/wjcp.v14.i1.97537","DOIUrl":"10.5409/wjcp.v14.i1.97537","url":null,"abstract":"<p><strong>Background: </strong>Neonatal screening (NS) is a public health policy to identify genetic pathologies such as cystic fibrosis (CF), sickle cell disease, and other diseases. Sickle cell disease is the comprehensive term for a group of hemoglobinopathies characterized by the presence of hemoglobin S. CF is an autosomal recessive multisystemic disease with pathophysiology involving deleterious mutations in the transmembrane regulatory gene that encodes a protein that regulates the activity of chloride and sodium channels in the cell surface epithelium. NS is crucial for early diagnosis and management, which ensures a better quality of life.</p><p><strong>Aim: </strong>To report a case of the coexistence of sickle cell anemia (SCA) and CF and perform an integrative literature review.</p><p><strong>Methods: </strong>This is an observational study and a review of the literature focusing on two rare genetic pathologies identified simultaneously in NS from the perspective of a clinical case. The authors identified only 5 cases of SCA associated with CF. No clinical trials or review articles were identified considering the rarity of the coexistence of these two pathologies.</p><p><strong>Results: </strong>Herein, the authors reported the case of a girl who after undergoing NS on day 8 of life was diagnosed with SCA with an alteration in the dosage of immunoreactive trypsin. The diagnosis of CF was confirmed by the Coulometry Sweat Test. The rarity of the co-occurrence of these two severe genetic pathologies (CF and SCA) is a challenge for medical science.</p><p><strong>Conclusion: </strong>This study adds to the few case reports present in the literature that highlight the identification of two severe diseases <i>via</i> NS.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"14 1","pages":"97537"},"PeriodicalIF":0.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous cord blood <i>vs</i> individualized supplements in autistic spectrum disorder: CORDUS study results.","authors":"Felician A Stancioiu, Raluca Bogdan, Bogdan Ivanescu, Radu Dumitrescu","doi":"10.5409/wjcp.v14.i1.96643","DOIUrl":"10.5409/wjcp.v14.i1.96643","url":null,"abstract":"<p><strong>Background: </strong>Cellular therapies have started an important new therapeutic direction in autistic spectrum disorder (ASD), and the ample diversity of ASD pathophysiology and the different types of cell therapies prompt an equally ample effort to employ clinical studies for studying the ASD causes and cell therapies. Stem cells have yielded so far mixed results in clinical trials, and at patient level the results varied from impressive to no improvement. In this context we have administered autologous cord blood (ACB) and a non-placebo, material intervention represented by an individualized combination of supplements (ICS) to ASD children.</p><p><strong>Aim: </strong>To compare the efficacy of ACB <i>vs</i> ICS and find markers correlated with the child's progress in order to better predict ACB efficacy.</p><p><strong>Methods: </strong>CORDUS clinical study is a crossover study in which both oral ICS and intravenous ACB were sequentially administered to 56 children; ACB was infused as an inpatient procedure. Treatment efficacy was evaluated pre-treatment and post-treatment at 6 months by an independent psychotherapist with Autism Treatment Evaluation Checklist, Quantitative Checklist for Autism in Toddlers and a 16-item comparative table score, after interviewing the children's parents and therapists. Before and after each intervention participants had a set of blood tests including inflammatory, metabolic and oxidative markers, and the neuronal specific enolase.</p><p><strong>Results: </strong>No serious adverse reactions were noted during and after cord blood or supplement administration. ACB improved evaluation scores in 78% of children with age 3-7-years (<i>n</i> = 28), but was much less effective in kids older than 8 years or with body weight of more than 35 kg (<i>n</i> = 28; only 11% of children improved scores). ICS yielded better results than ACB in 5 cases out of 28, while in 23 kids ACB brought more improvement than ICS (<i>P</i> < 0.05); high initial levels of inflammation and ferritin were associated with no improvement. Ample individual differences were noted in children's progress, and statistically significant improvements were seen after ACB on areas such as verbalization and social interaction, but not on irritability or aggressive behavior.