World journal of clinical pediatrics最新文献

{"title":"Therapeutic interventions and pulmonary function in pediatric patients with post-infectious bronchiolitis obliterans.","authors":"Serena Chiellino","doi":"10.5409/wjcp.v15.i1.111021","DOIUrl":"10.5409/wjcp.v15.i1.111021","url":null,"abstract":"<p><p>Post-infectious bronchiolitis obliterans (PIBO) is a rare chronic obstructive pulmonary disease affecting children after a severe respiratory infection. The primary goal of this narrative review is to synthesize evidence on pulmonary function in children with PIBO, with a focus on spirometric indices, and to evaluate the efficacy of therapies reported in the literature. It also provides an overview of the disease's epidemiology, risk factors, clinical presentation and diagnostic methods. Studies reported various spirometric parameters including forced expiratory volume in one second, forced vital capacity, the ratio between these two parameters, and forced expiratory flow at 25%-75%. A narrative synthesis described therapies including bronchodilators, corticosteroids, macrolides, combination regimens, novel therapies and non-pharmacological interventions. Most studies were small, but data showed moderate to severe impairments in pulmonary function in pediatric PIBO, with mild heterogeneity. Corticosteroids and combined therapies offered short-term relief, but long-term benefits were limited by adverse effects. Pulmonary rehabilitation may preserve lung function and quality of life, although evidence remains scarce. Given the limited research on therapy and pulmonary outcomes, further studies are necessary to understand the long-term effects of treatments. This review underscores the urgent need for multicenter studies and evidence-based guidelines to improve care for children with PIBO.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"15 1","pages":"111021"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not all that drains is gut - umbilical venous catheter extravasation masquerading as intestinal perforation: A case report.","authors":"Ayush Kumar, Sanju Sidaraddi, Prashali Patil, Amit Padmakar Ghawade, Prashant Moralwar, Anish Pillai","doi":"10.5409/wjcp.v15.i1.114242","DOIUrl":"10.5409/wjcp.v15.i1.114242","url":null,"abstract":"<p><strong>Background: </strong>Umbilical venous catheterisation (UVC) is frequently used in neonates but may be complicated by malposition or migration. Extravasation is rare and can mimic other abdominal pathologies.</p><p><strong>Case summary: </strong>We report a preterm infant, born at 27 weeks' gestation, who developed bilateral pneumothorax and spontaneous intestinal perforation requiring drainage. On day 8, the infant clinically deteriorated with persistent high-volume clear peritoneal drain output and worsening dehydration despite fluid escalation. Abdominal radiography confirmed UVC migration into the liver with possible extravasation. Following catheter removal, peritoneal drainage reduced dramatically, and the infant improved rapidly. He was discharged at 38 weeks' corrected age and remained well with age-appropriate development.</p><p><strong>Conclusion: </strong>UVC extravasation can masquerade as high-output peritoneal drainage in the setting of intestinal perforation, thereby delaying diagnosis. Persistent, unusually high peritoneal drainage should prompt consideration of catheter leakage. This rare presentation expands the spectrum of UVC-related complications described in the literature and emphasizes the importance of prompt recognition and management.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"15 1","pages":"114242"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal extensive anti-AMPA-GluR3-related transverse myelitis and favorable therapeutic response: A case report and review of literature.","authors":"Maria Elena Cucuzza, Piero Pavone, Maria T Garozzo, Maria C Finocchiaro, Filippo Greco, Pierluigi Smilari, Alessandra Di Nora, Martino Ruggieri, Vita A Di Stefano","doi":"10.5409/wjcp.v15.i1.113155","DOIUrl":"10.5409/wjcp.v15.i1.113155","url":null,"abstract":"<p><strong>Background: </strong>Longitudinally extensive transverse myelitis (LETM) is defined as a spinal cord lesion that extends over three or more consecutive vertebral segments. It is a key manifestation of various inflammatory and demyelinating disorders of the central nervous system. We have described a rare case of a probable association between LETM and the presence of high serum and cerebrospinal fluid levels of metabotropic glutamate receptor 3 antibodies (mGluR3abs) in a 5-year-old girl. LETM is a neurological disorder characterized by a spinal cord lesion extending over three or more vertebral segments.