Vessel plus最新文献_第2页

Diagnostic workup and treatment options for aneurysmal coronary artery disease 动脉瘤性冠状动脉疾病的诊断工作和治疗方案

Vessel plus Pub Date : 2024-03-13 DOI: 10.20517/2574-1209.2023.68

Alberto Barioli, Emanuele Visco, N. Pellizzari, Filippo Marzot, Davide Lanzellotti, Luca Favero, C. Cernetti

引用次数: 0

Acute type a aortic dissection: when not to operate, a review 急性 a 型主动脉夹层：何时不动手术，综述

Vessel plus Pub Date : 2024-03-11 DOI: 10.20517/2574-1209.2023.150

Thais Faggion Vinholo, Jake Awtry, Robert Semco, Paige Newell, Ashraf Sabe

{"title":"Acute type a aortic dissection: when not to operate, a review","authors":"Thais Faggion Vinholo, Jake Awtry, Robert Semco, Paige Newell, Ashraf Sabe","doi":"10.20517/2574-1209.2023.150","DOIUrl":"https://doi.org/10.20517/2574-1209.2023.150","url":null,"abstract":"Acute type A aortic dissection (ATAAD) is a surgical emergency with a nonoperative mortality rate of up to 1% per hour and an operative mortality rate as high as 24%. Therefore, evaluation of comorbidities and patient presentation characteristics prompts a pause for risk stratification before proceeding to the operating room, as emergent surgery may not always be the optimal approach. This comprehensive review explores key considerations in ATAAD management, emphasizing the need for nuanced decision making, by considering medical management and delayed surgery as an alternative management approach for high-risk populations such as the frail or patients who have a history of cardiac surgery. Beyond the immediate threat of aortic rupture, organ malperfusion stands out as the most feared complication of ATAAD, also elevating perioperative risk significantly. In such cases, careful assessment of patient’s hemodynamic status is paramount. For stable patients, a thorough preoperative strategy and multidisciplinary discussions are encouraged. Notably, the advent of endovascular techniques provides viable lower-risk alternatives to the traditional open approach. The consequences of ATAAD surgical intervention extend beyond the immediate procedural concerns, with a substantial impact on the patient’s overall function. Prioritizing patient-centered care becomes imperative in aligning management with individual goals of care. This review seeks to provide insights into these considerations by offering a stepwise approach to patient-centered decision-making in ATAAD management.","PeriodicalId":75299,"journal":{"name":"Vessel plus","volume":"46 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140252989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxychloroquine as a potential therapy for ANCA-associated vasculitis 羟氯喹作为 ANCA 相关性血管炎的一种潜在疗法

Vessel plus Pub Date : 2024-02-28 DOI: 10.20517/2574-1209.2023.142

Sahil Jain, S. Sangle, Sangmi Kim, Susan John, David D’Cruz

引用次数: 0

Cardiac blood vessels and irreversible electroporation: findings from pulsed field ablation 心脏血管与不可逆电穿孔：脉冲场消融的发现

Vessel plus Pub Date : 2024-01-31 DOI: 10.20517/2574-1209.2023.80

I. Chinyere, Shumpei Mori, Mathew D. Hutchinson

引用次数: 0

“Not much room for mushrooms” in the heart: knowns and unknowns of fungal infective endocarditis 心脏中的 "蘑菇空间不大"：真菌感染性心内膜炎的已知与未知数

Vessel plus Pub Date : 2024-01-10 DOI: 10.20517/2574-1209.2023.77

Wilhelm Mistiaen

{"title":"“Not much room for mushrooms” in the heart: knowns and unknowns of fungal infective endocarditis","authors":"Wilhelm Mistiaen","doi":"10.20517/2574-1209.2023.77","DOIUrl":"https://doi.org/10.20517/2574-1209.2023.77","url":null,"abstract":"Fungal infective endocarditis is a rare but highly lethal condition. Its diagnosis is often delayed due to nonspecific symptoms, inconclusive medical imaging, and negative blood cultures. Recent reviews of cases and series over the last 5 years indicate that the condition remains rare and lethal. If fungi are identified as the causative agents in more than 5% of patient cases with infective endocarditis, it is likely that risk factors such as immune suppression or cardiac implants are probably involved. A series derived from recent case reports indicates that Candida and Aspergillus are still the main causative infectious agents, with. C parapsilosis on the rise. From these cases, diagnostic clues (frequent embolisms, ophthalmic involvement, large, mobile and friable vegetation, non-valvular cardiac manifestations) are pointing towards fungal IE. These reports, however, are not standardized and a publication bias towards rare microorganisms or towards a favorable outcome might exist. Complications might be underreported, and important data such as diagnostic delay are absent or difficult to retrieve. Pharmacologic treatment is not fully standardized. Knowledge of resistant strains in this respect is important. Statistical analysis for the effect of complications and treatment modalities on outcome shows that any result should be treated cautiously. The current series is by no means a valid substitute for a well-designed series of fungal endocarditis. However, the better outcome with Candida and patients treated with surgery confirm earlier results. An international multicentric standardized registry of cases with fungal endocarditis in order to improve the outcome of this disease is highly needed. The effect of diagnostic delay on outcome remains elusive and should be resolved.","PeriodicalId":75299,"journal":{"name":"Vessel plus","volume":"6 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploitation of KATP channels for cardiac surgery 利用 KATP 通道进行心脏手术