</p><p><strong>Conclusion: </strong>ACB has superior efficacy to ICS in ASD; high inflammation, ferritin, age and body weight predict less improvement; more clinical studies are needed for studying ACB efficacy in ASD.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"14 1","pages":"96643"},"PeriodicalIF":0.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic comparison of Kawasaki disease Z-score formulas: Enhancing diagnostic accuracy and clinical applicability across populations.","authors":"Yan Pan, Fu-Yong Jiao","doi":"10.5409/wjcp.v14.i1.102254","DOIUrl":"10.5409/wjcp.v14.i1.102254","url":null,"abstract":"<p><p>This study aims to evaluate the performance of six distinct Z-score formulas in diagnosing coronary artery dilation in Kawasaki disease (KD) patients, with a focus on their clinical applicability across diverse populations. A retrospective analysis was conducted using comparative statistical methods to assess the sensitivity and specificity of each formula. The Kobayashi and Dallaire formulas demonstrated the highest sensitivity in China, particularly in younger patients with prolonged fever duration. Our findings provide evidence-based recommendations for selecting Z-score formulas to optimize diagnostic precision in KD patients.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"14 1","pages":"102254"},"PeriodicalIF":0.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of social media on maternal decision-making and breastfeeding practices.","authors":"Gowda Parameshwara Prashanth","doi":"10.5409/wjcp.v13.i4.94755","DOIUrl":"10.5409/wjcp.v13.i4.94755","url":null,"abstract":"<p><p>Breastfeeding practices are influenced by multifactorial determinants including individual characteristics, external support systems, and media influences. This commentary emphasizes such complex factors influencing breastfeeding practices. Potential methodological limitations and the need for diverse sampling in studying breastfeeding practices are highlighted. Further research must explore the interplay between social influences, cultural norms, government policies, and individual factors in shaping maternal breastfeeding decisions.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"13 4","pages":"94755"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indian perspective on childhood malnutrition: Prevalence, pathophysiology, risk factors, and prevention.","authors":"Malvika Mishra, Yashwant Kumar Rao, Dharmsheel Shrivastav, Prashant Tripathi, Desh Deepak Singh","doi":"10.5409/wjcp.v13.i4.91971","DOIUrl":"10.5409/wjcp.v13.i4.91971","url":null,"abstract":"<p><strong>Background: </strong>Childhood malnutrition contributes over half of the childhood mortality around the world, predominantly in South-Asian and sub-Saharan countries.</p><p><strong>Aim: </strong>To summarize the childhood malnutrition epidemiology along with the comorbid factors associated with it and its management within the community.</p><p><strong>Methods: </strong>The data collection process involved conducting a comprehensive search using specific keywords such as child nutrition disorders and India with Boolean operators. The search was conducted in the Scopus and PubMed electronic databases.</p><p><strong>Results: </strong>Inadequate energy consumption initiates pathological alterations in the form of growth retardation, fat, visceral, and muscle loss, a reduction in basal metabolic rate, and a significant reduction in total energy expenditure. It has become evident that malnutrition shows an increased prevalence and incidence rate, despite available guidelines for the management of malnutrition.</p><p><strong>Conclusion: </strong>Malnutrition can be a major player in the establishment of severe infections that result in significant post discharge mortalities in children. Future trials are required to fill the prime gaps in knowledge regarding the identification of other contributory factors in the pathogenesis of malnutrition and post-discharge infection. New biomarkers for early detection of malnutrition should be the priority of the scientific community for the early management of malnutrition.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"13 4","pages":"91971"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variation features of neonatal hyperbilirubinemia caused by inherited diseases.","authors":"Jin-Ying You, Ling-Yun Xiong, Min-Fang Wu, Jun-Song Fan, Qi-Hua Fu, Ming-Hua Qiu","doi":"10.5409/wjcp.v13.i4.98462","DOIUrl":"10.5409/wjcp.v13.i4.98462","url":null,"abstract":"<p><strong>Background: </strong>Genetic factors play an important role in neonatal hyperbilirubinemia (NH) caused by genetic diseases.