</p><p><strong>Case summary: </strong>We report a case of a 5-year-old Caucasian girl affected by LETM, along with a review of the literature. The patient presented with lower back pain, varying degrees of bilateral sensory and motor deficits, and autonomic dysfunction. Magnetic resonance imaging showed hyperintense signals involving the spinal cord from C3 to the conus medullaris, suggesting a diagnosis of LETM. Laboratory analysis revealed high levels of mGluR3abs in both serum and cerebrospinal fluid. The patient responded favorably to treatment with high doses of intravenous methylprednisolone and immunoglobulin therapy, which has been shown to be particularly effective in children.</p><p><strong>Conclusion: </strong>The frequency of LETM associated with mGluR3abs is unknown; this report may contribute to expanding the understanding of it.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"15 1","pages":"113155"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of biomarkers in pediatric sepsis: What evidence says?","authors":"Amit Agrawal, Dalwinder Janjua, Gaurav Jadon","doi":"10.5409/wjcp.v15.i1.111999","DOIUrl":"10.5409/wjcp.v15.i1.111999","url":null,"abstract":"<p><p>Sepsis is common in hospitalized pediatric patients, leading to increased morbidity, including multiple organ dysfunction and mortality. Fluid resuscitation and antibiotic administration are the primary protective mechanisms for sepsis. However, not all infections are bacterial, and unnecessary antibiotic use increases the risk of developing multidrug resistance; therefore, it is essential to distinguish bacterial from viral or other infections. Routine laboratory investigations cannot always identify the cause of diseases, but assessing different biomarker levels can help identify these infections and treat sepsis accordingly. This mini-review aims to critically analyze the available evidence supporting the use of biomarkers in pediatric sepsis. We have used the search engines PubMed, Cochrane Library, and Google Scholar to retrieve relevant information. We reviewed studies evaluating various biomarkers used for sepsis diagnoses, like C-reactive protein, ferritin, lactate, procalcitonin, tumor necrosis factor-alpha, <i>etc.</i> Apart from the diagnosis, trials are being conducted to assess the role of these biomarkers in monitoring and guiding antibiotic therapy to promote early recovery. The sensitivity of each biological marker varied in different studies, and no single biomarker can identify all types of infections. More robust studies are necessary to compare the roles of various biomarkers in diagnosing and guiding the appropriate therapy.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"15 1","pages":"111999"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaping during pregnancy and its impact on neonatal outcomes: A systematic review and meta-analysis.","authors":"Maneeth Mylavarapu, Sree Mahathi Chavali, Ananya D Buddharaju, Sruthi Veldurthy, Pratyusha Cheruvu, Abhinav G Parikh","doi":"10.5409/wjcp.v15.i1.108069","DOIUrl":"10.5409/wjcp.v15.i1.108069","url":null,"abstract":"<p><strong>Background: </strong>Vaping during pregnancy is becoming more prevalent, with nearly 7% of individuals using e-cigarettes. This increase may result from tobacco companies targeting younger users with e-cigarette marketing, similar to their strategies with traditional tobacco. While e-cigarette use continues to rise, evidence regarding its effects on neonatal outcomes remains inconsistent.</p><p><strong>Aim: </strong>To examine research on the connection between vaping during pregnancy and negative neonatal outcomes, exploring the potential adverse effects.