Edith Labos, Claudia Verónica Bavec, Diana Cristalli, Florencia Deschle, Cristian Isaac, Guido Dorman, Juan Ollari, Valeria Rubiño, María Julieta Russo
{"title":"Diagnostic criteria in dementing illness. What's new?","authors":"Edith Labos, Claudia Verónica Bavec, Diana Cristalli, Florencia Deschle, Cristian Isaac, Guido Dorman, Juan Ollari, Valeria Rubiño, María Julieta Russo","doi":"10.53680/vertex.v34i160.460","DOIUrl":"https://doi.org/10.53680/vertex.v34i160.460","url":null,"abstract":"<p><p>The spectrum of neurodegenerative diseases that primarily affect cognition and behaviorspreads from asymptomatic preclinical disease to very mild cognitive impairment to frank dementia. Alzheimer's disease (AD) is the most common cause of a decline in cognitive ability. Also, it is a devastating condition that affects patients and their entirefamilies of caregivers, exacting tremendous financial hardships. Diagnosis may be complicated by other forms of dementia that have symptoms and pathologies similar to AD. Knowing the key features and pathology of each type of dementia can help in the accurate diagnosis of patients, so they will receive the treatment and support services appropriate for their condition and maintain the highest possible functioning in daily life and quality of life. Differentiate, based on clinical criteria, neuropathology, and biomarkers, AD and its atypical variants from other common dementias including Dementia with Lewy Bodies, Vascular Cognitive Impairment, Frontotemporal Degeneration, and less frequent cognitive\u0000disorders. The importance of getting an accurate and early diagnosis of dementiais now increasingly significant to make important decisions about treatment, support, and care. Nonpharmacological as well as pharmacological interventions should be initiated once the diagnosis is obtained. Biochemical markers to identify Alzheimer's disease play a central role in the new diagnostic criteria for the disease and in the recent biological definition of AD. This review article presents up-to-date data regarding the recent diagnostic criteria of Alzheimer´s disease and related disorders, emphasizing\u0000its usefulness in routine clinical practice.</p>","PeriodicalId":75297,"journal":{"name":"Vertex (Buenos Aires, Argentina)","volume":"34 160, abr.-jun.","pages":"54-78"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9997420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"21st Century Psychedelic Science","authors":"Nahuel Enrique Baca","doi":"10.53680/vertex.v34i160.461","DOIUrl":"https://doi.org/10.53680/vertex.v34i160.461","url":null,"abstract":"<p><p>We are currently witnessing a renaissance of psychedelic science in clinical research. In Argentina, the challenges related to its study and the development of new treatments in the field of Psychiatry are subject to the adoption of certain regulatory policies. The evolution of the knowledge about the effects, mechanisms of action and therapeutic potential of serotonergic psychedelics warrants a change in the regulatory framework for their use in clinical research. In a world that demands rapid flexibility and adaptation, we should avoid waiting for advances from developed countries. It is evident\u0000that psychopharmacological progress in the last thirty years have not been up to the expectations of the so-called \"decade of the brain\". Aware of these limitations, in this paper we carry out a historical and ethnopharmacological review of the classic psychedelics, from the 50's to the present -without ignoring their ancestral uses-, in order to highlight the political and cultural controversies that these molecules have raised in the field of Psychiatry. We hope to promote in the local environment an approach devoid of stigmas and that considers the therapeutic potential of these substances,\u0000with the ultimate goal of providing relief to severe mental illnesses that to this day continue to remain unanswered.</p>","PeriodicalId":75297,"journal":{"name":"Vertex (Buenos Aires, Argentina)","volume":"34 160, abr.-jun.","pages":"79-86"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10050691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Danger of Being Sane","authors":"Nicole M Moreno","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Book Review: El peligro de estar cuerda, by Rosa Montero</p>","PeriodicalId":75297,"journal":{"name":"Vertex (Buenos Aires, Argentina)","volume":"34 160, abr.-jun.","pages":"138-139"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10050695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tamara Chernoff, Bruno Kliger, Dante Hernán Venturini
{"title":"Psychedelic Experiences: Phenomenology, Therapeutic Potentials and Explanatory Models","authors":"Tamara Chernoff, Bruno Kliger, Dante Hernán Venturini","doi":"10.53680/vertex.v34i160.463","DOIUrl":"https://doi.org/10.53680/vertex.v34i160.463","url":null,"abstract":"<p><p>Traditional psychedelics, such as LSD, psilocybin, or DMT, are psychoactive compounds that exert their effects mainly through agonism over serotonergic receptors. In appropriate doses and contexts, they produce profound changes in the subjective experience, configuring altered states of consciousness that, upon reaching a critical point, involve the appearance of phenomena of mystical, transcendental, or ego dissolution experiences. These events are associated with diverse therapeutic effects in several mental conditions. Psychedelics are safe substances, with minimal risk of serious or long-lasting adverse effects and without addictive potential. Current evidence comes from systematic reviews and meta-analyses based on phase II clinical studies, with small groups of subjects, strict exclusion criteria, and difficulties in applying the double-blind methodology. Worldwide there is a growing number of clinical trials, which seek to promote the approval of psychedelic-assisted therapies as therapeutic tools in the coming years. In this bibliographic review, we will address the phenomenological characteristics of the psychedelic experience, its potential therapeutic uses, and the\u0000mechanisms that underlie them.