</p><p><strong>Aim: </strong>To explore the characteristics of genetic mutations associated with NH and analyze the correlation with genetic diseases.</p><p><strong>Methods: </strong>This was a retrospective cohort study. One hundred and five newborn patients diagnosed with NH caused by genetic diseases were enrolled in this study between September 2020 and June 2023 at the Second Affiliated Hospital of Xiamen Medical College. A 24-gene panel was used for gene sequencing to analyze gene mutations in patients. The data were analyzed <i>via</i> Statistical Package for the Social Sciences 20.0 software.</p><p><strong>Results: </strong>Seventeen frequently mutated genes were found in the 105 patients. <i>Uridine 5'-diphospho-glucuronosyltransferase 1A1</i> (<i>UGT1A1</i>) variants were identified among the 68 cases of neonatal Gilbert syndrome. In patients with sodium taurocholate cotransporting polypeptide deficiency, the primary mutation identified was <i>Na+/taurocholate cotransporting polypeptide Ntcp</i> (<i>SLC10A1</i>). <i>Adenosine triphosphatase 7B</i> (<i>ATP7B</i>) mutations primarily occur in patients with hepatolenticular degeneration (Wilson's disease). In addition, we found that <i>UGT1A1</i> and <i>glucose-6-phosphate dehydrogenase</i> mutations were more common in the high-risk group than in the low-risk group, whereas mutations in <i>SLC10A1</i>, <i>ATP7B</i>, and <i>heterozygous 851del4 mutation</i> were more common in the low-risk group.</p><p><strong>Conclusion: </strong>Genetic mutations are associated with NH and significantly increase the risk of disease in affected newborns.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"13 4","pages":"98462"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visceral adiposity index, cardiorespiratory fitness, and fasting plasma glucose associations in adolescents.","authors":"Danladi Ibrahim Musa, Rafiu O Okuneye, Joseph Ibrahim Momoh, Musa Haladu Darma, Mary O Onoja-Alexander, Francis M Mwangi","doi":"10.5409/wjcp.v13.i4.97105","DOIUrl":"10.5409/wjcp.v13.i4.97105","url":null,"abstract":"<p><strong>Background: </strong>The global rise in the prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents is partly linked to the increasing rates of childhood obesity and physical inactivity.</p><p><strong>Aim: </strong>To explore the independent relationships of visceral adiposity index (VAI) and cardiorespiratory fitness (CRF) with fasting plasma glucose (FPG) in adolescents.</p><p><strong>Methods: </strong>This descriptive cross-sectional study included 403 adolescents (202 boys and 201 girls) aged 11-19 years. Participants were evaluated for VAI, CRF, and FPG. Regression models, adjusted for age and maturity status, were used to assess the associations between VAI, CRF, and FPG.</p><p><strong>Results: </strong>The prevalence of T2DM risk was 15.3% (girls = 7.4%; boys = 7.9%). In boys, high VAI was positively associated with FPG (<i>β</i> = 0.190, <i>P</i> = 0.009), while low CRF was negatively associated with FPG (<i>β</i> = -0.206, <i>P</i> = 0.010). These associations persisted even after adjusting for CRF and VAI. However, no significant associations between VAI, CRF, and FPG were observed in girls (<i>P</i> > 0.05). Adolescents with high VAI and low fitness levels demonstrated poorer glycemic profiles.</p><p><strong>Conclusion: </strong>Among boys, both VAI and CRF were independently associated with T2DM risk, with CRF showing a stronger association. These associations were not observed in girls. Promoting regular aerobic exercise and healthy diets may serve as essential public health promotion strategies in preventing and managing T2DM risk in adolescents.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"13 4","pages":"97105"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular profiles and long-term outcomes of Thai children with hepatic glycogen storage disease in Thailand.","authors":"Jaravee Vanduangden, Rungnapa Ittiwut, Chupong Ittiwut, Teerasak Phewplung, Anapat Sanpavat, Palittiya Sintusek, Kanya Suphapeetiporn","doi":"10.5409/wjcp.v13.i4.100493","DOIUrl":"10.5409/wjcp.v13.i4.100493","url":null,"abstract":"<p><strong>Background: </strong>Thus far, genetic analysis of patients clinically diagnosed with glycogen storage diseases (GSDs) in Thailand has not been reported.</p><p><strong>Aim: </strong>To evaluate the clinical and biochemical profiles, molecular analysis and long-term outcomes of Thai children diagnosed with hepatic GSD.