</p><p><strong>Methods: </strong>According to PRISMA guidelines, we conducted a thorough review of studies from PubMed/MEDLINE, Google Scholar, Scopus, EMBASE, and Web of Science for eligible studies that reported on vaping during pregnancy and its effects on neonatal outcomes, including low birth weight (LBW), preterm birth (PTB), and small for gestational age (SGA). We utilized binary random-effects models to estimate pooled odds ratios (OR) and 95% confidence intervals (CI). A <i>P</i> value of ≤ 0.05 was deemed statistically significant.</p><p><strong>Results: </strong>A total of 14 studies with 523273 pregnant women were included in the analysis. Of them, 3840 (0.7%) vaped during pregnancy. In comparison to pregnant women who did not vape, neonates born to those who vaped had significantly higher odds of LBW (OR: 1.60; 95%CI: 1.23-2.09; <i>P</i> = 0.0005) and SGA (OR: 1.73; 95%CI: 1.34-2.22; <i>P</i> < 0.0001), as well as higher odds of PTB (OR: 1.95; 95%CI: 0.74-5.14; <i>P</i> = 0.17).</p><p><strong>Conclusion: </strong>Vaping during pregnancy is significantly associated with adverse neonatal outcomes, LBW, and SGA, emphasizing the potential risks of vaping during pregnancy and highlighting the necessity for public health initiatives to increase awareness and develop preventive strategies.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"15 1","pages":"108069"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of semirigid ureterolithotripsy in pediatric urolithiasis: Retrospective analysis from a tertiary center.","authors":"Ulugbek Khudaybergenov, Azizbek Shomarufov, Olimjon Abdukarimov, Yalkin Nadjimitdinov","doi":"10.5409/wjcp.v15.i1.115147","DOIUrl":"10.5409/wjcp.v15.i1.115147","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic ureterolithotripsy (EUL) is a minimally invasive and effective treatment for pediatric ureteral stones, offering high success rates while addressing anatomical challenges unique to children.</p><p><strong>Aim: </strong>To evaluate the success and safety of EUL in pediatric patients, focusing on lithotripsy technique, stone location, and patient-specific variables.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 250 children treated with EUL from 2015 to 2022. Laser and pneumatic lithotripsy techniques were compared in terms of stone-free rate (SFR), operative duration, and complication rates. Outcomes were also analyzed by stone location and patient age.</p><p><strong>Results: </strong>The overall SFR was 92.1%, with rates of 94% for distal, 89% for mid-ureteral, and 91% for proximal stones (<i>P</i> = 0.07). Laser lithotripsy showed a slightly higher success rate than pneumatic lithotripsy (<i>P</i> = 0.08) and slightly shorter operative times (<i>P</i> = 0.1). The mean procedure duration was 42.8 ± 16.3 minutes and was longer for proximal stones (<i>P</i> = 0.04). The overall complication rate was 12.4%, with the highest incidence among children aged 4-7 years (<i>P</i> = 0.02). Average hospital stay was 2.3 ± 0.5 days, with no significant intergroup differences.</p><p><strong>Conclusion: </strong>EUL is a safe and effective treatment for pediatric ureterolithiasis. Laser lithotripsy offers a slightly procedural time advantage, while younger patients are more prone to intraoperative challenges. These findings support EUL as a first-line treatment, with careful planning needed for younger children.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"15 1","pages":"115147"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal cholestasis is associated with cytochrome P450 1A2 detoxification defect: A single center pilot study.","authors":"Magd A Kotb, Manal M Wilson, Amani N Shafik, Noura A Ahmed, Veronia F Fahim, Nabil A Lotfi, Yasmin Mr Eissawy","doi":"10.5409/wjcp.v15.i1.113478","DOIUrl":"10.5409/wjcp.v15.i1.113478","url":null,"abstract":"<p><strong>Background: </strong>Evidence supports that biliary atresia (BA) in Egyptian infants is an aflatoxin-induced cholangiopathy acquired perinatally in infants with glutathione S-transferase M1 deficiency: The Kotb disease BA variant. This inability to detoxify aflatoxins leads to progressive inflammatory adhesions and obliterative cholangiopathy early in life.</p><p><strong>Aim: </strong>To investigate the cytochrome P450 1A2 (CYP1A2) detoxification enzyme levels in neonates with confirmed BA.