Vessel plus Pub Date : 2023-12-28 DOI: 10.20517/2574-1209.2023.121

AlleaBelle Bradshaw, Jennifer S. Lawton

引用次数: 0

Transesophageal echocardiography during surgery of the thoracic aorta in adults 成人胸主动脉手术期间的经食道超声心动图检查

Vessel plus Pub Date : 2023-12-25 DOI: 10.20517/2574-1209.2023.37

Tim Alberts, Susanne Eberl, Henning Hermanns

{"title":"Transesophageal echocardiography during surgery of the thoracic aorta in adults","authors":"Tim Alberts, Susanne Eberl, Henning Hermanns","doi":"10.20517/2574-1209.2023.37","DOIUrl":"https://doi.org/10.20517/2574-1209.2023.37","url":null,"abstract":"Thoracic aortic surgery poses significant challenges due to the complex anatomy and potential for life-threatening complications. Transesophageal echocardiography (TEE) has emerged as a crucial imaging tool in the management of patients undergoing these operations. TEE offers real-time, high-resolution imaging of the heart and aorta, enabling accurate assessment of aortic pathology, evaluation of cardiac function, and monitoring of intraoperative hemodynamics. Its semi-invasive nature, immediate availability, and ability to provide dynamic information make TEE an indispensable adjunct during these intricate procedures. One of the primary indications for TEE during thoracic aortic surgery is the assessment of aortic pathology, including aneurysms, dissections, and aortic valve diseases. TEE allows precise visualization of the extent, location, and severity of aortic lesions, facilitating decision-making regarding repair strategies, graft sizing, and intraoperative guidance. Furthermore, TEE aids in identifying associated cardiac abnormalities such as valvular or ventricular dysfunction, which may impact surgical planning and outcomes. This review aims to summarize the current evidence supporting the use of TEE during thoracic aortic surgical interventions and highlight its invaluable contributions to perioperative patient care.","PeriodicalId":75299,"journal":{"name":"Vessel plus","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139159077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of cardiac benefit after intramyocardial or intravenous injection of mesenchymal stem cell-derived extracellular vesicles supports the need for optimized cardiac delivery 心肌内或静脉注射间充质干细胞衍生的细胞外囊泡对心脏无益，因此需要优化心脏给药方式

Vessel plus Pub Date : 2023-12-21 DOI: 10.20517/2574-1209.2023.98

Cynthia M Xu, M. Broadwin, Patrick Faherty, R. Teixeira, Mohamed Sabra, Frank W. Sellke, M. Abid

{"title":"Lack of cardiac benefit after intramyocardial or intravenous injection of mesenchymal stem cell-derived extracellular vesicles supports the need for optimized cardiac delivery","authors":"Cynthia M Xu, M. Broadwin, Patrick Faherty, R. Teixeira, Mohamed Sabra, Frank W. Sellke, M. Abid","doi":"10.20517/2574-1209.2023.98","DOIUrl":"https://doi.org/10.20517/2574-1209.2023.98","url":null,"abstract":"Aim: To determine the differences in improvement in cardiac function by intramyocardial (IM) vs. intravenous (IV) injection of human bone mesenchymal stem cell-derived extracellular vesicles (HBMSC-EV) after acute MI.\u0000 Methods: FVB mice underwent acute MI via left anterior descending coronary artery ligation and subsequent injection of: (1) IM saline control; (2) IM HBMSC-EV; (3) IV saline control; and (4) IV HBMSC-EV. Cardiac function was evaluated with weekly postoperative echocardiography. On postoperative day 28, the mice were euthanized, and the heart, lungs, liver, spleen, and kidneys were harvested. Given previous studies showing HBMSC-EV hepatic uptake after IV injection, the liver was evaluated for changes in inflammation, fibrosis, and proliferation.\u0000 Results: On postoperative day 28, there were no significant differences in left ventricular ejection fraction (P = 0.6151), fractional shortening (P = 0.1135), or anterior border zone fibrosis (P = 0.6333) in any of the experimental groups. Interestingly, there was a strong trend demonstrating improvement in infarct size on fibrosis staining, which did not reach significance (P = 0.05620). There were no differences in hepatic inflammation, fibrosis, and proliferation.\u0000 Conclusions: Although there was a trend in the improvement in infarct size, a single-dose administration of neither IM nor IV injection of HBMSC-EV resulted in significant improvement in post-MI cardiac function. A major limitation of this study is the lack of trials determining the optimal dose of HBMSC-EV needed in this model. However, the current study demonstrates that future studies are required to either optimize administration or bioengineer HBMSC-EV with cardiac-homing properties.","PeriodicalId":75299,"journal":{"name":"Vessel plus","volume":"62 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138951657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal timing of surgical revascularization in patients with acute myocardial infarction 急性心肌梗死患者手术血管重建的最佳时机

Vessel plus Pub Date : 2023-12-18 DOI: 10.20517/2574-1209.2023.100

Amin Zahrai, K. Rahmouni, Fraser D. Rubens

引用次数: 0

The biomechanics and prevention of vein graft failure in coronary revascularization 冠状动脉血运重建中静脉移植失败的生物力学与预防

Vessel plus Pub Date : 2023-12-15 DOI: 10.20517/2574-1209.2023.97

Elbert E. Heng, Hanjay Wang, O. Obafemi, Alison Marsden, Y. J. Woo, Jack H. Boyd

引用次数: 0