</p>","PeriodicalId":75297,"journal":{"name":"Vertex (Buenos Aires, Argentina)","volume":"34 160, abr.-jun.","pages":"100-112"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9997419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Empathy as the axis of care. Rethinking Comprehensive Health Care Policies and Practices with a Gender Perspective","authors":"Mariela Verzero","doi":"10.53680/vertex.v34i160.465","DOIUrl":"https://doi.org/10.53680/vertex.v34i160.465","url":null,"abstract":"<p><p>This article arises from the work carried out in 2020 and 2021 as an interdisciplinary psychosocial team in a high complexity hospital in the town of Cañuelas, province of Buenos Aires, Argentina, during the COVID-19 pandemic, assisting people and their families in intensive care rooms. The proposal of this work aims to give a resignification to the practices of comprehensive health care for people, applying a gender and rights perspective to hospital practice. From this experience, the postulate of empathy as the central axis of care arises.</p>","PeriodicalId":75297,"journal":{"name":"Vertex (Buenos Aires, Argentina)","volume":"34 160, abr.-jun.","pages":"123-128"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9997421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mauro Damián Martini, Felipe Aníbal Gregalio, Fernando Javier Vázquez, María Lourdes Posadas, María Florencia Grande Ratti, Javier Alberto Pollán
{"title":"Prevalence of the use of antidepressants in patients with venous thromboembolism","authors":"Mauro Damián Martini, Felipe Aníbal Gregalio, Fernando Javier Vázquez, María Lourdes Posadas, María Florencia Grande Ratti, Javier Alberto Pollán","doi":"10.53680/vertex.v34i160.458","DOIUrl":"https://doi.org/10.53680/vertex.v34i160.458","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the prevalence of Antidepressant use in patients with a history of venous thromboembolism (VTE). Describe the patient's characteristics and which drugs are the most prescribed.</p><p><strong>Methods: </strong>A cross-sectional study involving a consecutive sample of patients included in the Registro de Enfermedad Tromboembólica (RIET) from the Hospital Italiano de Buenos Aires in a period between 01/01/2014 to 01/09/2018. All patients presented symptomatic VTE and confirmed diagnosis. Drugs considered included in this study were: Selective Serotonin Reuptake Inhibitors (SSRI), Dopamine and Norepinephrine Reuptake Inhibitors (NDRI), Serotonin and Norepinephrine Reuptake Inhibitors (SNRI) and Tricyclic antidepressants (TCA).</p><p><strong>Results: </strong>From a total of 2373 patients with VTE, 472 were active users of antidepressants, showing a prevalence of antidepressant use of 19.9% (CI 95%). The most frequently prescribed drugs by drug classification were: SSRI 83.9%, TCA 20.5%, ISRN 14.6%, and NDRI 2.5%. Patients presented a median age of 76 years, predominantly women (71.4%), with several comorbidities: 52.24% arterial hypertension, 37.29% overweight, and 34.75% history of smoking. Concerning relevant history, we observed: 29.03% active oncologic disease, 26.27% major surgery before the VTE, and 21.61% previous VTE.</p><p><strong>Conclusion: </strong>The prevalence of antidepressant use in patients with VTE is 19.9%, superior by far to that of the general population. Depression is a major cause of morbidity worldwide, and its prevalence is increasing over the years.</p>","PeriodicalId":75297,"journal":{"name":"Vertex (Buenos Aires, Argentina)","volume":"34 160, abr.-jun.","pages":"20-24"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9997423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The scientific character of psychoanalysis: Freud in the current discussion","authors":"Daniel Leserre","doi":"10.53680/vertex.v34i160.464","DOIUrl":"https://doi.org/10.53680/vertex.v34i160.464","url":null,"abstract":"<p><p>The discussion on the scientific character of psychoanalysis is continuous and multifaceted. Nowadays the extent and variety of the implied aspects in it is even increased. In this context this article presents for its analysis and assessment a reconsideration of Freud’s line of argument regarding the scientific character of psychoanalysis. Against a quite spread view that conceives Freud’s scientific perspective as a reflex of general traits of his time such as positivism, sustained by recent research on Freud this article proposes the reconsideration of Freud’s perspective in a more exhaustive and\u0000nuanced way and holds that it is based on a composed by integrated parts, unified and consistent line of argument maintained through all his work. The reconsideration of the design of Freud’s argument allows to hold that his own formulation is still fruitful and suitable for the present, particularly as it possibilitates, justifies and requires the connection of psychoanalysis to the development of knowledge.</p>","PeriodicalId":75297,"journal":{"name":"Vertex (Buenos Aires, Argentina)","volume":"34 160, abr.