</p><p><strong>Methods: </strong>Children aged < 18 years diagnosed with hepatic GSD and followed up at King Chulalongkorn Memorial Hospital were recruited. Whole-exome sequencing (WES) was performed to identify the causative gene variants. Medical records were assessed.</p><p><strong>Results: </strong>All eight children with histopathologically confirmed diagnosis were classified by WES into subtypes Ia (<i>n</i> = 1), III (<i>n</i> = 3), VI (<i>n</i> = 3), and IX (<i>n</i> = 1). A total number of 10 variants were identified including <i>G6PC</i> (<i>n</i> = 1), <i>AGL</i> (<i>n</i> = 4), <i>PYGL</i> (<i>n</i> = 5), and <i>PHKA2</i> (<i>n</i> = 1). <i>AGL</i> had two novel variants. The clinical manifestations were hepatomegaly (<i>n</i> = 8), doll-like facies (<i>n</i> = 3), wasting (<i>n</i> = 2), and stunting (<i>n</i> = 5). All patients showed hypoglycemia, transaminitis, and dyslipidemia. The mainstay of treatment was cornstarch supplementation and high-protein and low-lactose-fructose diet. After a median follow-up time of 9.59 years, height turned to normal for age in 3/5 patients and none had malnutrition. Liver enzymes, blood sugar, and lipid profiles improved in all.</p><p><strong>Conclusion: </strong>Hepatomegaly, transaminitis, and hypoglycemia are the hallmarks of GSD confirmed by liver histopathology. Molecular analysis can confirm the diagnosis or classify the subtype that might benefit from personalized treatment, prognosis, and long-term care.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"13 4","pages":"100493"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional management and autism spectrum disorder: A systematic review.","authors":"Mohammed Al-Beltagi","doi":"10.5409/wjcp.v13.i4.99649","DOIUrl":"10.5409/wjcp.v13.i4.99649","url":null,"abstract":"<p><strong>Background: </strong>Autism spectrum disorder (ASD) presents unique challenges related to feeding and nutritional management. Children with ASD often experience feeding difficulties, including food selectivity, refusal, and gastrointestinal issues. Various interventions have been explored to address these challenges, including dietary modifications, vitamin supplementation, feeding therapy, and behavioral interventions.</p><p><strong>Aim: </strong>To provide a comprehensive overview of the current evidence on nutritional management in ASD. We examine the effectiveness of dietary interventions, vitamin supplements, feeding therapy, behavioral interventions, and mealtime practices in addressing the feeding challenges and nutritional needs of children with ASD.</p><p><strong>Methods: </strong>We systematically searched relevant literature up to June 2024, using databases such as PubMed, PsycINFO, and Scopus. Studies were included if they investigated dietary interventions, nutritional supplements, or behavioral strategies to improve feeding behaviors in children with ASD. We assessed the quality of the studies and synthesized findings on the impact of various interventions on feeding difficulties and nutritional outcomes. Data extraction focused on intervention types, study designs, participant characteristics, outcomes measured, and intervention effectiveness.</p><p><strong>Results: </strong>The review identified 316 studies that met the inclusion criteria. The evidence indicates that while dietary interventions and nutritional supplements may offer benefits in managing specific symptoms or deficiencies, the effectiveness of these approaches varies. Feeding therapy and behavioral interventions, including gradual exposure and positive reinforcement, promise to improve food acceptance and mealtime behaviors. The findings also highlight the importance of creating supportive mealtime environments tailored to the sensory and behavioral needs of children with ASD.</p><p><strong>Conclusion: </strong>Nutritional management for children with ASD requires a multifaceted approach that includes dietary modifications, supplementation, feeding therapy, and behavioral strategies. The review underscores the need for personalized interventions and further research to refine treatment protocols and improve outcomes. Collaborative efforts among healthcare providers, educators, and families are essential to optimize this population's nutritional health and feeding practices. Enhancing our understanding of intervention sustainability and long-term outcomes is essential for optimizing care and improving the quality of life for children with ASD and their families.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"13 4","pages":"99649"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}