</p><p><strong>Methods: </strong>This prospective descriptive analytical study estimated CYP1A2 detoxification enzyme levels using enzyme-linked immunosorbent assay in 20 neonates with confirmed BA. The level CYP1A2 was also estimated in a control group of 20 infants with neonatal hepatitis (NH) and 20 age- and sex-matched healthy infants.</p><p><strong>Results: </strong>The mean age at enrollment in the study was 2.16 ± 0.58 months, 2.51 ± 1.05 months and 1.9 ± 0.81 months for the BA, NH and control group (<i>P</i> = 0.42). The mean ± SD of CYP1A2 among BA, NH and control group was 13.58 ± 9.73, 9.59 ± 9.95 and 31.68 ± 12.33 (<i>P</i> = 0.001). Within 3 months of follow up, of those with BA who underwent portoenterostomy 12 (60%) had successful outcome and cleared the jaundice, 5 (25%) had a stationary course and did not clear the jaundice while 3 (15%) died. The cholestasis resolved in 5 (25%) of the NH group, and improved in 15 (75%). CYP1A2 level did not correlate with age (<i>r</i> = 0.1559, <i>P</i> = 0.336), or total bilirubin level (<i>r</i> = 0.156, <i>P</i> = 0.336), alanine aminotransferase (<i>r</i> = -0.166, <i>P</i> = 0.305), aspartate aminotransferase (<i>r</i> = 0.091, <i>P</i> = 0.576), gamma glutamyl transferase (<i>r</i> = -0.0027, <i>P</i> = 0.99), alkaline phosphatase (<i>r</i> = 0.1059, <i>P</i> = 0.515), or outcome (<i>r</i> = 1.565, <i>P</i> = 0.23). A low CYP1A2 predicted a susceptibility to cholestasis by logistic regression (<i>P</i> = 0.000, 95% confidence interval: 0.8224-0.9327).</p><p><strong>Conclusion: </strong>Significantly low serum CYP1A2 was frequent among infants with BA and NH compared to the control group. The low serum CYP1A2 compromises the detoxification ability of neonates with cholestasis and may alter the pharmacokinetics of commonly used drugs. Careful consideration to drug dosing and toxicity risk should be given to those neonates. Further research on drug pharmacokinetics and detoxification in neonates with cholestasis is recommended.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"15 1","pages":"113478"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early inotropic support without fluid bolus <i>vs</i> standard resuscitation in pediatric septic shock: A randomized controlled trial.","authors":"Swasti Keshri, Anil K Goel, Ankit Kumar Garg, Varun Anand, Sanosh Kumar Rathia, Samreen Yusuf","doi":"10.5409/wjcp.v15.i1.109864","DOIUrl":"10.5409/wjcp.v15.i1.109864","url":null,"abstract":"<p><strong>Background: </strong>The current 2020 surviving sepsis guideline recommends fluid boluses of 10-20 mL/kg/bolus up to 40-60 mL/kg, but recent studies showed better outcomes when fluid boluses were restricted.</p><p><strong>Aim: </strong>To analyze the outcome of initial resuscitation of septic shock without giving fluid bolus and early initiation of inotropes.</p><p><strong>Methods: </strong>In this open label, randomized controlled clinical trial conducted at the Pediatric Emergency Medicine unit of a tertiary care hospital in central India, patients aged 1 month to 14 years who were hospitalized for septic shock were randomly allocated (1:1) to receive either inotropes (Group I) or fluid bolus as per surviving sepsis guideline (Group F). We analyzed the primary endpoint (either the resolution of shock or the patient's clinical status at 1 h from the initiation of resuscitation, whichever occurred first) by the intention-to-treat. Both the groups were compared in terms of reversal of shock, the mean time for reversal of shock, adverse effects including mortality at 48 h, and overall mortality.</p><p><strong>Results: </strong>Out of 119 patients with septic shock, 49 were included in the final analysis (24 patients in Group I and 25 patients in Group F. 16/49 (32.65%) patients had compensated shock, and 33/49 (67.35%) had hypotensive shock. During the initial resuscitation phase, shock resolved in all (100%) of the patients in Group I. In Group F only in 19/25 (76.00%) patients experienced resolution of shock. The mean time of resolution of shock was significantly shorter in Group I (83.98 + 42.02 min) compared with Group F (116.72 + 41.67 min, <i>P</i> = 0.015). Invasive mechanical ventilation was required in 34/49 (69.40%) and was comparable across the groups. In the comparator Group F, 16/25 (65.00%) of the patients had some features of fluid overload. There was no statistical difference in the initial vasoactive inotropic support score, the total duration of ventilation, total length of hospital stay, mortality at 48 h, and overall mortality across the two groups. In a subgroup analysis of patients with hypotensive shock, mortality at 48 h was significantly higher in patients of Group F (9/17, 52.94%) than in patients of Group I (3/16, 18.75%, <i>P</i> = 0.041). The overall mortality rate in the study subjects was 24/49 (49.00%), and it was positively correlated with the Pediatric Sequential Organ Failure Assessment- Lactate score and maximum vasoactive inotropic support scores.