-jun.","pages":"113-122"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9999430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Are there verbal hallucinations in autism? Review from a historical and transparadigmatic perspective","authors":"Federico Pace, Georgina Callaghan","doi":"10.53680/vertex.v34i160.462","DOIUrl":"https://doi.org/10.53680/vertex.v34i160.462","url":null,"abstract":"<p><p>The differential diagnosis between autism and schizophrenia in childhood has been the subject of numerous controversies. Because verbal hallucinations could be one of the main clinical phenomena when establishing a differential diagnosis, the objective was to investigate the presence or absence of verbal hallucinations in autism. For this, a selective and unsystematic review of the current scientific evidence was carried out. Added to this, the phenomenon of hallucination, and mainly verbal hallucination, was conceptualized from a historical perspective; the relevance given to hallucinations\u0000in the delimitation of the mentioned nosographic constructs was broached; and verbal hallucinations in autism were analyzed comparing different paradigms, including contributions from psychoanalysis. We observe that from the side of scientific evidence it is not possible to state strong conclusions regarding the presence or absence of verbal hallucinations in autism. In turn, the historical review of the concept of verbal hallucination from classical psychiatry together with contributions from psychoanalysis, invite us to think that one of the differential characteristics between autism and psychosis is the absence of verbal hallucinations in the first diagnosis, and that if there were hallucinations in autism, these would present different qualities from those of psychosis. We consider it highly relevant to be able to establish this differentiation in the hallucinatory phenomenon in autism, not only in order to establish a differential diagnosis between the two conditions, but also because of the implications that this could have in pharmacotherapy.</p>","PeriodicalId":75297,"journal":{"name":"Vertex (Buenos Aires, Argentina)","volume":"34 160, abr.-jun.","pages":"87-99"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9999428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcelo Cetkovich-Bakmas, Andrea Abadi, Sebastián Camino, Gerardo García Bonetto, Luis Herbst, Eliana Marengo, Fernando Torrente, Tomás Maresca, Julián Bustin, Carlos Morra, Ricardo Corral, Daniel Sotelo, Sergio Strejilevich, Julián Pessio, Juan José Vilapriño, Manuel Vilapriño, Gustavo Vázquez, Alejo Corrales
{"title":"Third Argentine Consensus statement on management Bipolar Disorders. Section 2 B","authors":"Marcelo Cetkovich-Bakmas, Andrea Abadi, Sebastián Camino, Gerardo García Bonetto, Luis Herbst, Eliana Marengo, Fernando Torrente, Tomás Maresca, Julián Bustin, Carlos Morra, Ricardo Corral, Daniel Sotelo, Sergio Strejilevich, Julián Pessio, Juan José Vilapriño, Manuel Vilapriño, Gustavo Vázquez, Alejo Corrales","doi":"10.53680/vertex.v34i160.459","DOIUrl":"10.53680/vertex.v34i160.459","url":null,"abstract":"<p><p>This document constitutes the second section B of the Third Argentine Consensus on the Management of Bipolar Disorders, focused on synthesizing the most updated evidence on therapeutic approaches for adult patients. The scope of this section is to provide therapeutic recommendations for managing bipolar disorders in adults, (i) acute mania (ii) bipolar depression (iii) mixed stated (iv) suicidality and (vi) psychological interventions. In addition, the current manuscript outlines the assessment and management of side effects of pharmacotherapeutic treatments.</p>","PeriodicalId":75297,"journal":{"name":"Vertex (Buenos Aires, Argentina)","volume":"34 160, abr.-jun.","pages":"25-53"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10050693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Quality of Violence Risk Formulation and a Quasi-Forensic Mental Health Training Experiment","authors":"Débora Moyano, Alejandra Estrada, Arturo Klenner, Adolfo Méndez, Marlene Vidal Quinde, Jorge O Folino","doi":"10.53680/vertex.v34i160.457","DOIUrl":"https://doi.org/10.53680/vertex.v34i160.457","url":null,"abstract":"<p><strong>Objectives: </strong>The study was aimed at measuring the impact of training on forensic case formulation in mental health and to provide more evidence on the reliability of the TEC-F.</p><p><strong>Method: </strong>Nine psychiatrists and six psychologists from various Latin American countries participated in a quasi-pedagogical experiment. The quality of formulations was independently and blindly measured pre- and post-intervention with the TEC-F and the assignment of two standard vignettes was also randomly manipulated. Quality mean differences and instrument reliability indicators were calculated.</p><p><strong>Results: </strong>The values of intraclass correlation coefficients were 0.92; 0.94; 0.83; 0.93 and 0.95 and the values of Cronbach's alpha coefficient were 0.83; 0.94; 0.63; 0.77 and 0.93, for the dimensions transparency, specificity, communication, reasoning and for the total TEC-F respectively. The results of the 19-day test-retest were excellent. The mean TEC-F total quality pre-course was 31.4 and the mean post-course, 38.4 (p = 0.003 and p = 0.001 for group test and paired test respectively).</p><p><strong>Conclusions: </strong>The pedagogical intervention produced a significant improvement in the quality of the expert’s formulations. The study added evidence supporting the TEC-F reliability.</p>","PeriodicalId":75297,"journal":{"name":"Vertex (Buenos Aires, Argentina)","volume":"34 160, abr.-jun.","pages":"7-19"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10050688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}