</p><p><strong>Conclusion: </strong>The use of fluid boluses in pediatric septic shock is dubious and contributes to fluid overload. The management of septic shock in children involves the use of adjuncts such as bedside ultrasound, early inotropes, and restricted and well-regulated fluid boluses.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"15 1","pages":"109864"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric urolithiasis: Medical & surgical management & sophistication.","authors":"Sunil Jain, Prem Kamal Jain","doi":"10.5409/wjcp.v15.i1.119008","DOIUrl":"10.5409/wjcp.v15.i1.119008","url":null,"abstract":"<p><p>Success and safety of endoscopic ureterolithotripsy (EUL) in pediatric patients has been studied by Khudaybergenov <i>et al</i> in a recent retrospective study<i>.</i> The findings support EUL as a first-line treatment, with careful planning needed for younger children. Urolithiasis is a well-known condition. It can affect any part of the urinary tract. It is quite rare in children (1%-7% of all urinary stones occur during childhood). However, its increasing incidence over last several decades is a cause of concern. Childhood urinary lithiasis is related to genetic, climatic, dietary, and socioeconomic factors. Advancing holistic approach is hope for health for all. Evaluation for aetiopathogenesis to expert management, and energetic prevention requires excellence conceptually. Conceptual frameworks present perspectives about a problem systematically and simplify understanding usefully about how complex things work. We discuss advancements as '5Ds' framework: (1) Diligent assessment: Clinically comprehensive. Investigation should be correct and comprehensive with attention to radiation risks. Results guide rationale methodical management; (2) Dedicated management: Correct intervention guided by best evidence; (3) Devoted monitoring: Immediate and long term; (4) Distinctive prevention: With attention to aetiologies; and (5) Developing professionalism: Expertise development with simulation. Special centres/clinics expertise can guide further refinements. In conclusion, early energetic management ensures cure lifelong.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"15 1","pages":"119008"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of plasma D-dimer levels as diagnostic and prognostic marker in neonatal sepsis: An insightful support.","authors":"Alessandro Boscarelli","doi":"10.5409/wjcp.v15.i1.115780","DOIUrl":"10.5409/wjcp.v15.i1.115780","url":null,"abstract":"<p><p>Neonatal sepsis remains a serious health problem with significant morbidity and mortality. Clinical diagnosis at presentation is often challenging due to nonspecific signs and symptoms. Laboratory biomarkers, blood cultures, and other diagnostic/prognostic tools such as the hematological scoring system developed by Rodwell and the neonatal organ failure assessment are not considered reliable for routine clinical use. Basiouny <i>et al</i> conducted a two-center prospective case-control study investigating the diagnostic and prognostic utility of D-dimer and heparin-binding protein in neonatal sepsis. Despite several limitations of their study, the present research provides novel insight into the role of plasma D-dimer levels in the diagnosis and prognosis of neonatal sepsis. While future multicenter studies with larger patient populations are required, these findings suggest the utility of D-dimer inclusion into sepsis multi-marker diagnostic models for newborns in order to complement rather than replace existing tools.</p>","PeriodicalId":75338,"journal":{"name":"World journal of clinical pediatrics","volume":"15 1","pages":"115780"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}